Порівняльна оцінка біопротекторної дії цинку в органічній та неорганічній формі на остеотропність свинцю в експериментальних умовах

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https://hal.archives-ouvertes.fr/hal-01450942

Submitted on 31 Jan 2017

HAL is a multi-disciplinary open access archive for the deposit and dissemination of sci-entific research documents, whether they are pub-lished or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.

L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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E.M. Biletska, N.M. Onul, V.V. Kalinichev�

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ȾɁ «Ⱦɧɿɩɪɨɩɟɬɪɨɜɫɶɤɚ ɦɟɞɢɱɧɚ ɚɤɚɞɟɦɿɹ ɆɈɁ ɍɤɪɚʀɧɢ» ɤɚɮɟɞɪɚ ɡɚɝɚɥɶɧɨʀ ɝɿɝɿɽɧɢ (ɡɚɜ. – ɞ. ɦɟɞ. ɧ., ɩɪɨɮ. ȿ.Ɇ. Ȼɿɥɟɰɶɤɚ) ɩɥ. ɋɨɛɨɪɧɚ, 4, Ⱦɧɿɩɪɨ, 49000, ɍɤɪɚʀɧɚ

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine» Department of General Higiene

Soborna Sq., 4, Dnipro, 49000, Ukraine ɟ-mail: enbelitska@ukr.net

Ʉɥɸɱɨɜɿɫɥɨɜɚ ɰɢɧɤ, ɫɜɢɧɟɰɶ, ɤɚɥɶɰɿɣ, ɨɫɬɟɨɩɨɪɨɡ, ɤɿɫɬɤɚ .H\ZRUGV zinc, plumbum, calcium, osteoporosis, bone

