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Age and WHO Performance Score are major clinical prognostic factors in glioblastoma

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Academic year: 2021

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(1)

Age and WHO Performance Score are

major clinical prognostic factors in

glioblastoma

(2)

—

Glioblastoma (GBM) = poor prognosis

—

Progression-Free Survival (PFS): variable

—

Recurrence: operate ?

(3)

Prognostic groups

Age

Gender

Extent of surgery

WHO PS

MMSE

Corticoïds

MGMT

Tumor location

0 or 1 2 or 3 < 47.5 > 47.5 Class 1 PFS = 346 PFS = 234 Class 2 < 60.5 > 60.5 Class 3 PFS = 144 PFS = 77 Class 4

EORTC 26981 (N=239)

Age

(4)

Surgery for recurrence

Class 1

PFS = 346 PFS = 234 Class 2 PFS = 144 Class 3 PFS = 77 Class 4

No treatment of recurrence Surgery

(5)

—

WHO PS & age

—

Resection appears beneficial

(6)

Acknowledgment

—

Department of Neurosurgery, CHU de Liège

—

Unit of Nervous System Disorders and Therapy,

GIGA-Neurosciences, Liège

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