HAL Id: hal-02620896
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Submitted on 26 May 2020
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Pierre Louis Teissedre, Creina Stockley, Mladen Boban, Jean-Claude Ruf, Marta Ortiz Alba, Philippe Gambert, Markus Flesh
To cite this version:
Pierre Louis Teissedre, Creina Stockley, Mladen Boban, Jean-Claude Ruf, Marta Ortiz Alba, et al..
The effects of wine consumption on cardiovascular disease and associated risk factors: a narrative
review. OENO One, Institut des Sciences de la Vigne et du Vin (Université de Bordeaux), 2018, 52
(1), pp.67-79. �10.20870/oeno-one.2018.52.1.2129�. �hal-02620896�
The effects of wine consumption on cardiovascular disease and associated risk factors: a narrative review
Pierre-Louis Teissedre
1, 2*, Creina Stockley
3, Mladen Boban
4, Philippe Gambert
5, Marta Ortiz Alba
6, Markus Flesh
7and Jean-Claude Ruf
81
Université de Bordeaux, Institut des Sciences de la Vigne et du Vin, EA 4577, Unité de recherche Œnologie, 210 chemin de Leysotte, CS 50008, F-33882 Villenave d’Ornon Cedex, France
2
INRA, ISVV, USC 1366 Œnologie, F-33882 Villenave d’Ornon, France
3
The Australian Wine Research Institute, PO Box 197, Glen Osmond, SA, 5064, Australia
4
Department of Pharmacology - University of Split, School of Medicine, Soltanska 2, 21 000 Split, Croatia
5
IFR 100 Santé STIC, Laboratoire de Biochimie Médicale, Plateau Technique de Biologie, 2 rue Angélique Ducoudray, BP 37013, 21070 Dijon Cedex, France
6
Universidad Nacional de Cuyo - Facultad de Ciencias Médicas, Química Biológica, Avenida Libertador 80, 5500 Mendoza, Argentina
7
Allgemeine Innere Medizin / Kardiologie, Marienkrankenhaus Soest, Widumgasse 5, 59494 Soest, Germany
8
International Organisation of Vine and Wine (OIV), Scientific coordinator, 18 rue d’Aguesseau, 75008 Paris, France
The authors are government delegates and/or experts to the International Organisation of Vine and Wine’s (OIV) Commission IV Safety and Health. Although this work was initiated under the auspices of the OIV
and its Consumption, Nutrition and Health expert group, the statements made herein are solely the responsibility of the authors.
Accumulating evidence suggests that regular moderate consumption of wine can positively influence risk factors associated with cardiovascular health. These effects are often attributed to grape and wine-derived phenolic compounds and their effects on risk factors such as atherosclerosis, for which mechanisms have been clearly identified, such as a decrease in the oxidation of LDL-cholesterol and reduction of oxidative stress, and an increase in nitric oxide and related restoration of endothelial function. In addition, the ethanol component of wine increases HDL-cholesterol, inhibits platelet aggregation, promotes fibrinolysis and reduces systemic inflammation.
Scientific research needs to be conducted, however, before we can begin to provide science-based dietary recommendations, although there is sufficient evidence to generally recommend consuming food sources rich in bioactive compounds such as wine in moderation.
This narrative review examines published evidence on the cardioprotective effects associated with wine-derived compounds, with a primary focus on the development and progression of atherosclerosis and thrombosis.
Keywords: wine, cardiovascular diseases, consumption, polyphenols, ethanol, pathophysiological mechanisms Abstract
Received : 26 December 2017; Accepted : 26 February 2018; Published : 29 March 2018 DOI: 10.20870/oeno-one.2018.52.1.2129
Volume 51 > Number 1 > 2018