Plasma and memory B-cell kinetics in infants following a primary schedule of CRM 197-conjugated serogroup C meningococcal

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Article

Reference

Plasma and memory B-cell kinetics in infants following a primary schedule of CRM 197-conjugated serogroup C meningococcal

polysaccharide vaccine

KELLY, Dominic F, et al .

Abstract

The induction of persistent protective levels of pathogen-specific antibody is an important goal of immunization against childhood infections. However, antibody persistence is poor after immunization in infancy versus later in life. Serogroup C meningococci (MenC) are an important cause of bacteraemia and meningitis in children. The use of protein-polysaccharide conjugate vaccines against MenC has been associated with a significant decline in the incidence of invasive disease. However, vaccine effectiveness is negligible by more than 1 year after a three-dose priming series in infancy and corresponds to a rapid decline in antibody following an initial immune response. The cellular mechanisms underlying the generation of persistent antibody in this age group are unclear. An essential prelude to larger studies of peripheral blood B cells is an understanding of B-cell kinetics following immunization. We measured MenC- and diphtheria-specific plasma and memory B-cell kinetics in infants receiving a CRM(197) (cross-reactive material; mutant diphtheria toxoid)-conjugated MenC vaccine at 2, 3 and 4 months of age. Plasma cell [...]

KELLY, Dominic F, et al . Plasma and memory B-cell kinetics in infants following a primary schedule of CRM 197-conjugated serogroup C meningococcal polysaccharide vaccine.

Immunology , 2009, vol. 127, no. 1, p. 134-143

PMID : 19175802

DOI : 10.1111/j.1365-2567.2008.02934.x

Available at:

http://archive-ouverte.unige.ch/unige:151758

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The relationship between human effector and memory T cells measured by ex vivo and cultured ELISPOT following recent and distal priming

Stephen M. Todryk, Ansar A. Pathan, Sheila Keating, David W. Porter, Tamara Berthoud, Fiona Thompson, Paul Klener- man, Adrian V. S. Hill

In this article the following funding information was missing:

The study was supported by funding from the NIHR Oxford Biomedical Research Centre programme.

Reference

1 Todryk SM, Pathan AA, Keating S, Porter DW, Berthoud T, Thompson F, Klenerman P, Hill AVS. The relationship between human effector and memory T cells measured byex vivoand cultured ELISPOT following recent and distal priming.Immunology2009;128:83–91.