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Host cell responses induced by hepatitis C virus binding.: Host cell responses induced by HCV

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HAL Id: inserm-00395766

https://www.hal.inserm.fr/inserm-00395766

Submitted on 3 Nov 2009

HAL is a multi-disciplinary open access

archive for the deposit and dissemination of sci-entific research documents, whether they are pub-lished or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.

L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

Host cell responses induced by hepatitis C virus binding.

Xinhua Fang, Mirjam B Zeisel, Jochen Wilpert, Bettina Gissler, Robert

Thimme, Clemens Kreutz, Thomas Maiwald, Jens Timmer, Winfried Kern,

Johannes Donauer, et al.

To cite this version:

Xinhua Fang, Mirjam B Zeisel, Jochen Wilpert, Bettina Gissler, Robert Thimme, et al.. Host cell responses induced by hepatitis C virus binding.: Host cell responses induced by HCV. Hepatology, Wiley-Blackwell, 2006, 43 (6), pp.1326-36. �10.1002/hep.21191�. �inserm-00395766�

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Fang et al. Host cell responses induced by HCV

FIG. 1

-10 -8 -6 -4 -2 0 2 4 6 8 10 Transport (n=57) [667] Transcription (n=47) [647] Signaling (n=268) [3302] Protein Metabolism (n=75) [806]

Oxygen and Radical Metabolism (n=10) [149] Motility (n=35) [318] Lipid Metabolism (n=15) [153] Ion metabolism (n=20) [208] Immuneresponse/Inflammation (n=151) [1805] DNA metabolism (n=54) [691] Development/Differentiation (n=320) [3940] Cytoskeleton (n=13) [88]

Complex functions of higher organisms (n=71) [785 Coagulation (n=4) [37]

Cell Cycle (n=211) [2785]

Carbohydrate metabolism (n=13) [122] Apoptosis (n=25) [305]

Adhesion/ECM (n=29) [264]

Direction of regulation in percent

downregulated upregulated

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Fang et al. Host cell responses induced by HCV

FIG. 2

GAPDH (351 bp) B Apo -100 Apo -100 (220 bp) HCV-LPs GUS GAPDH (351 bp) ApoE (150 bp) HBP (694 bp) GAPDH (351 bp) GAPDH (351 bp) IL1R2 (220 bp) HCV-LPs GUS HCV-LPs GUS HCV-LPs GUS GAPDH (351 bp) INFAR2 (218 bp) GAPDH (351 bp) FcR (221 bp) GAPDH (351 bp) Ga (218 bp) GAPDH (351 bp) LMP2 (242 bp) HCV-LPs GUS HCV-LPs GUS HCV-LPs GUS HCV-LPs GUS PCR: ↑1.8 Array : ↑2.6 PCR: ↑1.8 Array : ↑2.5 PCR: ↑1.7 Array : ↑2.1 PCR: ↑2.5 Array : ↑2.3 PCR: ↑1.6 Array : ↑2.8 PCR: ↑3.8 Array : ↑2.4 PCR: ↓2.0 Array : ↓1.8 PCR: ↓1.4 Array : ↓1.6

2

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Fang et al. Host cell responses induced by HCV

FIG. 3

A.

HepG2 + HCV-LPs # 2

HepG2 + HCV-LPs # 1

HepG2 + HCV-LPs # 3

HepG2 Control # 1

HepG2 Control # 2

HepG2 Control # 3

B.

3

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