• Aucun résultat trouvé

en fr

N/A
N/A
Protected

Academic year: 2021

Partager "en fr "

Copied!
238
0
0

Texte intégral

(1)

HAL Id: tel-01561771

https://tel.archives-ouvertes.fr/tel-01561771

Submitted on 13 Jul 2017

HAL is a multi-disciplinary open access

archive for the deposit and dissemination of sci-entific research documents, whether they are pub-lished or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.

L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

et métabolique de la personne en surpoids ou obèse

Monique Mendelson

To cite this version:

Monique Mendelson. Importance de l’activité physique, de l’exercice musculaire et du sommeil sur le risque cardiovasculaire et métabolique de la personne en surpoids ou obèse. Médecine humaine et pathologie. Université Grenoble Alpes, 2014. Français. �NNT : 2014GRENS002�. �tel-01561771�

(2)

Université Joseph Fourier / Université Pierre Mendès France / Université Stendhal / Université de Savoie / Grenoble INP

THÈSE

Pour obtenir le grade de

DOCTEUR DE L’UNIVERSITÉ DE GRENOBLE

Spécialité : Mouvement et Comportement pour la Santé et

l’Autonomie

Arrêté ministériel : 7 août 2006

Présentée par

Monique MENDELSON

Thèse dirigée par

Patrice FLORE

préparée au sein du Laboratoire Hypoxie Physiopathologie (HP2), INSERM U1042, Grenoble, France

dans l'École Doctorale Ingénierie pour la Santé, la Cognition et

l’Environnement

I

MPORTANCE DE L

ACTIVITE PHYSIQUE

,

DE

L

EXERCICE MUSCULAIRE ET DU SOMMEIL SUR LE

RISQUE CARDIOVASCULAIRE ET METABOLIQUE DE LA PERSONNE EN SURPOIDS OU OBESE

Thèse soutenue publiquement le 21 février 2014 devant le jury composé de :

Dr Jean-Frédéric BRUN

MCU-PH, Université de Montpellier Rapporteur M. Vincent PIALOUX

MCU, Université de Lyon 1 Rapporteur

Pr Henri BENOIT

PU-MCU, Université Grenoble Alpes Membre Pr Xavier BIGARD

Pr, Agence française de lutte contre le dopage Membre Pr Jean-Louis PEPIN

PU-PH, Université Grenoble Alpes Membre M. Patrice FLORE

MCU, Université Grenoble Alpes Directeur

Mme Fabienne MOUGIN-GUILLAUME

MCU, Université France-Comté Membre invité

Dr Matthieu DESPLAN

(3)

"#$%&'($)*!+,(&-.!/,0'$&'! !"#$%&'#"(#)*$%&+,-.,/%)/%&0#1)&$*&2*,(.3&$*&"#-,/(/#,&%(&$4%,5/)#,,%6%,(& 789&:;<3&=)%,#>$%& & & & & & & & 12-$)34!506! 7,/(.&?.'/"*$%&<0#)(2&@&;*(A#$#-/%2& 78&9%"A%)"A%&!B%)"/"%&@&<*,(.& =)%,#>$%& & & & & & 738,'3),$'&!19-,:$&!;.9($,-3).,4,<$&! +,2%)6&7CDEF& =)%,#>$%&

(4)

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

K.5(" 80" *-.,.)/" 40" *?2(0" 5%6(" .,%5(" 4%58" 0L1/%-'" /." -0/.*)%5" 05*-0" /$.8*),)*'" 1?B()760+" /$%&'()*'+"/0"(%330)/"0*"/0("<.8*06-("40"-)(760"8.-4)%,.(86/.)-0"0*"3'*.&%/)760".((%8)'("8?0M"40(" .46/*0(" 05" (6-1%)4(N%&2(0(" 1-'(05*.5*" 65" DEFD" 0*" 40(" .4%/0(805*(" %&2(0(+" 1%16/.*)%5" 4.5(" /.760//0"80"-)(760"0(*"05"8%6-("4$)5(*.//.*)%5:" E1-2(" .,%)-" 3%5*-'" /$)31%-*.580" 40" /$.8*),)*'" 1?B()760" (1%5*.5'0" 4.5(" /." 3.H*-)(0" 40" /$?B10-*05()%5" .-*'-)0//0" 46" (%)-" 8?0M" 40(" 10-(%550(" 1%-*06-(" 4$65" DEFD" 9" ?.6*" -)(760" 8.-4)%,.(86/.)-0"0*"/."<.)&/0((0"40("5),0.6L"4$EO"4.5("80**0"1%16/.*)%5+"5%6(".,%5(",'-)<)'"/$0<<0*" 46" DEFD" (6-" /." 8%54)*)%5" 1?B()760" .'-%&)0" 0*" /$%LB4.*)%5" /)1)4)760" 4.5(" 65" ;-%610" 40" 1.-*)8)1.5*("DEFD"5%5"%&2(0(:"" #."(6-8?.-;0";-.)((06(0"*?%-.8)760"106*"3.@%-0-"/."8%5*-.)5*0",05*)/.*%)-0"9"/$0L0-8)80"0*" 8%5*-)&60-" 9" /$)5*%/'-.580" 9" /$0<<%-*" 4.5(" /$%&'()*':" P%6(" .,%5(" -08?0-8?'" ()" /0(" <.8*06-(" ,05*)/.*%)-0(" 1%6,.)05*" -054-0" 8%31*0" 40" /$)5*%/'-.580" 9" /$0<<%-*" 40" /$.4%/0(805*" %&2(0:" I0**0" 1%16/.*)%5" 4.5(" /.760//0" /." 3%-&)4)*'" 8.-4)%Q3'*.&%/)760" 5$0(*" 1.(" 058%-0" 8%31/2*0305*" )5(*.//'0+"."'*'"8?%)()0"1%6-"/)3)*0-"/$)31.8*"40"80**0"40-5)2-0"(6-"/."8%54)*)%5"1?B()760"0*")(%/0-" /0("<.8*06-(",05*)/.*%)-0("',05*60//0305*"-0(1%5(.&/0("40"80**0")5*%/'-.580:"P%6(".,%5("3)("05" ',)40580" 650" -0(1)-.*)%5" 9" 1/6(" &.(" 5),0.6" 40" ,%/630" 16/3%5.)-0" .)5()" 76$650" 8%5*-.)5*0" ,05*)/.*%)-0" 0*" 65" 0((%6<</0305*" 3.@%-'(" /%-(" 4$65" 0L0-8)80" .,08" 1%-*" 46" 1%)4(" C3.-8?0G+" -',0-()&/0("1.-"65"1-%;-.330"4$0L0-8)80"40"R!"(03.)50("S"-',0-()&)/)*'"1%6,.5*"0L1/)760-"650" 1.-*)0" 40" /$.3'/)%-.*)%5" 40" /." 8%54)*)%5" 1?B()760" )546)*0" 1.-" /$05*-.H50305*:" P%6(" .,%5(" ';./0305*"8%5<)-3'"/."1-'(0580"4$.5%3./)0("3'*.&%/)760("0*"8.-4)%,.(86/.)-0("1-'8%80("8?0M"/0" @0650"%&2(0"C)5</.33.*)%5+"(*-0(("%LB4.5*+")5(6/)5%Q-'()(*.580G"0*"650"./*'-.*)%5"40"/."76./)*'"0*" 40"/."46-'0"46"(%330)/:"" I%31*0" *056" 40(" 4)<<)86/*'(" 9" 10-4-0" 46" 1%)4(" 4.5(" /." 46-'0+" 5%6(" .,%5(" '*64)'" /$0<<0*" 4$65"1-%;-.330"4$0L0-8)80"(06/+"(.5("-0(*-)8*)%5"8./%-)760+"(6-"/0("3.-7606-("1-'Q8/)5)760("40" 3%-&)4)*'"3'*.&%/)760"0*",.(86/.)-0".)5()"760"/0"(%330)/"4.5("65";-%610"4$.4%/0(805*("%&2(0(:" P%6(" .,%5(" 3%5*-'" 650" 8%--08*)%5" 1.-*)0//0" 40(" .5%3./)0(" 3'*.&%/)760(" 0*" 8.-4)%,.(86/.)-0(+" 650" .3'/)%-.*)%5" 40(" 76.5*)*'" 0*" 76./)*'" 40" (%330)/" .)5()" 76$650" .6;305*.*)%5" 40(" 5),0.6L" 4$.8*),)*'"1?B()760"3./;-'"/$.&(0580"40"10-*0"40"1%)4(:"#0(".4%/0(805*("76)"4)3)56.)05*"/0"1/6(" /06-"3.((0";-.((0",)(8'-./0"&'5'<)8).)05*"4$.3'/)%-.*)%5("3'*.&%/)760(""1/6("3.-76'0(:" #0"3.)5*)05"9"/%5;" *0-30"40(".876)(".1-2("65"-'05*-.H50305*"05"8/)5)760"8%5(*)*60"65" 05@06" )31%-*.5*:" E)5()+" 650" 1.-*)0" 3'*?%4%/%;)760" 40" 80" *-.,.)/" .,.)*" 1%6-" &6*" 4$',./60-" /." *-.5(<'-.&)/)*'"(6-"/0"*0--.)5"4$)54)8.*06-("3'*.&%/)760("30(6-'("05"/.&%-.*%)-0"C):0:"#)1%L3.L"0*" 1%)5*" 40" 8-%)(0305*" ;/68)4%Q/)1)4)760G" 05" ,60" 40" <.,%-)(0-" /." 3)(0" 05" T6,-0" 4$E8*),)*'(" O?B()760(" E4.1*'0(:" I0**0" '*640" ." 10-3)(" 40" (%6/);50-" /." 5'80(()*'" 4$650" 4'*0-3)5.*)%5" (1'8)<)760"05"<%58*)%5"40"/$.8*),)*'"1?B()760".4.1*'0"05,)(.;'0:""

