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Target-Mediated Drug Disposition Population Pharmacokinetics Model of Alirocumab in Healthy Volunteers and Patients: Pooled Analysis of Randomized Phase I/II/III Studies

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Academic year: 2021

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Figure

Fig. 1 Mechanism of action of alirocumab, a PCSK9 inhibitor (adapted from Lambert et al
Table 2 Summary of bioanalysis assay characteristics for total alirocumab, total and free PCSK9 concentrations (measured by ELISA in human serum), and detection of ADAs at three different evaluations per serum sample
Fig. 6 Predicted total alirocumab, total PCSK9, and free PCSK9 levels using the final model on alirocumab 75 mg Q2W for up to weeks 10–12
Fig. 8 Visual predictive check results for total PCSK9 (n = 14877) per study (STUD) for the expanded data set

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