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Curriculum vitaePERSONAL INFORMATION
HUREAU-SABATER Christelle (French Citizen) – Orcid :
0000-0003-3339-0239
Date of birth: 27/08/1976; URL for web site:https://www.lcc-toulouse.fr/auteur59.html
EDUCATION2012 Habilitation degree in bio-inorganic chemistry, University Paul Sabatier, Toulouse, France 2003 PhD in coordination chemistry, Paris-Sud University, Orsay, France
2000 Molecular physical chemistry degree - Paris-Sud University, Orsay, France 2000 MSc in molecular chemistry in the Ecole Polytechnique, Palaiseau, France CURRENT POSITION(S)
Since 2015 Leader of the “Alzheimer and amyloids” team, Coordination Chemistry Laboratory (LCC), Toulouse - CNRS researcher director since 2017.
PREVIOUS POSITIONS
2016-2020 Co-leader of the BIOMAPS “team-project”, ITAV (Institute of advanced technology for life science) unit for a dedicated 4-years project (in parallel with regular team leader position at LCC).
“Synthesis and studies of amyloid-specific probes”
2007-2015 CNRS researcher in the Biological Chemistry Group headed by Prof. P. Faller (LCC).
“Role of metal ions in the amyloid cascade linked to Alzheimer’s disease"
2006-2007 Post-doctoral studies at the University Denis Diderot in Paris (France) with Drs. B. Limoges
"Electrochemical studies of a Laccase immobilized on gold electrodes"
2004-2006 Post-doctoral studies at the CEA Saclay (France) with Dr. S. Un.
"HF-EPR studies of Mn enzymes and chemical models"
2004 Post-doctoral studies at the University J. Fourier in Grenoble (France) with Prof. L. Charlet.
"Cu binding site to the fifth site of the Prion protein"
2003 PhD in Inorganic Chemistry, University of Orsay (France) Supervisor: Prof. J.-J. Girerd, Drs. G.
Blondin and E. Anxolabéhère-Mallart.
"Investigations of new PSII structural models electrochemically generated"
HONORS AND AWARDS
2017 (Co-)Chair of the ISABC-14 (International Symposium on Applied Bio-Inorganic Chemistry) 2017 Prize of excellence from the University P. Sabatier, Toulouse
2017 Access to research director grade (category A, top grade researcher, according to OECD's Frascati Manual 2015)
2016 EuroBIC medal award (European medal for Bio-Inorganic Chemist)
2015 Fellowship USIAS (University of Strasbourg - Institute for advanced studies) 2014 ERC "Starting Grant" aLzINK
2013 "Prix Junior" of the Coordination Chemistry Division from the French Chemical Society.
2013 Award from France-Alzheimer Foundation
2012 Bronze medal of the CNRS (Highest French distinction for young tenured scientist, medals in chemistry per year)
2011 - … CNRS Scientific Excellence Award (attributed three times for four years) 2011 Young Investigator Award from the Chemistry Institute of Toulouse.
ORGANISATION OF SCIENTIFIC MEETINGS
2017 (Co-)chair of the ISABC (International Symposium on Applied Bio-Inorganic Chemistry, Toulouse, France, 3 days, 300 participants)
2016 - 17 Chair of FrenchBic (French National Bio-Inorganic symposium, 2 days, 80 participants) 2016 Chair of the French Coordination days (two days, 120 participants)
2014 Member of local organising committee of GECOM-CONCOORD (5 days, 70 participants) INSTITUTIONAL RESPONSIBILITIES
2021 Co-applicant for a MSCA - Doctoral Networks Grant (to be submitted in November), “Metals and Health”, on behalf of the LCC
2021- … Elected vice-president (2021-23) and president (2023-27) of French Bioinorganic Chemistry community (300 members)
2016 - 17 Member of steering committee for Gender Equality in CNRS
2010 - … Organizer of Internal seminars of the team (3 days per year, with international speakers).
2010 - … Graduate Student Advisor, University Paul Sabatier, Toulouse, France.
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2011 - 18 Responsible of "sustainable development" and member of “budget” working groups, LCC.
REVIEWING ACTIVITIES AND COMMISSIONS OF TRUST
2018 - 19 Member of the French Research Agency (ANR – committee: biomedical innovation) 2018 - … Editorial member for Inorganics
2017 - … Evaluator for EuroBIC medal and LOREAL-UNSECO Grants (one evaluation every two years) 2011 - … Regular participation to recruitment committees for professor positions and assistant professor
positions (one per year).
2010 - … Reviewer of PhD and “habilitation” degree (in average: two defenses per year).
2010 - … Member of the scientific board of the FrenchBIC
2007 - … Active reviewer for scientific journals including top chemistry journals such as Angew. Chem.
