YASS: Similarity search in DNA sequences
24
0
0
Texte intégral
(2) INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET EN AUTOMATIQUE. YASS: Similarity search in DNA sequences Laurent Noé — Gregory Kucherov. N° 4852 Juin 2003. ISSN 0249-6399. ISRN INRIA/RR--4852--FR+ENG. THÈME 2. apport de recherche.
(3)
(4)
(5)
(6) !#"%$ & ' ( !) * +-,/.0214365798:<;>=0214?@8@0
(7) ACB.DFE1G0H8JI KMLONHPRQTSVUXWZYH[O\]Q^`_ba4\`c
(8) \]QH^ Q
(9) dec
(10) fg^hcij^lknmoPVp/_b^`\hq4ijQ r>st_guvQd-w xOfbabQ yefgzOz/_bs{d-xJQs{Q2cLOQ
(11) scLOQ|[/}~G44SU 4iO\`[Sbb4UXSb zfgabQ2k. 9 H
(12) FObb% QxJQHktcst\`pQZoJoT9fV[jQ
(13) Cdt_o_b^/_bs*j[jxO\][Oa ^`_Jc
(14) fg^6k{\]P \`^`fbs{\]d{\`QHk*\`[Zew|k{QHqGiOQH[jcQ2k
(15) KMLjQoOoVfb^]a4_bst\dtLOPjstknd k{cHfg[jkd{LOQk{QHqGiOQH[jcQGk fb[jx9c
(16) s{Q2fFd{Q2k_4[¡d{LjQ¢m¡abst_biOzjk£_g¤¥¥¦§¤e¨knP¡fb^]^ Q
(17) ©OfbcªdMstQ
(18) z/QHfFdk*_bpJdfg\`[OQHx)pom¡Ljfbk{LO\`[OaG *fbcHc_4stxJ\`[OaVd{_¡kvdfFdt\`knd{\hc
(19) fb^]^`mGǬ_4iO[jxJQ2x9cst\]d{Q
(20) st\hfOKMLOQ
(21) [\dMdts{\`QHk dt_ Q©od{QH[jx)d{LO_GknQ¬abst_bijzjk*\][Gd{_k{\`PR\`^hfgst\dvm¡stQ
(22) a4\]_4[jk*_b[)d{LOQpjf4kn\hkM_g®fR[OQ
(23) ¯Q©odtQ
(24) [jk{\]_4[c
(25) s{\]d{QHs{\`_b[& KMLOQ°P QdtLO_Jx±cHfg[±pQk{Q
(26) Q
(27) [²fbk f³c_bP zOst_bP \hknQp/Qdv*Q
(28) Q
(29) [²kn\`[Oa4^]Q
(30) «´k{Q
(31) Q2xC¶µO·GOb¸O Vfg[jx±PViO^]d{\`zO^`Q« k{Q
(32) Q2x¹ºoJ4¸o@»GµJ·Go¸O *fgzOzOst_4f4cLOQHkH»ofg[jx°fbcLj\]QH¼bQHkMfRa4fb\][\`[p/_gdtLknQH[jkn\]d{\`¼o\dvm)fg[jx°k{Q
(33) ^`QHcªdt\]¼o\]dvmb>KMLOQ P Q
(34) d{LO_Jx°\hk-¢jQ
(35) ©J\]pO^`QVfb[jxc
(36) fb[pQTP¡f4xJQTP _bstQTQ½c
(37) \]QH[4dpGmijk{\][ja9knzfbcQ2xknQHQHxOkH»fb[jx°\`[zjfgs{d{\hciO^hfgs dtstfb[jk{\dt\]_4[J«´c
(38) _b[jknd{sfg\`[OQ2xknzfbcQ2x)k{Q
(39) Q2xOkH QzOs{_F¼o\hxJQ³Q©OfgP zO^`QHk_g fgzOzj^]mo\`[Oa±oOo¾d{_¯¿@À4ÁtÁÂOÀgÃ{ÄFÅRÆbÁ¥ª¤ÈÇ>¥Ãt¥É2Êh¤ªÊÀb¥Ëfb[jxÌTÃ{ÄF¤
(40) ÄtÍOÂJʶÎ]À Ï¥
(41) Î]ÀFÐ@Ä{ÑGÀ§¤ªÒӥà cLOst_bP _Gkn_4PRQ2k
(42) ÔÕGÖ@×tØVÙ FÚ bÜÛ wZÝOÝ@»^]_Jc
(43) fb^lfg^`\]a4[OP Q
(44) [GdH»Ok{zjf4cQHxk{Q
(45) QHxjk
(46) »odtstfb[jkn\]d{\`_b[k. Unité de recherche INRIA Lorraine LORIA, Technopôle de Nancy-Brabois, Campus scientifique, 615, rue du Jardin Botanique, BP 101, 54602 Villers-Lès-Nancy (France) Téléphone : +33 3 83 59 30 00 — Télécopie : +33 3 83 27 83 19.
(47) | Ë M )
(48) )V!) ' () ! * nÜ"%$
(49)
(50) -_4ijk-zOstYHk{Q
(51) [Gdt_b[jkMoOo 9iO[[O_4iO¼bQH^l_biJdt\]^zjfgs ^hf¡stQHcLOQHstcLjQ^`_Jc
(52) fg^`QTxJQVk{\`PR\`^hfgst\dtY
(53) QHk xjfg[jk9^]Q2k9k{YHqGiOQ
(54) [cQHk9x wV fg^`ab_bst\]d{LOP QxJQoOozjfbstc
(55) _biOsk¡^hf<knY2qGiOQ
(56) [jc
(57) QËxOfg[kiO[Czjs{QHPR\`Q
(58) s dtQ
(59) P zjkH»Q
(60) d¡c
(61) s{YHQxOQHkRabst_biOz/QHk xJQ°a4stfb\][OQ2k)zQ
(62) d{\]d{Q2k s{YHzY
(63) d{\]d{\`_b[jk Q
(64) ©Jf4cªdtQHk _bpJdtQ
(65) [oiOQHk zfgsRLjfbcLjfbabQ§ k{Q
(66) ^`_b[²xJQHk9cst\dtN
(67) stQHkRs{QHz_Gk{fb[Gd k{iOs¡xJQHk zjs{_4zOs{\`YdtY
(68) Q2kRkndtfgd{\hkvdt\`qGiOQ2k
(69) Zfg[jk ij[²xJQHiJ©J\]NHP Q°d{Q
(70) P zjkH»*\]^ Q2k{ktfg\`Qx Y
(71) d{Q
(72) [xJs{Q¬cQ2k*abst_biOz/QHk*Q
(73) [)s{YHab\`_b[jk*xJQ¬kn\`P \]^hfgst\]d{Y
(74) Q2kMknQH^]_4[9iO[)[O_biO¼4QHfbi)cst\]d{N
(75) stQx Q
(76) ©GdtQ
(77) [jk{\`_b[l f°PRQ
(78) d{LO_JxJQ9zOs{_4z_GknYHQ zQHiJd
(79) d{stQ¡¼GijQc_bP P P Q¡iO[<c_4P zOs{_4P \`k¬QH[4dts{Q¡^`QHk kvdtstfgd{YHab\`QHk °iO[OQ k{Q
(80) ij^]Q absfg\`[OQ9¶µO·GO4¸J *Q
(81) d¬c
(82) Q
(83) ^`^]Q2 k 9PViO^]d{\`zO^`QHkabsfg\`[OQHk ºoO4¸G@»JµO·Go¸O ª»jQH^]^`Q fFdndtQ
(84) \`[jxËxJQ2keaGfg\`[j k 9^`f _4\`k k{iOs ^hf knQH[jkn\`pO\`^]\]d{YHQ¬Qd-^hfRk{Q
(85) ^`QHcd{\`¼o\dtYb &fRP YdtLO_JxJQstQHknd{Q¢jQ©J\`pO^]QQ
(86) d-zQHiJ d dts{Q¬stQ
(87) [jxOiOQ¬Q
(88) [jc
(89) _bstQ zj^]ijkTQ½c
(90) f4cQ Q
(91) [ iJdt\]^`\hk{fb[4dVxOQHka4stfb\][OQ2kZQHk{zjfbc
(92) Y
(93) QHkH»&zfgs{d{\hciO^`\]NHs{QHP Q
(94) [GdQ
(95) [ c_4[jkn\hxJYHstfb[4dTxJQ2kabsfg\`[OQ2k Q2knzfbcYHQHkMc_4[Gd{Q
(96) [fg[Gd-xJQHkMQH^]QHPRQH[Gdtk-k{zY2c\]qGiOQHk c
(97) _b[Gd{sfg\`[GdtkMfgiO©d{sfg[jk{\]d{\`_b[jkH e_bijk®xJ_4[O[O_4[jkxJQHk Q©OfbPRzj^]Q2k®x iOd{\`^]\hk{fgd{\`_b[RxJQMGOoZknijs>xJQHkcLOst_bP _4k{_bP Q2kxJQ¿@À4ÁÁtÂjÀFÃ{ÄgÅ ÆbÁ¥¤ Ç>¥
(98) Ã{¥
(99) ÉHÊh¤ªÊÀb¥eQdeÌVÃ{ħ¤
(100) ÄÍOÂoʶÎ`ÀÏ¥
(101) Î]ÀFÐ@Ä{ÑGÀ§¤ªÒӥê Ù 2 × !
