D.4 Annexes Bibliographiques
Alvarez-Castelao, B., and Castano, J. G. (2005). Mechanism of direct degradation of IkappaBalpha by 20S proteasome. FEBS Lett 579, 4797-4802.
Alvarez, M., Rhodes, S. J., and Bidwell, J. P. (2003). Context-dependent transcription: all politics is local. Gene 313, 43-57.
Anderson, J. D., Lowary, P. T., and Widom, J. (2001). Effects of histone acetylation on the equilibrium accessibility of nucleosomal DNA target sites. J Mol Biol 307, 977-985.
Andrews, N. C. (1998). The NF-E2 transcription factor. Int J Biochem Cell Biol 30, 429-432.
Andrews, N. C., Erdjument-Bromage, H., Davidson, M. B., Tempst, P., and Orkin, S. H.
(1993). Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein. Nature 362, 722-728.
Angel, P., Imagawa, M., Chiu, R., Stein, B., Imbra, R. J., Rahmsdorf, H. J., Jonat, C., Herrlich, P., and Karin, M. (1987). Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell 49, 729-739.
Appeddu, P. A., and Shur, B. D. (1994). Molecular analysis of cell surface beta-1,4- galactosyltransferase function during cell migration. Proc Natl Acad Sci U S A 91, 2095- 2099.
Aravind, L., Anantharaman, V., Balaji, S., Babu, M. M., and Iyer, L. M. (2005). The many faces of the helix-turn-helix domain: transcription regulation and beyond. FEMS Microbiol Rev 29, 231-262.
Arber, S., Ladle, D. R., Lin, J. H., Frank, E., and Jessell, T. M. (2000). ETS gene Er81 controls the formation of functional connections between group Ia sensory afferents and motor neurons. Cell 101, 485-498.
Arias, J., Alberts, A. S., Brindle, P., Claret, F. X., Smeal, T., Karin, M., Feramisco, J., and Montminy, M. (1994). Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature 370, 226-229.
Arvand, A., and Denny, C. T. (2001). Biology of EWS/ETS fusions in Ewing's family tumors.
Oncogene 20, 5747-5754.
Ausio, J., Abbott, D. W., Wang, X., and Moore, S. C. (2001). Histone variants and histone modifications: a structural perspective. Biochem Cell Biol 79, 693-708.
Azizkhan, J. C., Jensen, D. E., Pierce, A. J., and Wade, M. (1993). Transcription from TATA- less promoters: dihydrofolate reductase as a model. Crit Rev Eukaryot Gene Expr 3, 229-254.
Baba, D., Maita, N., Jee, J. G., Uchimura, Y., Saitoh, H., Sugasawa, K., Hanaoka, F., Tochio, H., Hiroaki, H., and Shirakawa, M. (2006). Crystal structure of SUMO-3-modified thymine- DNA glycosylase. J Mol Biol 359, 137-147.
Baert, J. L., Beaudoin, C., Coutte, L., and de Launoit, Y. (2002). ERM Transactivation Is Up- regulated by the Repression of DNA Binding after the PKA Phosphorylation of a Consensus Site at the Edge of the ETS Domain. J Biol Chem 277, 1002-1012.
Baert, J. L., Beaudoin, C., Monte, D., Degerny, C., Mauen, S., and de Launoit, Y. (2006). The 26S proteasome system degrades the ERM transcription factor and regulates its transcription- enhancing activity. Oncogene.
Baert, J. L., Monte, D., Musgrove, E. A., Albagli, O., Sutherland, R. L., and de Launoit, Y.
(1997). Expression of the PEA3 group of ETS-related transcription factors in human breast- cancer cells. Int J Cancer 70, 590-597.
Bailly, R. A., Bosselut, R., Zucman, J., Cormier, F., Delattre, O., Roussel, M., Thomas, G., and Ghysdael, J. (1994). DNA-binding and transcriptional activation properties of the EWS- FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma. Mol Cell Biol 14, 3230-3241.
Bannister, A. J., Schneider, R., and Kouzarides, T. (2002). Histone methylation: dynamic or static? Cell 109, 801-806.
Batchelor, A. H., Piper, D. E., de la Brousse, F. C., McKnight, S. L., and Wolberger, C.
(1998). The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA. Science 279, 1037-1041.
Benz, C. C., O'Hagan, R. C., Richter, B., Scott, G. K., Chang, C. H., Xiong, X., Chew, K., Ljung, B. M., Edgerton, S., Thor, A., and Hassell, J. A. (1997). HER2/Neu and the Ets transcription activator PEA3 are coordinately upregulated in human breast cancer. Oncogene 15, 1513-1525.
Bestor, T. H. (1988). Cloning of a mammalian DNA methyltransferase. Gene 74, 9-12.
Bhattacharya, G., Lee, L., Reddy, E. S., and Rao, V. N. (1993). Transcriptional activation domains of elk-1, delta elk-1 and SAP-1 proteins. Oncogene 8, 3459-3464.
Bieche, I., Lazar, V., Nogues, C., Poynard, T., Giovangrandi, Y., Bellet, D., Lidereau, R., and Vidaud, M. (1998). Prognostic value of chorionic gonadotropin beta gene transcripts in human breast carcinoma. Clin Cancer Res 4, 671-676.
Bieche, I., Tozlu, S., Girault, I., Onody, P., Driouch, K., Vidaud, M., and Lidereau, R. (2004).
Expression of PEA3/E1AF/ETV4, an Ets-related transcription factor, in breast tumors:
positive links to MMP2, NRG1 and CGB expression. Carcinogenesis 25, 405-411.
Bielska, A. A., and Zondlo, N. J. (2006). Hyperphosphorylation of tau induces local polyproline II helix. Biochemistry 45, 5527-5537.
Blok, L. J., de Ruiter, P. E., and Brinkmann, A. O. (1998). Forskolin-induced dephosphorylation of the androgen receptor impairs ligand binding. Biochemistry 37, 3850- 3857.
Boedefeld, W. M., 2nd, Soong, R., Weiss, H., Diasio, R. B., Urist, M. M., Bland, K. I., and Heslin, M. J. (2005). E1A-F is overexpressed early in human colorectal neoplasia and associated with cyclooxygenase-2 and matrix metalloproteinase-7. Mol Carcinog 43, 13-17.
Bojovic, B. B., and Hassell, J. A. (2001). The PEA3 Ets transcription factor comprises multiple domains that regulate transactivation and DNA binding. J Biol Chem 276, 4509- 4521.
Bosc, D. G., Goueli, B. S., and Janknecht, R. (2001). HER2/Neu-mediated activation of the ETS transcription factor ER81 and its target gene MMP-1. Oncogene 20, 6215-6224.
Boulanger, J., Vezina, A., Mongrain, S., Boudreau, F., Perreault, N., Auclair, B. A., Laine, J., Asselin, C., and Rivard, N. (2005). Cdk2-dependent phosphorylation of homeobox transcription factor CDX2 regulates its nuclear translocation and proteasome-mediated degradation in human intestinal epithelial cells. J Biol Chem 280, 18095-18107.
Boulukos, K. E., Pognonec, P., Begue, A., Galibert, F., Gesquiere, J. C., Stehelin, D., and Ghysdael, J. (1988). Identification in chickens of an evolutionarily conserved cellular ets-2 gene (c-ets-2) encoding nuclear proteins related to the products of the c-ets proto-oncogene.
Embo J 7, 697-705.
Boulukos, K. E., Pognonec, P., Rabault, B., Begue, A., and Ghysdael, J. (1989). Definition of an Ets1 protein domain required for nuclear localization in cells and DNA-binding activity in vitro. Mol Cell Biol 9, 5718-5721.
Boulukos, K. E., Pognonec, P., Sariban, E., Bailly, M., Lagrou, C., and Ghysdael, J. (1990).
Rapid and transient expression of Ets2 in mature macrophages following stimulation with cMGF, LPS, and PKC activators. Genes Dev 4, 401-409.
Brown, L. A., Amores, A., Schilling, T. F., Jowett, T., Baert, J. L., de Launoit, Y., and Sharrocks, A. D. (1998). Molecular characterization of the zebrafish PEA3 ETS-domain transcription factor. Oncogene 17, 93-104.
Brown, T. A., and McKnight, S. L. (1992). Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins. Genes Dev 6, 2502- 2512.
Buck, M. (1998). Trifluoroethanol and colleagues: cosolvents come of age. Recent studies with peptides and proteins. Q Rev Biophys 31, 297-355.
Buratowski, S., and Zhou, H. (1992). Transcription factor IID mutants defective for interaction with transcription factor IIA. Science 255, 1130-1132.