=5" 8%58/6()%5+" 5%(" -'(6/*.*(" (%6/);505*" /$)5*'-U*" 3.@06-" 40" /$.8*),)*'" 1?B()760" 0*" 40" /$0L0-8)80" C(.5(" -0(*-)8*)%5" 8./%-)760G" 4.5(" /." 1-)(0" 05" 8?.-;0" 40" /." 10-(%550" 05" (6-1%)4(" %6" %&2(0"1-'(05*.5*"%6"5%5"65"DEFD:"

"

%'()& *+,)& -& %&'()*'+" (B54-%30" 4$.15'0(" %&(*-68*),0(" 46" (%330)/+" .8*),)*'" 1?B()760+" 0L0-8)80+"

-)(760"8.-4)%,.(86/.)-0+"(%330)/"""

(5)

V"

.54" 30*.&%/)8" 3%-&)4)*B:" X0805*" (*64)0(" 6540-/)50" *?0" 1%*05*)./" &)4)-08*)%5./" .((%8).*)%5" &0*W005"(/001".54"%&0()*B>"(/001"(003("*%"8%5*-)&6*0"*%"*?0"1.*?%;050()("%<"%&0()*B".54"%&0()*B" ./(%" .110.-(" *%" 1/.B" .5" 0*)%/%;)8./" -%/0" )5" *?0" 40,0/%1305*" %<" (/001" 4)(*6-&.580(+" (68?" .(" %&(*-68*),0" (/001" .150." CFDEG:" O?B()8./" .8*),)*B" )(" .5" )31%-*.5*" 3%4./)*B" <%-" *?0" *-0.*305*" %<" %&0()*B" .54" FDE" .54" 8.5" 8%5*-)&6*0" *%" 408-0.()5;" 8.-4)%,.(86/.-" .54" 30*.&%/)8" -)(Y" <.8*%-(:" Z%W0,0-+"&%*?"%&0()*B".54"FDE"?.,0"&005".((%8).*04"W)*?"0L0-8)(0")5*%/0-.580:"

[5" *?)(" *?0()(+" W0" 0L1/%-04" *?0" -0/.*)%5" &0*W005" 1?B()8./" .8*),)*B+" %&0()*B+" (/001" .54" .((%8).*04"8.-4)%,.(86/.-".54"30*.&%/)8"-)(Y"<.8*%-(")5"%,0-W0);?*N%&0(0".46/*("W)*?"FDE".54" %&0(0".4%/0(805*(:"

\0"(?%W04"*?.*"1?B()8./".8*),)*B")("*?0"3.@%-"40*0-3)5.5*"<%-"0,05)5;"&/%%4"1-0((6-0")5" .46/*(" W)*?" FDE" 1-0(05*)5;" ?);?" 8.-4)%,.(86/.-" -)(Y:" \0" *?05" 0L1/%-04" *?0" 0<<08*(" %<" FDE" %5" 8.-4)%-0(1)-.*%-B"<)*50((".54"/)1)4"%L)4.*)%5")5"5%5Q%&0(0".46/*("W)*?"FDE:""

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

(6)

_" #$"%&'(')*"+,"%-./,",/%"*,"0&1)%"+21$"%&'(')*"34**,3%)0!"5,"%),$/"6"&,7,&3),&"%41%,/"*,/"8,&/4$$,/" 72'9'$%"')+:"+,"8&./"41"+,"*4)$"%41%"'1"*4$;"+,"74$"8'&341&/!" " !"#$%&' ' E"3%5"4)-08*06-"40"*?2(0+"<'%&)3,"=*4&,"1%6-".,%)-"8-'0"40("8%54)*)%5(")4'./0("1%6-"3%5" '1.5%6)((0305*" (8)05*)<)760" 0*" 40" 3$.,%)-" *-.5(3)(" ,%*-0" 1.(()%5" 1%6-" /." -08?0-8?0:" ^0-8)"1%6-",%*-0"4)(1%5)&)/)*'")58-%B.&/0:"#."(6)*0"40("0(1)%55.;0("0(*"9",05)-"`" " >"?!"@)$3,$%"<)'*41A"0*"B&"5,'$C=&:+:&)3"D&1$"76)"3$%5*"<.)*"/$?%5506-"4$.8801*0-"4$U*-0" /0("-.11%-*06-("40"80"*-.,.)/!"" " a0"-030-8)0"8?./06-06(0305*"<&"5,'$CE41)/"<:8)$+"76)"30"<.)*"/$?%5506-"40"1.-*)8)10-"9"80" @6-B:" ^0-8)" ';./0305*" 1%6-" *%6(" /0(" '8?.5;0(" (8)05*)<)760(" 76)" %5*" 8%5*-)&6'" 9" /$',%/6*)%5"40"80"*-.,.)/"40"*?2(0:" "

E6" <&" F'(),&" D);'&+G" <&" H,$&)" D,$4)%G" ?7," ='I),$$," ?41;)$CJ1)**'17," ,%" B&" ?'%%-),1"

B,/8*'$/"4$.,%)-".8801*'"40"@6;0-"80"*-.,.)/"0*"4$B".11%-*0-"65"-0;.-4"8-)*)760:" " " E6"B&"D,&$'&+"K19'7+"1%6-"(%5".8860)/"4.5("/$'76)10"=L0-8)80NZB1%L)0+"(%5"(%6*)05".6" 8%6-("40"80**0"*?2(0"0*"(%5"05*?%6().(30"05,%6*.5*:" " E6"<&"<'%&)3L"E,(9"1%6-"3$.,%)-".8860)//)0"4.5("/0"/.&%-.*%)-0"ZO!"0*"1%6-"/."8%5<).580" .88%-4'0".6"<)/"40(".55'0(:" " >1"B&">$$,"='(&,C51()$G"30-8)"1%6-"/$.8860)/".6"(0)5"40"/$b5)*'"D1%-*("c"O.*?%/%;)0("0*"B&" ?)3-,*"d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

