Valeur pronostique

L’indication du Plaquenil® comme traitement de base des diverses connectivites a multiplié le nombre des patients sous ce traitement à long terme. La toxicité rétinienne liée à l’absorption d’hydroxychloroquine est très rare, mais elle peut être irréversible si elle est détectée à un stade avancé. Par conséquent, la prévention de la toxicité rétinienne prend une importance primordiale, car la détection précoce des signes de toxicité permet la réversion

de l’effet secondaire. Dans ce but, le mfERG s’avère être un examen idéal. Il est non invasif, objectif et spécifique pour la fonction rétinienne ainsi que très sensible à la détection des altérations précoces. Néanmoins, il n’est pas encore prouvé si les altérations précoces du mfERG sont associées de façon directe avec le risque de toxicité rétinienne, afin de pouvoir être utilisées comme indicatifs du besoin d’un suivi plus rapproché des patient à risque.

Des études plus étendues seront nécessaires pour évaluer la valeur pronostique des réponses de mfERG dans la détection précoce des patients présentant un risque de rétinotoxicité.

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