Supplementary file 2.
Gene pathway logFC logCPM LR PValue FDR
IL18RAP inflammation -4.153264431 0.730516916 18.20476653 1.98E-05 0.019936359
MZB1 lymphocytes -5.375597634 0.744547529 18.08395961 2.11E-05 0.019936359
CD79A lymphocytes -4.330478534 1.300376531 17.67544207 2.62E-05 0.021373345
JCHAIN lymphocytes -5.448976785 3.882571941 16.32283538 5.34E-05 0.028549268
CCL13 leukocyte -6.809059566 -1.200870531 16.23016404 5.61E-05 0.029013172
GZMA lymphocytes -3.866261247 0.972168322 15.44083301 8.51E-05 0.035919898
ZNF683 lymphocytes -4.648730115 0.47065906 14.55249698 0.000136308 0.049671834
IDO1 myeloid -4.061021733 0.633210916 14.3301173 0.000153391 0.054654958
OS9 vessel -2.510152406 10.35322674 13.97447029 0.00018531 0.058259963
AMICA1 leukocyte -3.045652836 3.314361791 13.84350366 0.000198682 0.061262959 IL18R1 inflammation -2.789677752 0.408661036 13.29933865 0.0002655 0.066610519
CLEC4E myeloid -3.124206471 1.12639729 13.29442426 0.000266197 0.066610519
LAX1 lymphocytes -3.168435326 0.618226934 13.07865786 0.000298679 0.071477989
GBP5 inflammation -2.915117404 4.380775761 13.03681783 0.000305427 0.0720178
ITK lymphocytes -2.747427427 2.665788039 12.76896657 0.000352417 0.079586788
HSH2D lymphocytes -3.586933849 0.022710343 12.5182668 0.000402993 0.085020823 ICOS lymphocytes -3.938655671 -0.210706225 12.31542229 0.000449231 0.090037136
IRF4 inflammation -3.496735742 1.99420656 12.2025417 0.000477244 0.092556781
NUGGC lymphocytes -3.63405648 -0.693573965 12.1952242 0.00047912 0.092556781
TNFRSF9 lymphocytes -2.847621403 -0.854559606 12.12996232 0.000496181 0.093597291
SLAMF7 leukocyte -3.56532639 2.445760395 11.92782246 0.000553018 0.097950774
FCGR3B myeloid -2.823944665 3.343373585 11.89773429 0.000562023 0.097950774
FCER2 lymphocytes -3.908256642 0.539621491 11.69170445 0.000627794 0.103773641
TDO2 myeloid -2.425646646 1.907906532 11.60012026 0.000659476 0.106501749
CXCR2 leukocyte -2.633365705 1.149680437 11.49930072 0.000696224 0.108381088
IKZF3 lymphocytes -3.07062004 1.150680345 11.51725767 0.00068953 0.108381088
CLEC12A myeloid -3.027461354 0.345793392 11.42843595 0.000723285 0.110449133
CD209 myeloid -2.886122672 4.157920521 11.18770035 0.000823413 0.121124857
CCR2 leukocyte -2.820165135 0.223621064 11.02028428 0.000901202 0.127875051
PTGFR inflammation -3.274904359 -0.810672948 10.89789177 0.000962738 0.129718795 CD27 lymphocytes -3.407155372 0.310726925 10.65570817 0.001097317 0.136390575 ZBP1 inflammation -2.27414501 0.925442705 10.63851426 0.001107566 0.136605507
CXCL10 leukocyte -2.87512665 4.327648185 10.60735773 0.001126385 0.136821689
IL1R2 inflammation -3.307764069 3.258700924 10.35738385 0.001289578 0.143900276
CXCL9 leukocyte -3.635646081 2.857936181 10.35341154 0.001292356 0.143900276
CD79B lymphocytes -2.291000242 0.27901493 10.11667579 0.001469338 0.150181702 CD3G lymphocytes -2.990295544 1.897950122 10.02471223 0.001544538 0.152871131 MEFV inflammation -1.964100514 2.339233052 9.727902123 0.001814915 0.167252862
GZMK lymphocytes -3.48706089 0.614053188 9.712337432 0.001830351 0.167252862
CD3D lymphocytes -3.083879589 2.757974759 9.576251563 0.001971104 0.172703208 MS4A1 lymphocytes -2.890201272 -0.729277468 9.430667317 0.002133866 0.180075852 TRAT1 lymphocytes -3.216124598 -0.745709061 9.248124383 0.002357367 0.190373362 SH2D1A lymphocytes -2.815400394 -0.376780203 9.234771021 0.002374621 0.190373362 CRTAM lymphocytes -2.723886201 -1.040080591 9.260879247 0.002341006 0.190373362 IL1R1 inflammation -2.170242791 4.83605029 9.019207976 0.002671571 0.206002269 SLAMF1 lymphocytes -3.074323612 0.978672616 9.009860865 0.002685269 0.206002269
ANPEP myeloid -2.692382888 5.557072645 8.989853153 0.002714828 0.206002269
NLRP12 inflammation -1.959245298 1.723294614 8.838170296 0.002949947 0.214997534