 Ɋɟɮɟɪɚɬ ɋɪɚɜɧɢɬɟɥɶɧɚɹ ɨɰɟɧɤɚ ɛɢɨɩɪɨɬɟɤɬɨɪɧɨɝɨ ɞɟɣɫɬɜɢɹ ɰɢɧɤɚ ɜ ɨɪɝɚɧɢɱɟɫɤɨɣ ɢ ɧɟɨɪɝɚɧɢɱɟɫɤɨɣ ɮɨɪɦɟɧɚɨɫɬɟɨɬɪɨɩɧɨɫɬɶɫɜɢɧɰɚɜɷɤɫɩɟɪɢɦɟɧɬɚɥɶɧɵɯɭɫɥɨɜɢɹɯȻɟɥɟɰɤɚɹɗɇɈɧɭɥɇɆɄɚɥɢɧɢɱɟɜɚ ȼȼ ɏɢɦɢɱɟɫɤɚɹ ɚɝɪɟɫɫɢɹ ɬɟɯɧɨɝɟɧɧɨɝɨ ɡɚɝɪɹɡɧɟɧɢɹ ɨɤɪɭɠɚɸɳɟɣ ɫɪɟɞɵ, ɩɨ ɦɧɟɧɢɸ ɫɩɟɰɢɚɥɢɫɬɨɜ, ɹɜɥɹɟɬɫɹ ɜɟɞɭɳɢɦ ɮɚɤɬɨɪɨɦ ɪɢɫɤɚ ɞɥɹ ɩɨɩɭɥɹɰɢɨɧɧɨɝɨ ɡɞɨɪɨɜɶɹ ɧɚɫɟɥɟɧɢɹ. ɋɢɫɬɟɦɚɬɢɱɟɫɤɨɟ ɩɨɫɬɭɩɥɟɧɢɟ ɤɨɧɬɚ-ɦɢɧɚɧɬɨɜ ɜ ɫɦɟɠɧɵɟ ɠɢɡɧɟɨɛɟɫɩɟɱɢɜɚɸɳɢɟ ɫɪɟɞɵ – ɜɨɡɞɭɯ, ɜɨɞɭ, ɪɚɫɬɢɬɟɥɶɧɵɟ ɢ ɠɢɜɨɬɧɵɟ ɩɢɳɟɜɵɟ ɩɪɨ-ɞɭɤɬɵ ɡɚ ɩɪɹɦɵɦɢ ɢ ɨɩɨɫɪɟɞɨɜɚɧɧɵɦɢ ɦɢɝɪɚɰɢɨɧɧɵɦɢ ɰɟɩɹɦɢ, ɫɨɡɞɚɟɬ ɢ ɤɨɦɩɥɟɤɫɧɨɟ, ɢ ɤɨɦɛɢɧɢɪɨɜɚɧɧɨɟ ɢɯ ɜɥɢɹɧɢɟ ɧɚ ɨɪɝɚɧɢɡɦ. ɉɪɢ ɷɬɨɦ ɫɥɟɞɭɟɬ ɨɬɦɟɬɢɬɶ, ɱɬɨ ɢɦɟɧɧɨ ɯɢɦɢɱɟɫɤɢɣ ɮɚɤɬɨɪ, ɫ ɨɞɧɨɣ ɫɬɨɪɨɧɵ, ɹɜ-ɥɹɟɬɫɹ ɧɚɢɦɟɧɟɟ ɢɡɭɱɟɧɧɵɦ ɜ ɷɬɨɦ ɨɬɧɨɲɟɧɢɢ, ɫ ɞɪɭɝɨɣ ɫɬɨɪɨɧɵ ɨɧ ɩɪɟɞɫɬɚɜɥɹɟɬ ɧɚɢɛɨɥɟɟ ɫɭɳɟɫɬɜɟɧɧɭɸ ɢ ɪɟɡɤɨ ɜɨɡɪɚɫɬɚɸɳɭɸ ɷɤɨɥɨɝɢɱɟɫɤɭɸ ɭɝɪɨɡɭ ɞɥɹ ɡɞɨɪɨɜɶɹ ɱɟɥɨɜɟɤɚ. ȼ ɨɪɝɚɧɢɡɦɟ ɱɟɥɨɜɟɤɚ ɤɨɫɬɧɚɹ ɬɤɚɧɶ ɢɦɟɟɬ ɧɚɢɛɨɥɶɲɢɟ ɤɭɦɭɥɹɬɢɜɧɵɟ ɫɜɨɣɫɬɜɚ ɩɨ ɨɬɧɨɲɟɧɢɸ ɤɨ ɦɧɨɝɢɦ ɤɫɟɧɨɛɢɨɬɢɤɚɦ, ɜ ɱɚɫɬɧɨɫɬɢ ɤ ɝɪɭɩɩɟ ɬɹɠɟɥɵɯ ɦɟɬɚɥɥɨɜ, ɫɪɟɞɢ ɤɨɬɨɪɵɯ ɫɜɢɧɟɰ ɹɜɥɹɟɬɫɹ ɥɢɞɟɪɨɦ ɩɨ ɫɬɟɩɟɧɢ ɪɨɞɫɬɜɚ ɤ ɤɨɫɬɧɨɣ ɬɤɚɧɢ. ȼ ɫɜɹɡɢ ɫ ɷɬɢɦ ɰɟɥɶɸ ɹɜɥɹɟɬɫɹ ɷɤɫɩɟɪɢɦɟɧɬɚɥɶɧɨɟ ɢɫɫɥɟɞɨɜɚɧɢɟ ɨɫɨɛɟɧɧɨɫɬɟɣ ɜɥɢɹɧɢɹ ɪɚɡɥɢɱɧɵɯ ɮɨɪɦ ɰɢɧɤɚ ɧɚ ɫɨɞɟɪɠɚɧɢɟ ɤɚɥɶ-ɰɢɹ ɜ ɤɨɫɬɧɨɣ ɬɤɚɧɢ ɩɪɢ ɫɜɢɧɰɨɜɨɣ ɢɧɬɨɤɫɢɤɚɰɢɢ. ȼ ɪɟɡɭɥɶɬɚɬɟ ɩɪɨɜɟɞɟɧɧɵɯ ɢɫɫɥɟɞɨɜɚɧɢɣ ɭɫɬɚɧɨɜɥɟɧɨ, ɱɬɨ ɧɢɡɤɨɞɨɡɨɜɨɟ ɜɥɢɹɧɢɟ ɫɜɢɧɰɚ ɜ ɭɫɥɨɜɢɹɯ ɩɨɞɨɫɬɪɨɝɨ ɨɩɵɬɚ ɨɛɭɫɥɚɜɥɢɜɚɟɬ ɞɨɫɬɨɜɟɪɧɨɟ ɭɦɟɧɶɲɟɧɢɟ ɫɨɞɟɪɠɚɧɢɹ ɤɚɥɶɰɢɹ ɜ ɤɨɫɬɧɨɣ ɬɤɚɧɢ ɧɚ 28% ɜ ɫɪɚɜɧɟɧɢɢ ɫ ɚɧɚɥɨɝɢɱɧɵɦɢ ɞɚɧɧɵɦɢ ɤɨɧɬɪɨɥɶɧɨɣ ɝɪɭɩɩɵ ɠɢɜɨɬɧɵɯ, ɱɬɨ ɫɧɢ-ɠɚɟɬ ɟɟ ɩɥɨɬɧɨɫɬɶ ɢ ɫɬɚɧɨɜɢɬɫɹ ɮɚɤɬɨɪɨɦ ɪɢɫɤɚ ɪɚɡɜɢɬɢɹ ɨɫɬɟɨɩɟɧɢɣ ɢ ɨɫɬɟɨɩɨɪɨɡɧɵɯ ɫɨɫɬɨɹɧɢɣ ɨɪɝɚɧɢɡɦɚ. Ʉɨɦɛɢɧɢɪɨɜɚɧɧɨɟ ɜɨɡɞɟɣɫɬɜɢɟ ɫɜɢɧɰɚ ɢ ɨɪɝɚɧɢɱɟɫɤɢɯ ɢ ɧɟɨɪɝɚɧɢɱɟɫɤɢɯ ɮɨɪɦ ɰɢɧɤɚ ɞɨɫɬɨɜɟɪɧɨ ɭɜɟɥɢɱɢɜɚɟɬ ɫɨɞɟɪɠɚɧɢɟ ɤɚɥɶɰɢɹ ɧɚ 16,43% ɢ 22,04% ɫɨɨɬɜɟɬɫɬɜɟɧɧɨ, ɩɨ ɫɪɚɜɧɟɧɢɸ ɫɨ ɫɜɢɧɰɨɜɨɣ ɝɪɭɩɩɨɣ, ɱɬɨ ɩɨɡɜɨɥɹɟɬ ɩɪɟɞɩɨɥɨɠɢɬɶ ɩɪɨɬɟɤɬɨɪɧɵɟ ɫɜɨɣɫɬɜɚ ɰɢɧɤɚ ɩɪɢ ɫɜɢɧɰɨɜɨɣ ɢɧɬɨɤɫɢɤɚɰɢɢ ɡɚ ɫɱɟɬ ɷɮɮɟɤɬɚ ɛɢɨɚɧɬɚɝɨɧɢɡɦɚ. ɉɪɢ ɢɡɨɥɢɪɨɜɚɧɧɨɦ ɜɜɟɞɟɧɢɢ ɨɪɝɚɧɢɱɟɫɤɢɯ ɢ ɧɟɨɪɝɚɧɢɱɟɫɤɢɯ ɮɨɪɦ ɰɢɧɤɚ ɫɨɞɟɪɠɚɧɢɟ ɤɚɥɶɰɢɹ ɜ ɤɨɫɬɧɨɣ ɬɤɚɧɢ ɭɜɟɥɢɱɢɜɚɟɬɫɹ ɜ 1,4 ɢ 2,04 ɪɚɡɚ ɫɨɨɬɜɟɬɫɬɜɟɧɧɨ ɩɨ ɫɪɚɜɧɟɧɢɸ ɫ ɤɨɧɬɪɨɥɶɧɨɣ ɝɪɭɩɩɨɣ. ɉɨɥɭɱɟɧɧɵɟ ɪɟɡɭɥɶɬɚɬɵ ɩɨɞɬɜɟɪɠɞɚɸɬ ɨɫɬɟɨɩɪɨɬɟɤɬɨɪɧɨɫɬɶ ɰɢɧɤɚ, ɨɫɨɛɟɧɧɨ ɨɪɝɚɧɢɱɟɫɤɢɯ ɟɝɨ ɮɨɪɦ, ɩɪɢ ɫɜɢɧɰɨɜɨɣ ɢɧɬɨɤɫɢɤɚɰɢɢ ɢ ɞɚɸɬ ɨɫɧɨɜɚɧɢɟ ɫɱɢɬɚɬɶ, ɱɬɨ ɜ ɫɢɫɬɟɦɟ «ɫɜɢɧɟɰ – ɰɢɧɤ» ɮɨɪɦɢɪɭɟɬɫɹ ɷɮɮɟɤɬ ɛɢɨɥɨɝɢɱɟɫɤɨɝɨ ɚɧɬɚɝɨɧɢɡɦɚ.  $EVWUDFW&RPSDUDWLYHHYDOXDWLRQRIELRSURWHFWLYHDFWLRQRI]LQFLQRUJDQLFDQGLQRUJDQLFIRUPRQRVWHRWURSLVP RI OHDG LQ H[SHULPHQWDO FRQGLWLRQV %LOHWVND (0 2QXO 10 .DOLQLFKHYɚ 99 Chemical aggression of

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