Structure-morphology relationship of polyphosphate-based polymer micelles

Structure-morphology relationship of polyphosphate containing

Molin*, Léo Koole

1

Center for Education and Research on Macromolecules, University of Liège,B6a Sart

2

Louvain Drug Research Institute, Pharmaceutics and Drug Delivery, Université catholique de Louvain,73 Avenue Mounier, B1.73.12, B

*

BioMIMedics Interreg EMR IV

Universiteitssingel 50, 6229ER Maastricht, The Netherlands

Thanks to their biocompatibility, biodegradability and their structure similar to natural biomacromolecules, such as nucleic acids [1],

biomedical applications. In contrast to poly are easily tuned via the chemical

varying the length of the alkyl chain

In this work, a series of amphiphilic PEO synthesized by organo-catalyzed ring

work aims at changing the length and architecture of goal is to study the investigation of the

micellization of these amphiphilic copolymers in water, (ii) on the of these micelles of an hydrophobic drug

Acknowledgements

This study was performed within the Interreg Euregion Meuse

2014). The University of Liège (Belgium), Maastricht University (the Netherlands), University of Hasselt (Belgium), RWTH Aachen (Germany) and Fachhochschul

small biotechnological enterprises cooperate in BioM Interreg EMR and region Wallonie.

[1] Y-C. Wang, Y-Y. Yuan, J-Z. Du, X

[2] B. Clément, B. Grignard, L. Koole, C. Jérôme and P. Lecomte, Macromolecules

morphology relationship of polyphosphate containing

polymer micelles

, Benoît Clément1*, Raphaël Riva1, Guy Broze1, Véronique Préat , Léo Koole*, Philippe Lecomte1* and Christine Jérôme

Education and Research on Macromolecules, University of Liège,B6a Sart 4000 Liège, Belgium

Louvain Drug Research Institute, Pharmaceutics and Drug Delivery, Université catholique de Louvain,73 Avenue Mounier, B1.73.12, B-1200 Brussels, Belgium

Medics Interreg EMR IV-A Consortium: Lead Partner Maastricht University Universiteitssingel 50, 6229ER Maastricht, The Netherlands

Thanks to their biocompatibility, biodegradability and their structure similar to natural biomacromolecules, such as nucleic acids [1], polyphosphates are appealing polymers for

. In contrast to polyesters, polyphosphate properties a chemical nature of the lateral chains (R on the scheme)

varying the length of the alkyl chain allows adjusting the hydrophobicity of polyphosphates

a series of amphiphilic PEO-block-polyphosphate copolymers were lyzed ring-opening polymerization of cyclic phosphates

work aims at changing the length and architecture of the lateral chain of polyphosphates. the investigation of the influence of this structural modification of these amphiphilic copolymers in water, (ii) on the encapsulation

hydrophobic drug and, finally, (iii) on the release of this drug.

This study was performed within the Interreg Euregion Meuse-Rhine IV-A consortium BioM

2014). The University of Liège (Belgium), Maastricht University (the Netherlands), University of Hasselt (Belgium), RWTH Aachen (Germany) and Fachhochschule Aachen (Germany), together with several local small biotechnological enterprises cooperate in BioMIMedics and for this study with financial support of

P.L. is Research associate by the FRS-FNRS.

Z. Du, X-Z. Yang, J. Wang, Macromol. Biosci. 2009, 9, 1154 [2] B. Clément, B. Grignard, L. Koole, C. Jérôme and P. Lecomte, Macromolecules 2012, 45, 4476

morphology relationship of polyphosphate containing

Education and Research on Macromolecules, University of Liège,B6a Sart-Tilman,

B-Louvain Drug Research Institute, Pharmaceutics and Drug Delivery, Université catholique de 1200 Brussels, Belgium

A Consortium: Lead Partner Maastricht University Universiteitssingel 50, 6229ER Maastricht, The Netherlands

Thanks to their biocompatibility, biodegradability and their structure similar to natural are appealing polymers for properties and functionality (R on the scheme). For example, allows adjusting the hydrophobicity of polyphosphates.

polyphosphate copolymers were opening polymerization of cyclic phosphates [2]. Our lateral chain of polyphosphates. Our structural modification (i) on the encapsulation in the core and, finally, (iii) on the release of this drug.

A consortium BioMIMedics (2011-2014). The University of Liège (Belgium), Maastricht University (the Netherlands), University of Hasselt

e Aachen (Germany), together with several local and for this study with financial support of

, 9, 1154-1164 , 45, 4476-4486