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List of Abbreviations APC: antigen presenting cell AP-1:

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List of Abbreviations

APC: antigen presenting cell AP-1: activating protein 1

ATF-2: activating transcription factor 2 BAF: BRM-associated factor

CARD: caspase activating and recruitment domain

CBP: CREB-binding protein

C/EBP: CAAT element binding protein CIA: collagen-induced arthritis

CLP: common lymphoid precursor CMP: common myeloid precursor CpG-ODN: CpG motif-containing oligonucleotides

CREB: cAMP-responsive element binding protein

CTL: cytotoxic T lymphocyte

CTLA-4: cytotoxic T lymphocyte antigen 4 DAG: diacylglycerol

DC: dendritic cell DD: death-domain ds: double-stranded

Dif: drosophila immunity factor EAE: experimental autoimmune encephalitis

EBV: Epstein Barr virus EBI3: EBV-induced gene 3

Foxp3: forkhead box-containing protein 3 GATA-3: GATA-binding protein 3 GCN5: general control of amino acid synthesis 5

GM-CSF: granulocyte-macrophage colony stimulating factor

HAT: histone acetyltransferase HDAC: histone deacetyltransferase HEK 293: human embryonic kidney 293 HMG: high mobility group

ICSBP: IFN consensus sequence binding protein

IFN: interferon IκB: inhibitor of κB IKK: IκB kinase IL: interleukin

Imd: immune deficiency IPC: interferon-producing cell IPS: interferon-β promoter stimulator protein

IRAK: IL-1R-associated kinase IRF: interferon regulatory factor ISG: interferon stimulated gene ISRE: interferon-stimulated response element

JAK: Janus kinase

JNK: c-Jun N-terminal kinase LBP: LPS-binding protein LC: langerhans cell LPS: lipopolysaccharide LRR: leucine-rich repeat LTA: lipoteichoic acid MAL: MyD88-like adaptor

MALP-2: macrophage-activating lipopetide 2

MDA-5: melanoma differentiation associated gene 5

mDC: myeloid DC

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MAPK: mitogen-activated protein kinase MDP: GlcNAc-MurNAc-dipeptide MΦ: macrophage

MHC: major histocompatibility complex MyD88: myeloid differentiation factor 88 NAP: NAK-associated protein

NBS: nucleotide-binding site NK: natural killer

NF-κB: nuclear factor-κB NO: nitric oxide

Nod: nucleotide-binding oligomerization domain

PAM

3

CSK

4:

Pam

3

CysteinSerineLysine

4

PAMP: pathogen-associated molecular pattern

PBMC: peripheral blood mononuclear cells PCAF: p300/CBP associated factor

pDC: plasmacytoid DC PGE2: prostaglandin E2 PGN: peptidoglycan

PGRP: peptidoglycan recognition proteins PKC: protein kinase C

poly(I:C): polyinosinic-polycytidylic acid PRD: positive regulatory domain

PRR: pathogen recognition receptor PKR: protein kinase RNA-dependent RIG: retinoic acid-inducible gene RIP: receptor-interacting protein ss: single stranded

SH2: Src homology domain 2

SIGIRR: single Ig IL-1R-related molecule SLE: systemic lupus erythematosus STAT: signal transducer and activator of transcription

T-bet: Th1-specific T box TAK1: TGFβ-activated kinase

TAP: transporter associated with antigen processing

TBK: TANK-binding kinase

TCCR: T cell cytokine receptor (also called WSX)

TCR: T cell receptor

TGF-β: Transforming growth factor β Th: T helper

T1DM: type I diabetes mellitus TIR: Toll/IL-1 receptor TLR: Toll-like receptor TNF: tumor necrosis factor Treg: regulatory T cell

TRAF: TNF receptor-associated factor

TRAM: TRIF-related adaptor molecule

TRIF: TIR-domain containing adaptor

inducing IFN-β

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