(7)

e" 1%6-"/0("1.6(0("8.<'+"/0("&%5("-01.(".6"(0/<"0*"/0("4)(86(()%5("1.-*.;'0(:"" " E">$$,CR48-),"?)3-'**,%"1%6-"*%6*"/0"*-.,.)/"-'./)('"05".3%5*"1%6-"/."3)(0"05"1/.80"0*"/0" 4'3.--.;0"46"1-%*%8%/0"h05*)/%&0"0*"51*)'"U4$)$)+"1%6-"/."8%//.&%-.*)%5"(8)05*)<)760"0*"/0(" '8?.5;0("760"5%6(".,%5("06(:"" " >1A"34**.;1,/"+1"*'I4&'%4)&,"H<W+"1%6-"/0("&%5("3%305*("1.(('(".6L"('3)5.)-0("40"/.&%+" .6L"(%)-'0("-.760**0("4.5("/."50);0"0*"*%6("/0(".6*-0("3%305*("8%5,),).6L:"" "

E" 30(" .3)(" (1%-*)<(" 46" dbI" C?'&)$,G" <'1*)$,G" O4&'*)$,G" O:+&)3G" >*,A)'G" >$$');G" @'$,//G"

R4&'9'G"<'/3'*)$,G"O-&)/%.*,G"0*"4$=8?)-%//0("]-).*?/%5"CO*:7,$3,G+"30-8)"1%6-"/0("*%6-("40" 1)(*0+"/0("/%5;606-("40"&.(()5+"/0("&./.40("9",'/%:"" " >"7,/"'7)/"X"Y)$:/",%"3),:"i"0*"/$'76)10"Y)$:8-9/)4G"1%6-"/$)5*'-U*"760",%6("1%-*0M"9"80"760" @0"<.)("`"^0-8)"9"51"Z"O*,7"1%6-"/0"(%6*)05"4.5("80**0"40-5)2-0"/);50"4-%)*0:" "" >"7'"I,**,C0'7)**,+"40,0560"3."<.3)//0+"30-8)"1%6-",%*-0"(%6*)05:"b5";-.54"30-8)"9"E:'G" R'*47:",%"R9*(')$"76)"%5*"1.-*)8)1'"9"h05*)/%&0"`" " >"%41%,"7'"0'7)**,"'1"O'$'+'+"76)"(%5*"*%6@%6-("/9"3./;-'"/."4)(*.580:"" " >"7'";&'$+C7.&,"N4[+"76)"0(*"65"3%42/0"40"10-(','-.580"1%6-"3%):" " >"74$"0&.&,"<-)*)88,+"76)"4%)*"U*-0"<)0-"40"(.";-.540"(T6-"`" " >" 7,/" 8'&,$%/G" =&,+" Z" >$)%'+" 1%6-" 3$.,%)-" 10-3)(" 4$.--),0-" )8)" .6@%6-4$?6)+" 1%6-" /06-" (%6*)05"4016)("*%6@%6-(:"" " >"?'$1:"]6"0("3%5"8%Q8?0-8?06-"(.5("<.)//0+"3%5"1.(()%55'"40"16&304"C0*"4$.8*6Y)5'"`G" 0*" 3%5" 1-03)0-" <.5:" ^0-8)" 1%6-" /0(" g"-0(*%(" 16&/)("i+" *%5" 05*?%6().(30" 0*" *0(" 058%6-.;0305*("76)"30"<%5*".,.580-"*%6("/0("@%6-(:""" " >"74$"82%)%"?'&3,*+" 3%5" .(()(*.5*" -'4.8*)%550/+" 76)" ." ,6" /0" @%6-" 1054.5*" 80**0" C<)5" 40G" *?2(0j"`"" " " " " T$0)$G"/2)*"0'**')%"+:+),&"3,"%&'(')*"3,"/,&')%"6"7'"?'77),"<),&&,%%,G"P1)"72'",$341&';:," +,81)/"*,"+:I1%"+,"74$"8'&341&/",%"P1)"'1&')%"%'$%"(41*1"\%&,"*6"841&"7,"(4)&"/41%,$)&"3,%%," %-./,"'1]41&+2-1)!

(8)

k" "

!

890!:;$108:9&<"9"!.=>jjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjj::R_&

?

!>%8>!>&?.!08>

&-

&

!

>@$>&;>&=.&=800>!.0$!>

&

1A.?80!>&BC&:/>#80>&CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC&BD&

R:R"K'<)5)*)%5"40"/$%&'()*'":::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"Rl" R:!"=1)4'3)%/%;)0"::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"Rl" R:V"X)(760"8.-4)%,.(86/.)-0"0*"3'*.&%/)760".((%8)'"9"/$%&'()*'"::::::::::::::::::::::::::::::::::::::::::::::::::"!m" R:V:R"F&'()*'"0*"*)((6".4)106L":::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"!m" R:V:!"[5</.33.*)%5"::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"!!" R:V:_"E5%3./)0("3'*.&%/)760(":::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"!k" E5%3./)0("46"1-%<)/"/)1)4)760":::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"!k" [5(6/)5%Q-'()(*.580"::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"!n" R:V:e"F&'()*'"0*".5%3./)0("8)-86/.*%)-0("::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"!o" R:_"E8*),)*'"1?B()760"8%330"*-.)*0305*"40"/$%&'()*'"::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"VR" R:_:R"p'5'<)80("40"/$.8*),)*'"1?B()760"(6-"/."3%-&)Q3%-*./)*'"::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"V!" R:e"[5*%/'-.580"9"/$0<<%-*"4.5("/$%&'()*'"::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"_R" R:e:R"q.8*06-("-0(1)-.*%)-0("0*")5*%/'-.580"9"/$0<<%-*"::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"_!" R:e:!"q.8*06-("8.-4)%Q,.(86/.)-0("0*"3'*.&%/)760("40"/$)5*%/'-.580"9"/$0<<%-*":::::::::::::::::::::::::::::"_k" R:e:V"q.8*06-("%(*'%Q.-*)86/.)-0(":::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"_o" 1A.?80!>&EC&#F9;!:%>&;G.?9>>#&:/#0!$108@>#&;$&#:%%>8=&H#.:#I&CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC&JD&

!:R:"K'<)5)*)%5"0*"'1)4'3)%/%;)0":::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"_l" !:!"X)(760"8.-4)%,.(86/.)-0"0*"3'*.&%/)760".((%8)'".6"DEFD"::::::::::::::::::::::::::::::::::::::::::::::::::::::"em" !:!:R"ZB10-*05()%5".-*'-)0//0"::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"em" !:!:!"^./.4)0"8%-%5.-)0550":::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"eR" !:V"]-.)*0305*"46"DEFD"::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"eR" !:_"XA/0"1%*05*)0/"40"/$.8*),)*'"1?B()760"4.5("/0"*-.)*0305*"46"DEFD"::::::::::::::::::::::::::::::::::::::"e!" !:e"DEFD"0*".1*)*640"9"/$0<<%-*":::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"e!"

;

>$K8>%>&?.!08>&

-

&

1

:90!8/$08:9&?>!#:99>==>

&

:/L>108M#&#18>908M8N$>#&CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC&OP&

BC&%.0>!8>=&Q&%>0A:;>#&CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC&OD&

R:R"I%31%()*)%5"8%-1%-0//0"(6-"8%-1("05*)0-"1.-")3.;0-)0"1.-"-'(%5.580"3.;5'*)760":::"el" E876)()*)%5"40(")3.;0("::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"el" ]-.)*0305*"40(")3.;0("::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"el" R:!"=L1/%-.*)%5"q%58*)%550//0"X0(1)-.*%)-0":::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"kR" D1)-%3'*-)0"/05*0"0*"<%-8'0"::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"kR" O/'*?B(3%;-.1?)0"::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"k!" R:V""^0(6-0"40"/$.8*),)*'"1?B()760"(1%5*.5'0"::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"kV" R:_""^0(6-0"40"/."-'.8*),)*'",.(86/.)-0"1.-"*%56(".-*'-)0/"1'-)1?'-)760"C054%OE]G"::::::::::"k_" R:e"O%/B(%35%;-.1?)0":::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"ke" R:k"=L1/%-.*)%5"<%58*)%550//0"9"/$0L0-8)80"C=qrG"::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"kk" =1-06,0"4$0<<%-*"3.L)3./0"1-%;-0((),0":::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"kk" K'*0-3)5.*)%5"40"/."/)3)*.*)%5",05*)/.*%)-0"9"/$0L0-8)80":::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"ko" R:n"=1-06,0"4$0<<%-*"3'*.&%/)760":::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"nm" R:o"]0(*"40"3.-8?0"40"k"3)56*0("::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"nR"