Int. Ed.; Chem. Eur. J.... (about 30 articles referred per year, top 5% reviewer for Angew. Chem.
Int. Ed. in 2018)
2012 - … Evaluator for CEFIPRA, American Alzheimer Association, British, Polish, French and regional research councils (about two projects / year)
2012 - … Guest Editor for Coord. Chem. Rev. (metal ions in neurodegenerative dieses) MEMBERSHIPS OF SCIENTIFIC SOCIETIES
2016 - 17 Member of the American and British Chemical societies (ACS and RSC) 2013 - 17 Co-chair of the Midi-Pyrénées Section of the French Chemical Society.
2014 - 18 Member COST Action ECOSTBIO
2013 - … Co-chair of the Midi-Pyrénées Section of the "Chemistry and Society" association.
2013 - … Member of the Society of Biological Inorganic Chemistry
2012 - … Member of the French Association of Electronic Paramagnetic Resonance (ARPE) 2007 - … Member of the French Chemical Society
ACTIVE MAJOR COLLABORATIONS (in addition to those mentioned in the project) Prof. W. Bal, Wroclaw University, Poland (Investigations of Cu(II) binding to peptides);
Dr. S. Blanchard, Sorbonne University, France (POM to tune and probe peptides self-assembly) ; Dr. D. Crans, Colorado State University, U.S.A. (Kinetic studies of metal exchange between peptides);
Prof. P. Faller, University of Strasbourg, France (Shuttles to deliver Cu(II) intracellularly);
Dr. P. Genevaux, Universitry of Toulouse, France (Biological chaperones of amyloids formation);
Prof. N. Kulak, Freie Universität Berlin, Germany ([N,S] macrocycles to target Cu(I)/Cu(II));
Prof. S. Signorella, Instituto de Quimica Rosario, Argentina (Mn-based biomimetic complexes);
Dr. E. Jakab Toth, Molecular Biophysic Center, Orléans, France (Amyloid-selective MRI probes).
Publications 112 international peer-reviewed publications (including 3 book chapters): Acc. Chem. Res.
(1); Angew. Chem. Int. Ed. (5); Chem. Comm. (4); Chem. Soc. Rev. (2); Chem. Sci. (1); Chem. Eur. J. (16);
Inorg. Chem. (22); Redox Biology (1).
94 publications as independent researcher (without PhD or post-doc supervisors) +18 international conference proceedings referenced in the WoS database 53 publications as corresponding authors; 18 publications as first author
H-index: 40, and average citations: 37.7; citations: 5050 without self-citations: 4300 Invited conferences in international and national conferences
16 invitations in international conferences (6 as keynote and 3 as plenary) 9 in national conferences (as plenary) and 19 in universities
Brief description of research profile. During my doctoral studies, I focused my interests on coordination chemistry of Mn-based structural models of the water-oxidizing centre in the Photosystem II. After the major expertise in bioinorganic chemistry and related spectroscopies acquired during my training, I have gained more experience in research fields at the frontier between chemistry, biochemistry and advanced spectroscopy. In 2007, I joined the Coordination Chemistry Laboratory (LCC) as a tenured CNRS researcher. Since then, I have developed a main research theme on metal ions coordination to the amyloid-β peptide (Aβ) involved in Alzheimer's Disease. Recently, at the edges with funded projects, including aLzINK, my interest has shifted towards the complex process of Aβ self-assembly. My skills in physico-chemistry of peptides, the strong experience acquired in the studies of self-assembly and in-depth characterizations of peptide interactions with other biochemical partners (metal ions, polyphosphate) will be an asset for the success of ASPECT.
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TEN MAIN REGULAR PAPER PUBLICATIONS AS CORRESPONDING AUTHOR
1 Esmieu, C.; Balderrama-Martinez-Sotomayor, R.; Conte-Daban, A.; Iranzo, O.; Hureau, C.* "Unexpected Trends in Copper Removal from Aβ Peptide: When Less Ligand Is Better and Zn Helps" Inorg. Chem. 2021, 60, 1248-56, 10.1021/acs.inorgchem.0c03407.
2 Esmieu, C.; Ferrand, G.; Borghesani, V.; Hureau, C.* "Impact of N-Truncated Aβ Peptides on Cu- and Cu(Aβ)-Generated ROS: Cu(I) Matters!" Chem. Eur. J. 2021, 27, 1777-86, 10.1002/chem.202003949.
3 Stefaniak, E.; Atrian-Blasco, E.; Goch, W.; Sabater, L.; Hureau, C.;* Bal, W. "The Aggregation Pattern of Aβ1-40 is Altered by the Presence of N-Truncated Aβ4-40 and/or Cu(II) in a Similar Way through Ionic Interactions" Chem. Eur. J. 2021, 27, 2798-09, 10.1002/chem.202004484.