(102) ) Û wÝjÝ@»jfg^`\`ab[OQHPRQH[GdM^`_Jc
(103) fb^¨»Ja4stfb\][OQ2k*QHk{zjfbc
(104) Y
(105) QHkH»od{sfg[kn\]d{\`_b[jk.
(106) Z¿j¿6¿/ʶŠʶÎ`ÀFÃªÊ¶Ò Æ¡¤
(107) ¥tÀgÃ{ÁÂÊ¶Ð°Ì ¤¥ j¥Ð@Á¥ª¤. . . ! & () T! KMLjQ*Q
(108) ^`^«o[O_F [TÝoP \dtLJ« fFdtQ
(109) stP¡fg[Vfb^]a4_bst\dtLOP SgGzOst_F¼o\`xOQHk&fb[Q©Ofbcd k{_b^`iJd{\`_b[¬dt_-dtLOQ£zjs{_4pO^]QHP _b c
(110) _bP zOiJdt\][ja_bzJdt\]P¡fg^^]_JcHfg^jfb^]\`ab[OP QH[4dk
(111) -_F*Q
(112) ¼4Q
(113) s2»g\]dtk®dt\]P Qec
(114) _bP zO^`Q©J\]dvm \hk®LO\`abLË »4stQHxJic\`pO^]Q dt_!"$)#&*,% + '$'( e LOQ
(115) st.Q -\`kdtLOQ k{QHqGiOQH[jcQ Q
(116) [Gd{st_bzom/ ¶ »lfg[jxsfgzj\`xLjQ
(117) iOst\`knd{\hcVfb^]a4_bst\dtLOP¡k-Ljf§¼4QVp/Q
(118) QH[ zjs{_4z_GknQ2xd{_¬[jx kn\`ab[O\]cHfg[Gd>fgzOzOst_§©J\]P¡fgd{Q
(119) ^`mstQ
(120) z/QHfFdtQHxRknQ2qGiOQ
(121) [jc
(122) QHk ¨kn\`P \]^hfgst\dvmVs{QHab\`_b[jk ª w-^`^Jd{LO_GknQ fb^]a4_bst\dtLOP¡k£fbs{Qpjfbk{QHx)_b[f c
(123) _bP P _b[)zOs{\`[jc
(124) \]zO^`&Q 0®fgd*dtLOQZjskvd kvdfga4Qb»Gd{LOQHm9k{QHfgscL¡_4s*_4[OQZ_bsMP _bstQ k{P¡fg^`^£Q
(125) ©OfbcªdRs{QHzQ2fFdk9cHfg^`^]Q2x ¤
(126) ¥¥¦§¤n Vf4k{k{iOP QHx³dt_¹_JcHciOs \][²fgzOzOst_§©J\]P¡fgd{QstQ
(127) z/QHfgdtkH¹KMLOQ°knQ2c_4[jx kndtfbabQ¬fFd{d{Q
(128) P zJdkMd{_¡Q
(129) ©od{Q
(130) [xdtLO_4k{QTknQHQHxOk*dt_¡c_bP zOiOd{Q^`_b[Oa4Q
(131) s fgzOzjs{_§©J\`P fgd{QZs{QHzQ2fFdk
(132) K£mozO\`cHfg^ stQ
(133) zOstQHk{Q
(134) [GdfFd{\`¼bQ2kR_gedtLO\hkfgzOzjs{_GfbcL±fbs{Q°ºoO4¸G1 32
(135) ~4» 22 fb[jx±µO·4O45¸ S »*dtLjfFdp/_gdtL kndtfbsnd> \]d{L¡\hxJQH[4dt\mo\`[Oaj»Gijk{\][jaLjfbk{L¡P Qd{Lj_oxjk
(136) »oknP¡fb^]^OQ
(137) ©Ofbcªd>P¡fgdtcLOQ2k®_g@O©JQHx¡k{3\ 6
(138) Qb -_F*Q
(139) ¼4Q
(140) s2»Fd{LjQ
(141) m xO8\ 7@Q
(142) s \`[d{LOQMf§m d{LOQHmdts{Q2fFdMd{LO_GknQk{Q
(143) Q2xOk*d{_ Q©odtQ
(144) [jx)d{LjQ
(145) P \`[Gd{_¡k{\]P \`^`fbs{\]dvm¡s{QHab\`_b[jkHºoJ4¸o ^]_o9_ ok _4s abst_biOzkM_g®c^`_4k{Q
(146) ^`m4«´^`_ocHfFdtQHx9k{Q
(147) Q2xOkTÄFгÒÂO¥T¤ÀgÅ ¥R¦bÄgÒÍ/Î]ÄgÒ ¦gÊÀ
(148) ÑGÄFÐ@ÀFÎJdts{mo\`[OaRd{_¡\hxJQ
(149) [Gd{\]m°f ^`_b[jabQ
(150) s k{\`PR\`^hfgst\dvm¡stQ
(151) a4\]_4[l; :Ó[°c_4[Gd{sfbkndH»GµO·4O4¸¡knmJknd{QHP fgd{\hc
(152) fb^]^`m d{st\]Q2k*d{_ Q©odtQ
(153) [jx)QHf4cLˤ
(154) ¥¥t¦ ¨c_4[jkn\hxJQHs{Q2x¡d{_ p/Q¡fËÂoʶҶ d{_fz_Gk{k{\]pj^]<Q Ýor = -\`abL<ÝJc_4s{\`[Oar®fg\`s »lijk{\][Oa°fg?[ >A@n¦gÃ{ÄtÍ fg^`ab_4s{\]d{LOP°Rw PR_JxJ\]jQ2x ¦4Ä CB
(155) Î] ¥ @´¤¥¥¦¬cst\]d{Q
(156) st\`_b[9Lfbk*pQHQ
(157) [°zOst_bz/_4k{QHx¡\`E[ DGF$HHCIKJ²µO·4O4!¸ »JdtLjfFd-xJQ
(158) j[OQ2k fVLO\]defbk£dv*_ [j_b[J« _F¼4Q
(159) st^`fbzOzO\`[Oa k{Q
(160) Q2xOkM_Jc
(161) c
(162) iOs{st\`[Oa _4[9dtLOQTktfgP QxJ\`fbab_4[jfg^ 8\ 7@Q
(163) stQ
(164) [GdËQ
(165) ©GdtQ
(166) [jk{\`_b[jk_g d{LOQ2knQ³dv*_±P Q
(167) d{LO_JxOkLf§¼bQ³pQHQ
(168) [¯zOs{_4z_GknQ2xCpomC_bd{LOQHs°fb^]a4_bst\dtLOP¡k
(169) OoM LONP1 Sg ¬fbzOzO^`\]Q2kf sfg[jxJ_4P Mfg3^ ¾LOQHiOst\`knd{\hc
(170) k dt_<z/Q
(171) s{_bstP dtLOQËQ©odtQ
(172) [jk{\]_4[ zOLjf4knQ4¯we[O_gdtLOQ
(173) s a4Q
(174) [OQHstfb^]3\ 6Hfgd{\`_b[9c
(175) _b[jc
(176) Q
(177) st[jk*d{LjQ¬_bstP _g£¤¥¥¦§Q¤ 0>ºJ·GO9 RSUT fg[jx)P _bstQZstQHc
(178) Q
(179) [Gd{^`m VWF9XXGI9YKZGRK[KZGXWI9Y32]\O c
(180) _b[jk{\hxJQ
(181) s¤ ÍjÀbÁ¥¦ ¤
(182) ¥¥¦§¤ª»Md{LfFd9stQHqGiO\`s{QP¡fgdtcLOQ2k¡d{_ _JcHciOsfFd)c
(183) Q
(184) s{dtfg\`[Èz_Gkn\]d{\`_b[k \]d{LO\`[Cf ab\`¼bQH[ ^`Q
(185) [jagd{L&» f4c
(186) c_4stxO\][Oadt_Ëf°zOs{Q
(187) «´k{z/QHc\]jQ2x¾¤
(188) ¥¥¦Å¡ÄFÒ Ê ^e_4iOpO^`Q«ÓknQHQHxfg[jxk{zjfbc
(189) QHxk{Q
(190) QHxjkTfgzOzjs{_GfbcLOQ2k Lf§¼bQZpQHQ
(191) [c_4PVpO\`[OQHx)\`[)µO·GO4G¸ _`32]aJb» 2HO ´ c dtLOQ
(192) s£PRQ
(193) d{LO_JxOk>d{stmTdt_dt&f bQ-fbxO¼§fb[Gdtfga4Q _g@z_F*Q
(194) s{iO^/kvdts{\`[OaP¡fFdcLO\][ja¬d{QHcLj[O\`qGiOQ2k
(195) »G\`[¡zjfgs{d{\hciJ« ^hfgs*pom ijkn\`[Oa fVk{iJ½ ©¡d{stQ
(196) Q¬xOfFdfVknd{stijcªdtiOstQfg[x9fT^`\`[OQHfbs*fb^]a4_bst\dtLOP_bsMc_b[kvdts{ijcd{\`[OaV\]Ad S4S ´KMLj\`k \hk*xJ_b[OQZ\`"[ NdV9[GXWI9Y"32HO lfb[jx e9fWe$ghI9Y` a$ »Gd{_ c_4[jknd{stijcªd*s{Q2knz/QHcd{\`¼bQ
(197) ^`m ^]_JcHfg^/_bs*ab^`_bpjfb^/fb^]\`ab[OP QH[4dk
