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Analysis of radiation induced DNA damage by LC-MS/MS in isolated and cellular DNA

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Academic year: 2021

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Figure 3: Direct and indirect damage of ionizing radiation. The direct effect is the absorption of radiation by the DNA, while in the indirect effect damage is mainly caused by highly reactive •OH, which can damage further to DNA
Figure 9: Guanine oxidative end products generated by •OH. 1.5.2.1.5 Adenine base derived oxidative modification:
Figure 12: Different types of methods developed for the measurement of DNA damage in cells (Figure based on (JL Ravanat, 2005 and Jean Cadet et al., 2012) )
Figure 15: Modified nucleoside (5ohU) from cytosine nucleoside, •OH induced modification to cytosine in DNA
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