CD96 lymphocytes -2.52287592 2.270915378 8.853805599 0.002924784 0.214997534
IL7R lymphocytes -2.18440487 2.593555404 8.827362447 0.00296747 0.215295972
LY9 lymphocytes -2.855696566 0.643125394 8.769458915 0.003063163 0.217321931
CD2 lymphocytes -2.60693327 2.313079919 8.784849732 0.003037426 0.217321931
KLRB1 lymphocytes -2.651520384 -0.349464565 8.669308007 0.003236141 0.228218939
CCR4 leukocyte -2.813648003 -1.049516196 8.621181505 0.003322762 0.230637117
UBASH3A lymphocytes -3.179392477 0.613005916 8.535070492 0.003483678 0.232900504 GZMH lymphocytes -3.281925938 0.936544565 8.470790975 0.003608945 0.235226906
CCL5 leukocyte -2.592469333 3.339892439 8.299195431 0.003966265 0.24276496
CD3E lymphocytes -2.731101302 3.440750894 8.140301324 0.004329209 0.250194245 CD19 lymphocytes -1.920927485 -0.603099622 8.130151496 0.004353511 0.250194245
BLK lymphocytes -2.84946737 -0.688913428 8.00319479 0.004669489 0.261785271
LCK lymphocytes -2.728014183 1.544981216 7.713720591 0.005480269 0.28488932
MRC1 myeloid -2.308394201 8.670322218 7.710432964 0.005490258 0.28488932
IL20RB inflammation -1.474441819 0.216246029 7.595135404 0.0058526 0.290502186
MMP3 leukocyte -2.91649096 -0.553769856 7.425149096 0.00643185 0.290502186
IL2RG leukocyte -1.934736258 2.068316473 7.446726412 0.006355193 0.290502186
FCRL3 lymphocytes -2.859347234 -1.205090214 7.463220612 0.006297224 0.290502186 SLAMF6 lymphocytes -2.495225857 0.830649684 7.529117304 0.006070965 0.290502186 TNFSF10 lymphocytes -1.582931868 2.865164842 7.573377404 0.005923668 0.290502186 CCL26 leukocyte -2.732748481 -0.536825421 7.405381699 0.006502904 0.291250197 GRAP2 lymphocytes -2.315053262 0.654988894 7.302127504 0.006887301 0.297865411 PTGIS inflammation -2.13472251 4.434969637 7.253778539 0.007075198 0.300445801
CXCR6 leukocyte -2.900341086 0.082519068 7.232798655 0.007158353 0.301134293
CXCL11 leukocyte -2.363720611 0.987843944 7.219420729 0.007211898 0.301134293
CD5 lymphocytes -2.770016064 1.066538885 7.190262939 0.007330024 0.302911348
SKAP1 lymphocytes -2.520485329 -0.071840971 7.194915895 0.007311042 0.302911348 ADAMDEC1 myeloid -2.096642857 2.783242325 7.096024613 0.007725511 0.308260384
PDGFRA vessel -2.06881184 8.809476008 7.125553785 0.007599294 0.308260384
HMGB2 inflammation -1.085908741 5.968141327 7.016105088 0.008077976 0.31105412
CD8A lymphocytes -2.283108616 3.137934204 7.002813528 0.008138171 0.31105412
PTGER2 inflammation -3.255583691 -0.325129491 6.919201476 0.008527505 0.315229586
DEFA3 myeloid -3.958582809 1.343507011 6.907671011 0.008582671 0.315229586
CD48 leukocyte -2.065945901 2.113645986 6.817615855 0.009026299 0.319898344
SIT1 lymphocytes -3.338414142 -1.945434727 6.702241164 0.00962918 0.329198879 PSMA2 antigenpres -0.741927183 6.131076612 6.689611619 0.009697633 0.330256547 EOMES lymphocytes -2.561062343 -0.137908189 6.666139119 0.009826183 0.330617876 FCRL6 lymphocytes -2.508756064 -0.221397431 6.612631262 0.010125793 0.334372567
BST1 myeloid -1.206750189 2.406773656 6.605856927 0.010164388 0.334372567
MNDA myeloid -1.24985842 3.392638933 6.513540393 0.010705615 0.342978327
SELE vessel -2.160901864 0.097640779 6.401231337 0.011404124 0.348378749
AIM2 inflammation -2.203149074 1.122624672 6.334860798 0.011838741 0.35205476
CTSW lymphocytes -2.12393559 1.744790974 6.244519593 0.012457817 0.352772863
SCUBE1 vessel -2.155018498 0.793808747 6.233066323 0.012538643 0.353124766
FASLG lymphocytes -2.866320269 -0.524489363 6.166534062 0.013018943 0.355609157 IFITM1 leukocyte -1.430702045 4.768138683 6.078746291 0.013681783 0.361620692 KLRD1 lymphocytes -1.879420576 -0.188845877 6.079515615 0.013675826 0.361620692
BPI myeloid -2.074105622 -0.859500355 6.070217897 0.013748 0.361620692
GZMB lymphocytes -2.452563464 0.775947726 6.047281708 0.013927722 0.362921154
