Additional data (SNIFF 87)

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1

Additional data

Related to article entitled: “A single test combining blood markers and elastography is more accurate than other fibrosis tests in the main causes of chronic liver diseases”

Table S2. Accuracy by AUROCs of non-invasive tests in the CHC population (641 patients).

AUROC

Target Significant fibrosis Severe fibrosis Cirrhosis

APRI 0.751 0.768 0.814

Fib-4 0.762 0.773 0.802

Fibrotest 0.769 0.800 0.822

Hepascore 0.776 0.804 0.849

FibroMeter^V2G 0.812 0.830 0.863

CirrhoMeter^V2G 0.785 0.816 0.858

FibroMeter^V3G 0.798 0.816 0.844

CirrhoMeter^V3G 0.771 0.796 0.840

LSM 0.788 0.839 0.897

FibroMeter^{VCTE2G a} 0.843 0.878 0.922

FibroMeter^{VCTE3G a} 0.842 0.877 0.922

FibroMeter^ALD 0.777 0.812 0.847

Zeng score 0.757 0.791 0.810

p <0.001 <0.001 <0.001

a Optimized accuracy due to optimism bias (derivation population) LSM: liver stiffness measurement

Color codes: AUROC: insufficient: <0.7, fair: 0.7-0.8, satisfactory: 0.8-0.9, optimal: >0.9

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2 Table S3. Accuracy by AUROCs of non-invasive tests in the CHB population (152 patients).

AUROC

APRI 0.748 0.801 0.810

Fib-4 0.775 0.814 0.890

Fibrotest 0.806 0.844 0.887

Hepascore 0.801 0.866 0.912

FibroMeter^V2G 0.844 0.857 0.918

CirrhoMeter^V2G 0.814 0.873 0.940

FibroMeter^V3G 0.832 0.856 0.909

CirrhoMeter^V3G 0.805 0.868 0.940

LSM 0.790 0.828 0.906

FibroMeter^VCTE2G 0.866 0.903 0.951

Zeng score 0.804 0.851 0.921

p 0.0006 0.0023 0.0046

LSM: liver stiffness measurement

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3 Table S4. Accuracy by AUROCs of non-invasive tests in the NAFLD population (225

patients).

AUROC

APRI 0.747 0.742 0.679

Fib-4 0.769 0.784 0.691

Fibrotest 0.748 0.721 0.697

Hepascore 0.830 0.815 0.920

FibroMeter^V2G 0.855 0.821 0.836

CirrhoMeter^V2G 0.805 0.818 0.857

FibroMeter^V3G 0.839 0.807 0.794

CirrhoMeter^V3G 0.787 0.796 0.808

LSM 0.833 0.886 0.951

NAFLD fibrosis score 0.694 0.744 0.775

FibroMeter ^NAFLD 0.762 0.759 0.820

QuantiMeter^NAFLD 0.844 0.866 0.950

Zeng score 0.839 0.867 0.920

p <0.001 <0.001 <0.001

LSM: liver stiffness measurement

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4 Table S5. Accuracy by AUROCs of non-invasive tests in the ALD population #4 (115

patients).

AUROC

APRI 0.556 0.507 0.527

Fib-4 0.720 0.687 0.707

Hepascore 0.922 0.942 0.920

FibroMeter^V2G 0.891 0.901 0.903

CirrhoMeter^V2G 0.894 0.904 0.900

FibroMeter^V3G 0.834 0.827 0.819

CirrhoMeter^V3G 0.853 0.853 0.849

FibroMeter^{ALD2G a} 0.930 0.941 0.929

Zeng score 0.906 0.903 0.871

p <0.001 <0.001 <0.001

a Optimized accuracy due to optimism bias (derivation population)

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5 Table S6. Accuracy by AUROCs of non-invasive tests in the HIV/CHC population # 5 (444 patients).

AUROC

APRI 0.706 0.701 0.678

Fib-4 0.693 0.725 0.743

Fibrotest 0.698 0.735 0.793

Hepascore 0.725 0.790 0.819

FibroMeter^V2G 0.760 0.798 0.785

CirrhoMeter^V2G 0.719 0.823 0.832

FibroMeter^V3G 0.753 0.780 0.758

CirrhoMeter^V3G 0.712 0.799 0.809

Zeng score 0.711 0.743 0.790

p <0.001 <0.001 0.0009

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6 Table S7. Accuracy by AUROCs of non-invasive tests in the ALD population #6 (150

patients).

