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Negative symptoms Positive symptoms

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Negative symptoms Positive symptoms

Predicted SMD for negative symptoms Predicted SMD for positive symptoms

Dose spl.pred 95% CI Dose spl.pred 95% CI

0 0.000 (0.000 ; 0.000) 0 0.000 (0.000 ; 0.000)

20 -0.072 (-0.520; 0.376) 20 -0.432 (-0.862 ; 0.120)

40 0.023 (-0.282; 0.328) 40 -0.331 (-0.638 ; 0.064)

60 0.190 (-0.201; 0.582) 60 0.172 (-0.409 ; 0.399)

80 0.360 (-0.487; 1.206) 80 0.792 (-0.582 ; 1.146)

Supplementary Figure S4. Sensitivity analysis for the dose-response meta-analysis: exclusion of Modabbernia et al. for negative symptoms (n=8) and positive symptoms (n=6).

In this sensitivity analysis, we excluded the outlier study of Modabbernia et al..

For positive symptoms, the trend-level effect significance found prior to exclusion of this study dissipated.

For negative and positive symptoms, both effect sizes were nonsignificant (SMD, 0.011; 95% CI, -0.03 to +0.05; p=0.62; and; SMD, 0.03; 95% CI, -0.015 to +0.07; p=0.27; respectively).

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