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Targeting the DNA-binding activity of the human ERG transcription factor using new heterocyclic dithiophene diamidines

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Academic year: 2021

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Figure

Table 1. Structure of the chemical compounds. The general sheme of the compounds is presented on the top of the table
Figure 1. EPDBi for screening the ERG/EBS-WT binding inhibitors. EPDBi was performed on streptavidin-coated plates in which biotinylated EBS-WT oligonucleotides were fixed
Figure 2. Validation of the ERG/EBS complex inhibition by the evaluated diamidine compounds
Figure 3. DNA-binding characteristics of the selected compound DB1255. (A) Temperature melting assay of the EBS-WT  oligonucleo-tide in presence of the DB1255
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