(9)

n" !:R"O/.80"40"/$EO"(1%5*.5'0"0*"40(".5%3./)0("46"(%330)/"4.5("/0"-)(760"8.-4)%,.(86/.)-0" 0*"3'*.&%/)760"46"05"(6-1%)4("%6"%&2(0":::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"nV" !:!"X)(760"8.-4)%Q3'*.&%/)760"0*"8.1.8)*'"9"/$0<<%-*"4.5("/0"DEFD"::::::::::::::::::::::::::::::::::::::::::::"ol" !:V"[31.8*"40("<.8*06-(",05*)/.*%)-0("(6-"/."*%/'-.580"9"/$0<<%-*"46"@0650"%&2(0"::::::::::::::::::"ln" !:_"[31.8*"4$65"1-%;-.330"4$0L0-8)80"(06/+"(.5("-0(*-)8*)%5"8./%-)760"(6-"/0"-)(760" 8.-4)%,.(86/.)-0"0*"3'*.&%/)760"40"/$.4%/0(805*"%&2(0":::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"RVm" !:e"[31.8*"4$65"1-%;-.330"4$0L0-8)80"(06/+"(.5("-0(*-)8*)%5"8./%-)760"(6-"/."76.5*)*'"0*" 76./)*'"40"(%330)/"0*"/0("5),0.6L"4$.8*),)*'"1?B()760"40"/$.4%/0(805*"%&2(0"::::::::::::::::::::"R__" !:k"E(108*("3'*?%4%/%;)760("40"/."30(6-0"40(")54)8.*06-("3'*.&%/)760("4$0<<%-*"0*" .11/)8.&)/)*'"4.5("/0"8.4-0"40("EOE"::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"Rek"

0

!:8#8>%>&?.!08>&

-

&

;

8#1$##8:9&

Q

&?>!#?>108@>#

&

O/.80"40"/$EO"(1%5*.5'0"0*"40(".5%3./)0("46"(%330)/"4.5("/0"-)(760"8.-4)%,.(86/.)-0"0*" 3'*.&%/)760"40"/."10-(%550"05"(6-1%)4("%6"%&2(0"::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"Rkk" [31.8*"40("<.8*06-(",05*)/.*%)-0("(6-"/."*%/'-.580"9"/$0<<%-*"46"@0650"%&2(0"::::::::::::::::::::::"Rkn" =L0-8)80"0*"-)(760"8.-4)%,.(86/.)-0"0*"3'*.&%/)760"40"/$.4%/0(805*"%&2(0":::::::::::::::::::::::::"Rkl" =L0-8)80+"76.5*)*'"0*"76./)*'"40"(%330)/"0*"5),0.6L"4$.8*),)*'"1?B()760"40"/$.4%/0(805*" %&2(0"::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"RnR" E(108*("3'*?%4%/%;)760("40"/."30(6-0"40(")54)8.*06-("3'*.&%/)760("0*"*-.5(<'-.&)/)*'" (6-"/0"*0--.)5":::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"RnV" #)3)*0-"/0("8%31%-*0305*("('405*.)-0("0*".6;305*0-"/0("5),0.6L"4$.8*),)*'"1?B()760">"65" 05@06"40"*.)//0":::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::"RnV" & 1:91=$#8:9&<"9"!.=>TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTCCBPO& & !"M"!>91>#TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTCBPU& & .99>K>#TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTCBDO& "

(10)

o" "

<1I*)3'%)4$/"+'$/"+,/"&,(1,/"8:&)4+)P1,/"6"347)%:"+,"*,3%1&,")$%,&$'%)4$'*",%"$'%)4$'*"

"

#0*)"]+"^0540/(%5"^+"#.1/.64"K+"q/%-0"O:"?637V*(V'W&'X&YSZVYS+&+S*(S(3&)(3S74&)(S(3&VW& 6RWW36)& 5V([& SW& VW*63Y3W(S+& (3)(& 'W& ([3& XV3+7:" 541&$'*" 40" R84&%/" R3),$3,/" !mR!S" VmCkG">kmlQkRk"

"

^0540/(%5" ^+" a)5W./." s+" \6B.3" p+" #0,B" O+" q/%-0" O:" 1SW& *6'))'\36& SW7& YSZVYS+& XS(& 'ZV7S(V'W& 6S(3& ]'VW()& ^3& R)37& 3_RS++4& X'6& 36`'*4*+VW`& SW7& 5S+aVW`b6RWWVW`& 'W& S& (6S*ac&B)'I,%,/"Z"?,%'I4*)/7"!mR!S"Vo">V">!k_Q!nm"

"

^0540/(%5"^+"^)8?.//0*"EQD+"=(*2,0"q+"O0--)5"I+"#0,B"O+"\6B.3"p+"q/%-0"O:& @3W(V+S('64& 63)]'W)3)& ('& 3Z36*V)3& (6SVWVW`& VW& '^3)3& S7'+3)*3W()C& N,/8)&'%4&9" <-9/)4*4;9" Z"

M,1&4I)4*4;9""!mR!+"Ro_">!"nVQnl""

"

^0540/(%5"^+"^)8?.//0*"EQD+"]%5)5)"a+"d6)5%*"^+"p-)8%6*"h+"q/%-0"O:"8W('+,6SW*3&d&+G3XX'6(& 73& +S& ]36)'WW3& '^e)3& -& Y'7S+V(,)& 7G,\S+RS(V'W& 3(& *'W),_R3W*3)& ]'R6& +S& ]63)*6V](V'W&73&+GS*(V\V(,&][4)V_R3C&^I:/)%:+"!mR!+"h%/"n+")((60"_+"11"!!!Q!!n"

"

^0540/(%5" ^+" ^)8?.//0*" EQD+" ]%5)5)" a+" d6)5%*" ^+" p-)8%6*" h+" q/%-0" O:& .*(V\V(,& ][4)V_R3& 7SW)& +S& ]6V)3& 3W& *[S6`3& 73& +G'^,)V(,f-& 3XX3()& ^,W,XV_R3)& 3(& Y'7S+V(,)& ]6S(V_R3)C& ?[4)V*S+&S*(V\V(4&VW&([3&(63S(Y3W(&'X&'^3)V(4f-&^3W3XV()&SW7&Y'7S+V(V3)C&^I:/)%:+"!mR!+" h%/"n+")((60"V+"11"RkmQRko"

"