AUROC

APRI 0.587 0.549 0.643

Fib-4 0.627 0.602 0.732

Fibrotest 0.663 0.706 0.757

Hepascore 0.770 0.805 0.772

FibroMeter^V2G 0.731 0.715 0.780

CirrhoMeter^V2G 0.760 0.755 0.858

FibroMeter^V3G 0.701 0.666 0.735

CirrhoMeter^V3G 0.723 0.689 0.818

FibroMeter^ALD2G 0.795 0.802 0.820

Zeng score 0.786 0.771 0.770

LSM 0.922 0.861 0.909

p 0.988 0.056 0.015

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7 Table S8. Accuracy by AUROCs of non-invasive tests in the HIV-coinfected population #7 (184 patients).

AUROC

APRI 0.735 0.763 0.746

Fib-4 0.714 0.794 0.831

Fibrotest 0.823 0.815 0.732

Hepascore 0.834 0.850 0.786

FibroMeter^V2G 0.829 0.835 0.793

CirrhoMeter^V2G 0.818 0.835 0.845

FibroMeter^V3G 0.824 0.808 0.757

CirrhoMeter^V3G 0.809 0.797 0.827

FibroMeter^ALD2G 0.793 0.841 0.853

Zeng score 0.793 0.808 0.804

LSM 0.802 0.864 0.903

p 0.999 0.699 0.302

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8 Table S9. Comparison of AUROCs (Delong test) for each test pair in CHC population #1 (641 patients).

AUROC for significant fibrosis:

FM2G CM2G FM3G CM3G LSM APRI FIB4 FT HS EFM2G EFM3G FMA

FM2G - 0.0145 0.0097 0.0007 0.2752 <.0001 0.0006 0.0020 0.0079 0.0071 0.0094 0.0089 CM2G - 0.2888 0.0301 0.9046 0.0569 0.1372 0.3463 0.5470 <.0001 <.0001 0.4745

FM3G - 0.0105 0.6530 0.0030 0.0128 0.0234 0.1420 0.0001 0.0001 0.1605

CM3G - 0.4617 0.2902 0.5619 0.9341 0.7897 <.0001 <.0001 0.7000

LSM - 0.1037 0.2883 0.4232 0.5778 0.0002 0.0002 0.6197

APRI - 0.4356 0.3887 0.2548 <.0001 <.0001 0.2305

FIB4 - 0.7246 0.5448 <.0001 <.0001 0.6914

FT - 0.6716 <.0001 <.0001 0.6914

HS - <.0001 <.0001 0.9364

EFM2G - 0.8586 <.0001

EFM3G - <.0001

FMA -

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9 AUROC for severe fibrosis:

FM2G - 0.2237 0.0433 0.0102 0.6439 <.0001 0.0002 0.0254 0.0522 <.0001 <.0001 0.1696 CM2G - 0.9773 0.0071 0.2671 0.0065 0.0065 0.3512 0.4603 <.0001 <.0001 0.7309 FM3G - 0.0783 0.2614 0.0026 0.0051 0.2066 0.4307 <.0001 <.0001 0.7718

CM3G - 0.0454 0.1348 0.1376 0.7964 0.6693 <.0001 <.0001 0.3102

LSM - 0.0006 0.0037 0.0653 0.0802 0.0008 0.0014 0.1817

APRI - 0.7070 0.1085 0.0844 <.0001 <.0001 0.0296

FIB4 - 0.1741 0.1576 <.0001 <.0001 0.0531

FT - 0.7956 <.0001 <.0001 0.5073

HS - <.0001 <.0001 0.5009

EFM2G - 0.3956 <.0001

EFM3G - <.0001

FMA -

AUROC for cirrhosis:

FM2G CM2G FM3G CM3G VCTE APRI FIB4 FT HS EFM2G EFM3G FMA

FM2G - 0.7720 0.0126 0.2046 0.0863 0.0047 0.0036 0.0099 0.3622 <.0001 <.0001 0.3019 CM2G - 0.4351 0.0179 0.1029 0.0451 0.0066 0.1292 0.6536 0.0002 0.0003 0.4938 FM3G - 0.8228 0.0173 0.1013 0.0312 0.1466 0.8049 <.0001 <.0001 0.8906