(198) c dtLOQ
(199) s d{_o_4^`kLjf§¼4Qp/Q
(200) QH[RxJQ2kn\`ab[jQHxVd{_¬c_bP zOiOd{Q knz/QHc
(201) \`fb^GdvmGz/QM_g@fg^`\]a4[OP Q
(202) [Gdt]k 0 edGD4GµO·GObi ¸ Sg~ O_bs o4 RoS 32OT &fgstQ¬k{z/QHc\hfg^`3\ 6
(203) QHx9\][j[xJ\][jaR^hfgstabQ¬fg[x9LO\`abLj^]m9k{\`PR\`^hfgsMs{QHab\`_b[j]k jOM L ek!32H l_4s*µJ·GoE¸ 32&2Q fbs{Q9_bst\]QH[4dtQHxdt_³c
(204) _bP zOiJdt\][ja<¤ Í/Î ÊÁ¥¦ ÀFÎÊÑgÐÅ ¥
(205) ÐjÒ¨¤ª»>ijk{QiO^M\`[¾P¡fgzOzj\][Oay-w dtstfb[jk{c
(206) s{\`zJdkT_b[¾d{LOQ a4Q
(207) [O_4P \`cZelw jj[fg^`^]m4»£µO·GO4K¸ mn WS 2Q\hk9xJQ2kn\`ab[jQHx±d{_<P¡fgdtcL w qGiOQHs{\`QHkfba4fb\][jknd9fzOst_gdtQ
(208) \`[ xjfFdtfbpjfbk{Qb c dtLOQ
(209) s£s{QH^`fgd{QHx dt_G_4^`k>Ljf§¼bQMdtLOQ-ab_Gfg^O_b[jxJ\`[OaÒÓÀFÐ/¦4¥Å Ãt¥´Íj¥ÀFÒ¨¤ c [OQ-k{ijcLk{_g¶dvMfgstQM\`k®W ¸ F&ZWJGI g NWI&HCIF&X p º o ZWJGI&Y/ ~ ´»&dtLjfFd\hkTfg^hkn_pjf4knQ2x_4[c
(210) _b^`^]Q2cªdt\][Oa°k{Q
(211) QHxjk \dtL f)Lfbk{LO\][ja)dtQHcLO[j\`qGiOQ4»lijk{\][Oa fa4s{_4iOz¹c
(212) s{\]d{QHs{\`_b[fbxOfbzJd{Q2xËdt_°\`xJQH[Gd{\]mG\`[Oa°dfg[jxJQHP ^]mG«´s{QHzQ2fFd{Q2x¹k{QHqGiOQH[jcQ2k
(213) Ýo_4P QR\hxJQ2fbk¬_g*d{Lj\`k fbzOzOst_4f4cL¾ \`^]^-p/QËijk{QHx²\`[²d{LO\hk¡zjfbzQHsHq gMYWI&Hprst2§S e\hkfg[O_bd{LOQHs¡zOst_babsfgP _4s¡j[jxO\][Oadfg[jxOQ
(214) P stQ
(215) z/QHfgdtkM \]d{Lk{iOpjknd{\]d{iJdt\]_4[QHs{st_bskH»4pjf4knQ2x9_4[)Q
(216) ½c\`Q
(217) [Gdec_4PVpO\`[jfFdt_bst\`fb^6fg^`ab_bst\]d{LOP¡kH
(218). uwvyx{z1||yxW}~M. KMLjQdv£_b«´kndtfbabQfgzjzOs{_GfbcLÈxJQHktcst\`pQ2x fgp/_F¼bQ\`PRzj^]\`QHk)f<xJ\`^]QHPRP¡f p/Qdv*Q
(219) QH[Èd{LOQ¹knQH[jkn\]d{\`¼o\dvmÈfg[x k{Q
(220) ^`QHcd{\`¼o\dvm4®ÝJQ
(221) [jk{\dt\]¼o\]dvmc
(222) fb[9p/QP QHf4knijs{Q2xpomRd{LOQ¬zOst_bpjfbpO\`^]\]dvmRd{LjfgdMf ab_o_Jx9fb^]\`ab[OP QH[4d¬_4[OQ \]d{L f)LO\`abL³k{c
(223) _bstQ2 \hk_biO[xpom°d{LjQRfb^]a4_bst\dtLOP°VÝoQ
(224) ^`QHcd{\`¼G\]dvmËc
(225) fb[p/Q¡fbktkn_Jc\hfFdtQHx \]d{Ld{LOQ [oiOP pQHsZ_b ; WQQ.
(226) ~. VÄ. jÁtÂj¥ÃtÄFÉ. i. cHfg[jxO\`xOfgd{Q-ÂoʶҨ¤ c
(227) _bP zOiJdtQHxRfFdd{LOQ*jskndkndtfbabQ£d{LjfgdxJ_b[ d®mo\]QH^`xRkn\`ab[j\cHfg[Gd®fgzOzOst_§©J\]P¡fgd{QstQ
(228) z/QHfgdtkfFd dtLOQ>Q
(229) ©GdtQ
(230) [jk{\`_b[Tkndtfga4Q-k{P¡fg^`^]QHs6d{LO\hkl[oiOP pQHsH»§LO\`abLjQ
(231) s6dtLOQk{Q
(232) ^`QHcªdt\]¼o\]dvmO ª£Lj_G_Gkn\`[Oa *QHf&bQ
(233) slc
(234) s{\]d{QHs{\hf£_bs xOQj[O\`[OaZf-LO\]d-Qb aj xJQHc
(235) s{Q2fbk{\][ja d{LOQMk{Q
(236) QHxVkn3\ 6
(237) Q§ l\`[jcstQHf4knQ2k6dtLOQ£k{Q
(238) [jk{\]d{\`¼G\]dvmpOiJdP¡$f 4QHk6dtLOQMfg^`ab_bst\]d{LOP ^`QHktkVk{Q
(239) ^`QHcd{\`¼bQfb[jx \`[jcstQHf4knQ2kZd{LOQ9d{\`PRQknz/Q
(240) [GdV_4[<Q©odtQ
(241) [jxJ\`[Oak{zOiOst\`_bijkLj\dk
(242) K_c
(243) _bz/Q \dtL d{Lj\`k zjs{_4pO^]QHP fg[jx9d{_ \`[jcstQHf4knQed{LOQ¬Q
(244) ½¡c
(245) \]QH[jcm4»Okn_4P QZfb^]a4_bst\dtLOP¡kdts{m dt_¡knz/Q
(246) Q2x9iOz)d{LjQQ©od{QH[jkn\`_b[kvdfga4Q pom³ijk{\][Oa¹fg[<LOQHiOst\`knd{\hc
(247) "k SbO »®_bd{LOQHstkV\][Gdts{_JxJijc
(248) Q9fg[<f4xOxJ\]d{\`_b[jfb^>dts{Q2fFd{P QH[4d d{_Ësfgzj\`xJ^`m¹j^dtQ
(249) sR_biJd dtLO_4k{Q LO\]dtk>d{Ljfgd£fgstQ iO[O^`t\ 4Q
(250) ^`mVdt_zOst_oxOijcQefk{\`ab[O\]c
(251) fb[Gd>^]_Jc
(252) fb^jfg^`\`ab[OP Q
(253) [Gd 32HO ´ c [ d{LOQe_gd{LjQ
(254) s>Ljfb[jx6» cLj_G_Gkn\`[OafP _bstQknd{st\][Oa4Q
(255) [GdVcst\]d{Q
(256) st\hf_bs xOQj[O\`[Oaf°Lj\d°Qb aj°\`[jcstQHf4kn\`[Oad{LjQ9knQHQHx k{t\ 6HQ2 ¬P¡&f bQHk dtLOQjskndekvdfgabQ¬P _bstQTk{Q
(257) ^`QHcªdt\]¼4Qb»jktf§¼bQ2k£d{\`PRQ4»jpOiOdc
(258) fb[P \hk{kkn\`ab[j\cHfg[Gd-kn\`P \]^hfgst\]d{\`QHk-fb[jx)d{LOQHs{Q
(259) _bstQ stQHk{iO^]dtkM\`[f ^`QHktk k{Q
(260) [jk{\dt\]¼4Qfg^`ab_bst\]d{LOP° KMLOQHs{Q
(261) _bstQb»§j[xJ\][ja¬fb[V_4zJd{\`P¡fg^od{sfbxOQ«´$_ 7 pQ
(262) dv£QHQ
(263) [ d{LOQ k{Q
(264) [jk{\dt\]¼o\]dvmTfg[jxRk{Q
(265) ^`QHcªdt\]¼o\]dvm LO\`^]Q bQHQ
(266) zJ« \`[Oad{LOQMQ
(267) ½¡c
(268) \]QH[jcm\hkyf 4Q
(269) m¬\hk{k{iOQ£_bs d{LOQMQH[4dt\]stQMfgzOzOst_4f4cLl O_4sQ©OfgP zO^`Qb»§dtLOQ xJ_biOpj^]Q
(270) «´k{Q
(271) Q2xP Qd{Lj_ox _b DF&HHCIKJ²µJ·GO4¸TLjf4k>p/Q
(272) Q
(273) [)knLO_F [¡P _4s{QMdt_TpQZknQH[jk{\dt\]¼4Q d{Ljfb[ µO·4O4¸T_4s ÝJrk \]d{L)fpO\]dn«Ók{c
