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Клинические, микробиологические, иммунологические и
метаболические особенности возникновения гнойного
процесса в пародонте у больных хроническим
генерализованным пародонтитом
А.А. Gudaryan, N.B. Kuznyak, I.I. Dronik
To cite this version:
ɄɅȱɇȱɑɇȺ ɆȿȾɂɐɂɇȺ
ɆȿȾɂɑɇȱ ɉȿɊɋɉȿɄɌɂȼɂ
ɍȾɄ Ⱥ.Ⱥ. Ƚɭɞɚɪɶɹɧ, ɇ.Ȼ. Ʉɭɡɧɹɤ *, ɂ.ɂ. Ⱦɪɨɧɢɤ *
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Ƚɍ «Ⱦɧɟɩɪɨɩɟɬɪɨɜɫɤɚɹ ɦɟɞɢɰɢɧɫɤɚɹ ɚɤɚɞɟɦɢɹ ɆɁ ɍɤɪɚɢɧɵ» ɤɚɮɟɞɪɚ ɯɢɪɭɪɝɢɱɟɫɤɨɣ ɫɬɨɦɚɬɨɥɨɝɢɢ, ɢɦɩɥɚɧɬɨɥɨɝɢɢ ɢ ɩɚɪɨɞɨɧɬɨɥɨɝɢɢ (ɡɚɜ. – ɤ. ɦɟɞ. ɧ. ɇ.Ƚ. ɂɞɚɲɤɢɧɚ) ɭɥ. Ⱦɡɟɪɠɢɧɫɤɨɝɨ, 9, Ⱦɧɟɩɪ, 49044, ɍɤɪɚɢɧɚ Ƚɍ «Ȼɭɤɨɜɢɧɫɤɢɣ ɝɨɫɭɞɚɪɫɬɜɟɧɧɵɣ ɦɟɞɢɰɢɧɫɤɢɣ ɭɧɢɜɟɪɫɢɬɟɬ» * ɤɚɮɟɞɪɚ ɨɪɬɨɩɟɞɢɱɟɫɤɨɣ ɫɬɨɦɚɬɨɥɨɝɢɢ (ɡɚɜ. – ɤ. ɦɟɞ. ɧ. ɇ.Ȼ. Ʉɭɡɧɹɤ) Ɍɟɚɬɪɚɥɶɧɚɹ ɩɥ., 2, ɑɟɪɧɨɜɰɵ, 58002, ɍɤɪɚɢɧɚ
SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine» Oral surgery, implantology and periodontology department
Dzerzhinsky str., 9, Dnipro, 49044, Ukraine e-mail: gudaryan@list.ru
SE «Bukovinian state medical university» *
Department of prosthetic dentistry
Theatralna sq., 2, Chernivtsi, 58002, Ukraine e-mail: office@bsmu.edu.ua
Ʉɥɸɱɟɜɵɟɫɥɨɜɚ ɝɟɧɟɪɚɥɢɡɨɜɚɧɧɵɣ ɩɚɪɨɞɨɧɬɢɬ, ɩɟɪɟɤɢɫɧɨɟ ɨɤɢɫɥɟɧɢɟ ɥɢɩɢɞɨɜ, ɢɦɦɭɧɨɞɟɮɢɰɢɬ, ɛɢɨɰɟɧɨɡ .H\ZRUGV generalized periodontitis, lipid peroxidation, immunodeficiency, biocenosis.
