HAL Id: inserm-02612304
https://www.hal.inserm.fr/inserm-02612304
Submitted on 19 May 2020
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Didac Carmona-Gutierrez, Maria Bauer, Andreas Zimmermann, Katharina Kainz, Sebastian Hofer, Guido Kroemer, Frank Madeo
To cite this version:
Didac Carmona-Gutierrez, Maria Bauer, Andreas Zimmermann, Katharina Kainz, Sebastian Hofer,
et al.. Digesting the crisis: autophagy and coronaviruses. Microbial Cell , Shared Science Publishers
OG, 2020, 7 (5), pp.119-128. �10.15698/mic2020.05.715�. �inserm-02612304�
www.microbialcell.com
Viewpoint
ABSTRACT Autophagy is a catabolic pathway with multifaceted roles in cellular homeostasis. This process is also involved in the antiviral response at multiple levels, including the direct elimination of intruding viruses (virophagy), the presentation of viral antigens, the fitness of immune cells, and the inhibition of excessive inflam- matory reactions. In line with its central role in immunity, viruses have evolved mechanisms to interfere with or to evade the au- tophagic process, and in some cases, even to harness autophagy or constituents of the autophagic machinery for their replication. Giv- en the devastating consequences of the current COVID-19 pandem- ic, the question arises whether manipulating autophagy might be an expedient approach to fight the novel coronavirus SARS-CoV-2. In this piece, we provide a short overview of the evidence linking au- tophagy to coronaviruses and discuss whether such links may pro- vide actionable targets for therapeutic interventions.
Digesting the crisis: autophagy and coronaviruses
Didac Carmona-Gutierrez
1,*, Maria A. Bauer
1, Andreas Zimmermann
1,2, Katharina Kainz
1, Sebastian J. Hofer
1, Guido Kroemer
3-7and Frank Madeo
1,2,8,*
1
Institute for Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
2
BioHealth Graz, Graz, Austria.
3
Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, IN- SERM U1138, Institut Universitaire de France, Paris, France.
4
Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France.
5
Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.
6
Suzhou Institute for Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China.
7
Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden.
8