CM3G - 0.0293 0.2474 0.0372 0.4447 0.7285 <.0001 <.0001 0.7537

LSM - 0.0006 0.0011 0.0015 0.0176 0.0235 0.0282 0.0218

APRI - 0.5014 0.7800 0.1764 <.0001 <.0001 0.2214

FIB4 - 0.5034 0.1145 <.0001 <.0001 0.1014

FT - 0.1090 <.0001 <.0001 0.2466

HS - <.0001 <.0001 0.8831

EFM2G - 0.7972 <.0001

EFM3G - <.0001

FMA -

FM2G: FibroMeter^V2G, CM2G: CirrhoMeter^V2G, FM3G: FibroMeter^V3G, CM3G: CirrhoMeter^V3G, LSM: Fibroscan, FT: Fibrotest, HS:

Hepascore, EFM2G: FibroMeter^VCTE2G, EFM3G: FibroMeter^VCTE3G, FMA: FibroMeter^ALD. Significant differences are indicated in bold.

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10 Table S10. Comparison of AUROCs (Delong test) for each test pair in CHB population #2 (152 patients).

FM2G - 0.2324 0.1577 0.1065 0.2219 0.0068 0.0188 0.4082 0.1663 0.3923 0.4082 0.1270 CM2G - 0.4660 0.2744 0.6303 0.1165 0.2687 0.8209 0.7075 0.0858 0.0880 0.5356

FM3G - 0.2126 0.3553 0.0224 0.0477 0.2606 0.3313 0.1864 0.1837 0.2848

CM3G - 0.7593 0.1688 0.3654 0.9669 0.9135 0.0439 0.0417 0.8180

LSM - 0.3873 0.7762 0.7175 0.8041 0.0104 0.0131 0.8441

APRI - 0.4151 0.1787 0.2560 0.0377 0.0034 0.2499

FIB4 - 0.3971 0.5422 0.0084 0.0093 0.5987

FT - 0.8628 0.0380 0.0359 0.8544

HS - 0.0377 0.0458 0.9542

EFM2G - 0.6746 0.0410

EFM3G - 0.0416

FMA -

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FM2G - 0.2754 0.8543 0.3485 0.5979 0.2584 0.0889 0.6852 0.8629 0.1270 0.1252 0.8832 CM2G - 0.2962 0.5784 0.3725 0.1251 0.0381 0.4004 0.8496 0.2150 0.2310 0.2305

FM3G - 0.3000 0.6190 0.2958 0.1245 0.6901 0.8377 0.1242 0.1181 0.9397

CM3G - 0.4544 0.1844 0.0331 0.4559 0.9513 0.2194 0.2257 0.5196

LSM - 0.6738 0.8178 0.7795 0.3972 0.0346 0.0510 0.6170

APRI - 0.7637 0.4851 0.2684 0.0357 0.0431 0.1922

FIB4 - 0.4818 0.3279 0.0387 0.0398 0.2004

FT - 0.5651 0.0895 0.0949 0.8160

HS - 0.2617 0.3216 0.7907

EFM2G - 0.4146 0.0760

EFM3G - 0.0875

FMA -

FM2G - 0.2035 0.2289 0.1581 0.7529 0.0686 0.4416 0.2531 0.8127 0.0665 0.1211 0.9250 CM2G - 0.1418 0.9320 0.3757 0.0199 0.1396 0.1358 0.2790 0.5899 0.7423 0.2152

FM3G - 0.0965 0.9426 0.1064 0.6215 0.3940 0.8957 0.0222 0.0402 0.8565

CM3G - 0.3707 0.0213 0.1228 0.1080 0.2723 0.5457 0.7049 0.2842

LSM - 0.2025 0.7447 0.5795 0.8625 0.0416 0.0485 0.8570

APRI - 0.0481 0.2752 0.0955 0.0323 0.0406 0.0265

FIB4 - 0.9384 0.5216 0.1187 0.1595 0.4156

FT - 0.2862 0.0129 0.0231 0.5279

HS - 0.0706 0.1343 0.9304

EFM2G - 0.2565 0.2744

EFM3G - 0.3487

FMA -

Hepascore, EFM2G: FibroMeter^VCTE2G, EFM3G: FibroMeter^VCTE3G, FMA: FibroMeter^ALD. Significant differences are indicated in bold.

