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Gene constraint and genotype–phenotype correlations in neurodevelopmental disorders

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Academic year: 2021

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Figure

Figure 1. gnomAD constraint metrics of NDD genes. The majority of the genes implicated in autosomal dominant  (AD) and X-linked (XL) forms of NDDs are highly constrained for PTVs and/or missense variants
Figure  2.  Distribution  of  truncating  variants  in  gnomAD  across  SHANK2  transcripts

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