ɊɟɮɟɪɚɬɄɥɿɧɿɱɧɿɦɿɤɪɨɛɿɨɥɨɝɿɱɧɿɿɦɭɧɨɥɨɝɿɱɧɿɬɚɦɟɬɚɛɨɥɿɱɧɿɨɫɨɛɥɢɜɨɫɬɿɜɢɧɢɤɧɟɧɧɹɝɧɿɣɧɨɝɨɩɪɨɰɟɫɭ ɜɩɚɪɨɞɨɧɬɿɭɯɜɨɪɢɯɧɚɯɪɨɧɿɱɧɢɣɝɟɧɟɪɚɥɿɡɨɜɚɧɢɣɩɚɪɨɞɨɧɬɢɬȽɭɞɚɪ¶ɹɧɈɈɄɭɡɧɹɤɇȻȾɪɨɧɿɤȱȱ ɍ ɫɬɚɬɬɿ ɞɨɜɟɞɟɧɨ ɡɧɚɱɟɧɧɹ ɩɪɨɰɟɫɿɜ ɜɿɥɶɧɨɪɚɞɢɤɚɥɶɧɨɝɨ ɨɤɢɫɧɟɧɧɹ, ɦɿɫɰɟɜɢɯ ɿɦɭɧɨɥɨɝɿɱɧɢɯ ɩɨɪɭɲɟɧɶ ɬɚ ɨɫɨɛɥɢɜɨɫɬɟɣ ɛɿɨɰɟɧɨɡɭ ɩɚɪɨɞɨɧɬɚɥɶɧɢɯ ɬɤɚɧɢɧ, ʀɯ ɪɨɥɶ ɭ ɜɢɧɢɤɧɟɧɧɿ ɝɧɿɣɧɨɝɨ ɩɪɨɰɟɫɭ ɜ ɩɚɪɨɞɨɧɬɿ ɭ 64 ɯɜɨɪɢɯ ɧɚ ɯɪɨɧɿɱɧɢɣ ɝɟɧɟɪɚɥɿɡɨɜɚɧɢɣ ɩɚɪɨɞɨɧɬɢɬ I-II ɫɬɭɩɟɧɹ ɬɹɠɤɨɫɬɿ. Ɂɚ ɫɭɤɭɩɧɿɫɬɸ ɤɥɿɧɿɱɧɢɯ, ɦɿɤɪɨɛɿɨɥɨɝɿɱɧɢɯ ɿ ɦɟɬɚɛɨɥɿɱɧɢɯ ɪɟɡɭɥɶɬɚɬɿɜ ɞɨɫɥɿɞɠɟɧɶ, ɩɪɨɜɟɞɟɧɢɯ ɭ ɯɜɨɪɢɯ, ɜɢɹɜɥɟɧɨ, ɳɨ ɮɨɪɦɭɜɚɧɧɹ ɝɧɿɣɧɨɝɨ ɩɪɨɰɟɫɭ ɜ ɩɚɪɨɞɨɧɬɚɥɶɧɢɯ ɬɤɚɧɢɧɚɯ ɩɨɜ'ɹɡɚɧɨ ɡ ɞɨɦɿɧɭɜɚɧɧɹɦ ɜ ɹɫɟɧɧɿɣ ɟɤɨɧɿɲɿ ɫɬɚɮɿɥɨɤɨɤɨɜɨʀ, ɮɭɡɨɫɩɿɥɿɚɪɧɨʀ ɿɧɮɟɤɰɿʀ, ɞɟɮɿɰɢɬɨɦ ɫɟɤɪɟɬɨɪɧɨɝɨ ɿɦɭɧɿɬɟɬɭ ɫɥɢɡɨɜɨʀ ɨɛɨɥɨɧɤɢ ɩɨɪɨɠɧɢɧɢ ɪɨɬɚ, ɿɧɬɟɧɫɢɜɧɿɫɬɸ ɩɟɪɟɤɢɫɧɨɝɨ ɨɤɢɫɧɟɧɧɹ ɥɿɩɿɞɿɜ ɿ ɩɪɢɝɧɿɱɟɧɧɹɦ ɚɧɬɢɨɤɫɢɞɚɧɬɧɨɝɨ ɡɚɯɢɫɬɭ. ȼɫɬɚɧɨɜɥɟɧɨ, ɳɨ ɧɨɪɦɚɥɿɡɚɰɿɹ ɪɿɜɧɿɜ ɿɦɭɧɨɝɥɨɛɭɥɿɧɿɜ, ɨɫɨɛɥɢɜɨ sIgA, ɰɢɬɨɤɿɧɿɜ (ȱɅ-1ȕ, Ɏɇɉ-Į), ɮɭɧɤɰɿɨɧɭɜɚɧɧɹ ɉɈɅ ɿ ȺɈ3 ɽ ɨɫɧɨɜɧɢɦɢ ɦɚɪɤɟɪɚɦɢ ɩɨɥɿɩɲɟɧɧɹ ɤɥɿɧɿɱɧɨʀ ɤɚɪɬɢɧɢ ɡɚɯɜɨɪɸɜɚɧɧɹ. $EVWUDFW&OLQLFDOPLFURELRORJLFDOLPPXQRORJLFDODQGPHWDEROLFIHDWXUHVRISXUXOHQWSURFHVVRFFXUUHQFHLQWKH SHULRGRQWLXP LQ SDWLHQWV ZLWK FKURQLF JHQHUDOL]HG SHULRGRQWLWLV *XGDU\DQ ȺȺ .X]Q\DN 1% 'URQLN ,,
Significance of processes of free lipid peroxidation, local immunological disorders and features of biocenosis of periodontal tissues and their role in the occurrence of purulent process in the periodontium in 64 patients with chronic generalized periodontitis of I-II severity degree is proved. By total of results of clinical, microbiological and metabolic studies in patients it was showed, that formation of purulent process in periodontal tissues is due to the dominance in the gingival econiche of staphylococus, fuzospiliar infection, deficiency of secretory immunity of the oral mucosa, intensity of lipid peroxidation and inhibition of antioxidant protection. It was found that the normalization of the levels of immunoglobulins, especially of sIgA, cytokines (IL-1ȕ, TNF-Į), the operation of POL and AOP are the main markers of improved clinical picture of the disease.
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