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12 Table S11. Comparison of AUROCs (Delong test) for each test pair in NAFLD population #3 (225 patients).

FM2G CM2G FM3G CM3G FMN LSM EFM2G EFM3G HS FMA QMN FT NFS APRI FIB4

FM2G - 0.0069 0.0139 0.0004 0.0003 0.5188 0.0534 0.0741 0.2268 0.8378 0.6422 <.0001 <.0001 0.0012 0.0004 CM2G - 0.0684 0.0035 0.1591 0.4933 0.0005 0.0008 0.3649 0.0348 0.1072 0.0344 0.0004 0.1477 0.2229 FM3G - 0.0030 0.0044 0.8619 0.0088 0.0122 0.7418 0.5953 0.8056 <.0001 <.0001 0.0075 0.0050 CM3G - 0.4212 0.2514 <.0001 <.0001 0.1524 0.0083 0.0254 0.1507 0.0038 0.3307 0.5459 FMN - 0.0488 <.0001 <.0001 0.0228 0.0051 0.0005 0.7312 0.0200 0.6752 0.7237

LSM - 0.0015 0.0026 0.9612 0.5984 0.7138 0.0357 0.0003 0.0291 0.1134

EFM2G - 0.1636 0.0063 0.0459 0.0287 <.0001 <.0001 <.0001 <.0001

EFM3G - 0.0114 0.0648 0.0427 <.0001 <.0001 <.0001 <.0001

HS - 0.3312 0.5654 0.0029 0.0003 0.0293 0.0565

FMA - 0.7054 0.0008 <.0001 0.0095 0.0132

QMN - 0.0132 <.0001 0.0053 0.0067

FT - 0.1894 0.9736 0.5358

NFS - 0.2123 0.0166

APRI - 0.4401

FIB4 -

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FM2G - 0.8946 0.1207 0.2605 0.0520 0.1081 0.0003 0.0006 0.8596 0.0784 0.1313 <.0001 0.0791 0.0473 0.2103 CM2G - 0.6003 0.0107 0.1240 0.1050 0.0007 0.0012 0.9476 0.0487 0.1027 0.0033 0.0537 0.0967 0.3041 FM3G - 0.5865 0.1501 0.0602 0.0001 0.0002 0.7835 0.0431 0.0649 <.0001 0.1628 0.1048 0.4141 CM3G - 0.3356 0.0362 0.0001 0.0002 0.5997 0.0132 0.0228 0.0194 0.1817 0.2321 0.6894 FMN - 0.0009 <.0001 <.0001 0.1383 0.0028 0.0003 0.3448 0.6910 0.6423 0.4190

LSM - 0.0734 0.1040 0.0732 0.5832 0.4822 0.0004 0.0005 0.0008 0.0139

EFM2G - 0.0973 0.0004 0.0202 0.0249 <.0001 <.0001 <.0001 <.0001

EFM3G - 0.0008 0.0334 0.0391 <.0001 <.0001 <.0001 0.0001

HS - 0.0486 0.1296 0.0070 0.1080 0.1388 0.4500

FMA - 0.8650 0.0001 0.0012 0.0054 0.0292

QMN - 0.0005 0.0013 0.0017 0.0132

FT - 0.6452 0.6408 0.0771

NFS - 0.9617 0.2957

APRI - 0.2243

FIB4 -

FM2G - 0.3973 0.0695 0.3826 0.8166 0.1495 0.0711 0.1024 0.2146 0.0549 0.0320 0.0001 0.5620 0.0342 0.0001 CM2G - 0.0542 0.0078 0.5791 0.2415 0.1547 0.2020 0.3486 0.1292 0.0693 0.0004 0.4080 0.0297 <.0001 FM3G - 0.6134 0.7475 0.0806 0.0383 0.0547 0.1166 0.0279 0.0128 0.0013 0.8785 0.1700 0.0231 CM3G - 0.8733 0.1042 0.0630 0.0842 0.1573 0.0450 0.0160 0.0112 0.7649 0.1309 0.0149

