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Leishmania major Promastigotes Evade LC3-Associated Phagocytosis through the Action of GP63

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Academic year: 2021

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Fig 1. Infection with L. major promotes LC3 conversion and p62 expression. (A) Kinetics of LC3-I to LC3-II conversion induced by opsonized L
Fig 2. L. major GP63 prevents LC3 recruitment to phagosomes. (A, C) Confocal microscopy images of BALB/c BMM infected for 1 h with opsonized WT, Δgp63, or Δgp63+gp63 L
Fig 3. L. major promastigote-induced ROS production is required for LC3 recruitment to the phagosome
Fig 4. L. major GP63 inhibits gp91 phox recruitment to the phagosome. (A) Confocal microscopy images of C57BL/6 peritoneal exudate macrophages (PEM) fed zymosan particles or infected with opsonized WT, Δgp63, or Δgp63+gp63 L
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