Análise imunofenotípica, no contexto ex vivo, mostrou alteração na homeostase das subpopulações de leucócitos circulantes no grupo Tb, quando comparado ao Co:
Redução na frequência dos monócitos CD14LowCD16+ e aumento na densidade de expressão de HLA-DR nos monócitos CD14LowCD16+
Redução na contagem das células NK, células CD3+CD56+CD16+/- (NKT), linfócitos T CD4+, linfócitos B (CD19+) e subpopulações (CD19+CD5+, CD19+CD23+ e CD19+CD23high)
Elevado padrão migratório e de ativação dos linfócitos T CD4+ e T CD8+ Análise funcional dos leucócitos circulantes, in vitro, após cultura de curta duração com Ag-Mtb, no grupo Tb, quando comparado ao Co:
Aumento de indivíduos alto produtores de citocinas no grupo Tb, quando comparado ao Co
Perfil misto de mediadores pró-inflamatórios e reguladores no grupo Tb, quando comparado ao Co
Análise dos biomarcadores solúveis mostrou no grupo Tb, em relação ao Co:
Aumento na concentração de biomarcadores inflamatórios e reguladores no grupo Tb, quando comparado ao Co
Distinta assinatura de biomarcadores solúveis no grupo Tb, quando comparado ao Co, caracterizada por alta frequência de indivíduos alto produtores para todos os analitos avaliados
Análise entre o perfil imune e a gravidade da tuberculose mostrou no grupo Bi, quando comparado ao Uni:
Redução no percentual dos linfócitos B CD19+CD5+
Redução na densidade de expressão de HLA-DR nos monócitos
CD14LowCD16+ circulantes
Redução na frequência de alto produtores de IL-4 por neutrófilos, linfócitos T total, linfócitos T CD4+, linfócitos T CD8+ e linfócitos B (CD19+)
Aumento na frequência de indivíduos alto produtores CD4+IL-17+ e CD8+ IL- 17+
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