FMN - 0.0253 0.0129 0.0214 0.1087 0.0128 0.0038 0.1290 0.5157 0.0203 0.0637

LSM - 0.6655 0.9105 0.4996 0.9625 0.9870 0.0056 0.0049 0.0034 0.0030

EFM2G - 0.2530 0.2333 0.5262 0.7517 0.0010 0.0089 0.0014 0.0006

EFM3G - 0.3811 0.8743 0.9413 0.0021 0.0099 0.0019 0.0012

HS - 0.3495 0.4877 0.0034 0.0351 0.0165 0.0031

FMA - 0.9646 0.0003 0.0216 0.0015 0.0003

QMN - <.0001 0.0307 0.0006 0.0001

FT - 0.5138 0.8277 0.9169

NFS - 0.3690 0.3797

APRI - 0.8592

FIB4 -

Hepascore, EFM2G: FibroMeter^VCTE2G, EFM3G: FibroMeter^VCTE3G, FMA: FibroMeter^ALD, FMN: FibroMeter^NAFLD, QMN: QuantiMeter^NAFLD, NFS: NAFLD fibrosis score. Significant differences are indicated in bold.

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14 Table S12. Comparison of AUROCs (Delong test) for each test pair in ALD population #4 (115 patients).

FM2G CM2G FM3G CM3G APRI FIB4 HS FMA

FM2G - 0.8866 0.0033 0.1973 <.0001 0.0002 0.1897 0.1095 CM2G - 0.0962 0.0038 <.0001 0.0006 0.2683 0.0988

FM3G - 0.5779 <.0001 0.0071 0.0259 0.0150

CM3G - <.0001 0.0042 0.0491 0.0147

APRI - <.0001 <.0001 <.0001

FIB4 - 0.0004 0.0002

HS - 0.5098

FMA -

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FM2G - 0.8756 0.0002 0.0487 <.0001 <.0001 0.0261 0.0352 CM2G - 0.0105 0.0006 <.0001 <.0001 0.0459 0.0463

FM3G - 0.3502 <.0001 0.0002 0.0009 0.0012

CM3G - <.0001 <.0001 0.0032 0.0027

APRI - <.0001 <.0001 <.0001

FIB4 - <.0001 <.0001

HS - 0.8521

FMA -

FM2G - 0.8853 0.0001 0.0475 <.0001 <.0001 0.2882 0.1023 CM2G - 0.0063 0.0013 <.0001 <.0001 0.3990 0.1756

FM3G - 0.2637 <.0001 0.0030 0.0034 0.0012

CM3G - <.0001 0.0006 0.0403 0.0135

APRI - <.0001 <.0001 <.0001

FIB4 - <.0001 <.0001

HS - 0.2484

FMA -

FM2G: FibroMeter^V2G, CM2G: CirrhoMeter^V2G, FM3G: FibroMeter^V3G, CM3G: CirrhoMeter^V3G, HS: Hepascore, FMA: FibroMeter^ALD. Significant differences are indicated in bold.

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16 Table S13. Comparison of AUROCs (Delong test) for each test pair in ALD population #6 (150 patients).

APRI FIB4 HS FM2G CM2G FM3G CM3G FMA Zeng LSM EFM2G EFM3G

APRI - 0.2613 0.0133 0.0016 0.0068 0.0089 0.0245 0.0047 0.0002 <.0001 <.0001 <.0001 FIB4 - 0.0461 0.0092 0.0118 0.0642 0.0491 0.0164 0.0123 <.0001 <.0001 <.0001

HS - 0.5051 0.8405 0.3014 0.4800 0.5327 0.7215 0.0042 0.0068 0.0194

FM2G - 0.4800 0.0644 0.8145 0.2403 0.2689 <.0001 <.0001 <.0001

CM2G - 0.1486 0.0457 0.3778 0.6391 0.0011 0.0002 0.0006

FM3G - 0.5427 0.1104 0.1048 <.0001 <.0001 <.0001

CM3G - 0.1616 0.3069 0.0002 <.0001 0.0001

FMA - 0.8489 0.0156 0.0153 0.0367

Zeng - 0.0056 0.0123 0.0271

LSM - 0.2591 0.0970

EFM2G - 0.0337

EFM3G -

AUROC for severe fibrosis:

