High alcohol consumption in middle-aged adults is associated with poorer cognitive performance only in the low socio-economic group. Results from the GAZEL cohort study.

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Submitted on 15 Sep 2011

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High alcohol consumption in middle-aged adults is

associated with poorer cognitive performance only in

the low socio-economic group. Results from the GAZEL

cohort study.

Séverine Sabia, Alice Guéguen, Claudine Berr, Lisa Berkman, Joël Ankri,

Marcel Goldberg, Marie Zins, Archana Singh-Manoux

To cite this version:

Séverine Sabia, Alice Guéguen, Claudine Berr, Lisa Berkman, Joël Ankri, et al.. High alcohol con-sumption in middle-aged adults is associated with poorer cognitive performance only in the low socio-economic group. Results from the GAZEL cohort study.. Addiction/British Journal of Addictions, 2011, 106 (1), pp.93-101. �10.1111/j.1360-0443.2010.03106.x�. �inserm-00530157�

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Figure S1. Analyses restricted to participants without depressive symptoms (CESD<16;

N=2992)

†

Adjusted for age, screening centre, marital status, and smoking history.

B. Non-depressed participants (CESD<16)

36 38 40 42 44 46 48 50 52 54 56

Alcohol consumption (drinks/week)

D ig it -S y m b o l S u st it u ti o n S c o re 0 30 1 - 3 4 - 14 15 - 21 > 21 32 34 36 38 40 42 44 46 48 50 52 54

Alcohol consumption 10 years before cognitive exam (drinks/week)

D ig it-S y m b o l S u sti tu ti o n S c o r e Lower SEP (N=439) Intermediate SEP (N=1940) Higher SEP (N=613) D ig it Sy m b o l S u b st it u ti o n Sco re

*

36 38 40 42 44 46 48 50 52 54 56

*

36 38 40 42 44 46 48 50 52 54 56

Change in alcohol consumption (drinks/week)

D ig it -S y m b o l S u st it u ti o n S c o re 30 32 34 36 38 40 42 44 46 48 50 52 54

D ig it-S y m b o l S u sti tu ti o n S c o r e Lower SEP (N=439) Intermediate SEP (N=1940) Higher SEP (N=613) D ig it Sy m b o l S u b st it u ti o n Sco re ≤-11 -10 to -4 -3 to +4 +5 to +11 ≥12

*

36 38 40 42 44 46 48 50 52 54 56

D ig it -S y m b o l S u st it u ti o n S c o re 30 32 34 36 38 40 42 44 46 48 50 52 54

D ig it-S y m b o l S u sti tu ti o n S c o r e Lower SEP (N=439) Intermediate SEP (N=1940) Higher SEP (N=613) D ig it Sy m b o l S u b st it u ti o n Sco re ≤-11 -10 to -4 -3 to +4 +5 to +11 ≥12

*

Legend

30 32 34 36 38 40 42 44 46 48 50 52 54

D ig it-S y m b o l S u sti tu ti o n S c o r e Low (N=439) Intermediate (N=1940) Higher SEP (N=613)

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Figure S2. Mean Digit-Symbol Substitution Test score

†

and 95% Confidence Interval as a

function of categories of average alcohol consumption in different SEP groups estimated

using weighed regression.

†

Adjusted for age, screening centre, marital status, and smoking history.

36 38 40 42 44 46 48 50 52 54 56

D ig it -S y m b o l S u st it u ti o n S c o re 0 1 - 3 4 - 14 15 - 21 > 21 D ig it Sy m b o l S u b st it u ti o n Sco re

*

Legend

30 32 34 36 38 40 42 44 46 48 50 52 54

D ig it-S y m b o l S u sti tu ti o n S c o r e Low (N=684) Intermediate (N=2607) High (N=782) 32 34 36 38 40 42 44 46 48 50 52

D ig it -S y m b o l S u st it u ti o n S c o re 0 1 - 3 4 - 14 15 - 21 > 21 D ig it Sy m b o l S u b st it u ti o n Sco re

*

Legend

30 32 34 36 38 40 42 44 46 48 50 52 54

D ig it-S y m b o l S u sti tu ti o n S c o r e Low (N=171) Intermediate (N=2723) High (N=1179)

Analyses stratified by occupational groups

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Figure S3. Mean Digit-Symbol Substitution Test score

†

and 95% Confidence Interval as a

function of categories of trajectories of alcohol consumption in different SEP groups

estimated using weighed regression.

†

Adjusted for age, screening centre, marital status, and smoking history.

36 38 40 42 44 46 48 50 52 54 56

D ig it -S y m b o l S u st it u ti o n S c o re D ig it Sy m b o l S u b st it u ti o n Sco re ≤-11 -10 to -4 -3 to +4 +5 to +11 ≥12 * *

Legend

30 32 34 36 38 40 42 44 46 48 50 52 54

D ig it-S y m b o l S u sti tu ti o n S c o r e Low (N=684) Intermediate (N=2607) High (N=782) 34 36 38 40 42 44 46 48 50 52 54

D ig it -S y m b o l S u st it u ti o n S c o re D ig it Sy m b o l S u b st it u ti o n Sco re ≤-11 -10 to -4 -3 to +4 +5 to +11 ≥12

Legend

30 32 34 36 38 40 42 44 46 48 50 52 54

D ig it-S y m b o l S u sti tu ti o n S c o r e Low (N=171) Intermediate (N=2723) High (N=1179)