Cao, R., Wang, L., Wang, H., Xia, L., Erdjument-Bromage, H., Tempst, P., Jones, R. S., and Zhang, Y. (2002). Role of histone H3 lysine 27 methylation in Polycomb-group silencing.
Science 298, 1039-1043.
Chakrabarti, S. R., and Nucifora, G. (1999). The leukemia-associated gene TEL encodes a transcription repressor which associates with SMRT and mSin3A. Biochem Biophys Res Commun 264, 871-877.
Chen, C., Ouyang, W., Grigura, V., Zhou, Q., Carnes, K., Lim, H., Zhao, G. Q., Arber, S., Kurpios, N., Murphy, T. L., et al. (2005). ERM is required for transcriptional control of the spermatogonial stem cell niche. Nature 436, 1030-1034.
Chen, J. H., Vercamer, C., Li, Z., Paulin, D., Vandenbunder, B., and Stehelin, D. (1996).
PEA3 transactivates vimentin promoter in mammary epithelial and tumor cells. Oncogene 13, 1667-1675.
Chotteau-Lelievre, A., Desbiens, X., Pelczar, H., Defossez, P. A., and de Launoit, Y. (1997).
Differential expression patterns of the PEA3 group transcription factors through murine embryonic development. Oncogene 15, 937-952.
Chotteau-Lelievre, A., Dolle, P., Peronne, V., Coutte, L., de Launoit, Y., and Desbiens, X.
(2001). Expression patterns of the Ets transcription factors from the PEA3 group during early stages of mouse development. Mech Dev 108, 191-195.
Chotteau-Lelievre, A., Montesano, R., Soriano, J., Soulie, P., Desbiens, X., and de Launoit, Y. (2003). PEA3 transcription factors are expressed in tissues undergoing branching morphogenesis and promote formation of duct-like structures by mammary epithelial cells in vitro. Dev Biol 259, 241-257.
Chotteau-Lelievre, A., Revillion, F., Lhotellier, V., Hornez, L., Desbiens, X., Cabaret, V., de Launoit, Y., and Peyrat, J. P. (2004). Prognostic value of ERM gene expression in human primary breast cancers. Clin Cancer Res 10, 7297-7303.
Conaway, R. C., Brower, C. S., and Conaway, J. W. (2002). Emerging roles of ubiquitin in transcription regulation. Science 296, 1254-1258.
Courey, A. J., Holtzman, D. A., Jackson, S. P., and Tjian, R. (1989). Synergistic activation by the glutamine-rich domains of human transcription factor Sp1. Cell 59, 827-836.
Cousins, D. J., Lee, T. H., and Staynov, D. Z. (2002). Cytokine coexpression during human Th1/Th2 cell differentiation: direct evidence for coordinated expression of Th2 cytokines. J Immunol 169, 2498-2506.
Coutte, L. (1998). Caractérisation et étude du rôle du facteur de transcription ER81. Thèse de Doctorat, Université des Sciences et technologie de Lille.
Coutte, L., Monte, D., Baert, J., and de Launoit, Y. (1999a). Genomic organization of the human e1af gene,a member of Ets transcription factors. Gene 240, 201-207.
Coutte, L., Monte, D., Imai, K., Pouilly, L., Dewitte, F., Vidaud, M., Adamski, J., Baert, J. L., and de Launoit, Y. (1999b). Characterization of the human and mouse ETV1/ER81 transcription factor genes: role of the two alternatively spliced isoforms in the human.
Oncogene 18, 6278-6286.
Cowley, D. O., and Graves, B. J. (2000). Phosphorylation represses Ets-1 DNA binding by reinforcing autoinhibition. Genes Dev 14, 366-376.
Crawford, H. C., Fingleton, B., Gustavson, M. D., Kurpios, N., Wagenaar, R. A., Hassell, J.
A., and Matrisian, L. M. (2001). The PEA3 subfamily of Ets transcription factors synergizes with beta-catenin-LEF-1 to activate matrilysin transcription in intestinal tumors. Mol Cell Biol 21, 1370-1383.
Cuthbert, G. L., Daujat, S., Snowden, A. W., Erdjument-Bromage, H., Hagiwara, T., Yamada, M., Schneider, R., Gregory, P. D., Tempst, P., Bannister, A. J., and Kouzarides, T. (2004).
Histone deimination antagonizes arginine methylation. Cell 118, 545-553.
Daniel, J. A., Pray-Grant, M. G., and Grant, P. A. (2005). Effector proteins for methylated histones: an expanding family. Cell Cycle 4, 919-926.
Davidson, B., Goldberg, I., Gotlieb, W. H., Kopolovic, J., Ben-Baruch, G., and Reich, R.
(2003). PEA3 is the second Ets family transcription factor involved in tumor progression in ovarian carcinoma. Clin Cancer Res 9, 1412-1419.
Davidson, B., Goldberg, I., Tell, L., Vigdorchik, S., Baekelandt, M., Berner, A., Kristensen, G. B., Reich, R., and Kopolovic, J. (2004). The clinical role of the PEA3 transcription factor in ovarian and breast carcinoma in effusions. Clin Exp Metastasis 21, 191-199.
de Jongh, H. H., Goormaghtigh, E., and Ruysschaert, J. M. (1996). The different molar absorptivities of the secondary structure types in the amide I region: an attenuated total reflection infrared study on globular proteins. Anal Biochem 242, 95-103.
de Launoit, Y., Audette, M., Pelczar, H., Plaza, S., and Baert, J. L. (1998). The transcription of the intercellular adhesion molecule-1 is regulated by Ets transcription factors. Oncogene 16, 2065-2073.
de Launoit, Y., Baert, J. L., Chotteau-Lelievre, A., Monte, D., Coutte, L., Mauen, S., Firlej, V., Degerny, C., and Verreman, K. (2006). The Ets transcription factors of the PEA3 group:
Transcriptional regulators in metastasis. Biochim Biophys Acta.
de Launoit, Y., Baert, J. L., Chotteau, A., Monte, D., Defossez, P. A., Coutte, L., Pelczar, H., and Leenders, F. (1997). Structure-function relationships of the PEA3 group of Ets-related transcription factors. Biochem Mol Med 61, 127-135.
Defossez, P. A., Baert, J. L., Monnot, M., and de Launoit, Y. (1997). The ETS family member ERM contains an alpha-helical acidic activation domain that contacts TAFII60. Nucleic Acids Res 25, 4455-4463.
Degerny, C., Monte, D., Beaudoin, C., Jaffray, E., Portois, L., Hay, R. T., de Launoit, Y., and Baert, J. L. (2005). SUMO modification of the Ets-related transcription factor ERM inhibits its transcriptional activity. J Biol Chem 280, 24330-24338.
Degnan, B. M., Degnan, S. M., Naganuma, T., and Morse, D. E. (1993). The ets multigene family is conserved throughout the Metazoa. Nucleic Acids Res 21, 3479-3484.
Delattre, O., Zucman, J., Plougastel, B., Desmaze, C., Melot, T., Peter, M., Kovar, H., Joubert, I., de Jong, P., Rouleau, G., and et al. (1992). Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Nature 359, 162-165.
Dempsey, E. C., Newton, A. C., Mochly-Rosen, D., Fields, A. P., Reyland, M. E., Insel, P.
A., and Messing, R. O. (2000). Protein kinase C isozymes and the regulation of diverse cell responses. Am J Physiol Lung Cell Mol Physiol 279, L429-438.
Denu, J. M. (2005). The Sir 2 family of protein deacetylases. Curr Opin Chem Biol 9, 431- 440.
Ding, F., LaRocque, J. J., and Dokholyan, N. V. (2005). Direct observation of protein folding, aggregation, and a prion-like conformational conversion. J Biol Chem 280, 40235-40240.
Dittmer, J. (2003). The biology of the Ets1 proto-oncogene. Mol Cancer 2, 29.
Dittmer, J., and Nordheim, A. (1998). Ets transcription factors and human disease. Biochim Biophys Acta 1377, F1-11.
Donaldson, L. W., Petersen, J. M., Graves, B. J., and McIntosh, L. P. (1994). Secondary structure of the ETS domain places murine Ets-1 in the superfamily of winged helix-turn- helix DNA-binding proteins. Biochemistry 33, 13509-13516.
Donaldson, L. W., Petersen, J. M., Graves, B. J., and McIntosh, L. P. (1996). Solution structure of the ETS domain from murine Ets-1: a winged helix-turn-helix DNA binding motif. Embo J 15, 125-134.
Dover, J., Schneider, J., Tawiah-Boateng, M. A., Wood, A., Dean, K., Johnston, M., and Shilatifard, A. (2002). Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6. J Biol Chem 277, 28368-28371.
