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Supplementary results. Table S2. Quality assessment of the included studies using the ‘risk of bias’ tool. Based on the Risk of Bias tool* for assessing the quality of prevalence studies

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Supplementary results. Table S2. Quality assessment of the included studies using the ‘risk of bias’ tool.

Based on the Risk of Bias tool* for assessing the quality of prevalence studies

Included studies (n=

20)

External validity Internal validity

Summary for the overall

riskb 1. Adequate

definition of casesa

2.

Representativeness of cases

3. Random selection of

cases

4. Non-response bias minimal

5. Data collected directly from

the subjects

6. Acceptable case definition used in the

study

7. Reliability and validity of

study instrument

8. Same mode of data collection for

all subjects

9. Appropriate length of the

shortest prevalence period

10. Appropriate numerator and denominator Current use of cocaine (n= 3)

(Elangovan et

al. , 1993) High risk High risk High risk High risk Low risk High risk High risk Low risk Low risk High risk High risk

(Kalayasiri et

al. , 2006b) High risk High risk Low risk Low risk Low risk Low risk Low risk Low risk Low risk Low risk Low risk

(Mooney et al.

, 2006) High risk High risk Low risk High risk Low risk Low risk Low risk Low risk Low risk Low risk Low risk

Lifetime use of cocaine (n= 17) (Araos et al. ,

2015) Low risk High risk High risk High risk Low risk Low risk Low risk Low risk Low risk Low risk Low risk

(Brady et al. ,

1991) High risk High risk High risk High risk Low risk Low risk Low risk Low risk Low risk Low risk Low risk

(Cubells et al.

, 2005) Low risk High risk High risk High risk Low risk Low risk Low risk Low risk Low risk Low risk Low risk

(Floyd et al. ,

2006) High risk High risk High risk High risk Low risk Low risk Low risk Low risk Low risk Low risk Low risk

(Gonzalez- Saiz et al. ,

2014)

High risk High risk High risk High risk Low risk Low risk Low risk Low risk Low risk Low risk Low risk

(Kalayasiri et

al. , 2006a) Low risk High risk High risk High risk Low risk Low risk Low risk Low risk Low risk Low risk Low risk

(Miguel et

al. , 2018) High risk High risk High risk High risk Low risk High risk High risk Low risk Low risk Low risk High risk

(Reid et al. ,

2004) High risk High risk High risk High risk Low risk Low risk Low risk Low risk Low risk Low risk Low risk

(Roncero et

al. , 2017) High risk High risk High risk High risk Low risk Low risk Low risk Low risk Low risk Low risk Low risk

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Supplementary results. Table S2. Quality assessment of the included studies using the ‘risk of bias’ tool.

(Satel et al. ,

1991) High risk High risk High risk High risk Low risk Low risk Low risk Low risk Low risk Low risk Low risk

(Smith et al. ,

2009) High risk High risk High risk High risk Low risk Low risk Low risk Low risk Low risk Low risk Low risk

(Tang et al. ,

2007) Low risk High risk High risk High risk Low risk Low risk Low risk Low risk Low risk Low risk Low risk

(Trape et al. ,

2014) High risk High risk High risk High risk Low risk Low risk Low risk Low risk Low risk Low risk Low risk

(Vergara- Moragues et

al. , 2012)

High risk High risk High risk High risk Low risk Low risk Low risk Low risk Low risk Low risk Low risk

(Vergara- Moragues et

al. , 2014)

High risk High risk High risk High risk Low risk High risk High risk Low risk Low risk High risk High risk

(Willi et al. ,

2017) High risk High risk High risk High risk Low risk High risk High risk Low risk Low risk Low risk High risk

(Zayats et al. ,

2013) Low risk High risk High risk High risk Low risk Low risk Low risk Low risk Low risk Low risk Low risk

(a) The target population of our study are cocaine users, defined as cocaine users in the general population with exclusion of primary psychosis.

(b) ‘Low risk’ studies were defined on the basis or the risk concerning external and internal validity, and studies using adequate tools/interview to assess the primary outcome

References

Araos P, Pedraz M, Serrano A, Lucena M, Barrios V, Garcia-Marchena N, et al. Plasma profile of pro-inflammatory cytokines and chemokines in cocaine users under outpatient treatment: influence of cocaine symptom severity and psychiatric co-morbidity. Addict Biol. 2015;20:756-72.

Brady KT, Lydiard RB, Malcolm R, Ballenger JC. Cocaine-induced psychosis. J Clin Psychiatry. 1991;52:509-12.

Cubells JF, Feinn R, Pearson D, Burda J, Tang Y, Farrer LA, et al. Rating the severity and character of transient cocaine-induced delusions and hallucinations with a new instrument, the Scale for Assessment of Positive Symptoms for Cocaine-Induced Psychosis (SAPS-CIP). Drug Alcohol Depend. 2005;80:23-33.