TLR8 myeloid -1.522299179 1.647997136 5.989462791 0.014391585 0.363214439
CD70 lymphocytes -3.146440062 -1.638346194 5.90923608 0.015061702 0.367032987
CLEC10A myeloid -2.365438102 0.585523889 5.877900218 0.015332096 0.369768588
HLA.DRA antigenpres -1.176901504 8.946265676 5.801552382 0.016012031 0.37425206
NKG7 lymphocytes -2.542441829 -0.008326756 5.65826478 0.017373303 0.38400883
CXCL13 leukocyte -2.997432595 -0.201143936 5.627637183 0.017679446 0.385178932
LILRA1 myeloid -1.160960704 3.36904753 5.603978025 0.017919744 0.387753277
IRF1 inflammation -1.087985599 4.941783895 5.559476449 0.01838091 0.39258865
CD6 lymphocytes -1.825023751 2.100772582 5.511118215 0.018895962 0.397608738
CD200R1 myeloid -1.53803539 0.784651347 5.488139522 0.019145906 0.397925286
LAMP3 myeloid -1.517440742 1.453585647 5.499117198 0.019026076 0.397925286
PSMA6 antigenpres -0.567586388 6.177728299 5.395675526 0.02018671 0.401438555 TBX21 lymphocytes -2.097810877 -0.544475863 5.373013529 0.020450616 0.402860782
CD80 myeloid -1.434943889 0.300587331 5.350067518 0.020721468 0.403990982
LILRA6 myeloid -1.545350415 2.834353332 5.333569564 0.0209185 0.404510332
SLA2 lymphocytes -1.841483674 0.428178694 5.316505692 0.021124331 0.405235572
LILRA5 myeloid -1.691579168 1.628518641 5.293300877 0.021407606 0.40621249
LYVE1 vessel -1.879094917 4.166647692 5.282562511 0.021540024 0.407760025
POMP antigenpres -0.582665946 6.534657933 5.146394003 0.0232947 0.411143603
PSMD13 antigenpres -0.519012285 6.391766469 5.207084843 0.022495022 0.411143603
LYZ myeloid -1.552016118 5.58202151 5.217457316 0.022361224 0.411143603
FCAR myeloid -1.426027175 0.995364198 5.154980556 0.023179795 0.411143603
TIGIT lymphocytes -2.230611023 -1.106505428 5.112092234 0.023759651 0.411406311 PSMB9 antigenpres -0.888495149 4.693469173 5.083721602 0.024151476 0.412304354 PLA2G4A inflammation -0.727522994 4.744650706 5.075502625 0.024266236 0.412351048 SIRPG lymphocytes -2.101301646 0.247701534 5.035446056 0.024833691 0.414774374
SIGLEC1 myeloid -1.674574901 4.611056293 5.014922819 0.02512975 0.416250418
FCRLA lymphocytes -1.859388271 4.399127884 4.94986097 0.026092767 0.426909614
SIRPB1 myeloid -1.645760771 3.103953561 4.908712042 0.026721559 0.429112456
PTPRC leukocyte -0.959164208 7.431345382 4.814967027 0.028213611 0.432779805
FPR2 leukocyte -1.729012289 1.954599832 4.7339921 0.029572171 0.440622912
ILF2 lymphocytes -0.617838438 7.427484514 4.655472792 0.030954707 0.445167542 HMGB3 inflammation -0.890230967 4.496371539 4.6334572 0.031354323 0.446950576
ITGA4 leukocyte -1.084940511 5.187145548 4.592978616 0.032103178 0.447404353
IL2RB lymphocytes -1.728900916 1.566485055 4.45656391 0.034767367 0.449470207 CD247 lymphocytes -1.427387881 1.860602263 4.441568767 0.035074005 0.449470207
PSMC2 antigenpres -0.499021 6.969387534 4.333171787 0.037376535 0.450173168
SERPINE1 vessel -1.767870717 9.389752893 4.307014724 0.037955512 0.451238652
ICAM3 leukocyte -1.146055907 2.28332873 4.19956817 0.040434275 0.461768632
HLA.DQB2 antigenpres -1.574235005 1.650041403 4.158201462 0.041433378 0.467404217 IFNAR2 inflammation -0.578224733 5.171201026 4.125391519 0.042244245 0.469074943 PSMA5 antigenpres -0.52437206 5.779634598 4.022110915 0.044907473 0.476588965 IL16 inflammation -0.911323583 4.292761784 4.007150997 0.04530765 0.477063246
CD300E myeloid -1.535067103 -0.515574528 3.931374482 0.047393194 0.480342901
HLA.DQA2 antigenpres -1.354833813 4.299462942 3.889627524 0.048585198 0.483579188 PSMB1 antigenpres -0.55709886 6.470513505 3.888529404 0.048616976 0.483579188 PSMD6 antigenpres -0.500710915 5.480600948 3.737201342 0.053213504 0.497017287 STAT1 inflammation -0.791426099 9.026575365 3.725136643 0.053599242 0.497017287
SDC1 vessel -1.461126803 1.346032713 3.726272912 0.053562787 0.497017287