Dowdy, S. C., Mariani, A., and Janknecht, R. (2003). HER2/Neu- and TAK1-mediated up- regulation of the transforming growth factor beta inhibitor Smad7 via the ETS protein ER81. J Biol Chem 278, 44377-44384.
Duhr, S., Torres-Montaner, A., Astola, A., Garcia-Cozar, F. J., Pendon, C., Bolivar, J., and Valdivia, M. M. (2001). Molecular analysis of the 5' region of human ribosomal transcription factor UBF. DNA Seq 12, 267-272.
Edwards, J., and Bartlett, J. M. (2005). The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 1: Modifications to the androgen receptor. BJU Int 95, 1320-1326.
Eferl, R., and Wagner, E. F. (2003). AP-1: a double-edged sword in tumorigenesis. Nat Rev Cancer 3, 859-868.
El-Tanani, M., Platt-Higgins, A., Rudland, P. S., and Campbell, F. C. (2004). Ets gene PEA3 cooperates with beta-catenin-Lef-1 and c-Jun in regulation of osteopontin transcription. J Biol Chem 279, 20794-20806.
Evans, R. M. (1988). The steroid and thyroid hormone receptor superfamily. Science 240, 889-895.
Firlej, V., Bocquet, B., Desbiens, X., de Launoit, Y., and Chotteau-Lelievre, A. (2005). Pea3 transcription factor cooperates with USF-1 in regulation of the murine bax transcription without binding to an Ets-binding site. J Biol Chem 280, 887-898.
Fischle, W., Dequiedt, F., Fillion, M., Hendzel, M. J., Voelter, W., and Verdin, E. (2001).
Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo. J Biol Chem 276, 35826-35835.
Forneris, F., Binda, C., Vanoni, M. A., Battaglioli, E., and Mattevi, A. (2005). Human histone demethylase LSD1 reads the histone code. J Biol Chem 280, 41360-41365.
Friedman, L. S., Ostermeyer, E. A., Lynch, E. D., Szabo, C. I., Anderson, L. A., Dowd, P., Lee, M. K., Rowell, S. E., Boyd, J., and King, M. C. (1994). The search for BRCA1. Cancer Res 54, 6374-6382.
Fuchs, B., Inwards, C., Scully, S. P., and Janknecht, R. (2004). hTERT Is highly expressed in Ewing's sarcoma and activated by EWS-ETS oncoproteins. Clin Orthop Relat Res, 64-68.
Fuchs, B., Inwards, C. Y., and Janknecht, R. (2003). Upregulation of the matrix metalloproteinase-1 gene by the Ewing's sarcoma associated EWS-ER81 and EWS-Fli-1 oncoproteins, c-Jun and p300. FEBS Lett 553, 104-108.
Fuks, F. (2003). [DNA methyltransferases: from chromatin remodeling to cancer]. Med Sci (Paris) 19, 477-480.
Fuks, F. (2005). DNA methylation and histone modifications: teaming up to silence genes.
Curr Opin Genet Dev 15, 490-495.
Fuks, F., Burgers, W. A., Godin, N., Kasai, M., and Kouzarides, T. (2001). Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription. Embo J 20, 2536-2544.
Funaoka, K., Shindoh, M., Yoshida, K., Hanzawa, M., Hida, K., Nishikata, S., Totsuka, Y., and Fujinaga, K. (1997). Activation of the p21(Waf1/Cip1) promoter by the ets oncogene family transcription factor E1AF. Biochem Biophys Res Commun 236, 79-82.
Galang, C. K., Muller, W. J., Foos, G., Oshima, R. G., and Hauser, C. A. (2004). Changes in the expression of many Ets family transcription factors and of potential target genes in normal mammary tissue and tumors. J Biol Chem 279, 11281-11292.
Gallant, S., and Gilkeson, G. (2006). ETS transcription factors and regulation of immunity.
Arch Immunol Ther Exp (Warsz) 54, 149-163.
Gao, L., Cueto, M. A., Asselbergs, F., and Atadja, P. (2002). Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family. J Biol Chem 277, 25748-25755.
Garvie, C. W., Pufall, M. A., Graves, B. J., and Wolberger, C. (2002). Structural analysis of the autoinhibition of Ets-1 and its role in protein partnerships. J Biol Chem 277, 45529- 45536.
Gegonne, A., Leprince, D., Duterque-Coquillaud, M., Vandenbunder, B., Flourens, A., Ghysdael, J., Debuire, B., and Stehelin, D. (1987). Multiple domains for the chicken cellular sequences homologous to the v-ets oncogene of the E26 retrovirus. Mol Cell Biol 7, 806-812.
Geiger, J. H., Hahn, S., Lee, S., and Sigler, P. B. (1996). Crystal structure of the yeast TFIIA/TBP/DNA complex. Science 272, 830-836.
Gill, G. (2003). Post-translational modification by the small ubiquitin-related modifier SUMO has big effects on transcription factor activity. Curr Opin Genet Dev 13, 108-113.
Gill, G. (2004). SUMO and ubiquitin in the nucleus: different functions, similar mechanisms?
Genes Dev 18, 2046-2059.
Girdwood, D., Bumpass, D., Vaughan, O. A., Thain, A., Anderson, L. A., Snowden, A. W., Garcia-Wilson, E., Perkins, N. D., and Hay, R. T. (2003). P300 transcriptional repression is mediated by SUMO modification. Mol Cell 11, 1043-1054.
Glozak, M. A., Sengupta, N., Zhang, X., and Seto, E. (2005). Acetylation and deacetylation of non-histone proteins. Gene 363, 15-23.
Gocke, C. B., Yu, H., and Kang, J. (2005). Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates. J Biol Chem 280, 5004-5012.
Goel, A., and Janknecht, R. (2003). Acetylation-mediated transcriptional activation of the ETS protein ER81 by p300, P/CAF, and HER2/Neu. Mol Cell Biol 23, 6243-6254.
Goodson, M. L., Hong, Y., Rogers, R., Matunis, M. J., Park-Sarge, O. K., and Sarge, K. D.
(2001). Sumo-1 modification regulates the DNA binding activity of heat shock transcription factor 2, a promyelocytic leukemia nuclear body associated transcription factor. J Biol Chem 276, 18513-18518.
Goueli, B. S., and Janknecht, R. (2004). Upregulation of the Catalytic Telomerase Subunit by the Transcription Factor ER81 and Oncogenic HER2/Neu, Ras, or Raf. Mol Cell Biol 24, 25- 35.
Graf, T., McNagny, K., Brady, G., and Frampton, J. (1992). Chicken "erythroid" cells transformed by the Gag-Myb-Ets-encoding E26 leukemia virus are multipotent. Cell 70, 201- 213.
Graves, B. J., and Petersen, J. M. (1998). Specificity within the ets family of transcription factors. Adv Cancer Res 75, 1-55.
Green, S., and Chambon, P. (1988). Nuclear receptors enhance our understanding of transcription regulation. Trends Genet 4, 309-314.
Gross, I., Lhermitte, B., Domon-Dell, C., Duluc, I., Martin, E., Gaiddon, C., Kedinger, M., and Freund, J. N. (2005). Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation. Oncogene 24, 7955-7963.
Gu, W., and Roeder, R. G. (1997). Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90, 595-606.
Guenther, M. G., Barak, O., and Lazar, M. A. (2001). The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3. Mol Cell Biol 21, 6091-6101.
Guerra-Vladusic, F. K., Vladusic, E. A., Tsai, M. S., and Lupu, R. (2001). Signaling molecules implicated in heregulin induction of growth arrest and apoptosis. Oncol Rep 8, 1203-1214.
Guo, R. J., Suh, E. R., and Lynch, J. P. (2004). The role of Cdx proteins in intestinal development and cancer. Cancer Biol Ther 3, 593-601.
Haase, G., Dessaud, E., Garces, A., de Bovis, B., Birling, M., Filippi, P., Schmalbruch, H., Arber, S., and deLapeyriere, O. (2002). GDNF acts through PEA3 to regulate cell body positioning and muscle innervation of specific motor neuron pools. Neuron 35, 893-905.
Habelhah, H., Okada, F., Kobayashi, M., Nakai, K., Choi, S., Hamada, J., Moriuchi, T., Kaya, M., Yoshida, K., Fujinaga, K., and Hosokawa, M. (1999). Increased E1AF expression in mouse fibrosarcoma promotes metastasis through induction of MT1-MMP expression.
Oncogene 18, 1771-1776.
Hakuma, N., Kinoshita, I., Shimizu, Y., Yamazaki, K., Yoshida, K., Nishimura, M., and Dosaka-Akita, H. (2005). E1AF/PEA3 activates the Rho/Rho-associated kinase pathway to increase the malignancy potential of non-small-cell lung cancer cells. Cancer Res 65, 10776- 10782.