(274) _bstQ _b£fFd^`QHf4kvdb)pO\]dtk¡¶_4sZd{LOQ¡xJQ
(275) fgiO^]dTknQHQHx³kn3\ 6
(276) SQ 2H9_bsZµO·GJ4 ¸ °fg[jqx 2&2V_bAs DGF$HHCIKJ²µO·4O4¸O ª»/pOiJd fb^`k{_RPR_4s{Qk{Q
(277) ^`QHcd{\`¼bQb»Of4kM^]Q2k{k*dt\]P Q\hk knz/Q
(278) [Gd-_4[9dts{Q2fFd{\`[Oa sfg[jxJ_4P ^]m_JcHciOsts{\`[OaRLO\]dtkH :Ó[dtLO\hke*_b,s @»j*QVabQH[OQ
(279) sfg^`3\ 6
(280) Q¬d{Lj\`kZfgzOzjs{_GfbcLfg[jxËzOs{_4z_GknQTfb[fg^`ab_4s{\]d{LjP pjf4knQ2x°_b[Ëf¢jQ©J\`pO^]Q Å JÎ Ò Ê Í/Î] ¥ @´¤
(281) ¥¥t¦9ÁêʶÒӥêÊÄgÐ d{Ljfgd-fg^`^]_F-k*fg[ ÀF à B
(282) ʶҨÃtÀFêơCÐ JÅ B¥ÃÄ ^£Íjħ¤¤ª Ê B
(283) Î Æ)ÄFÉF¥
(284) êÎ]ÀtÍ4Í/ʶÐGÑ9¤
(285) ¥¥¦§¤ª
(286) _bstQ« . _F¼4Q
(287) s2»k{Q
(288) Q2xOk fbs{Q¡[j_gd stQHqGiO\`stQHx³d{__ocHciOs _b[dtLOQ)ktfgP Q9xJ_bd zO^`_gd xJ\hfgab_4[jfg^ ! :Ó[<_gdtLOQ
(289) s £_4stxjk
(290) » £Q f4xJP \dMfT¼Ffgst\hfFd{\`_b[¡_b6d{LOQZxJ\hkvdfg[jc
(291) Qep/Qdv*Q
(292) Q
(293) [)c_bststQHk{z_4[jxJ\`[OaTknQHQHxOk\][9QHfbcL)c_bzom4»b LO\hcL9fg^`^`_F-k>ijk dt_¡fbc
(294) c
(295) _biO[GdM_bs \`[jxJQH^`k-_ocHciOstst\][OaR\`[)\`[Gd{Q
(296) s{«ÓknQHQHx)\][Gd{QHs{¼Ffb^`kH £_4[jkn\hxJQHs{\`[Oa PViO^]d{\`zO^`QVk{Q
(297) QHxjk fg[jx)d{stmo\][ja d{_¡abst_bijz9dtLOQ
(298) P Ljfbk*dtLOQVf4xJ¼Ffg[GdtfbabQZ_g®c
(299) fFdcLO\`[Oa d{LOQ Lj_b^`Q stfb[OabQ _b6fk{\`PR\`^hfgst\dvm s{QHab\`_b[ stfgd{LOQHs®d{Lfg[k{z_bdnd{\`[OaVfVkn\`[Oab^`Q zjfbsnd_b6\d2 j_bs®dtLOQek{Q
(300) [jk{\]d{\`¼G\]dvm stQHf4kn_4[jkH»F£QMijk{Q fknP¡fg^`^`Q
(301) s®knQHQHx k{t\ 6HQbKMLO\`k\`P zO^`\]Q2k®abQH[OQ
(302) sfFdt\][OaZP _bstQ knQHQHxOk>fgdd{LOQMjskndkvdfgabQ4»FpOiJd _4[O^`m)f¡k{P fb^]^lstf4cªd{\`_b[_gdtLOQ
(303) P _bstP abst_bijzjkM¼bQHs{\]mo\][Oa dtLOQQ©odtQ
(304) [jk{\]_4[cst\dtQ
(305) st\]_4[fb[jx°\`k d{LOQHs{Q
(306) _bstQ zjs{_JcQ2k{k{QHx9pom¡d{LOQQ
(307) ©od{Q
(308) [kn\`_b[°kvdtQ
(309) zl c ¼4Q
(310) sfg^`^¨»/d{LjQRk{Q
(311) [jk{\]d{\`¼G\]dvm\hk\`[jc
(312) s{Q2fbk{QHxËxJijQVdt_fknP¡fb^]^`Q
(313) s¬knQHQHx¹kn3\ 6
(314) Q fg[jxËd{LOQ ¢jQ
(315) ©o\`pO\`^]\]dvm_g£d{LOQ Q
(316) ©od{Q
(317) [kn\`_b[°cst\dtQ
(318) st\]_4[l»Ofg[x9dtLOQTk{Q
(319) ^`QHcªdt\]¼o\]dvm9\hk zOstQHk{Q
(320) st¼bQ2x9fbk*dtLOQTcst\]d{Q
(321) st\`_b[s{Q2q4ij\]stQHk*dtLOQzOstQHk{Q
(322) [jc
(323) QZ_b k{Q
(324) ¼4Q
(325) sfg^>k{Q
(326) Q2xOkdt_°d{st\]a4abQ
(327) sTd{LOQQ
(328) ©od{Q
(329) [kn\`_b[lKMLOQ)cst\dtQ
(330) st\]_4[³\hkTQ2fbk{mËdt_˼bQHs{\]mb»fg[jx³dtLOQQ
(331) ©Gdtstfdt\]P Q k{z/Q
(332) [Gd_b[c_bP zOiOd{\`[Oak{P¡fg^`^]QHsknQHQHxOkfgdZdtLOQRjskvdTkndtfga4Q \hkZabstQHfgd{^`mËc_bP z/Q
(333) [jktfFdtQHxpGmËd{LOQ a4fb\][³\`[ dt\]P QTk{zQH[Gd-_b[°c_bP zOiOd{\`[Oa¡kn\`P \]^hfgst\dvm9s{QHab\`_b[jk£st_bP dtLOQTknQHQHxOkH KMLOQzjfgz/Q
(334) s*\hk>_bsta4fb[O3\ 6
(335) QHx f4k>_4^]^`_F-k
(336) ÝoQHcd{\`_b[)STzOstQHk{Q
(337) [Gdtk£fg[¡_F¼bQHs{¼o\`Q
(338) ²_g6dtLOQeoOoTfg^`ab_4s{\]d{LjP ÝJQHcªdt\]_4[¾xOQj[OQ2k d{LOQ°cst\dtQ
(339) st\`fËijknQ2xd{_³abst_bijz<knQHQHxOkH»>fg[jx¾xJQHktcst\]p/QHkVd{LjQ)a4s{_4iOzO\`[Oafg^`ab_4s{\]d{LjP ÝJQHcªdt\]_4[T~xOQHfg^hk \dtLTd{LjQ£Q
(340) ©GdtQ
(341) [jk{\`_b[Tcst\]d{Q
(342) st\`_b[Vfb[jxTk{Q
(343) [jk{\dt\]¼o\]dvm¬\]P zOst_F¼bQHPRQH[GdtkHÝoQHcd{\`_b[ ec_4[jcQHs{[jk k{zjf4cQHx9knQHQHxOkMfg[xP _JxJQ
(344) ^6\`P zOs{_F¼4Q
(345) P Q
(346) [Gdk
(347) ®ÝoQHcd{\`_b[jk \RxJQHktcst\`pQs{Q2kniO^]dtkMfb[jxQ
(348) ©oz/Q
(349) st\`PRQH[GdtkH»Ofbk££QH^]^ f4kMz_Gk{k{\`pO^]Q¬_4zJd{\`P t\ 62fFd{\`_b[kM_g&dtLOQP QdtLO_Jx6 Ü ° TM ¡ KMLjQ)\`[O\]d{\hfg^MkvdtQ
(350) z¾_b-d{LjQfb^]a4_bst\dtLOP c_b[kn\hkvdkT_bc_4^]^`QHcd{\`[OaËdtLOQ)\`[J_4s{P¡fFdt\]_4[¾fgp/_biOd fb^]^*z_Gk{k{\`pO^]Q k{Q
(351) Q2xOk¬c_4[4dfg\`[OQHx\][¹d{LjQR\`[OzOiOdVknQ2q4ijQ
(352) [jc
(353) Q4k ªRKMLO\hk¬\`k¬xJ_4[OQ \][¹d{LOQRdtstf4xJ\dt\]_4[jfg^P¡fg[j[OQ
(354) s 0ea4\]¼4Q
(355) [¹f k{3\ 6
(356) Q @»/*Q knd{_bstQT\`[f¡Ljf4knL°dfgpO^`QTdtLOQVz/_4k{\]d{\`_b[jke_gfg^`^ G« *_bsxOkM_Jc
(357) c
(358) iOsts{\`[Oa\`[d{LjQ k{QHqGiOQ
(359) [cQb O_bs Q2fbcL G«´£_4stx6»GdtLOQ¬Ljfbk{Ldtfgpj^]Qc_4[Gdtfg\`[jk fR^`\]W[ 4QHx)^]\hknd-_g\dkMz_Gkn\]d{\`_b[jkM\`[d{LOQTk{QHqGiOQH[jcQ4 .
