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Transforming Growth Factor-beta and Interleukin-1beta Signaling Pathways Converge on the Chemokine CCL20 Promoter.

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Academic year: 2021

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FIGURE 2. CCL20 expression correlates with ␣v␤8 and IL-1␤ expression. Linear regression analysis of protein levels ␣v␤8, IL-1␤, and CCL20 expressed as natural log (Ln) of protein (mg/ml) is shown
FIGURE 3. ␣ v ␤ 8-mediated SMAD4 signaling is required for IL-1 ␤ -mediated CCL20 expression.A, pSMAD2/3 phosphorylation as determined by ELISA (Cell Signaling) is increased by IL-1 ␤ and inhibited by antibody inhibition of ␣ v ␤ 8-mediated TGF- ␤ activati
FIGURE 5. SMAD4 and NF- ␬ B cooperate to mediate IL-1 ␤ - and ␣ v ␤ 8-dependent CCL20 expression

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