Hampsey, M. (1998). Molecular genetics of the RNA polymerase II general transcriptional machinery. Microbiol Mol Biol Rev 62, 465-503.
Hanna-Rose, W., and Hansen, U. (1996). Active repression mechanisms of eukaryotic transcription repressors. Trends Genet 12, 229-234.
Hanzawa, M., Shindoh, M., Higashino, F., Yasuda, M., Inoue, N., Hida, K., Ono, M., Kohgo, T., Nakamura, M., Notani, K., et al. (2000). Hepatocyte growth factor upregulates E1AF that induces oral squamous cell carcinoma cell invasion by activating matrix metalloproteinase genes. Carcinogenesis 21, 1079-1085.
Hart, A. H., Reventar, R., and Bernstein, A. (2000). Genetic analysis of ETS genes in C.
elegans. Oncogene 19, 6400-6408.
Hassig, C. A., Tong, J. K., Fleischer, T. C., Owa, T., Grable, P. G., Ayer, D. E., and Schreiber, S. L. (1998). A role for histone deacetylase activity in HDAC1-mediated transcriptional repression. Proc Natl Acad Sci U S A 95, 3519-3524.
Hida, K., Shindoh, M., Yasuda, M., Hanzawa, M., Funaoka, K., Kohgo, T., Amemiya, A., Totsuka, Y., Yoshida, K., and Fujinaga, K. (1997a). Antisense E1AF transfection restrains oral cancer invasion by reducing matrix metalloproteinase activities. Am J Pathol 150, 2125- 2132.
Hida, K., Shindoh, M., Yoshida, K., Kudoh, A., Furaoka, K., Kohgo, T., Fujinaga, K., and Totsuka, Y. (1997b). Expression of E1AF, an ets-family transcription factor, is correlated with the invasive phenotype of oral squamous cell carcinoma. Oral Oncol 33, 426-430.
Higashino, F., Yoshida, K., Fujinaga, Y., Kamio, K., and Fujinaga, K. (1993). Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein: a new human member of the ets oncogene family. Nucleic Acids Res 21, 547-553.
Higashino, F., Yoshida, K., Noumi, T., Seiki, M., and Fujinaga, K. (1995). Ets-related protein E1A-F can activate three different matrix metalloproteinase gene promoters. Oncogene 10, 1461-1463.
Hiroumi, H., Dosaka-Akita, H., Yoshida, K., Shindoh, M., Ohbuchi, T., Fujinaga, K., and Nishimura, M. (2001). Expression of E1AF/PEA3, an Ets-related transcription factor in human non-small-cell lung cancers: its relevance in cell motility and invasion. Int J Cancer 93, 786-791.
Holmstrom, S., Van Antwerp, M. E., and Iniguez-Lluhi, J. A. (2003). Direct and distinguishable inhibitory roles for SUMO isoforms in the control of transcriptional synergy.
Proc Natl Acad Sci U S A 100, 15758-15763.
Hong, Y., Rogers, R., Matunis, M. J., Mayhew, C. N., Goodson, M. L., Park-Sarge, O. K., and Sarge, K. D. (2001). Regulation of heat shock transcription factor 1 by stress-induced SUMO-1 modification. J Biol Chem 276, 40263-40267.
Horiuchi, S., Yamamoto, H., Min, Y., Adachi, Y., Itoh, F., and Imai, K. (2003). Association of ets-related transcriptional factor E1AF expression with tumour progression and overexpression of MMP-1 and matrilysin in human colorectal cancer. J Pathol 200, 568-576.
Horton, H. R. (2006). Principles of biochemistry, 4th edn (Upper Saddle River, N.J., Pearson Prentice Hall).
Houde, M., Laprise, P., Jean, D., Blais, M., Asselin, C., and Rivard, N. (2001). Intestinal epithelial cell differentiation involves activation of p38 mitogen-activated protein kinase that regulates the homeobox transcription factor CDX2. J Biol Chem 276, 21885-21894.
Howe, L. R., Crawford, H. C., Subbaramaiah, K., Hassell, J. A., Dannenberg, A. J., and Brown, A. M. (2001). PEA3 is up-regulated in response to Wnt1 and activates the expression of cyclooxygenase-2. J Biol Chem 276, 20108-20115.
Hsu, T., and Schulz, R. A. (2000). Sequence and functional properties of Ets genes in the model organism Drosophila. Oncogene 19, 6409-6416.
Huang, E. Y., Zhang, J., Miska, E. A., Guenther, M. G., Kouzarides, T., and Lazar, M. A.
(2000). Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3- independent repression pathway. Genes Dev 14, 45-54.
Humbert, O., Achour, I., Lautier, D., Laurent, G., and Salles, B. (2003). hMSH2 expression is driven by AP1-dependent regulation through phorbol-ester exposure. Nucleic Acids Res 31, 5627-5634.
Hung, M. C., and Wang, S. C. (2000). Suppressing HER2/neu-mediated cell transformation by transcriptional repressors. Breast Dis 11, 133-144.
Iguchi, A., Kitajima, I., Yamakuchi, M., Ueno, S., Aikou, T., Kubo, T., Matsushima, K., Mukaida, N., and Maruyama, I. (2000). PEA3 and AP-1 are required for constitutive IL-8 gene expression in hepatoma cells. Biochem Biophys Res Commun 279, 166-171.
Imhof, A., Yang, X. J., Ogryzko, V. V., Nakatani, Y., Wolffe, A. P., and Ge, H. (1997).
Acetylation of general transcription factors by histone acetyltransferases. Curr Biol 7, 689- 692.
Iniguez-Lluhi, J. A., and Pearce, D. (2000). A common motif within the negative regulatory regions of multiple factors inhibits their transcriptional synergy. Mol Cell Biol 20, 6040-6050.
Ishida, S., Higashino, F., Aoyagi, M., Takahashi, A., Suzuki, T., Shindoh, M., Fujinaga, K., and Yoshida, K. (2006). Genomic structure and promoter activity of the E1AF gene, a member of the ETS oncogene family. Biochem Biophys Res Commun 339, 325-330.
Isobe, M., Yamagishi, F., Yoshida, K., Higashino, F., and Fujinaga, K. (1995). Assignment of the ets-related transcription factor E1A-F gene (ETV4) to human chromosome region 17q21.
Genomics 28, 357-359.
Izumiyama, Y., Ohiro, Y., Higashino, F., Yoshida, K., Taguchi, K., Todo, S., Kohgo, T., Totsuka, Y., and Shindoh, M. (2005). E1AF expression is closely correlated with malignant phenotype of tongue squamous cell carcinoma through activation of MT1-MMP gene promoters. Oncol Rep 13, 715-720.
Janknecht, R. (1996). Analysis of the ERK-stimulated ETS transcription factor ER81. Mol Cell Biol 16, 1550-1556.
Janknecht, R. (2001). Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase 2. J Biol Chem 276, 41856-41861.
Janknecht, R. (2005). EWS-ETS oncoproteins: the linchpins of Ewing tumors. Gene 363, 1- 14.
Janknecht, R., Monte, D., Baert, J. L., and de Launoit, Y. (1996). The ETS-related transcription factor ERM is a nuclear target of signaling cascades involving MAPK and PKA.
Oncogene 13, 1745-1754.
Jeon, I. S., Davis, J. N., Braun, B. S., Sublett, J. E., Roussel, M. F., Denny, C. T., and Shapiro, D. N. (1995). A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1. Oncogene 10, 1229-1234.
Jimenez, G., Guichet, A., Ephrussi, A., and Casanova, J. (2000). Relief of gene repression by torso RTK signaling: role of capicua in Drosophila terminal and dorsoventral patterning.
Genes Dev 14, 224-231.
Jones, P. L., Veenstra, G. J., Wade, P. A., Vermaak, D., Kass, S. U., Landsberger, N., Strouboulis, J., and Wolffe, A. P. (1998). Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat Genet 19, 187-191.
Jones, S. (2004). An overview of the basic helix-loop-helix proteins. Genome Biol 5, 226.
Jousset, C., Carron, C., Boureux, A., Quang, C. T., Oury, C., Dusanter-Fourt, I., Charon, M., Levin, J., Bernard, O., and Ghysdael, J. (1997). A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein. Embo J 16, 69-82.
Kamio, T., Toki, T., Kanezaki, R., Sasaki, S., Tandai, S., Terui, K., Ikebe, D., Igarashi, K., and Ito, E. (2003). B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs. Blood 102, 3317-3322.
