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Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13

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Academic year: 2021

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Fig. 2 Expression of progeria and SMC markers in HGPS Δ 2-iPSC SMCs. a gRNA directs Cas9 nuclease against mutated exon 11 of LMNA gene, upstream the HGPS mutation, disrupting progerin, without altering lamin A and lamin C
Fig. 5 MMP13 inhibition signi fi cantly increases SMC number in aortic arch of Lmna G609G/G609G mice
Fig. 6 Proteins differentially expressed in the aortic arch at week 10 on wild-type and mutant ( Lmna G609G/G609G Mmp13 −/− and Lmna G609G/
Fig. 8 MMP13 expression in SMCs is triggered by an increase in heparan sulfate. a Cells were cultured under fl ow conditions for 4 days and the expression of heparan sulfate was evaluated by immuno fl uorescence

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