^0540/(%5"^+"].3)()0-"X+"#.1/.64"K+"K).(QK%3)5;%("D+"p.;60*"aQO+"^%-0.6"#+"s%/*0("I+" I?.,0M"#+"40"#.3&0-*0-)0"d+"Z0-05;*"q+"#0,B"O+"q/%-0"O+"O'1)5"aQ#:"='5&][4)V*S+&S*(V\V(4& V)& S& 73(36YVWSW(& X'6& 3+3\S(37& ^+''7& ]63))R63& VW& [V`[& *S67V'\S)*R+S6& 6V)a& '^)(6R*(V\3&)+33]&S]W3S&]S(V3W()C&N,/8)&'%4&9"O'&,+"!mRV:"D%6("1-0((0""" & ^0540/(%5"^+"d6)5%*"^+"q.,-0Qa6,)5"E+"\6B.3"p+"q/%-0"O:".)]3*()& Y,(['7'+'`V_R3)& 73&+S&Y3)R63&7R&=V]'ZYSZ-&*'W7V(V'W)&7GS]]+V*S(V'W&]'R6&+3)&]36)'WW3)&S((3VW(3)& 73&]S(['+'`V3)&Y,(S^'+V_R3)('R3),$3,"Z"?4%&)3)%:+"!mRV:"D%6("1-0((0"" " ^0540/(%5"^+"^)8?.//0*"EQD+"]%5)5)"a+"O0--)5"I+"q.,-0Qa6,)5"E+"d6)5%*""^+"\6B.3"p+"q/%-0" O:"1S67V'63)]V6S('64&XV(W3))&SW7&\3W(V+S('64&*'W)(6SVW(&-&V)&([363&S&+VWa&c&<,+)'%&)3" TA,&3)/,"R3),$3,:"=5"-',)()%5" " ^0540/(%5"^+"^)8?.//0*"EQD+"p%-%W)Y"E+"^%550-0*"K+"q.6-0"O+"O0--)5"I+"=(*2,0"q+"#0,B"O+" O'1)5"aQ#+\6B.3"p+"q/%-0"O:">Z36*V)3&(6SVWVW`&VY]6'\3)&)+33]&_RS+V(4&SW7&7R6S(V'W& SW7&][4)V*S+&S*(V\V(4&VW&'^3)3&S7'+3)*3W()C&D%63)("9"<,+)'%&)3/"CR_"5%,03&-0"!mRVG:"" "

^0540/(%5" ^+" ^)8?.//0*" EQD+" O0--)5" I+" #0,B" O+" \6B.3" p+" q/%-0" O:" >Z36*V)3& (6SVWVW`& VY]6'\3)&^63S([VW`&)(6S(3`4&SW7&]36X'6YSW*3&7R6VW`&([3&)VZgYVWR(3&5S+a&(3)(&VW& '^3)3&S7'+3)*3W()C&D%63)("9"<,+)'%&)3"^I,/)%9"_n"4'803&-0"!mRVG"

(11)

l"

" "

"

^0540/(%5"^+"].3)()0-"X+"#.1/.64"K+"K).(QK%3)5;%("D+"p.;60*"aQO+"^%-0.6"#+"s%/*0("I+" I?.,0M" #+" 40" #.3&0-*0-)0" d+" Z0-05;*" q+" #0,B" O+" q/%-0" O+" O'1)5" aQ#:"1?.?& (63S(Y3W(& )R]]'6(37&^4&(3+3Y37V*VW3&VY]6'\3)&)+33]VW3))&SW7&_RS+V(4&'X&+VX3&^R(&W'(&^+''7& ]63))R63&VW&[V`[&*S67V'\S)*R+S6&6V)a&:#.&]S(V3W()-&S&6SW7'YVi37h&*'W(6'++37&(6VS+:"

D%63)("9"D?O"?,+)3)$,"C!_"4'803&-0"!mRVG"" "

^0540/(%5" ^h& ]%5)5)" a+" ].3)()0-" X+" O'1)5" a#+" p.;60*" aO+" #',B" O+" \6B.3" p+" q/%-0" O:" 1S67V'Y3(S^'+V*& 6V)a& SW7& 3Z36*V)3& S7S](S(V'W)& VW& '^)(6R*(V\3& )+33]& S]W3S& ]S(V3W()C"R417)//)4$",$"341&/"

& & "

(12)

Rm" "

^0540/(%5"^+"h),%4*M0,"[+"].3)()0-"X+"#.1/.64"K+"K).(QK%3)5;%("D+"p.;60*"aQO+"^%-0.6" #+" s%/*0(" I+" I?.,0M" #+" K0" #.3&0-*0-)0" d+" Z0-05;*" q+" #0,B" O+" q/%-0" O+" O'1)5" aQ#:" 1?.?& (63S(Y3W(&)R]]'6(37&^4&(3+3Y37V*VW3&VY]6'\3)&)+33]VW3))&SW7&_RS+V(4&'X&+VX3&^R(& W'(& ^+''7& ]63))R63& VW& [V`[& *S67V'\S)*R+S6& 6V)a& :#.& ]S(V3W()-& S& 6SW7'YVi37h& *'W(6'++37& (6VS+C" T1&48,'$" N,/8)&'%4&9" R43),%9" O4$;&,//G" D01*03&0-" !mRV+" p.-80/%5.+" D1.)5:"E,"O4$;&./"+1"R477,)*G"!mRV+"^.-(0)//0:&

&

^0540/(%5"^+"].3)()0-"X+"#.1/.64"K+"K).(QK%3)5;%("D+"p.;60*"aQO+"^%-0.6"#+"s%/*0("I+" I?.,0M"#+"K0"#.3&0-*0-)0"d+"Z0-05;*"q+"#0,B"O+"q/%-0"O+"O'1)5"aQ#:&='5&][4)V*S+&S*(V\V(4& V)& S& 73(36YVWSW(& X'6& 3+3\S(37& ^+''7& ]63))R63& VW& [V`[& *S67V'\S)*R+S6& 6V)a& '^)(6R*(V\3& )+33]& S]W3S& ]S(V3W()C& >7,&)3'$" U-4&'3)3" R43),%9" O4$;&,//G" O?)/.40/1?).+" =*.*(Qb5)(!"O4$;&./"+,"8$,174*4;),"+,"*'$;1,"0&'$S')/,G"!mRV+"#)//0+"q-.580!"E,"34$;&./"+1" /477,)*G"!mR!+"p%-40.6L+"q-.580:& & ^0540/(%5"^+"^)8?.//0*"ED+"O0--)5"I+"=(*0,0"q+"^%550-0*"K+"q.6-0"O+"\6B.3"p+"q/%-0"O:" 8Y]S*(&7GRW&]6'`6SYY3&7GS*(V\V(,&][4)V_R3&)R6&+S&_RS+V(,&3(&_RSW(V(,&73&)'YY3V+& 73&+GS7'+3)*3W(&'^e)3:"@,"O4$;&./"O4771$"R43):%:"=&'$S')/,"+,"?:+,3)$,"+,"*2TA,&3)3,",%" +1"R84&%"Z"R43):%:"=&'$S')/,"+,"U&'17'%4*4;),"+1"R84&%+"!mR!+"d-05%&/0+"q-.580:" ^0540/(%5"^+"^)8?.//0*"ED+"O0--)5"I+"=(*0,0"q+"^%550-0*"K+"q.6-0"O+"\6B.3"p+"q/%-0"O:" 8W)R+VW'g6,)V)(SW*3h&)(S(R(&VWX+SYYS('V63&3(&X'W*(V'W&3W7'([,+VS+3&73&+GS7'+3)*3W(& '^e)3C& .]]'6(& 73& +G3Z36*V*3& )SW)& 63)(6V*(V'W& *S+'6V_R3C" @,"O4$;&./"O4771$"R43):%:"

=&'$S')/,"+,"?:+,3)$,"+,"*2TA,&3)3,",%"+1"R84&%"Z"R43):%:"=&'$S')/,"+,"U&'17'%4*4;),"+1" R84&%+"d-05%&/0+"q-.580:"<&)A"+1"],1$,"3-,&3-,1&!"'

"

^0540/(%5" ^+" a)5W./." s+" \6B.3" p+" #',B" O+" q/%-0" O:" =3& =8?:KYSZ& 7,(36YVW,& )R6& 36`'*4*+3& 3W& +S^'6S('V63& 3)(gV+& (6SW)X,6S^+3& d& +S& YS6*[3b*'R6)3& )R6& +3& (366SVW& 3W& \R3&73&]6']')36&73)&.?.c""rh[0"541&$:,/"+`T%1+,/"=&'$348-4$,/",$">3%)()%:/"<-9/)P1,/" >+'8%:,/:"!mR!+"F-(.B+"q-.580:" " ^0540/(%5"^+"^)8?.//0*"ED+"O0--)5"I+"=(*0,0"q+"\6B.3"p+"q/%-0"O:"@3W(V+S('64& XS*('6)& SW7&*S67V'63)]V6S('64&XV(W3))&VW&'^3)3&S7'+3)*3W()"O4$;&./"+,"*'"R43):%:"0&'$S')/,"+," <-9/)4*4;),"<WU"C1%(*0-G+"!mRR+"d-05%&/0+"q-.580+:" " ^0540/(%5"^+"a)5W./."s+"\6B.3"p+"#',B"O+"q/%-0"O:"C!mRRG"=3&=8?:KYSZ&3(&+3&]'VW(&73& *6'V)3Y3W(& `+R*V7'g+V]V7V_R3& 7,(36YVW,)& )R6& 36`'*4*+3& 3W& +S^'6S('V63& )'W(gV+)& (6SW)X,6S^+3)& )R6& +3& (366SVW&c" a@," O4$;&./" O4771$" R43):%:" =&'$S')/," +," ?:+,3)$," +,"

*2TA,&3)3," ,%" +1" R84&%" Z" R43):%:" =&'$S')/," +," U&'17'%4*4;)," +1" R84&%+" I.05+" q-.580+"

(13)

"" RR"

!