Kaneko, Y., Yoshida, K., Handa, M., Toyoda, Y., Nishihira, H., Tanaka, Y., Sasaki, Y., Ishida, S., Higashino, F., and Fujinaga, K. (1996). Fusion of an ETS-family gene, EIAF, to EWS by t(17;22)(q12;q12) chromosome translocation in an undifferentiated sarcoma of infancy. Genes Chromosomes Cancer 15, 115-121.
Kao, H. Y., Downes, M., Ordentlich, P., and Evans, R. M. (2000). Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression.
Genes Dev 14, 55-66.
Karim, F. D., Urness, L. D., Thummel, C. S., Klemsz, M. J., McKercher, S. R., Celada, A., Van Beveren, C., Maki, R. A., Gunther, C. V., Nye, J. A., and et al. (1990). The ETS-domain:
a new DNA-binding motif that recognizes a purine-rich core DNA sequence. Genes Dev 4, 1451-1453.
Kawamura-Saito, M., Yamazaki, Y., Kaneko, K., Kawaguchi, N., Kanda, H., Mukai, H., Gotoh, T., Motoi, T., Fukayama, M., Aburatani, H., et al. (2006). Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation. Hum Mol Genet 15, 2125-2137.
Kaya, M., Yoshida, K., Higashino, F., Mitaka, T., Ishii, S., and Fujinaga, K. (1996). A single ets-related transcription factor, E1AF, confers invasive phenotype on human cancer cells.
Oncogene 12, 221-227.
Kee, B. L., Arias, J., and Montminy, M. R. (1996). Adaptor-mediated recruitment of RNA polymerase II to a signal-dependent activator. J Biol Chem 271, 2373-2375.
Kim, S., Na, J. G., Hampsey, M., and Reinberg, D. (1997). The Dr1/DRAP1 heterodimer is a global repressor of transcription in vivo. Proc Natl Acad Sci U S A 94, 820-825.
Kim, W. Y., Sieweke, M., Ogawa, E., Wee, H. J., Englmeier, U., Graf, T., and Ito, Y. (1999).
Mutual activation of Ets-1 and AML1 DNA binding by direct interaction of their autoinhibitory domains. Embo J 18, 1609-1620.
Kingston, R. E., and Narlikar, G. J. (1999). ATP-dependent remodeling and acetylation as regulators of chromatin fluidity. Genes Dev 13, 2339-2352.
Kinoshita, J., Kitamura, K., Tanaka, S., Sugimachi, K., Ishida, M., and Saeki, H. (2002).
Clinical significance of PEA3 in human breast cancer. Surgery 131, S222-225.
Klambt, C. (1993). The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells. Development 117, 163-176.
Klein, S. L., Strausberg, R. L., Wagner, L., Pontius, J., Clifton, S. W., and Richardson, P.
(2002). Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Dev Dyn 225, 384-391.
Klemsz, M. J., and Maki, R. A. (1996). Activation of transcription by PU.1 requires both acidic and glutamine domains. Mol Cell Biol 16, 390-397.
Kodandapani, R., Pio, F., Ni, C. Z., Piccialli, G., Klemsz, M., McKercher, S., Maki, R. A., and Ely, K. R. (1996). A new pattern for helix-turn-helix recognition revealed by the PU.1 ETS-domain-DNA complex. Nature 380, 456-460.
Korber, P., and Horz, W. (2004). SWRred not shaken; mixing the histones. Cell 117, 5-7.
Kurpios, N. A., Sabolic, N. A., Shepherd, T. G., Fidalgo, G. M., and Hassell, J. A. (2003).
Function of PEA3 Ets transcription factors in mammary gland development and oncogenesis.
J Mammary Gland Biol Neoplasia 8, 177-190.
Kwok, R. P., Lundblad, J. R., Chrivia, J. C., Richards, J. P., Bachinger, H. P., Brennan, R. G., Roberts, S. G., Green, M. R., and Goodman, R. H. (1994). Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature 370, 223-226.
Lacoste, N., and Cote, J. (2003). [The epigenetic code of histones]. Med Sci (Paris) 19, 955- 959.
Ladle, D. R., and Frank, E. (2002). The role of the ETS gene PEA3 in the development of motor and sensory neurons. Physiol Behav 77, 571-576.
Laget, M. P., Defossez, P. A., Albagli, O., Baert, J. L., Dewitte, F., Stehelin, D., and de Launoit, Y. (1996). Two functionally distinct domains responsible for transactivation by the Ets family member ERM. Oncogene 12, 1325-1336.
Lagrange, T., Kapanidis, A. N., Tang, H., Reinberg, D., and Ebright, R. H. (1998). New core promoter element in RNA polymerase II-dependent transcription: sequence-specific DNA binding by transcription factor IIB. Genes Dev 12, 34-44.
Laing, M. A., Coonrod, S., Hinton, B. T., Downie, J. W., Tozer, R., Rudnicki, M. A., and Hassell, J. A. (2000). Male sexual dysfunction in mice bearing targeted mutant alleles of the PEA3 ets gene. Mol Cell Biol 20, 9337-9345.
Langst, G., and Becker, P. B. (2004). Nucleosome remodeling: one mechanism, many phenomena? Biochim Biophys Acta 1677, 58-63.
Laudet, V., Hanni, C., Stehelin, D., and Duterque-Coquillaud, M. (1999). Molecular phylogeny of the ETS gene family. Oncogene 18, 1351-1359.
Le Drean, Y., Mincheneau, N., Le Goff, P., and Michel, D. (2002). Potentiation of glucocorticoid receptor transcriptional activity by sumoylation. Endocrinology 143, 3482- 3489.
Ledent, V., Paquet, O., and Vervoort, M. (2002). Phylogenetic analysis of the human basic helix-loop-helix proteins. Genome Biol 3, RESEARCH0030.
Lee, C. J., Chan, W. I., Cheung, M., Cheng, Y. C., Appleby, V. J., Orme, A. T., and Scotting, P. J. (2002). CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons. Brain Res Mol Brain Res 106, 151-156.
Lee, C. J., Chan, W. I., and Scotting, P. J. (2005). CIC, a gene involved in cerebellar development and ErbB signaling, is significantly expressed in medulloblastomas. J Neurooncol 73, 101-108.
Lee, D. Y., Hayes, J. J., Pruss, D., and Wolffe, A. P. (1993). A positive role for histone acetylation in transcription factor access to nucleosomal DNA. Cell 72, 73-84.
Lee, T. I., and Young, R. A. (2000). Transcription of eukaryotic protein-coding genes. Annu Rev Genet 34, 77-137.
Lehninger, A. L., Nelson, D. L., and Cox, M. M. (2005). Lehninger principles of biochemistry, 4th edn (New York, W.H. Freeman).
Leon, O., and Roth, M. (2000). Zinc fingers: DNA binding and protein-protein interactions.
Biol Res 33, 21-30.
Leprince, D., Gegonne, A., Coll, J., de Taisne, C., Schneeberger, A., Lagrou, C., and Stehelin, D. (1983). A putative second cell-derived oncogene of the avian leukaemia retrovirus E26.
Nature 306, 395-397.
Levy-Wilson, B. (1983). Glycosylation, ADP-ribosylation, and methylation of Tetrahymena histones. Biochemistry 22, 484-489.
Li, Q. J., Yang, S. H., Maeda, Y., Sladek, F. M., Sharrocks, A. D., and Martins-Green, M.
(2003). MAP kinase phosphorylation-dependent activation of Elk-1 leads to activation of the co-activator p300. Embo J 22, 281-291.
Liang, H., Mao, X., Olejniczak, E. T., Nettesheim, D. G., Yu, L., Meadows, R. P., Thompson, C. B., and Fesik, S. W. (1994). Solution structure of the ets domain of Fli-1 when bound to DNA. Nat Struct Biol 1, 871-875.
Lin, B., Ferguson, C., White, J. T., Wang, S., Vessella, R., True, L. D., Hood, L., and Nelson, P. S. (1999). Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2. Cancer Res 59, 4180-4184.
Lin, J. H., Saito, T., Anderson, D. J., Lance-Jones, C., Jessell, T. M., and Arber, S. (1998).
Functionally related motor neuron pool and muscle sensory afferent subtypes defined by coordinate ETS gene expression. Cell 95, 393-407.
Lin, S., Perl, A. K., and Shannon, J. M. (2006). Erm/thyroid transcription factor 1 interactions modulate surfactant protein C transcription. J Biol Chem 281, 16716-16726.
Liu, N., Lucibello, F. C., Korner, K., Wolfraim, L. A., Zwicker, J., and Muller, R. (1997).