Elangovan N, Berman S, Meinzer A, Gianelli P, Miller H, Longmore W. Substance abuse among patients presenting at an inner-city psychiatric emergency room. Hosp Community Psychiatry. 1993;44:782-4.

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Supplementary results. Table S2. Quality assessment of the included studies using the ‘risk of bias’ tool.

Floyd AG, Boutros NN, Struve FA, Wolf E, Oliwa GM. Risk factors for experiencing psychosis during cocaine use: a preliminary report. J Psychiatr Res.

2006;40:178-82.

Gonzalez-Saiz F, Vergara-Moragues E, Verdejo-Garcia A, Fernandez-Calderon F, Lozano OM. Impact of psychiatric comorbidity on the in-treatment outcomes of cocaine-dependent patients in therapeutic communities. Subst Abus. 2014;35:133-40.

Kalayasiri R, Kranzler HR, Weiss R, Brady K, Gueorguieva R, Panhuysen C, et al. Risk factors for cocaine-induced paranoia in cocaine-dependent sibling pairs. Drug Alcohol Depend. 2006a;84:77-84.

Kalayasiri R, Sughondhabirom A, Gueorguieva R, Coric V, Lynch WJ, Morgan PT, et al. Self-reported paranoia during laboratory "binge" cocaine self- administration in humans. Pharmacol Biochem Behav. 2006b;83:249-56.

Miguel AQC, Madruga CS, Cogo-Moreira H, Yamauchi R, Simoes V, Da Silva CJ, et al. Sociodemographic Characteristics, Patterns of Crack Use, Concomitant Substance Use Disorders, and Psychiatric Symptomatology in Treatment- Seeking Crack-Dependent Individuals in Brazil. J Psychoactive Drugs.

2018;50:367-72.

Mooney M, Sofuoglu M, Dudish-Poulsen S, Hatsukami DK. Preliminary observations of paranoia in a human laboratory study of cocaine. Addict Behav.

2006;31:1245-51.

Reid MS, Ciplet D, O'Leary S, Branchey M, Buydens-Branchey L, Angrist B. Sensitization to the psychosis-inducing effects of cocaine compared with measures of cocaine craving and cue reactivity. Am J Addict. 2004;13:305-15.

Roncero C, Grau-Lopez L, Palma-Alvarez RF, Rodriguez-Cintas L, Ros-Cucurull E, Esojo A, et al. Higher severity of cocaine addiction is associated with tactile and somatic hallucinations. Eur Psychiatry. 2017;42:63-9.

Satel SL, Southwick SM, Gawin FH. Clinical features of cocaine-induced paranoia. Am J Psychiatry. 1991;148:495-8.

Smith MJ, Thirthalli J, Abdallah AB, Murray RM, Cottler LB. Prevalence of psychotic symptoms in substance users: a comparison across substances. Compr Psychiatry. 2009;50:245-50.

Tang YL, Kranzler HR, Gelernter J, Farrer LA, Cubells JF. Comorbid psychiatric diagnoses and their association with cocaine-induced psychosis in cocaine- dependent subjects. Am J Addict. 2007;16:343-51.

Trape S, Charles-Nicolas A, Jehel L, Lacoste J. Early cannabis use is associated with severity of Cocaine-Induced Psychosis among cocaine smokers in

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Supplementary results. Table S2. Quality assessment of the included studies using the ‘risk of bias’ tool.

Martinique, French West Indies. J Addict Med. 2014;8:33-9.

Vergara-Moragues E, Gomez PA, Gonzalez-Saiz F, Rodriguez-Fonseca F. Cocaine-induced psychotic symptoms in clinical setting. Psychiatry Res.

2014;217:115-20.

Vergara-Moragues E, Gonzalez-Saiz F, Lozano OM, Betanzos Espinosa P, Fernandez Calderon F, Bilbao-Acebos I, et al. Psychiatric comorbidity in cocaine users treated in therapeutic community: substance-induced versus independent disorders. Psychiatry Res. 2012;200:734-41.

Willi TS, Barr AM, Gicas K, Lang DJ, Vila-Rodriguez F, Su W, et al. Characterization of white matter integrity deficits in cocaine-dependent individuals with substance-induced psychosis compared with non-psychotic cocaine users. Addict Biol. 2017;22:873-81.

Zayats T, Yang BZ, Xie P, Poling J, Farrer LA, Gelernter J. A complex interplay between personality domains, marital status and a variant in CHRNA5 on the risks of cocaine, nicotine dependences and cocaine-induced paranoia. PLoS One. 2013;8:e49368.

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