!"#$%&$"%'!()*$""

!

!!"#$%"&'

"

MV`R63&BC&D)*0("40"4'1A*"46"*)((6".4)106L"::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::!R" MV`R63&EC"=L031/0"40"/."-0/.*)%5"05*-0"/0(",%)0("40"/$)5</.33.*)%5+"/0"(*-0(("%LB4.*)<+"/0(" ,%)0("40"/."();5./)(.*)%5"40"/$)5(6/)50"0*"/0"(B(*230"-'5)50".5;)%*05()50Q./4%(*'-%50".6" 5),0.6"46"*)((6"36(86/.)-0:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::!e" MV`R63& jC" O-%;-0(()%5" 1%*05*)0//0" 46" (*-0((" %LB4.*)<" 0*" 46" 4',0/%110305*" 40" /." 3%-&)4)*'"8.-4)%Q3'*.&%/)760"/)'0"9"/$%&'()*'"*%6*".6"/%5;"40"/.",)0:::::::::::::::::::::::::::::::::::::::::!k" MV`R63& JC" E((%8).*)%5" 05*-0" %&'()*'+" *-%6&/0(" 3'*.&%/)760(" 0*" 8%31/)8.*)%5(" ,.(86/.)-0(j:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::!l" MV`R63&OC"X0/.*)%5"05*-0"/$)5</.33.*)%5+"/0"(*-0(("%LB4.5*"0*"/."4B(<%58*)%5"054%*?'/)./0" 4.5("/$%&'()*'"8?0M"/$05<.5*::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::Vm" MV`R63& kC"O-%;-0(()%5"?B1%*?'*)760"40"/."4B(<%58*)%5"054%*?'/)./0"40"/$05<.580"9"/$J;0" .46/*0"8?0M"/$05<.5*"%&2(0::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::VR" MV`R63&P:"I%6-&0"40"8%31/).580"46"(B(*230"-0(1)-.*%)-0:":::::::::::::::::::::::::::::::::::::::::::::::::::::::::::_!" MV`R63& UC& I%6-&0("4'&)*",%/630".6"-01%(+".6"(06)/",05*)/.*%)-0"0*"9"/$0L0-8)80"3.L)3./" (1%5*.5'0"1%()*)%55'0("4.5("/."8%6-&0"05,0/%110"8?0M"650"<0330"%&2(0"0*"650"<0330" 5%-3%Q1%54'-'0:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::__& MV`R63& DC" ^'8.5)(30(" 1%*05*)0/(" )31/)76'(" 4.5(" /0" 80-8/0" ,)8)06L" %t" /$%&'()*'" 106*" 05*-.H50-"65"DEFD"%6"65"DEFD"106*"05*-.H50-"650"1-)(0"40"1%)4(:::::::::::::::::::::::::::::::::::::::::::::em"" MV`R63&BlC"[X^"1-'(05*.5*"650"8%610"40"406L"86)((0(:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::km" MV`R63&BBC"D1)-%;-.330"%&*056"/%-("4$650"(1)-%3'*-)0"/05*0"8?0M"65"(6@0*"(.)5::::::::::::::k!" MV`R63&BEC&E88'/'-%32*-0"D05(0\0.-::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::k_& MV`R63&BjC"O-'(05*.*)%5"40"/$.11.-0)/"=54%O.*::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::ke" MV`R63&BJC"#)3)*.*)%5"0L1)-.*%)-0"40"4'&)*"::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::kl""" 0S^+3SR&BC"I/.(()<)8.*)%5")5*0-5.*)%5./0"40"/."3.((0"8%-1%-0//0"8?0M"/$.46/*0"05"<%58*)%5" 40"/$)54)80"40"3.((0"8%-1%-0//0+"(0/%5"/$F^D:"::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::Rl" 0S^+3SR&EC&O-)58)1.6L"()*0("40"4'1A*("46"*)((6".4)106L".6*-0"760"(%6(Q86*.5':::::::::::::::::!!" 0S^+3SR& j:" E8*)%5" 40(" 1-)58)1./0(" 8B*%Y)50(+" .4)1%Y)50(+" 8?'3%Y)50(+" 3B%Y)50(+" 1-%*')50("40"/."1?.(0".);6u"76)"(%5*")31/)76'0("4.5("/$)5</.33.*)%5"&.(";-.40".((%8)'0"9" /$%&'()*':::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::!V

(14)

"" R!"

!

!"#$%&'%()*

"

.?" " .8*),)*'"1?B()760" .?." " E8*),)*'"O?B()760"E4.1*'0" /!" " -'(0-,0",05*)/.*%)-0" 1;@" " 8%6-&0"4'&)*Q,%/630" 18" " 8.1.8)*'")5(1)-.*%)-0" 1?0" " 8.1.8)*'"16/3%5.)-0"*%*./0" 1!M& & 8.1.8)*'"-'()460//0"<%58*)%550//0" 1!?& & 1-%*')50"I"-'.8*),0""

10" " 8?%/0(*'-%/"*%*./" 1@& & 8.1.8)*'",)*./0" 1@M& & 8.1.8)*'",)*./0"<%-8'0" ;>%EOgPO" 4'&)*"0L1)-.*%)-0"3.L)3./"05*-0"!e"0*"ne"v"40"/."8.1.8)*'",)*./0" ;>%&EOm" 4'&)*"0L1)-.*%)-0"3.L)3./")5(*.5*.5'"9"!e"v"40"/."8.1.8)*'",)*./0"<%-8'0" ;>%&Olm" 4'&)*"0L1)-.*%)-0"3.L)3./")5(*.5*.5'"9"em"v"40"/."8.1.8)*'",)*./0"<%-8'0" ;>%&POm" 4'&)*"0L1)-.*%)-0"3.L)3./")5(*.5*.5'"9"ne"v"40"/."8.1.8)*'",)*./0"<%-8'0" >>=@" " ,%/630"16/3%5.)-0"40"<)5"4$0L1)-.*)%5" >8=@&&&&&&&&&&&&&&&&&,%/630"16/3%5.)-0"40"<)5"4$)5(1)-.*)%5" >:!& & 0(1280("-.4)8./.)-0("%LB;'5'0(" M1& & <-'760580"8.-4).760"" M1YSZ" " <-'760580"8.-4).760"3.L)3./0" M!"41"M^"" <-'760580"-0(1)-.*%)-0" <=$0J" *-.5(1%-*06-"46";/68%(0"_" A;&" " ?B10-)5</.*)%5"4B5.3)760" A;=&& & /)1%1-%*')50"40"?.6*0"405()*'" A;=g1&& *.6L"40"8?%/0(*'-%/"1%-*'"1.-"/."/)1%1-%*')50"40"?.6*0"405()*'" A:%.Eg8!& Z%30%(*.()("^%40/"E((0((305*"[5(6/)5"X0()(*.580" 8.A&& & )54)80"4$.15'0N?B1%15'0" 8!& & )5(6/)5%Q-'()(*.580" 8=Bg!S& .5*.;%5)(*0"46"-'801*06-"9"/$)5*0-/06Y)50QR" 8=gk& & )5*0-/06Y)50"k"