(360) Z¿j¿6¿/ʶŠʶÎ`ÀFÃªÊ¶Ò Æ¡¤
(361) ¥tÀgÃ{ÁÂÊ¶Ð°Ì ¤¥ j¥Ð@Á¥ª¤. . . w-¶d{Q
(362) sed{LO\hkzOs{QHzjfgsfFdt_bstmkvdtQ
(363) zl»jd{LOQ fg^`ab_bst\]d{LOP \`k-c
(364) _bP z/_4k{QHx_gdv*_¡zjfgs{dtkH*KMLjQjskvd-zjfbsnd\`k-f ΠʶÐgʶÐGÑÀgÎ ÑGÄFêʶÒÂoÅRi:´dc_4[jkn\hxJQHstkV¤
(365) ¥t¥¦F¤»&\¨ QbTstQ
(366) z/QHfgd{Q2x G«´£_4stxjkeQ
(367) ©Gdtstf4cªdtQHx°st_bPÜdtLOQ Ljfbk{LËdfgpO^`Qb» fb[jx zOst_JcQ2k{k{QHkTd{LOQHP d{_Ë_4s{P ÑbÃ{Ä 2Í/¤Ä ^9¤
(368) ¥¥t¦F¤ª»>fbc
(369) c
(370) _bsxJ\`[Oad{_³cst\dtQ
(371) st\`fËpjfbk{QHx _4[ d{LjQxJ\hkndtfg[cQHk p/Qdv*Q
(372) QH[c
(373) _bsts{Q2knz/_b[xJ\][ja G«´*_bsxOk
(374) KMLOQk{QHc
(375) _b[jxzjfgs{d\`kVfg[ ¥ 4ÒÓ¥Ðj¤ÊÄgоÀFÎ ÑGÄFêʶÒÂoÅ d{Ljfgdd{st\]a4abQHstk¬fg[xz/Q
(376) s{_bstP¡kedtLOQ¡Q©odtQ
(377) [jk{\]_4[¹_b k{_bP QR_g>dtLOQ¡c_4[jkvdts{icªd{Q2xËa4s{_4iOzjkZ_g£k{Q
(378) Q2xOkH Ks{\`aba4Q
(379) st\][Oad{LOQ Q©odtQ
(380) [jk{\]_4[\hkxJst\]¼4Q
(381) [pomËfknQH^]Q2cªdt\]_4[ c
(382) s{\]d{QHs{\`_b[&»lc
(383) fg^`^`QHx¹ÑbÃ{$Ä 2ÍÈÁêʶÒÓ¥
(384) êÊÄFÐj» pjf4knQ2xË_b[¹d{LjQÒÓÄFÒÓÀFήMÐ jÁÎ`¥tÄgҨʦ4¥ ¤ªÊ 2¥)Ä ^RÒ¶Âj¥VÑbÃ{Ä 2ͱ[O_gdtQ dtLjfFd k{Q
(385) Q2xOkc
(386) fb[¹_F¼4Q
(387) st^`fbz ª WZs{_4iOzjkZ_g k{Q
(388) QHxjk¼4Q
(389) st\mo\`[Oad{LO\hkcst\]d{Q
(390) st\`_b[fgstQRf4cªd{ifg^`^]mk{iOpOP \]dndtQHx¹_bs¬Q©o« dtQ
(391) [jk{\`_b[l4 :Ó[Ëc
(392) _b[Gd{sfbknd d{_9d{LOiQ > @n¦FÃ{ÄÍ fb^]a4_bst\dtLOP _b µO·GO4¸/»Od{LO\hkec
(393) s{\]d{QHs{\`_b[\hk-¼4Q
(394) stm9QHf4knm)d{_)cLOQH c fb[jx¹¼G\`s{d{ijfb^]^`mË[O_d{\`P Q\hkknz/Q
(395) [GdT_b[³¼bQHs{\]mo\][ja\]dH9ÝJQ
(396) ^`QHcªdtQHx³abst_bijzjk¬fgstQ dtLOQ
(397) [Q
(398) ©GdtQ
(399) [jxOQHx¹d{__bstP k{\`PR\`^hfgst\dvms{QHab\`_b[jkH O_4sedtLjfFd2»stQHk{z/QHcªdt\]¼4QV\`[Gd{Q
(400) s{«ÓknQHQHx°stQ
(401) ab\`_b[k-fgstQVfg^`\`ab[OQ2x°ijkn\`[OafxJmo[jfgP \hcTzOst_g« a4stfbP PR\`[OaTfb^]a4_bst\dtLOP° *QHk{\hxJQHkH»Gfb[9fbxjxJ\dt\]_4[jfg^LOQ
(402) ijs{\hkvdt\`cezOst_oc
(403) QHxJijs{Q-\hkfbzOzO^`\]Q2x¡\`[_bsxJQ
(404) sd{_RcLOQH c LjQd{LjQ
(405) s¬d{LjQs{QHab\`_b[³c_b[kn\hkvdkfbcd{ijfb^]^`m_b£_b[jQ¡_bsTk{Q
(406) ¼bQHstfb^®kniOpO« stQ
(407) a4\]_4[jkZ_gMLO\]a4LOQ
(408) sTktc_4s{Q4¡KMLO\`kT\`k xO_b[OQ\`[°_bsxJQ
(409) sMdt_c_bststQHcªdMdtLOQVfgs{d{\]fbcd-_g d{LOQa4s{_4iOzcst\dtQ
(410) st\]_4[9dtLjfFdec
(411) _b[jk{\hkvdk _gz_Gk{k{\`pO^]Qpj\][jxO\][Oa _b c
(412) ^]_GknQH^]mG«´^]_Jc
(413) fgd{Q2xLO\`abLJ«Óktc_bst\`[Oa stQ
(414) a4\]_4[jk£d{Ljfg d nk{LjfbxO_F ZfR^]_FM«Ók{c
(415) _bst\][jaVstQ
(416) ab\`_b[)\][°p/Qdv*Q
(417) QH[l &\]W[ o\`[Oa°fg[jxQ
(418) ©od{Q
(419) [kn\`_b[fb^]a4_bst\dtLOP¡kefbs{Q s{iO[\][d{iOst[\`[_4stxJQHs-dt"_ bQHQ
(420) zdtLOQ ciOsts{QH[Gd{^`m°knd{_4s{Q2x k{Qd _b a4s{_4iOzjkMknP¡fb^]^6QH[O_biOa4Ll ! ¡ ! Ü T
(421) Q¡jskndV\][Gdts{_JxJijc
(422) Qkn_4P Q[O_gdfFdt\]_4[jkijk{QHx\`[d{LO\hkTzfgs{dH Q)fgstQ¡^]_o&_ o\`[Oa°_bsV^]_Jc
(423) fb^£k{\]P \`^`fbs{\]d{\`QHk p/Qdv*Q
(424) QH[fTZew qGiOQHs{mRknQ2qGiOQ
(425) [jc
(426) Q fb[jx¡fTZew k{iOpJuvQ2cªd£k{QHqGiOQH[jc Q ´" !f4cL¡_g@d{LO_GknQ k{QHqGiOQH[jcQ2k£cHfg[)pQ¬c_4[jkn\hxJQHs{Q2xfbk*f k{ijcHcQHktk{\]_4[_g" $# %& stQHk{zQ2cªdt\]¼4Q
(427) ^`.m # %&2 £kniOpkvdts{\`[Oa4k _bkn3\ 6
(428) Q @»6c
(429) fb^]^`QHx @('ÄFÃ{¦F¤K£_9P fgdtcLO\`[Oa G« *_bsxO k ) * *+% ,#-.fb[j/x 01 0 % )#23 _bstPÜf ¤
(430) ¥¥¦F»jxOQ
(431) [O_bd{QH5x 460178* 9>K£_ xJ\hkvdfg[jc
(432) QHkMp/Qdv*Q
(433) Q
(434) [ G«´*_bsxOkMfgstQZc
(435) _b[jk{\`xOQ
(436) stQHx 0 D ( < i1 , j1 > , < i2 , j2 > ) < i1 , j1 >. T. i1. < i2 , j2 >. Q. i2. j2. d ( < i2 , j2 > ) d ( < i1 , j1 > ). \`abiOstQ<2&0MʶÐjÒ Ã{À@´¤
(437) ¥¥¦9ÀgÐ/¦¡Ê¶ÐÒ´¥
(438) ÃQ@´¤
(439) ¥¥t¦9¦FÊh¤ªÒ´ÀgÐ/Á¥¤ . ; WQQ. j2.
