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Vitamin D, adipose tissue, and obesity

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HAL Id: hal-01571905

https://hal.archives-ouvertes.fr/hal-01571905

Submitted on 29 May 2020

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Vitamin D, adipose tissue, and obesity

Julie Marcotorchino, Franck Tourniaire, Jean-Francois Landrier

To cite this version:

Julie Marcotorchino, Franck Tourniaire, Jean-Francois Landrier. Vitamin D, adipose tissue, and obe-sity. Hormone Molecular Biology and Clinical Investigation, de Gruyter, 2013, 15 (3), �10.1515/hmbci-2013-0027�. �hal-01571905�

(2)

Cholecalciferol

(vitamin D )

₃

25-hydroxyvitamin D₃

1,25-dihydroxyvitamin D₃

Kidney

CYP27B1

Liver

CYP27A1 CYP 2R1 CYP3A4 CYP2J2

Dietary intake

7-dehydrocholesterol

Skin

7DHC dehydrogenase

UVB

CYP24A1

Endogenous

synthesis by UVB

Figure 1

24,25-dihydroxycholecalciferol

Calcitroic acid

CYP24A1

(3)

1,25(OH)2D

NF-κB

signalling

pathway

Dusp 10

MAPK p38

phosphorylation

 IL6, IL8, IL1β and MCP-1 expression

VDR

•

 IL6, IL8, MCP-1 release

•

 macrophage recruitment

•

 glucose uptake

Références

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