APRI - 0.0204 <.0001 <.0001 <.0001 0.0006 0.0025 <.0001 <.0001 <.0001 <.0001 <.0001 FIB4 - 0.0002 0.0003 0.0003 0.0404 0.0188 0.0002 0.0002 <.0001 <.0001 <.0001

HS - 0.0350 0.1884 0.0060 0.0172 0.8862 0.3472 0.1960 0.0884 0.2095

FM2G - 0.2209 0.0013 0.4202 0.0362 0.1173 0.0003 <.0001 <.0001

CM2G - 0.0173 0.0003 0.1164 0.7365 0.0097 0.0004 0.0025

FM3G - 0.4709 0.0041 0.0058 <.0001 <.0001 <.0001

CM3G - 0.0048 0.0876 <.0001 <.0001 <.0001

FMA - 0.4115 0.1262 0.0348 0.1159

Zeng - 0.0163 0.0057 0.0197

LSM - 0.7003 0.6879

EFM2G - 0.0059

EFM3G -

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17 AUROC for cirrhosis:

APRI - <.0001 0.0394 <.0001 <.0001 0.0065 <.0001 0.0029 0.0099 <.0001 <.0001 <.0001 FIB4 - 0.5203 0.1350 0.0012 0.9273 0.0082 0.1105 0.4497 0.0004 0.0001 0.0003

HS - 0.7990 0.0220 0.5098 0.3636 0.0470 0.9948 0.0029 0.0012 0.0037

FM2G - 0.0040 0.0151 0.2235 0.3155 0.7559 0.0020 0.0005 0.0012

CM2G - 0.0003 0.0752 0.2104 0.0403 0.1571 0.0819 0.1328

FM3G - 0.0027 0.0825 0.3907 0.0001 <.0001 <.0001

CM3G - 0.9623 0.3257 0.0251 0.0106 0.0143

FMA - 0.1886 0.0225 0.0092 0.0247

Zeng - 0.0018 0.0008 0.0021

LSM - 0.3867 0.3867

EFM2G - 0.1892

EFM3G -

FM2G: FibroMeter^V2G, CM2G: CirrhoMeter^V2G, FM3G: FibroMeter^V3G, CM3G: CirrhoMeter^V3G, LSM: Fibroscan, HS: Hepascore, EFM2G:

FibroMeter^VCTE2G, EFM3G: FibroMeter^VCTE3G, FMA: FibroMeter^ALD. Significant differences are indicated in bold.

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18 Table S14. Comparison of AUROCs (Delong test) for each test pair in HIV/CHC population #5 (444 patients).

FM2G CM2G FM3G CM3G APRI FIB4 FT HS FMA

FM2G - 0.0060 0.3476 0.0022 0.0137 0.0024 0.0006 0.0489 0.0912 CM2G - 0.0366 0.2582 0.6058 0.2897 0.3618 0.8179 0.5487

FM3G - 0.0049 0.0312 0.0052 0.0021 0.1647 0.2380

CM3G - 0.8161 0.4309 0.5730 0.6134 0.3738

APRI - 0.4574 0.8079 0.5279 0.4654

FIB4 - 0.8659 0.2946 0.2567

FT - 0.1619 0.2222

HS - 0.8214

FMA -

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FM2G - 0.0776 0.0078 0.9808 <.0001 0.0001 0.0005 0.5546 0.2689 CM2G - 0.0059 0.0009 <.0001 <.0001 <.0001 0.0536 0.6194

FM3G - 0.1993 0.0001 0.0059 0.0108 0.6030 0.0578

CM3G - 0.0001 0.0004 0.0022 0.6624 0.2728

APRI - 0.1249 0.2488 0.0010 <.0001

FIB4 - 0.7133 0.0099 0.0003

FT - 0.0023 0.0003

HS - 0.0699

FMA -

FM2G - 0.0026 0.0190 0.2215 <.0001 0.0904 0.7280 0.0421 0.0217 CM2G - 0.0003 0.0698 <.0001 0.0012 0.1427 0.4666 0.9150

FM3G - 0.0051 0.0037 0.5735 0.1152 0.0125 0.0058

CM3G - <.0001 0.0184 0.5650 0.6971 0.3599

APRI - 0.0008 0.0015 <.0001 <.0001

FIB4 - 0.1237 0.0108 0.0080

FT - 0.3019 0.1970

HS - 0.4618

FMA -

FM2G: FibroMeter^V2G, CM2G: CirrhoMeter^V2G, FM3G: FibroMeter^V3G, CM3G: CirrhoMeter^V3G, FT: Fibrotest, HS: Hepascore, FMA:

FibroMeter^ALD. Significant differences are indicated in bold.