CDF-1, a novel E2F-unrelated factor, interacts with cell cycle-regulated repressor elements in multiple promoters. Nucleic Acids Res 25, 4915-4920.
Liu, X. P., Kawauchi, S., Oga, A., Tsushimi, K., Tsushimi, M., Furuya, T., and Sasaki, K.
(2002). Prognostic significance of matrix metalloproteinase-7 (MMP-7) expression at the invasive front in gastric carcinoma. Jpn J Cancer Res 93, 291-295.
Liu, Y., Borchert, G. L., and Phang, J. M. (2004). Polyoma enhancer activator 3, an ets transcription factor, mediates the induction of cyclooxygenase-2 by nitric oxide in colorectal cancer cells. J Biol Chem 279, 18694-18700.
Liu, Y., Jiang, H., Crawford, H. C., and Hogan, B. L. (2003). Role for ETS domain transcription factors Pea3/Erm in mouse lung development. Dev Biol 261, 10-24.
Livet, J., Sigrist, M., Stroebel, S., De Paola, V., Price, S. R., Henderson, C. E., Jessell, T. M., and Arber, S. (2002). ETS gene Pea3 controls the central position and terminal arborization of specific motor neuron pools. Neuron 35, 877-892.
Lo, W. S., Duggan, L., Emre, N. C., Belotserkovskya, R., Lane, W. S., Shiekhattar, R., and Berger, S. L. (2001). Snf1--a histone kinase that works in concert with the histone acetyltransferase Gcn5 to regulate transcription. Science 293, 1142-1146.
Lopez, R. G., Carron, C., Oury, C., Gardellin, P., Bernard, O., and Ghysdael, J. (1999). TEL is a sequence-specific transcriptional repressor. J Biol Chem 274, 30132-30138.
Luckow, V. L. S., M.D. (1988). Trends in the development of baculovirus expression vectors.
Bio/Technology 6, 47-55.
Luger, K., Mader, A. W., Richmond, R. K., Sargent, D. F., and Richmond, T. J. (1997).
Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature 389, 251-260.
Ma, J., and Ptashne, M. (1987). Deletion analysis of GAL4 defines two transcriptional activating segments. Cell 48, 847-853.
Maira, S. M., Wurtz, J. M., and Wasylyk, B. (1996). Net (ERP/SAP2) one of the Ras- inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif.
Embo J 15, 5849-5865.
Malik, S., and Roeder, R. G. (2000). Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells. Trends Biochem Sci 25, 277-283.
Margolis, D. (2005). Depletion of Latent HIV Infection In Vivo: Moving Towards Eradication of HIV Infection. The Physician Research Network Notebook 10, 7-10.
Marmorstein, R., and Fitzgerald, M. X. (2003). Modulation of DNA-binding domains for sequence-specific DNA recognition. Gene 304, 1-12.
Martinez-Balbas, M. A., Bauer, U. M., Nielsen, S. J., Brehm, A., and Kouzarides, T. (2000).
Regulation of E2F1 activity by acetylation. Embo J 19, 662-671.
Martinez, E. (2002). Multi-protein complexes in eukaryotic gene transcription. Plant Mol Biol 50, 925-947.
Marzio, G., Wagener, C., Gutierrez, M. I., Cartwright, P., Helin, K., and Giacca, M. (2000).
E2F family members are differentially regulated by reversible acetylation. J Biol Chem 275, 10887-10892.
Matters, G. L., and Bond, J. S. (1999). Expression and regulation of the meprin beta gene in human cancer cells. Mol Carcinog 25, 169-178.
Mauën, S., Baert, J.-L., and de Launoit, Y. (in press). From gene to oncogenesis, the example of Ets transcription factors from the PEA3 group (Georgetown, Texas, USA, LANDES BIOSCIENCES).
Mauen, S., Huvent, I., Raussens, V., Demonte, D., Baert, J. L., Tricot, C., Ruysschaert, J. M., Van Lint, C., Moguilevsky, N., and de Launoit, Y. (2006). Expression, purification, and structural prediction of the Ets transcription factor ERM. Biochim Biophys Acta 1760, 1192- 1201.
Maurer, P., T'Sas, F., Coutte, L., Callens, N., Brenner, C., Van Lint, C., de Launoit, Y., and Baert, J. L. (2003). FEV acts as a transcriptional repressor through its DNA-binding ETS domain and alanine-rich domain. Oncogene 22, 3319-3329.
Megy, S., Bertho, G., Gharbi-Benarous, J., Baleux, F., Benarous, R., and Girault, J. P. (2005).
Solution structure of a peptide derived from the oncogenic protein beta-Catenin in its phosphorylated and nonphosphorylated states. Peptides 26, 227-241.
Mermod, N., O'Neill, E. A., Kelly, T. J., and Tjian, R. (1989). The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain. Cell 58, 741- 753.
Mo, Y., Vaessen, B., Johnston, K., and Marmorstein, R. (2000). Structure of the elk-1-DNA complex reveals how DNA-distal residues affect ETS domain recognition of DNA. Nat Struct Biol 7, 292-297.
Monte, D., Baert, J. L., Defossez, P. A., de Launoit, Y., and Stehelin, D. (1994). Molecular cloning and characterization of human ERM, a new member of the Ets family closely related to mouse PEA3 and ER81 transcription factors. Oncogene 9, 1397-1406.
Monte, D., Coutte, L., Baert, J. L., Angeli, I., Stehelin, D., and de Launoit, Y. (1995).
Molecular characterization of the ets-related human transcription factor ER81. Oncogene 11, 771-779.
Monte, D., Coutte, L., Dewitte, F., Defossez, P. A., Le Coniat, M., Stehelin, D., Berger, R., and de Launoit, Y. (1996). Genomic organization of the human ERM (ETV5) gene, a PEA3 group member of ETS transcription factors. Genomics 35, 236-240.
Munchberg, S. R., Ober, E. A., and Steinbeisser, H. (1999). Expression of the Ets transcription factors erm and pea3 in early zebrafish development. Mech Dev 88, 233-236.
Munchberg, S. R., and Steinbeisser, H. (1999). The Xenopus Ets transcription factor XER81 is a target of the FGF signaling pathway. Mech Dev 80, 53-65.
Muratani, M., and Tansey, W. P. (2003). How the ubiquitin-proteasome system controls transcription. Nat Rev Mol Cell Biol 4, 192-201.
Muscat, G. E., Burke, L. J., and Downes, M. (1998). The corepressor N-CoR and its variants RIP13a and RIP13Delta1 directly interact with the basal transcription factors TFIIB, TAFII32 and TAFII70. Nucleic Acids Res 26, 2899-2907.
Muth, V., Nadaud, S., Grummt, I., and Voit, R. (2001). Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription. Embo J 20, 1353-1362.
Muto, A., Hoshino, H., Madisen, L., Yanai, N., Obinata, M., Karasuyama, H., Hayashi, N., Nakauchi, H., Yamamoto, M., Groudine, M., and Igarashi, K. (1998). Identification of Bach2 as a B-cell-specific partner for small maf proteins that negatively regulate the immunoglobulin heavy chain gene 3' enhancer. Embo J 17, 5734-5743.
Muto, A., Tashiro, S., Tsuchiya, H., Kume, A., Kanno, M., Ito, E., Yamamoto, M., and Igarashi, K. (2002). Activation of Maf/AP-1 repressor Bach2 by oxidative stress promotes
apoptosis and its interaction with promyelocytic leukemia nuclear bodies. J Biol Chem 277, 20724-20733.
Naar, A. M., Lemon, B. D., and Tjian, R. (2001). Transcriptional coactivator complexes.
Annu Rev Biochem 70, 475-501.
Nagai, T., Igarashi, K., Akasaka, J., Furuyama, K., Fujita, H., Hayashi, N., Yamamoto, M., and Sassa, S. (1998). Regulation of NF-E2 activity in erythroleukemia cell differentiation. J Biol Chem 273, 5358-5365.
Nagano, M., and Shiokawa, K. (1999). Inhibition of transcription of class II, but not class III and I, genes in Xenopus postblastular embryos overexpressed with the TBP-binding protein, Dr1 (NC2beta). Biochem Biophys Res Commun 265, 644-651.
Naito, S., Shimizu, S., Maeda, S., Wang, J., Paul, R., and Fagin, J. A. (1998). Ets-1 is an early response gene activated by ET-1 and PDGF-BB in vascular smooth muscle cells. Am J Physiol 274, C472-480.
Nakae, K., Nakajima, K., Inazawa, J., Kitaoka, T., and Hirano, T. (1995). ERM, a PEA3 subfamily of Ets transcription factors, can cooperate with c-Jun. J Biol Chem 270, 23795- 23800.