8=gU&& & )5*0-/06Y)50"o" 8=gBl" " )5*0-/06Y)50"Rm" 8=gBO" " )5*0-/06Y)50QRe"

8%1& & )54)80"40"3.((0"8%-1%-0//0" V9:#& & PFQ(B5*?.(0")5468*)&/0"

8?gBl" " 1-%*')50QRm")546)*0"1.-"/$)5*0-<'-%5";.33." 8!%" " )3.;0-)0"1.-"-'(%5.580"3.;5'*)760" 8:0M" " [5*0-5.*)%5./"F&0()*B"].(Y"q%-80" =;=&" " /)1%1-%*')50("40"<.)&/0"405()*'" =V]'ZYSZ&" )5*05()*'"4$0L0-8)80".6"4'&)*"4$%LB4.*)%5"/)1)4)760"3.L)3./" %1?gB&" 3%5%8B*0"8?03%.**-.8*.5*"1-%*')50QR" %M:&& & *.6L"4$%LB4.*)%5"/)1)4)760"3.L)3./" %<&" " 3.((0";-.((0" %%&" " 3.((0"3.);-0" 9Mga/"" 568/0.-"<.8*%-"Y.11."p"

(15)

"" RV" 9:"" " 3%5%LB40"4$.M%*0" 9:#& & PFQ(B5*?.(0" :Eng&& & .5)%5"(610-%LB40" ?1<=&& & 1%)5*"40"8-%)(0305*";/68)4%Q/)1)4)760" ?>YSZ& " 1-0(()%5"0L1)-.*%)-0"3.L)3./0" ?3(1:E&" 1-0(()%5"1.-*)0//0"40"IF!"40"<)5"4$0L1)-.*)%5" ?8YSZ& & 1-0(()%5")5(1)-.*%)-0"3.L)3./0"

?2/& & 1-%*')50"Y)5.(0"p"C';./0305*".110/'0"EY*G" ?%.& & 16)((.580"3.L)3./0".'-%&)0"

??1& & 1-0(()%5"1%()*),0"8%5*)560"

?0.#&&& 1%6,%)-"*%*./".5*)%LB4.5*"46"('-63" N!&" " 76%*)05*"-0(1)-.*%)-0"

!.90>#& X0;6/.*04"61%5"E8*),.*)%5"P%-3./"]"80//"=L1-0((04".54"D08-0*04" !Ag?.0&& [54)80"40"Xh"30(6-'"1.-"*%5%3'*-)0".-*'-)0//0"1'-)1?'-)760"" !:#&& & -0.8*),0"%LB;05"(108)0(+"-.4)8.6L"/)&-0("4'-),'("40"/$F!"

!@&& & -'.8*),)*'",.(86/.)-0"

#S:E&& & (.*6-.*)%5".-*'-)0//0"05"%LB;250"

#.:#& & (B54-%30"4$.15'0"%&(*-68*)<"46"(%330)/" #9#& & (B(*230"50-,06L"(B31.*?)760" #:;&& & (610-%LB40"4)(36*.(0" )09Mg!88"" -'801*06-"!"(%/6&/0"46"]PqQw" #S:EYVW& (.*6-.*)%5".-*'-)0//0"05"%LB;250"3)5)3./0".**0)5*0".6"8%6-("40"/."56)*" #S:EY'4& (.*6-.*)%5".-*'-)0//0"05"%LB;250"3%B0550".**0)5*0".6"8%6-("40"/."56)*" #@&& & (06)/",05*)/.*%)-0" 01&& & 8?%/0(*'-%/"*%*./" 0<&& & *-);/B8'-)40(" 0%k&& & *0(*"40"3.-8?0"40"k"3)56*0(" 09Mgo"" *63%-"508-%()("<.8*%-"./1?." @.#&& & ,%)0(".'-)0550("(61'-)06-0(" @>&& & 4'&)*",05*)/.*%)-0"%6",05*)/.*)%5"

@>%#&&& ,%/630"0L1)-.*%)-0"3.L)363"(08%540" @>#& & ,%/630"4$'@08*)%5"(B(*%/)760" @>b@:E&& '76),./05*"-0(1)-.*%)-0"1%6-"/$%LB;250" @>b@1:E&& '76),./05*"-0(1)-.*%)-0"1%6-"/0"4)%LB40"40"8.-&%50" @=;=&&& /)1%1-%*')50("40"*-2("<.)&/0"405()*'" @!& & ,%/630"-'()460/" @!>&" " ,%/630"40"-'(0-,0"0L1)-.*%)-0" @!8&" " ,%/630"40"-'(0-,0")5(1)-.*%)-0" @:E&" " 8%5(%33.*)%5"4$%LB;250"" @:E]V*"" 8%5(%33.*)%5"3.L)3./0"4$%LB;250" @:EbM1&" 1%6/("4$%LB;250" @0&" " ,%/630"8%6-.5*"

(16)

"" R_"

"

"

"

!

!"#$%&'"($!)*+!+#,-+

"

(17)

"" Re" 0("3./.4)0("8.-4)%,.(86/.)-0("(%5*"05"8%5(*.5*0".6;305*.*)%5"4016)("1/6("40"em" .5("0*"-01-'(05*05*".6@%6-4$?6)"/$650"40("1-)58)1./0("8.6(0("40"3%-*./)*':"I0/." -'(6/*0+"05"1.-*)0+"4$650".6;305*.*)%5")31%-*.5*0"40"/."1-',./0580"40"4)<<'-05*(" <.8*06-(" 40" -)(760" .((%8)'(" 9" 80(" 3./.4)0(" 4%5*" /$%&'()*'+" /$)5(6/)5%Q-'()(*.580" 0*" /." 4B(/)1)4'3)0+" .6*.5*" 8?0M" /$.46/*0" 760" 8?0M" /$.4%/0(805*:" E)5()+" 4.5(" /0" 8%5*0L*0" .8*60/+" /$%&'()*'" 0(*" 65" ,'-)*.&/0" 1-%&/230" 40" (.5*'" 16&/)760" 0*" (%5" )31%-*.580" 0(*" (%6/);5'0" 1.-"/."16&/)8.*)%5"4$650"(*-.*';)0"3%54)./0"1%6-"/$./)305*.*)%5+"/$0L0-8)80"1?B()760"0*"/." (.5*'"1.-"/$F-;.5)(.*)%5"^%54)./0"40"/."D.5*':"=5"q-.580+"80**0"(*-.*';)0"0(*"'/.&%-'0"1.-" /0"O/.5"P.*)%5./"P6*-)*)%5"D.5*':"" #0(" .5%3./)0(" 46" (%330)/+" <-'7603305*" -.11%-*'0(" 4.5(" /$%&'()*'+" 8%5(*)*605*" 65"<.8*06-".;;-.,.5*"40"/."3%-&)Q3%-*./)*'"8.-4)%,.(86/.)-0".((%8)'0"9"/$%&'()*':"=5"0<<0*+" /." 1-',./0580" 46" (B54-%30" 4$.15'0(" %&(*-68*),0(" 46" (%330)/" CDEFDG" 0(*" 1-%1%-*)%550//0" 9" /$)54)80" 40" 3.((0" 8%-1%-0//0" C[^IG" 0*" .**0)5*" @6(76$9" lo" v" 4.5(" /$%&'()*'" 3%-&)40:" #." -0/.*)%5" 05*-0" (%330)/" 0*" %&'()*'" 0(*" &)4)-08*)%550//0:" b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b5"(%330)/"40"8%6-*0"46-'0"0*"40"<.)&/0"76./)*'" <.,%-)(0"/."(%35%/0580+"76)"106*"40,05)-"65"<-0)5"1%6-"/$.8*),)*'"1?B()760"0*"05*-.H50-"/." 10-(%550" 76)" 05" (%6<<-0" 4.5(" 65" 80-8/0" ,)8)06L" 16)(76$65" <.)&/0" 5),0.6" 4$.8*),)*'" 1?B()760"106*"8%54)*)%550-"%6".;;-.,0-"/."1-)(0"40"1%)4(:"" E<)5"40"-'46)-0"/$)58)40580"40"80("3./.4)0("0*"40"4)3)560-"/0("4'105(0("40"(.5*'+" )/".11.-.)*")31'-.*)<"4$%-)05*0-"/0("0<<%-*("05"(.5*'"16&/)760",0-("/."1-',05*)%5:"E6"8T6-" 40("(*-.*';)0("1-',05*),0("(0"*-%6,0"/$.3'/)%-.*)%5"40("?.&)*640("40",)0+"05"1.-*)86/)0-" /$./)305*.*)%5" 0*" /$.8*),)*'" 1?B()760:" #$.8*),)*'" 1?B()760" CEOG" -';6/)2-0" 8%5(*)*60" 650" 3%4./)*'")31%-*.5*0"40"/."1-)(0"05"8?.-;0"40"/$%&'()*'"0*"46"DEFD"0*"106*"1.-*)8)10-"9"/." 3.H*-)(0"40("<.8*06-("40"-)(760"3'*.&%/)760("0*"8.-4)%,.(86/.)-0(:"I01054.5*+"760/"760" (%)*" /$J;0+" /$%&'()*'" 0*" /0" DEFD" %5*" (%6,05*" '*'" .((%8)'(" 9" 650" )5*%/'-.580" 9" /$0<<%-*:" D)"