(440) VÄ \. jÁtÂj¥ÃtÄFÉ. i. WZ\]¼4Q
(441) [fk{Q
(442) Q2x 460 7 * 9Z»4d{LjQTʶÐjÒ Ã{À@´¤
(443) ¥¥¦ xJ\hkvdfg[jc
(444) Qh 460178* 9y \hk %)* #0t :´d£cHfg[¡p/QeknQHQ
(445) [¡fbk>d{LOQ Jx \hkvdfg[jc
(446) Q p/Qdv*Q
(447) QH[Ëd{LjQ o« *_bsxOk) * * % # 3®fg[jx 0 0 % # 3\] \hk¬c_4[jc
(448) fgd{Q
(449) [fFd{Q2x d{_k{Q
(450) Q \]a4iOstQ.2§ ª» WZ\]¼4Q
(451) [dv£_knQHQHxOk 460 78* 9 fg[jx 460 78* 9Z»6 LjQ
(452) stQ 04 0 fg[jx *4 * »@dtLOQ)ʶÐÒ´¥
(453) ÃQ@´¤
(454) ¥¥t¦VxJ\hkv« dtfb[jcQ 460 78*39 7.460 7 * 9y £\`k d{LOQ¬ P¡fF ©J\`PViOP pQ
(455) dv£QHQ
(456) [ 0 #50fg[jx * #/*g K*_)¤
(457) ¥¥¦§ ¤ 460 78* 9¯fg[jx 460 7 * 9 fbs{Q¬^`\][CbQHx³a4s{_4iOz/QHxj £dt_babQ
(458) d{LOQHsM\ d{LOQ¡Ê¶ÐÒ´¥
(459) QÃ @´¤
(460) ¥¥t¦¬xO\`kndtfb[jcQ¬\hkMpQH^]_Ff d{LOstQHk{LO_b^h x Ë 460
(461) 78*39 7.460 7 * 9y J ª» d{LOQ ¼Ffbs{\hfFdt\]_4[ p/Qdv*Q
(462) QH[VdtLOQMdv£_ ʶÐÒ¨Ã{$À @´¤
(463) ¥t¥¦MxJ\hkndtfg[cQHk h 460 78* 9y fb[jx M 460 78* 9y \`kp/Q
(464) ^`_F f d{LOstQHk{LO_b^hx ) h 460 78* 9y #h 460 7 * 9y g KMLOQZjsknd*\`[Gd{Q
(465) s{«ÓknQHQHxc
(466) _b[jxJ\]d{\`_b[)\][kniOstQHkd{LfFdMd{LOQ¬k{Q
(467) QHxjk*fbs{QZc^`_4k{QQH[O_bijabLdt_ Q2fbcL_bd{LOQHsH®KMLOQ k{QHc
(468) _b[jxR\`[Gd{sfF«ÓknQHQHx c_4[jxJ\]d{\`_b[¡stQHqGiO\`s{Q2k d{Ljfgd£\`[¡p_bd{L9k{Q
(469) Q2xOkd{LjQ-dv*_ G« *_bsxOk_Jc
(470) c
(471) iOsZÀÍbÍ@Ã{.Ä 4ʶšÀFÒÓ¥Î Æ fgdd{LOQktfgP QxJ\hkndtfg[cQ st_bP Q2fbcL³_gdtLOQ
(472) s2 :Ó[_gdtLOQ
(473) sT*_bsxOkH»6d{LjQ¡dv£_k{Q
(474) Q2xOkTfgstQ ^]_JcHfFd{Q2xfFd)Á
(475) Î]ħ¤
(476) ¥ ¦gÊÀ
(477) ÑGÄFÐ@ÀFÎ ¤ª£we^]^`_F \`[Oa¡f ¼Ffbs{\hfFdt\]_4[9p/Qdv*Q
(478) Q
(479) [\`[4dtstfg«´k{Q
(480) Q2x9xJ\hkndtfg[cQHk f4c
(481) c
(482) _biO[Gdtk*_4s \][xJQ
(483) ^hk*d{Ljfgd-P \]a4L4d Lf§¼bQZ_ocHciOststQHx)pQ
(484) dv£QHQ
(485) [)d{LOQTc
(486) _bsts{Q2knz/_b[jxO\][Oa G«´£_4stxOk*\`[jk{\`xJQTf k{\]P \`^`fbs{\]dvmstQ
(487) a4\]_4[¹k{Q
(488) Q \`abiOst<Q 22 ª r®fgsfgP Q
(489) d{Q
(490) sk fg[jx o»Jijk{QHx)\][)d{LjQTfgp/_F¼bQc
(491) _b[jxO\dt\]_4[jk
(492) »Ofbs{QZQHknd{\`P¡fFdtQHxfbc
(493) c
(494) _bsxJ\`[OaVdt_Rkndtfgd{\hkvdt\`cHfg^ P _JxJQH^`kM_bdtLOQTw|knQ2qGiOQ
(495) [jc
(496) QZd{Ljfgd-£QxJQ2k{c
(497) s{\`pQ¬[O_F G~ ! p~#"%$}'&()" * H,+ ,+ Ù.- !/ K&*_k{\]P \`^`fbs Zew. s{QHab\`_b[jkVfgstQ9fbktknijPRQ2xd{_¹kvdtQ
(498) P st_bP fxJiOzj^]\hc
(499) fgd{\`_b[ _gef
(500) c _bP P _b[Tfb[jcQ2kvdt_bs&k{QHqGiOQH[jcQ4»H_4^]^`_F*QHx¬pom\`[jxJ\`¼o\`xOijfg^G\][xJQ
(501) z/Q
(502) [jxOQ
(503) [Gd k{iOpjknd{\]d{iJdt\]_4[VQH¼bQ
(504) [Gdk6_Jc
(505) cijs{st\][ja \`[QHf4cLËxJiOzO^`\hc
(506) fFdtQHxc
(507) _bzomb10e[jxJQ
(508) sed{LO\hkZfbktkniOP zJdt\]_4[l»OdtLOQTdv*_¡stQ
(509) ab\`_b[k Ljf§¼bQTfb[QHqGijfb^&^`Q
(510) [Oabd{LËfg[x dtLOQ
(511) \`s fg^`\]a4[OP Q
(512) [Gd \hk f¹knQ2qGiOQ
(513) [jc
(514) Q9_b-P fgdtcLOQ2x<fg[x P \`k{P¡fFdtcLjQHx zjfb\]skT_b-[oijc^`Q
(515) _bd{\hxJQHkH QdtLOQ
(516) [ P _JxJQH^6d{LO\hk-fb^]\`ab[OP QH[4d pom)f k{QHqGiOQH[jcQ¬_g\ \ x *Q
(517) st[O_4iO^]^`\6¼Ffgst\`fbpO^`QHkH»J \dtL)dtLOQTzOst_bpfgpO\`^]\]dv3m 2°_bs-f P¡fgdtcL9fb[jx #42h >_bs fVPR\hk{P fgdtcLl®K_ Q2kvdt\]P¡fgd{Qd{LOQZ\][GdtQ
(518) s{«´k{Q
(519) Q2xxJ\hkvdfg[jc
(520) Qb»o£QLjf§¼bQed{_RQHknd{\`P¡fFd{Q dtLOQ¬xJ\`kndtfb[jcQpQ
(521) dv£QHQ
(522) [9dv£_¡Q¤ jÁÁ¥ª¤¤ªÊ¶ÉF¥Qà JÐO¤¬Ä ^¬ÀFÒ>Î]¥ÀF¤Ò Å¡ÀFÒÓÁÂO¥¤>\][9d{LOQ *Q
(523) st[O_biO^`^`\/k{QHqGiOQH[jcQ4 :´d _4pQHmJk*d{LOQa4Q
(524) _bP Q
(525) d{st\`cZxJ\hkvdts{\`pOiJdt\]_4[_b_4stxJQHs )cHfg^`^]Q2xdtLO6Q 5RÀgʶҨʶÐoÑÒ Ê¶Å¡¥ ¦gÊh¤Ò ê Ê B JÒ¨ÊÄgEÐ t2 0 A _bs D = 4 _b's =F; 74894:<;>=@?<; B CE2 D : : #'2 G2 : #IHKJMN OL P L 7484:<; 0?. _b' s = 9 0kn\`[OaZd{Lj\`k£xJ\`knd{st\`pOiJd{\`_b[&»b*QMxOQj[O'Q knijcLRdtLjfFd®dtLOQ-zOst_bpjfbpO\`^]\]dvF m 7489 : Q? \`k®Lj\]a4L°d{LOQxJQfbiO^d ¼Ffb^]iOQ¬\hk D RTSVpOiJdecHfg[pQTcLfg[Oa4QHx)pGmd{LOQijk{Q
(526) sª ª e_gd{Qd{LfFdMd{LOQ fg\]d{\`[OaVdt\]P QxJ\hkvdts{\`pOiJdt\]_4[)fb^]^`_F-k>ijk£dt_ Q2kvdt\]P¡fFdtQZfb[O_gdtLOQ
(527) s*ijk{QiO^@zjfbstfbP Qd{QHs]0 dtLOQ9[oiOP pQHsV_b-s{iO[kT_g P¡fFdcLOQHkV_gek{t\ 6HQ9fFdR^]Q2fbknd ³\`[jkn\hxJQf *Q
(528) st[O_biO^`^`\£k{QHqGiOQ
(529) [cQ_b-^]QH[Oagdt6L =& :Ó[ f *Q
(530) st[O_bij^]^`\>knQ2qGiOQ
(531) [jc
(532) Q _gM^]QH[OagdtU L =»ldtLOQ¡zOst_bpjfbpO\]^`\]dvmË_g*d{LOQ¡QH¼bQH[4d VWX XYR_b£Ljf§¼o\`[Oa°Q©Ofbcd{^`[m Z Ð@ÄFMÐ @nÄFÉF¥ÃªÎ]ÀÍbÍ@ʶÐGÑ s{ij[jk_g/P fgdtcLOQ2k _g/k{3\ 6
(533) Q fFd®^`QHfbkn d T\hkab\`¼bQH[ pom¬d{LjQM_b^`^]_F J \`[OaZs{Q2ciOskn\`¼bQ_bstPViO^hWf 0 .