4 Gonzalez, P.; Bossak-Ahmad, K.; Vileno, B.; Wezynfeld, N. E.; El Khoury, Y.; Hellwig, P.; Hureau, C.;*
Bal, W.; Faller, P. "Triggering Cu-coordination change in Cu(ii)-Ala-His-His by external ligands" Chem.
Commun. 2019, 55, 8110-13, 10.1039/c9cc03174j.
5 Alies, B.; Borghesani, V.; Noël, S.; Sayen, S.; Guillon, E.; Testemale, D.; Faller, P.; Hureau, C.*
"Mutations of Histidine 13 to Arginine and Arginine 5 to Glycine Are Responsible for Different Coordination Sites of Zinc(II) to Human and Murine Peptides" Chem. Eur. J. 2018, 24, 14233-41, 10.1002/chem.201802759.
6 Cheignon, C.; Jones, M.; Atrian-Blasco, E.; Kieffer, I.; Faller, P.; Collin, F.; Hureau, C.* "Identification of key structural features of the elusive Cu-Aβ complex that generates ROS in Alzheimer's disease" Chem.
Sci. 2017, 8, 5107-18, 10.1039/c7sc00809k.
7 Conte-Daban, A.; Day, A.; Faller, P.; Hureau, C.* "How Zn can impede Cu detoxification by chelating agents in Alzheimer's disease: a proof-of-concept study" Dalton Trans. 2016, 45, 15671-8, DOI:
10.1039/c6dt02308h.
8 Alies, B.; Sasaki, I.; Proux, O.; Sayen, S.; Guillon, E.; Faller, P.; Hureau, C.* "Zn impacts Cu coordination to amyloid-beta, the Alzheimer's peptide, but not the ROS production and the associated cell toxicity" Chem.
Commun. 2013, 49, 1214-6, 10.1039/c2cc38236a.
9 Eury, H.; Bijani, C.; Faller, P.; Hureau, C.* "Copper(II) coordination to amyloid beta: murine versus human peptide" Angew. Chem. Int. Ed. 2011, 50, 901-5, 10.1002/anie.201005838.
10 Hureau, C.* Coppel, Y.; Dorlet, P.; Solari, P.-L.; Sayen, S.; Guillon, E.; Sabater, L.; Faller, P.
"Deprotonation of the Asp1-Ala2 peptide bond induces modification of the dynamic copper(II) environment in the Aβ peptide near physiological pH" Angew. Chem. Int. Ed. 2009, 48, 9522-5, 10.1002/anie.200904512.
SELECTED INVITED LECTURES IN INTERNATIONAL CONFERENCES
#“Probes of amyloids’formation and amyloid fibrils” IMBG 8th, 2019, France (keynote); #“POMs to counteract the effect of CuAβ interactions in the context of Alzheimer’s disease” ICBIC19, 2019, Interlaken, Suisse (keynote); #“Kinetics are crucial for designing efficient Copper chelators to fight against Alzheimer’s disease” SCF Meeting, 2018, Montpellier, France (keynote); #“Therapeutic approaches targeting Copper ions against Alzheimer’s disease” ISMEC, 2018, Firenze, Italy (PLENARY); #“Cu, Zn and A peptide: towards new therapeutic proof-of-concepts” ICBIC18, 2017, Florianopolis, Brazil. (keynote); #“Copper and Zinc as therapeutic players in Alzheimer's disease: with a little help from coordination chemistry” RICT53, 2017, Toulouse, France (keynote); #“Cu, Zn, A in Alzheimer’s disease: From fundamental insights to proof-of- principle studies for therapeutic purposes” Metals and Water 2nd edition, 2017, Jaca, Spain (PLENARY);
#"Bio-inorganic chemistry of Copper, Zinc and Aβ peptide in Alzheimer's disease" EuroBIC 13, 2016, Budapest, Hungary (PLENARY); #"Nitrogen ligands against Alzheimer's disease" 6th EuCheMS conference on N ligands, 2015, Beaune, France. (keynote)
SELECTED INVITED PLENARY LECTURES IN NATIONAL CONFERENCES
#“Cu-targeting ligands and chemical chaperones of the Aβ aggregation” Coordination Chemistry days, 2020;
#“Therapeutic approaches that target Cu ions and associated oxidative stress to combat Alzheimer’s disease”
Gecom-Concoord, 2018; “Cu and Zn in Alzheimer's: with a little help from coordination chemistry." Gecom- Concoord, 2016; #“How EPR reveals Cu coordination to flexible Aβ peptide", ARPE scientific day, 2014.
