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Table of Contents

Table of illustrations ... 2

Abbreviations ... 5

Summary - Résumé ... 11

Introduction ... 17

1. Psoriasis ... 18 1.1Epidemiology ... 18 1.2 Histopathological findings ... 19 1.3Clinical features ... 21 1.4Pathophysiology ... 30

1.5. Imiquimod-induced skin inflammation ... 52

1.6 Treatments ... 60

2. JNK1 ... 75

2.1 Generalities ... 75

2.2 Role of JNK1 in innate immune signaling ... 78

2.3 Role of JNK1 in immune related diseases ... 82

2.4 Role of JNK1 in metabolic diseases ... 84

2.5 Role of JNK1 in infectious diseases ... 85

2.6 Role of JNK in skin homeostasis ... 88

3. The EGFR pathway ... 91

3.1 EGFR expression ... 91

3.2 EGFR ligands ... 92

3.3 EGFR signal transduction ... 92

3.4 EGFR, c-Jun and the skin ... 93

3.5 EGFR pathway in psoriasis ... 94

Aim of the study ... 97

Experimental Section - Results ... 99

1. Evaluation of the role of JNK1 in an imiquimod-induced skin inflammation model. ... 100

2. Evaluation of the role of JNK1 in an acute epicutaneous Candida albicans infection. ... 130

Discussion ... 137

1. What is the contribution of JNK1 to IL-17R signaling? ... 138

2. What is the role of JNK1 in the context of the imiquimod-induced skin inflammation model? ... 142

3. Perspectives ... 147

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