Nakajima, N., Horikoshi, M., and Roeder, R. G. (1988). Factors involved in specific transcription by mammalian RNA polymerase II: purification, genetic specificity, and TATA box-promoter interactions of TFIID. Mol Cell Biol 8, 4028-4040.
Nan, X., and Bird, A. (2001). The biological functions of the methyl-CpG-binding protein MeCP2 and its implication in Rett syndrome. Brain Dev 23 Suppl 1, S32-37.
Narlikar, G. J., Fan, H. Y., and Kingston, R. E. (2002). Cooperation between complexes that regulate chromatin structure and transcription. Cell 108, 475-487.
Narlikar, L., and Hartemink, A. J. (2006). Sequence features of DNA binding sites reveal structural class of associated transcription factor. Bioinformatics 22, 157-163.
Netzer, S., Leenders, F., Dumont, P., Baert, J. L., and de Launoit, Y. (2002). Ectopic expression of the ets transcription factor ER81 in transgenic mouse mammary gland enhances both urokinase plasminogen activator and stromelysin-1 transcription. Transgenic Res 11, 123-131.
Nikolov, D. B., Chen, H., Halay, E. D., Usheva, A. A., Hisatake, K., Lee, D. K., Roeder, R.
G., and Burley, S. K. (1995). Crystal structure of a TFIIB-TBP-TATA-element ternary complex. Nature 377, 119-128.
Nosho, K., Yoshida, M., Yamamoto, H., Taniguchi, H., Adachi, Y., Mikami, M., Hinoda, Y., and Imai, K. (2005). Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis. Carcinogenesis 26, 892-899.
Nowak, S. J., and Corces, V. G. (2004). Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activation. Trends Genet 20, 214-220.
Nunn, M. F., Seeburg, P. H., Moscovici, C., and Duesberg, P. H. (1983). Tripartite structure of the avian erythroblastosis virus E26 transforming gene. Nature 306, 391-395.
Nusinzon, I., and Horvath, C. M. (2005). Histone deacetylases as transcriptional activators?
Role reversal in inducible gene regulation. Sci STKE 2005, re11.
Nye, J. A., Petersen, J. M., Gunther, C. V., Jonsen, M. D., and Graves, B. J. (1992).
Interaction of murine ets-1 with GGA-binding sites establishes the ETS domain as a new DNA-binding motif. Genes Dev 6, 975-990.
O'Hagan, R. C., Tozer, R. G., Symons, M., McCormick, F., and Hassell, J. A. (1996). The activity of the Ets transcription factor PEA3 is regulated by two distinct MAPK cascades.
Oncogene 13, 1323-1333.
O'Neill, E. M., Rebay, I., Tjian, R., and Rubin, G. M. (1994). The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway. Cell 78, 137-147.
Ogryzko, V. V., Schiltz, R. L., Russanova, V., Howard, B. H., and Nakatani, Y. (1996). The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87, 953-959.
Oikawa, T., and Yamada, T. (2003). Molecular biology of the Ets family of transcription factors. Gene 303, 11-34.
Okano, M., Bell, D. W., Haber, D. A., and Li, E. (1999). DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99, 247-257.
Orphanides, G., Lagrange, T., and Reinberg, D. (1996). The general transcription factors of RNA polymerase II. Genes Dev 10, 2657-2683.
Osborne-Lawrence, S., Welcsh, P. L., Spillman, M., Chandrasekharappa, S. C., Gallardo, T.
D., Lovett, M., and Bowcock, A. M. (1995). Direct selection of expressed sequences within a 1-Mb region flanking BRCA1 on human chromosome 17q21. Genomics 25, 248-255.
Ouyang, W., Jacobson, N. G., Bhattacharya, D., Gorham, J. D., Fenoglio, D., Sha, W. C., Murphy, T. L., and Murphy, K. M. (1999). The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway. Proc Natl Acad Sci U S A 96, 3888-3893.
Paratore, C., Brugnoli, G., Lee, H. Y., Suter, U., and Sommer, L. (2002). The role of the Ets domain transcription factor Erm in modulating differentiation of neural crest stem cells. Dev Biol 250, 168-180.
Parekh, D. B., Ziegler, W., and Parker, P. J. (2000). Multiple pathways control protein kinase C phosphorylation. Embo J 19, 496-503.
Parker, P. J., and Murray-Rust, J. (2004). PKC at a glance. J Cell Sci 117, 131-132.
Passaniti, A., and Hart, G. W. (1990). Metastasis-associated murine melanoma cell surface galactosyltransferase: characterization of enzyme activity and identification of the major surface substrates. Cancer Res 50, 7261-7271.
Pastorcic, M., and Das, H. K. (2003). Ets transcription factors ER81 and Elk1 regulate the transcription of the human presenilin 1 gene promoter. Brain Res Mol Brain Res 113, 57-66.
Pastorcic, M., and Das, H. K. (2004). Alternative initiation of transcription of the human presenilin 1 gene in SH-SY5Y and SK-N-SH cells. The role of Ets factors in the regulation of presenilin 1. Eur J Biochem 271, 4485-4494.
Patikoglou, G., and Burley, S. K. (1997). Eukaryotic transcription factor-DNA complexes.
Annu Rev Biophys Biomol Struct 26, 289-325.
Penno, M. B., Passaniti, A., Fridman, R., Hart, G. W., Jordan, C., Kumar, S., and Scott, A. F.
(1989). In vitro galactosylation of a 110-kDa glycoprotein by an endogenous cell surface galactosyltransferase correlates with the invasiveness of adrenal carcinoma cells. Proc Natl Acad Sci U S A 86, 6057-6061.
Perez, A., Barco, R., Fernandez, I., Price-Schiavi, S. A., and Carraway, K. L. (2003). PEA3 transactivates the Muc4/sialomucin complex promoter in mammary epithelial and tumor cells.
J Biol Chem 278, 36942-36952.
Peter, M., Couturier, J., Pacquement, H., Michon, J., Thomas, G., Magdelenat, H., and Delattre, O. (1997). A new member of the ETS family fused to EWS in Ewing tumors.
Oncogene 14, 1159-1164.
Petrie, K., Guidez, F., Howell, L., Healy, L., Waxman, S., Greaves, M., and Zelent, A. (2003).
The histone deacetylase 9 gene encodes multiple protein isoforms. J Biol Chem 278, 16059- 16072.
Phillips, K., and Luisi, B. (2000). The virtuoso of versatility: POU proteins that flex to fit. J Mol Biol 302, 1023-1039.
Planaguma, J., Abal, M., Gil-Moreno, A., Diaz-Fuertes, M., Monge, M., Garcia, A., Baro, T., Xercavins, J., Reventos, J., and Alameda, F. (2005). Up-regulation of ERM/ETV5 correlates with the degree of myometrial infiltration in endometrioid endometrial carcinoma. J Pathol.
Prakash, S., Tian, L., Ratliff, K. S., Lehotzky, R. E., and Matouschek, A. (2004). An unstructured initiation site is required for efficient proteasome-mediated degradation. Nat Struct Mol Biol 11, 830-837.
Pray-Grant, M. G., Daniel, J. A., Schieltz, D., Yates, J. R., 3rd, and Grant, P. A. (2005). Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation.
Nature 433, 434-438.
Prusiner, S. B. (1998). Prions. Proc Natl Acad Sci U S A 95, 13363-13383.
Pufall, M. A., Lee, G. M., Nelson, M. L., Kang, H. S., Velyvis, A., Kay, L. E., McIntosh, L.
P., and Graves, B. J. (2005). Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region. Science 309, 142-145.
Radke, K., Beug, H., Kornfeld, S., and Graf, T. (1982). Transformation of both erythroid and myeloid cells by E26, an avian leukemia virus that contains the myb gene. Cell 31, 643-653.
Raible, F., and Brand, M. (2001). Tight transcriptional control of the ETS domain factors Erm and Pea3 by Fgf signaling during early zebrafish development. Mech Dev 107, 105-117.
Ramakrishnan, V. (1997). Histone H1 and chromatin higher-order structure. Crit Rev Eukaryot Gene Expr 7, 215-230.
Rao, V. N., Ohno, T., Prasad, D. D., Bhattacharya, G., and Reddy, E. S. (1993). Analysis of the DNA-binding and transcriptional activation functions of human Fli-1 protein. Oncogene 8, 2167-2173.
Reddy, S. P., Vuong, H., and Adiseshaiah, P. (2003a). Interplay between proximal and distal promoter elements is required for squamous differentiation marker induction in the bronchial epithelium: role for ESE-1, Sp1, and AP-1 proteins. J Biol Chem 278, 21378-21387.