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20 Table S15. Comparison of AUROCs (Delong test) for each test pair in HIV population #7 (184 patients).

FM2G CM2G FM3G CM3G LSM EFM2G EFM3G HS FMA FT Zeng APRI FIB4

FM2G - 0.5071 0.4328 0.2645 0.4805 0.0377 0.0359 0.8809 0.1566 0.8237 0.1966 0.0015 0.0002 CM2G - 0.7488 0.3405 0.7046 0.0166 0.0175 0.5954 0.2891 0.8568 0.4721 0.0154 0.0013 FM3G - 0.4216 0.5760 0.0313 0.0277 0.7628 0.2653 0.9710 0.2514 0.0033 0.0005

CM3G - 0.8742 0.0123 0.0111 0.4710 0.5504 0.6506 0.6417 0.0311 0.0033

LSM - 0.0133 0.0150 0.4254 0.8249 0.5948 0.8125 0.0979 0.0439

EFM2G - 0.7186 0.1473 0.0042 0.0677 0.0087 0.0001 <.0001

EFM3G - 0.1745 0.0045 0.0689 0.0088 0.0001 <.0001

HS - 0.1814 0.6820 0.2537 0.0183 0.0055

FMA - 0.3869 0.9908 0.1783 0.0528

FT - 0.3802 0.0264 0.0100

Zeng - 0.1164 0.0291

APRI - 0.4257

FIB4 -

AUROC for severe fibrosis:

FM2G - 0.9844 0.0055 0.1261 0.3556 0.0220 0.0440 0.6436 0.8370 0.4840 0.3702 0.0257 0.2187 CM2G - 0.3256 0.0134 0.3935 0.0231 0.0634 0.6171 0.7967 0.5679 0.4475 0.0668 0.2323 FM3G - 0.6441 0.1193 0.0053 0.0080 0.2550 0.3360 0.8393 0.9855 0.1663 0.6699

CM3G - 0.0715 0.0029 0.0054 0.1642 0.1606 0.6326 0.7649 0.4003 0.9375

LSM - 0.2995 0.4454 0.7017 0.4689 0.2184 0.0954 0.0184 0.0828

EFM2G - 0.1404 0.1501 0.0946 0.0209 0.0202 0.0025 0.0148

EFM3G - 0.2785 0.1773 0.0358 0.0350 0.0042 0.0231

HS - 0.7619 0.1891 0.2587 0.0733 0.2562

FMA - 0.4805 0.2301 0.0953 0.2668

FT - 0.8455 0.2578 0.6550

Zeng - 0.3190 0.7261

APRI - 0.2993

FIB4 -

(21)

21 AUROC for cirrhosis:

FM2G - 0.1071 0.0120 0.3106 0.0018 0.0208 0.0186 0.9083 0.0899 0.1093 0.7600 0.3464 0.4226 CM2G - 0.0285 0.3583 0.1346 0.3359 0.3824 0.1879 0.8078 0.0211 0.4228 0.0784 0.7811 FM3G - 0.0492 0.0012 0.0111 0.0090 0.6045 0.0330 0.5822 0.2710 0.8227 0.1021

CM3G - 0.1086 0.2831 0.2985 0.4867 0.5616 0.0848 0.6747 0.1062 0.9178

LSM - 0.1755 0.1070 0.0056 0.1222 0.0001 0.0147 0.0101 0.2022

EFM2G - 0.8175 0.0078 0.5041 0.0005 0.1152 0.0370 0.4525

EFM3G - 0.0140 0.5337 0.0004 0.1145 0.0356 0.4569

HS - 0.0502 0.1531 0.7056 0.5814 0.5462

FMA - 0.0035 0.1309 0.1161 0.7154

FT - 0.0653 0.8277 0.1398

Zeng - 0.3954 0.6670

APRI - 0.0061

FIB4 -