HAL Id: hal-02347247
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Submitted on 5 Nov 2019
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Assembly of CNS Nodes of Ranvier in Myelinated Nerves Is Promoted by the Axon Cytoskeleton
Veronica Brivio, Catherine Faivre-Sarrailh, Elior Peles, Diane Sherman, Peter Brophy
To cite this version:
Veronica Brivio, Catherine Faivre-Sarrailh, Elior Peles, Diane Sherman, Peter Brophy. Assembly of
CNS Nodes of Ranvier in Myelinated Nerves Is Promoted by the Axon Cytoskeleton. Current Biology
- CB, Elsevier, 2017, 27 (7), pp.1068-1073. �10.1016/j.cub.2017.01.025�. �hal-02347247�
Report
Assembly of CNS Nodes of Ranvier in Myelinated Nerves Is Promoted by the Axon Cytoskeleton
Highlights
d Nodes of Ranvier are essential axonal domains in the vertebrate nervous system
d An axoglial adhesion complex promotes node formation by oligodendroglia in the CNS
d The axoglial adhesion complex is anchored to the axon cytoskeleton
d Loss of this anchorage disrupts the axon cytoskeleton and delays node formatfion
Authors
Veronica Brivio,
Catherine Faivre-Sarrailh, Elior Peles, Diane L. Sherman, Peter J. Brophy
Correspondence
peter.brophy@ed.ac.uk
In Brief
Brivio et al. show that an axoglial adhesion complex drives domain formation at nodes of Ranvier by organizing the axon cytoskeleton at the boundary between converging glial processes and nodal complexes at heminodes. Heminodes fuse to form the mature node, thus ensuring efficient formation of nodes of Ranvier and rapid nerve impulse conduction.
Brivio et al., 2017, Current Biology 27 , 1–6
April 3, 2017 ª 2017 The Author(s). Published by Elsevier Ltd.
http://dx.doi.org/10.1016/j.cub.2017.01.025
Current Biology
Report
Assembly of CNS Nodes of Ranvier in Myelinated Nerves Is Promoted by the Axon Cytoskeleton
Veronica Brivio,
1Catherine Faivre-Sarrailh,
2Elior Peles,
3Diane L. Sherman,
1and Peter J. Brophy
1,4,*
1
Centre for Neuroregeneration, University of Edinburgh, Edinburgh EH16 4SB, UK
2
Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille-UMR 7286, CNRS, 13344 Marseille, France
3
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
4