(534) Z¿j¿6¿/ʶŠʶÎ`ÀFÃªÊ¶Ò Æ¡¤
(535) ¥tÀgÃ{ÁÂÊ¶Ð°Ì ¤¥ j¥Ð@Á¥ª¤. . : 748V WX J X Y ?<;>7489V WX JML X Y ? [ % 2. T. #'2h 748V. WX JML : L X Y L ?. #. 7489V WX J
(536) L : L X Y ?. KMLO\hkTa4\]¼4QHk¬dtLOQzOst_bpfgpO\`^]\]dvm_b*Lf§¼G\`[OaQ
(537) ©Jf4cªdt^]m Z³Ð@ÄFÐM@nÄFÉF¥ÃªÎ]ÀÍbÍ@ʶÐGÑ k{Q
(538) Q2xOkT_bMk{\t6HQ9fFd ^]Q2fbknd \`[jk{\`xOQ-fstQ
(539) z/QHfgd®_g6kn\36
(540) Q =&®KMLOQ stQHc
(541) iOsts{QH[jcQMkvdfgs{dtk \]d{L d{LjQ-c
(542) fbk{QZ3; D \][ LO\hcL¡c
(543) fbk{Q7489V WX J X P ? ; 7484:+9=)# ?fb[jx)\`k-c
(544) _bP zOiJdtQHx)d{Ljs{_4iOabL9d{LOQ fg\]d{\`[Oa d{\`P QTxJ\hkvdts{\`pOiJdt\]_4[l KMLOQ£xJ\`knd{st\`pOiJd{\`_bF[ 748V WX X Y ?fb^]^`_F-k@dt_ \][JQHsfM^`_F£QHs6p_4iO[jx¬_4[dtLOQ>[oiOP pQHsl_gJ[O_4[J« _F¼4Q
(545) st^`fbzOzO\`[Oa k{Q
(546) Q2xOk Q
(547) ©oz/QHcd{Q2xd{_p/Q_bij[jJ x°\][kn\hxJQVfk{\`PR\`^hfgst\dvm)s{QHab\`_b[l :Ó[zjfgs{d{\hciO^hfgs2»O*QT \`^]^ijknQ¬dtLO\hkep/_biO[x f4k f jstknd QHknd{\`P¡fFd{Q_b&dtLOQabst_biOz°cst\]d{Q
(548) st\`_b[9\`[Gd{st_JxJijcQ2x9^hfFdtQ
(549) s \`[ËÝoQHcd{\`_b[~j - Ú Õ T/ Ð/¦4¥Î ¤\`[jk{Q
(550) s{d{\`_b [ gxJQ
(551) ^`Qdt\]_4[±_b[oijc
(552) ^]QH_gd{\hxJQ2kt fbs{Qs{Q2knz/_b[kn\`pO^`Q)_4sfxJ\`fbab_4[jfg^ k{LO\¶d_b k{Q
(553) Q2xOk-¼o\`Q
(554) *QHx°_4[ËfxJ_gdzO^]_bdZfb^]\`ab[OP QH[4d24 :Ó[Ë_gdtLOQ
(555) se£_4stxOkH»OdtLOQ
(556) m°P _JxJ\]m)dtLOQTstQ
(557) ^hfFdt\]_4[[ M 4 0 7 * 9 E; h 4 0 78* 9y *pGm)fbxOxJ\`[OafRz/_4ktkn\`pO^`Qk{P fb^]^¶ *pO\hfbkHK_RQ2kvdt\]P¡fgd{QTfRdvmozO\hc
(558) fg^lk{LO\]¶dk{t\ 6HQb»O*Qijk{Q¬f P Q
(559) d{LO_Jx°kn \`P \]^hfgsMdt_ _b[OQ¬zOst_bz/_4k{QHx)\][ $~ l_4sMdtfg[xJQ
(560) P s{QHzQ2fFdtkH KMLOQePRQ
(561) d{LO_Jxf4k{k{iOP QHk®d{Ljfgd£fkn\`[Oa4^]Q-[oijc
(562) ^]QH_gdt\`xJQ \`[jxJQH^/cHfg[ _Jc
(563) c
(564) iOs> \]d{L9fb[¡QHqGijfg^jzOs{_4pjfgpj\]^`\dv m fgd®QHfbcLR_g
(565) /[oijc^`Q
(566) _bd{\hxJQHk>k{Q
(567) zfgsfFd{\`[Oadv£_c
(568) _b[jk{QHc
(569) iJd{\`¼bQ k{Q
(570) QHxjk
(571) 0-[jxJQHs®d{Lj\`k>f4k{k{iOP zJdt\]_4[l»gQHknd{\`P¡fFdt\][Oa dtLOQ9xJ\hfga4_b[jfb^k{LO\¶dRzOst_oxOijcQ2xpGm³\`[jxJQ
(572) ^hkT\hkVxO_b[OQ¡dtLOst_biOa4L<fËxJ\hk{c
(573) s{Q
(574) d{Q¡_b[jQ«ÓxJ\]P QH[jkn\`_b[fg^-Ã{ÀgÐ/¦4ÄFÅ 'ÀgÎ ¬P _JxJQH^¨» LOQ
(575) stQ¬d{LOQVzOs{_4pjfgpj\]^`\dvm)_gP _F¼G\`[Oa¡^`Q¶de_4s-st\]a4L4d-\hk Q2q4ifg^6dt _ o»fb[jx)d{LOQTzjs{_4pjfgpO\`^`\dvm _bkvdf§mo\][Oa¡\`[zj^`f4cQT\h k # o c iOsZab_Gfg^l\hked{_9p/_bij[jx6»@ \dtLfa4\]¼4Q
(576) [zOst_bpfgpO\`^]\]dvmb»jd{LOQ xJQH¼G\hfFdt\]_4[ st_bP d{LOQTkndtfbsndt\][Oa z/_b\`[GdH KMLOQ)zOst_bpjfbpO\]^`\]dvm¹_beQ
(577) [jxO\][Oad{LOQ)stfb[jxJ_4PMfg3^ ³fgd z/_4k{\dt\]_4[ 0fF¶dtQ
(578) s -kvdtQ
(579) zjk \hkVa4\]¼4Q
(580) [<pom³d{LOQ _4^]^`_F \`[OaRk{iO!P 0 L N . O P. . * 3* % 0 #1 *% 0 . 2 N !@N . #". 2 N L. !@N. wCxO\]stQHcdc_bP zOiOdtfFdt\]_4[ _g@PViO^]d{\]« P _4[O_bP \hfg^jc
(581) _GQ
(582) ½c\`Q
(583) [Gdtk>qGiO\h c o^]mV^]Q2fbxOkdt_Tf¬P Q
(584) P _bstmT_F¼bQHsn¢_F» bf [jx9d{_f§¼b_4\`xd{LO\hkH»O£QiknQ2x)fb[\`[jxJ\`stQHcªd P QdtLO_Jx°pjfbk{QHx)_b[abQH[O Q
(585) sfFdt\][jaViO[ cªd{\`_b[k
(586) £_4[jk{« \` xJQHsMd{LOQ ij[jcªdt\]_4[ # =p ;$ = %? #% $ %'& fb[jx¡c_4[jk{\`xJQHs®d{LjQez/_F£QHs(# =p ;$) = %+*,*-* %.) = ®KMLOQH[ dtLOQVc
(587) _GQ
(588) ½c\`Q
(589) [Gd/) N c_4PRzjiJd{Q2k zOstQHc\hJ k{Q
(590) ^`m¡d{LOQ fgp/_F¼bQZ_bstPViO^hfO»fg[jx)d{LjQ
(591) stQ_b stQ¬ab\`¼bQ2k*d{LOQT« zjs{_4pjfgpO\`^`\dvm _b®Q
(592) [jxJ\`[Oa dtLOQVsfg[jxO_bP Mfg3^ )fgdez/_4k{\dt\]_4[ 0MfF¶dtQ
(593) 0s ®kvdtQ
(594) zjkH QdtLOQ
(595) [Ljf§¼bQZd{_)kniOP iOzËc
(596) _GQ
(597) ½c\`Q
(598) [Gdtk ) N _bs 0; 7.7n« 71 7n2« 7 .. 7! 7v « 6ij[4dt\]^/*Q-s{Q2fbcL fab\`¼bQH[ d{LOstQHk{LO_4^`xRzOst_bpjfbpO\`^]\]dvm) RTSZpomRxOQfgij^dª ª KMLjQ_4pJdtfb\][OD Q2x9¼Ffb^]iO3Q \`k£dtLOQ
(599) [)dt&f bQ
(600) [fbk£d{LjQZzfgsfgP QdtQ
(601) s Tijk{QHx9d{_Rp_4iO[jx9d{LOQ¬P¡D fF©J\`P¡fg^lxJ\hfga4_b[jfb^ k{LO\]¶d-pQ
(602) dv£QHQ
(603) [)dv£_¡k{Q
(604) Q2xOk
(605) 4 6 5/7 ! 598. z>" 8}xQ MW$. Q [O_F xOQHktcst\]p/Q _4iOs¬^]\`[Wo\`[Oafg^`ab_bst\]d{LOPÜdtLjfFdzOst_JcQHktk{QHk¬knQHQHxOkZ_4[dtLOQ ¢jmfb[jx¹c
(606) s{Q2fFdtQHkabst_biOzjk f4c
(607) c
(608) _bsxJ\][jad{_dtLOQ \][Gd{QHsn«-fb[jx\`[Gd{sfF«ÓknQHQHxËc
(609) s{\]d{QHs{\hfxJQHktcst\]p/QHx¹fgp/_F¼bQ4 KMLOQ¡fg^`ab_4s{\]d{LjP \hk¬ab\`¼bQH[_4[ \`abiOstQTSJ we^]_4[Oad{LOQa4Q
(610) [OQHstfgd{\`_b[²_gknQHQHxOkH»*£QËknd{_4s{Q°QHf4cL knQHQHx 4017 * 9 \`[Cf¹dtfgpj^]Q f4c
(611) c_4stxO\][Oa¹d{_ \]dtkT\][Gd{sfF«Ók{Q
(612) QHx¹xJ\hkvdfg[jc
(613) Q M 4 017 * 9y ¨fbcªdtijfg^`^`mb»&_4[O^`mz/_4k{\dt\]_45[ 0\`kTknd{_4s{Q2xj ª; :®QHs{\]mo\][ja\ f°[OQ
(614) ^`m a4Q
(615) [OQHstfgd{Q2x k{Q
(616) Q2xRk{LO_4iO^`x p/Q-^]\`W[ 4QHxR \dtL¡zOstQ
(617) ¼o\]_4ijk{^]mTc
(618) _bP zOiJdtQHx _b[jQHk\hk>xJ_b[jQ \][ dtLOQM_b^`^]_F \`[Oa¬Mf§hm 0 ; WQQ.