Reddy, S. Y., Obika, S., and Bruice, T. C. (2003b). Conformations and dynamics of Ets-1 ETS domain-DNA complexes. Proc Natl Acad Sci U S A 100, 15475-15480.
Rings, E. H., Boudreau, F., Taylor, J. K., Moffett, J., Suh, E. R., and Traber, P. G. (2001).
Phosphorylation of the serine 60 residue within the Cdx2 activation domain mediates its transactivation capacity. Gastroenterology 121, 1437-1450.
Roeder, R. G. (1991). The complexities of eukaryotic transcription initiation: regulation of preinitiation complex assembly. Trends Biochem Sci 16, 402-408.
Roehl, H., and Nusslein-Volhard, C. (2001). Zebrafish pea3 and erm are general targets of FGF8 signaling. Curr Biol 11, 503-507.
Ross, S., Best, J. L., Zon, L. I., and Gill, G. (2002). SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization. Mol Cell 10, 831-842.
Rountree, M. R., Bachman, K. E., Herman, J. G., and Baylin, S. B. (2001). DNA methylation, chromatin inheritance, and cancer. Oncogene 20, 3156-3165.
Roussigne, M., and Blader, P. (2006). Divergence in regulation of the PEA3 family of ETS transcription factors. Gene Expr Patterns.
Santos-Rosa, H., and Caldas, C. (2005). Chromatin modifier enzymes, the histone code and cancer. Eur J Cancer 41, 2381-2402.
Sapetschnig, A., Rischitor, G., Braun, H., Doll, A., Schergaut, M., Melchior, F., and Suske, G.
(2002). Transcription factor Sp3 is silenced through SUMO modification by PIAS1. Embo J 21, 5206-5215.
Schild-Poulter, C., Shih, A., Yarymowich, N. C., and Hache, R. J. (2003). Down-regulation of histone H2B by DNA-dependent protein kinase in response to DNA damage through modulation of octamer transcription factor 1. Cancer Res 63, 7197-7205.
Schneikert, J., Peterziel, H., Defossez, P. A., Klocker, H., Launoit, Y., and Cato, A. C. (1996).
Androgen receptor-Ets protein interaction is a novel mechanism for steroid hormone- mediated down-modulation of matrix metalloproteinase expression. J Biol Chem 271, 23907- 23913.
Schultz, J., Copley, R. R., Doerks, T., Ponting, C. P., and Bork, P. (2000). SMART: a web- based tool for the study of genetically mobile domains. Nucleic Acids Res 28, 231-234.
Scott, G. K., Daniel, J. C., Xiong, X., Maki, R. A., Kabat, D., and Benz, C. C. (1994). Binding of an ETS-related protein within the DNase I hypersensitive site of the HER2/neu promoter in human breast cancer cells. J Biol Chem 269, 19848-19858.
Sementchenko, V. I., and Watson, D. K. (2000). Ets target genes: past, present and future.
Oncogene 19, 6533-6548.
Seth, A., and Watson, D. K. (2005). ETS transcription factors and their emerging roles in human cancer. Eur J Cancer 41, 2462-2478.
Sgouras, D. N., Athanasiou, M. A., Beal, G. J., Jr., Fisher, R. J., Blair, D. G., and Mavrothalassitis, G. J. (1995). ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation. Embo J 14, 4781-4793.
Sharrocks, A. D. (2001). The ETS-domain transcription factor family. Nat Rev Mol Cell Biol 2, 827-837.
Sharrocks, A. D., Brown, A. L., Ling, Y., and Yates, P. R. (1997). The ETS-domain transcription factor family. Int J Biochem Cell Biol 29, 1371-1387.
Shenk, M. A., and Steele, R. E. (1993). A molecular snapshot of the metazoan 'Eve'. Trends Biochem Sci 18, 459-463.
Shepherd, T., and Hassell, J. A. (2001). Role of Ets transcription factors in mammary gland development and oncogenesis. J Mammary Gland Biol Neoplasia 6, 129-140.
Shepherd, T. G., Kockeritz, L., Szrajber, M. R., Muller, W. J., and Hassell, J. A. (2001). The pea3 subfamily ets genes are required for HER2/Neu-mediated mammary oncogenesis. Curr Biol 11, 1739-1748.
Shi, Y., Lan, F., Matson, C., Mulligan, P., Whetstine, J. R., Cole, P. A., Casero, R. A., and Shi, Y. (2004). Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 119, 941-953.
Shindoh, M., Higashino, F., Kaya, M., Yasuda, M., Funaoka, K., Hanzawa, M., Hida, K., Kohgo, T., Amemiya, A., Yoshida, K., and Fujinaga, K. (1996). Correlated expression of matrix metalloproteinases and ets family transcription factor E1A-F in invasive oral squamous-cell-carcinoma-derived cell lines. Am J Pathol 148, 693-700.
Shindoh, M., Higashino, F., and Kohgo, T. (2004). E1AF, an ets-oncogene family transcription factor. Cancer Lett 216, 1-8.
Siddique, H. R., Rao, V. N., Lee, L., and Reddy, E. S. (1993). Characterization of the DNA binding and transcriptional activation domains of the erg protein. Oncogene 8, 1751-1755.
Singh, S., Barrett, J., Sakata, K., Tozer, R. G., and Singh, G. (2002). ETS proteins and MMPs:
partners in invasion and metastasis. Curr Drug Targets 3, 359-367.
Singleton, T. P., and Strickler, J. G. (1992). Clinical and pathologic significance of the c- erbB-2 (HER-2/neu) oncogene. Pathol Annu 27 Pt 1, 165-190.
Slupsky, C. M., Gentile, L. N., Donaldson, L. W., Mackereth, C. D., Seidel, J. J., Graves, B.
J., and McIntosh, L. P. (1998). Structure of the Ets-1 pointed domain and mitogen-activated protein kinase phosphorylation site. Proc Natl Acad Sci U S A 95, 12129-12134.
Slupsky, C. M., Kay, C. M., Reinach, F. C., Smillie, L. B., and Sykes, B. D. (1995). Calcium- induced dimerization of troponin C: mode of interaction and use of trifluoroethanol as a denaturant of quaternary structure. Biochemistry 34, 7365-7375.
Sorensen, P. H., Lessnick, S. L., Lopez-Terrada, D., Liu, X. F., Triche, T. J., and Denny, C. T.
(1994). A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG. Nat Genet 6, 146-151.
Steinacher, R., and Schar, P. (2005). Functionality of human thymine DNA glycosylase requires SUMO-regulated changes in protein conformation. Curr Biol 15, 616-623.
Strelkov, I. S., and Davie, J. R. (2002). Ser-10 phosphorylation of histone H3 and immediate early gene expression in oncogene-transformed mouse fibroblasts. Cancer Res 62, 75-78.
Subbaramaiah, K., Norton, L., Gerald, W., and Dannenberg, A. J. (2002). Cyclooxygenase-2 is overexpressed in HER-2/neu-positive breast cancer: evidence for involvement of AP-1 and PEA3. J Biol Chem 277, 18649-18657.
Sun, Z. W., and Allis, C. D. (2002). Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast. Nature 418, 104-108.
T'Sas, F., Brenner, C., Mauen, S., Putmans, P., Monte, D., Van Lint, C., Moser, M., Baert, J.
L., and de Launoit, Y. (2005). Expression of the Ets transcription factor Erm is regulated through a conventional PKC signaling pathway in the Molt4 lymphoblastic cell line. FEBS Lett 579, 66-70.
Takahashi, A., Higashino, F., Aoyagi, M., Yoshida, K., Itoh, M., Kobayashi, M., Totsuka, Y., Kohgo, T., and Shindoh, M. (2005). E1AF degradation by a ubiquitin-proteasome pathway.
Biochem Biophys Res Commun 327, 575-580.
Talasz, H., Wasserer, S., and Puschendorf, B. (2002). Nonenzymatic glycation of histones in vitro and in vivo. J Cell Biochem 85, 24-34.
Tan, S., Hunziker, Y., Sargent, D. F., and Richmond, T. J. (1996). Crystal structure of a yeast TFIIA/TBP/DNA complex. Nature 381, 127-151.
Tang, Q., Mazur, M., and Mellon, P. L. (2005). The protein kinase C pathway acts through multiple transcription factors to repress gonadotropin-releasing hormone gene expression in hypothalamic GT1-7 neuronal cells. Mol Endocrinol 19, 2769-2779.
Thiagalingam, S., Cheng, K. H., Lee, H. J., Mineva, N., Thiagalingam, A., and Ponte, J. F.
(2003). Histone deacetylases: unique players in shaping the epigenetic histone code. Ann N Y Acad Sci 983, 84-100.