#"

(18)

"" Rk" /$0L82(" 40" 1%)4(" (03&/0" @%60-" 65" -A/0" 3.@06-" 0*" ',)405*" 4.5(" 80**0" )5*%/'-.580+" 05" .6;305*.5*" /0" 8%f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x65" DEFD" (',2-0" 0*" 4x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

(19)

"" Rn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b50" 46-'0"40"(%330)/")5(6<<)(.5*0"0*"650"76./)*'"40"(%330)/"./*'-'0"106,05*"8%5*-)&60-".6" 4',0/%110305*"40"/."3%-&)4)*'"8.-4)%,.(86/.)-0"0*"3'*.&%/)760"/)'0"9"/$%&'()*':"E)5()+".6" (0)5"40"80**0"3U30"1%16/.*)%5"4$.4%/0(805*("%&2(0(+"5%6(".,%5("-08?0-8?'"/."1-'(0580" 4$.5%3./)0(" 46" (%330)/" .)5()" 76$650" ./*'-.*)%5" 1%(()&/0" 40" /." 46-'0" 40" (%330)/+" 30(6-'0"%&@08*),0305*:"#$)31.8*"4$65"1-%;-.330"4$0L0-8)80".""';./0305*"'*'"',./6':"" b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

(20)

"" Ro"

!

"

" "

!

!"#$"!"%&'!($"

"

!

!"#!$%!$&'$&())!*')#!"

(21)

' "" Rl"

1[S]V(63&BC&:/"#80"&

" BCB&;,XVWV(V'W&73&+G'^,)V(,& #$F-;.5)(.*)%5" ^%54)./0" 40" /." D.5*'" CF^DG" 4'<)5)*" /$%&'()*'" 8%330" 650" g".88636/.*)%5" .5%-3./0" %6" 0L80((),0" 40" ;-.)((0" 8%-1%-0//0" 76)" -01-'(05*0" 65" -)(760" 1%6-" /." (.5*'"i:" I?0M" /$.46/*0+" /0" (6-1%)4(" 8%--0(1%54" 9" 65" )54)80" 40" 3.((0" 8%-1%-0//0" C[^IG"4'1.((.5*"!e"Y;:3Q!:"#$%&'()*'"(0"4'<)5)*"1.-"65"[^I".6Q40/9"40"Vm"Y;N3!"C].&/0.6"

RG:" ;VS`W')(V*" 8W7V*3&73&YS))3&*'6]'63++3&Ha`CYgEI" %SV`63R6" [^I"y"Ro+e" 9'6YS+" Ro+e"y"[^I"y"!_+l" #R6]'V7)" !e"y"[^I"y"!l+l" :^,)V(,&Y'7,6,3" Vm"y"[^I"y"V_+l" :^,)V(,&),\e63" Ve"y"[^I"y"Vl+l" :^,)V(,&Y'6^V73" z"_m" 0S^+3SR&BC"I/.(()<)8.*)%5")5*0-5.*)%5./0"40"/."3.((0"8%-1%-0//0"8?0M"/$.46/*0"05"<%58*)%5" 40"/$)54)80"40"3.((0"8%-1%-0//0+"(0/%5"/$F^D:" " =5"1'4).*-)0+"/0"4).;5%(*)8"46"(6-1%)4("0*"40"/$%&'()*'"(0"<.)*"1.-"/0"-01%-*"40"/$[^I" (6-" /0(" 8%6-&0(" 40" 8%-16/0580" 40" -'<'-0580" 1%6-" /0" (0L0:" #$a$%,&$'%)4$'*" ^I,/)%9" U'/L"

=4&3,"C[F]qG"."10-3)("40"1-%1%(0-"40("5%-30(")5*0-5.*)%5./0(".<)5"4$'*.&/)-"40("(06)/("

40" -'<'-0580" 1%6-" /0(" '*640(" '1)4'3)%/%;)760(" (6-" /." 1-',./0580" 46" (6-1%)4(" 8%31.-.&/0" 05*-0" /0(" 1.B(" >" (6-1%)4(" .6Q40((6(" 40" /$[F]qQ!e+" %&'()*'" .6Q40((6(" 40" /$[F]qQVm" 0*" %&'()*'" (',2-0" .6Q40/9" 40" /$[F]qQVe" CI%/0" 0*" ./:" !mmmS" I%/0" .54" #%&(*0)5" !mR!G"C8<:"E550L0(G:"

"

BCE&>]V7,YV'+'`V3&

K$.1-2(" /$F^D+" /0" 5%3&-0" 40" 8.(" 4$%&'()*'" ." 4%6&/'" 4016)(" Rlom:" #0" (6-1%)4(" 8%580-50" R+_" 3)//).-4" 40" 10-(%550(" 40" 1/6(" 40" !m" .5(+" 1.-3)" /0(760//0(" 1/6(" 40" !mm" 3)//)%5("4$?%330("0*"1-2("40"Vmm"3)//)%5("40"<0330("(%5*"%&2(0(:"O.-".)//06-(+"3U30"()" /0("4%55'0("-'805*0("(03&/05*")54)760-"760"/0("*.6L"4$%&'()*'"(0"(*.&)/)(05*"CF/4("0*"./:" !mRRG+"/$%&'()*'"40306-0"65"1-%&/230"40"(.5*'"16&/)760"3.@06-:""

Figure

Figure 3. Correlation between steps per day and self-measured evening SBP (A). Correlation  between time spent in sedentary behaviour and self-measured evening SBP (B)
Table  1.  Baseline  anthropometric,  clinical,  polysomnographic  and  exercise characteristics
Figure 1. Fat oxidation rate during submaximal exercise in  OSA (triangle) and control (square) participants
Table 2. Lung function.
+7

Références

Documents relatifs

magnetic PdSi interlayer between the hard and soft layer to tune the exchange coupling. SiO was doped into Pd layer to get magnetically isolated grains. Advantages of ECC media

[r]

The stronger decrease in graphite half-oxidation temperatures with increasing Cu content observed for CuPc-containing composites is consistent with the stronger interaction that the

The retrieved BrO concentrations can be further converted into mixing ratios. Assum- ing e.g.. Wagner et al. Title Page Abstract Introduction Conclusions References Tables Figures ◭ ◮

Between 20 and 30 m depth, the meadow is classified as medium density (Dn values around zero, i.e. close to the mean density) and high density, with the exception of a patch of

Au sein des structures d’inser- tion par l’activité économique, les chantiers d’insertion accueillent les personnes consi- dérées comme les plus éloi- gnées de l’emploi,

• Collect data on a longer period for observing the evolution of the profile indicator on each road section over time; On a longer term, the road manager would like to include

In the present study, we propose to extend the acromial method in order to capture, in addition to scapular rotations, the linear translations (displacements) of