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Activation of Interferon Signaling in Chronic Lymphocytic Leukemia Cells Contributes to Apoptosis Resistance via a JAK-Src/STAT3/Mcl-1 Signaling Pathway

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Academic year: 2021

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Table 1. Clinical characteristics of chronic lymphocytic leukemia (CLL) patients.
Figure 1. Type I and II IFNs induce resistance to apoptosis in CLL cells. (a) Representative cyto- cyto-grams of CLL cells cultured for 24 h in the presence or absence of IFN-α, -β, -γ (1000 U/mL);  detec-tion of apoptotic cells after annexin-V-FITC/PI sta
Figure 2. Type I and II IFNs promote CLL cell resistance to apoptosis through an STAT3/Mcl-1  signaling pathway
Figure 3. Type I and II IFNs induce CLL cell survival through the TYK2/Src and JAK2/Src signaling  pathways respectively
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