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Progressive signaling changes in the olfactory nerve of patients with Alzheimer’s disease

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Supplementary Table 1. List of specimens

NP ID

Age

Sex

Braak

CERAD

Latest MMSE

Group

OB

OT

AON

IHC

FIHC

Density Diameter

NP 12/132 67 F 1 no plaques not available CTL + + + + + + +

NP 12/161 69 M 1 no plaques not available CTL - + - + + + +

NP 13/074 70 F 1 no plaques not available CTL + + + + + + +

NP 13/081 70 M 1 no plaques not available CTL + + + + +

-

-RI 04/079 84 F 1 no plaques not available CTL + + + + + + +

RI 04/110 86 M 1 no plaques not available CTL + + + + + + +

RI 04/158 83 M 0 no plaques not available CTL - + - + +

-

-RI 03/205 84 F 1 no plaques not available CTL + + - + + + +

RI 03/211 85 M 0 no plaques not available CTL + + + + + + +

B 1208 72 M 0 no plaques not available CTL - + - + + + +

NP 15/008 87 F 2 no plaques 28/30 MCI + + + + + + +

NP 15/067 87 F 2 no plaques 29/30 MCI - + - + +

-

-NP 16/059 94 M 3 sparse neuritic plaques not available MCI + + + + + + +

NP 15/131 88 F 3 sparse neuritic plaques 26/30 MCI + + + + + + +

NP 15/065 90 F 3 no plaques 26/30 MCI - + - + +

-

-NP 14/092 96 F 3 no plaques 28/30 MCI - + - + +

-

-NP 16/086 94 F 2 no plaques 22/30 MCI - + - + + + +

RI 04/015 81 M 2 no plaques 26/30 MCI + + + + + + +

RI 04/043 85 F 3 no plaques not available MCI + + + + + + +

NP 13/160 88 F 4 not available 20/30 Moderate + + + + + + +

NP 13/163 89 F 4 moderately dense plaques 24/30 Moderate + + - + + + +

NP 14/003 93 M 4 highly dense plaques 30-Aug Moderate + + + + + + +

NP 14/010 88 M 4 highly dense plaques 30-Dec Moderate + + - + + + +

NP 15/099 83 M 4 moderately dense plaques 30-Oct Moderate + + - + +

-

-NP 14/127 89 F 4 highly dense plaques 26/30 Moderate + + + + + + +

NP 15/022 95 M 4 moderately dense plaques 14/30 Moderate + + - + + + +

RI 05/014 87 M 4 sparse plaques not available Moderate + + - + + + +

NP 14/115 75 M 5 highly dense plaques 0/30 Severe + + + + + + +

NP 14/151 72 M 6 highly dense plaques 0/30 Severe + + + + + + +

NP 14/109 78 M 6 highly dense plaques 0/30 Severe - + - + + + +

NP 14/105 87 F 5 highly dense plaques 0/30 Severe + + + + +

-

-NP 14/076 95 F 5 highly dense plaques 0/30 Severe - + - + +

-

-NP 14/054 77 M 6 highly dense plaques 0/30 Severe + + - + +

-

-NP 14/050 82 F 6 highly dense plaques 0/30 Severe + + + + + + +

NP 14/034 87 F 6 highly dense plaques 0/30 Severe + + + + + + +

NP 14/033 77 F 5 highly dense plaques 0/30 Severe + + - + +

-

-NP 13/165 98 F 5 highly dense plaques 0/30 Severe + + - + + + +

NP14/128 61 f 6 highly dense plaques not available Severe + + + + + + +

MMSE= minimal mental score evaluation; CERAD=Consortium to Establish a Registry for Alzheimer’s Disease; OB= olfactory bulb; OT= olfactory tract; AON= anterior olfactory

nucleus. In CERAD, plaques refer to neuritic plaques.

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Bathini et al.

1

Supplementary Table 2. Co-localization of Jagged1, Reelin and Notch1 puncta in CAm.

Staging

Jag1: Reelin (MCC)

Notch1: Reelin (MCC)

Notch1:Jag1 (MCC)

CTL

0.49±0.31

0.57±0.07

0.07±0.02

MCI

0.42±0.37

0.43±0.24

0.25±0.25

Moderate AD

0.47±0.29

0.53±0.07

0.12±0.02

Severe AD

0.53±0.29

0.58±0.16

0.30±0.25

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