(619) . VÄ. jÁtÂj¥ÃtÄFÉ. i. \`abiOstQTSG0ʶРFʶÐoÑ)ÀgÎ ÑGÄFêʶÒÂoÅ Ù § G«´£_4stx ;- 01 0 % #&. 3 0 q # %O Ú Ù Ù F *¡knicL9dtLjfFd * *% # 3lP¡fFdcLOQHk Ú Ù
(620) 0"#/* Ù 7 %7"# 7.. 17 % 7 # Ú Ù 0
(621) + 0"# 0 4 Õ *
(622) 0 # abst_biOz9d{_4abQdtLOQ
(623) s 460 78* 9 fg[5x 46017 *9 Õ # "%$$ X'&CI> (*) ++&H Õ - Ú + Õ - Ú Ù ,
(624) 0 Õ - Ú Ù F Õ - Ú Ù § . . k. ! k. \]skvd2»g*Q^`_G_9Z_bszOstQ
(625) ¼o\]_4ijk{^]mc_4P zOiJd{Q2xVk{Q
(626) Q2xOk&¼4Q
(627) st\mo\`[Oa-dtLOQ*\][Gd{sfF«Ók{Q
(628) QHxVcst\dtQ
(629) st\]_4[9^`\][jQ kO ª O_4s6d{LjfgdH»§*Q®s{Q
(630) d{st\]QH¼bQ s{_4PCdfgpO^`Q d{LOQ£knQHQHxOk6 \]d{LTfb[¬\][Gd{sfF«Ók{Q
(631) QHxZxJ\hkvdfg[jc
(632) Q®pQH^]_4[Oab\`[OaMdt_ d{LOQ \][GdtQ
(633) st¼§fb^ h 46017 *9y 6#U M 460 7 * 9y % ´»O\`[)dtLOQ\`[jcstQHf4kn\`[OaR_bsxJQ
(634) sM_g\]dtk xJt\ 7/QHs{QH[jcQ¬st_bP j Ost_bP d{LOQ2knQRc
(635) fb[jxJ\hxOfFdtQVknQHQHxOkH»j*QVk{Q
(636) ^`QHcded{LjQjskvdZ_b[OQT Lj\`cLËktfFdt\`knjQHk d{LOQ \][Gd{QHsn«Ók{Q
(637) QHxc
(638) _b[J« xJ\]d{\`_b[ ^`\][jQ w a4s{_4iOz\hkc_4P zO^]Q
(639) d{Q2x¹\]M\dk¬^`f4kvd^`\]W[ 4QHxk{Q
(640) QHx¹Ljf4kfg[³\][Gd{QHsn«Ók{Q
(641) QHx¹xJ\hkvdfg[jc
(642) QR_b*P _4s{Q d{Ljfb[ %K st_bP d{LOQTc
(643) iOs{stQ
(644) [Gd-k{Q
(645) QHxl .0/ !& T!#T l ª KMLjQ¡^]\`W[ o\][jaËfg^`ab_bst\]d{LOPzOs{Q2knQH[Gd{QHx¹\`[d{LOQzjs{QH¼G\`_bikknQ2cªd{\`_b[³_4s{P¡ka4s{_4iOzjk¬_g k{Q
(646) QHxjkz_bd{QH[4dt\`fb^]^`m p/Q
(647) ^`_b[jab\`[OaËdt_Ëd{LjQktfgP Q)k{\`PR\`^hfgst\dvmstQ
(648) ab\`_b[&³wePR_4[OaËdtLO_4k{Q9a4s{_4iOzjkH»abst_biOzjkRc_4[Gdtfg\`[O\`[Oaf^`fbs{a4Q [oiOP pQHs£_b&knQHQHxOk£ \]d{L)k{P¡fg^`^\`[Gd{sfF«ÓknQHQHx¡xJ\hkndtfg[cQHk£stQ
(649) zOstQHk{Q
(650) [Gd^hfgstabQefb[jx¡LO\`abLO«´ktc_4s{Q2x¡kn\`P \]^hfgst\dt\]Q2k
(651) e_F£QH¼bQHsH»GP¡fg[omabst_bijzjkM \]^`^lc_4[Gdtfg\`[°f¡knP¡fg^`^`Q
(652) sM[oiOPVp/Q
(653) s _bk{Q
(654) Q2xOk
(655) »Jz/_4ktk{\]pO^`m9k{Q
(656) zjfbstfgd{Q2x9pom^hfgstabQHs \`[Gd{QHsn«ÓknQHQHx xJ\hkndtfg[cQHkH KMLO_4k{Qa4s{_4iOzjk9Q
(657) \]d{LOQHs°c
(658) _bsts{Q2knz/_b[x¾dt_²k{\`PR\`^hfgst\dt\]Q2k9 \]d{L¯f<^`_F£QHs)ktc_bstQb» _4sxJ_[O_gd9c
(659) _bsts{Q2knz/_b[x d{_<fb[om¾kn\`P \]^hfgst\]dvm¾fFd9fb^]^V\¨ Qb xJ_b[ dp/Q
(660) ^`_b[Oa³d{_<fb[ fg^`\]a4[OP Q
(661) [Gd¡ \dtLÈf k{iJ½c\`Q
(662) [Gdt^]mRpO\`aVk{c
(663) _bstQ2 e_FÈcHfg[¡*QexJ\hkvdt\][jabiO\hknL¡p/Qdv*Q
Documents relatifs
[r]
Certes, une partie de la frontière Est avec l’Iran est globalement l’héritage d’une longue histoire marquant la séparation entre le monde ottoman et le monde iranien,
Dans House of Leaves, chaque voix ou presque a son caractère propre et l’hétérogénéité typographique qui en résulte donne à voir un théâtre de voix : Times pour Zampano,
On y présente d’abord une introduction générale à la radiothérapie, puis on cible plus particulièrement la SBRT et le suivi de marqueurs en temps réel pour en venir finalement
Selon les régions, les divers types sont plus ou moins bien représentés. Sont négligées de la même manière les zones montagneuses de l'Est, les Alpes et le Jura,
Ten microalgal strains indigenous to Quebec were examined for biomass and lipid productivity under different growth modes: photoautotrophic, mixotrophic (light), and
Dans le cas où entre les objets, les types d’énonciation, les concepts, les choix thématiques, on pourrait définir une régularité (un ordre, des corrélations,
Les vaccins anticancéreux ont donné des succès cliniques limités dans le cancer de la prostate. Le vaccin de cellules tumorales GVAX en est un exemple. L'immunosuppression
