cardiovasculaire
Nous avons vu que le rejet médié par les anticorps était capable d’induire dans le rein transplanté une artériosclérose et athéromatose accélérée. Une hypothèse de travail est donc de déterminer si cette maladie retrouvée dans l’organe transplanté pouvait être étendue à une atteinte plus diffuse et systémique pouvant avoir des conséquences sur d’autres organes que le rein.
Ce projet étudiera sur l’ensemble des patients du réseau DIVAT (8500 patients transplantés rénaux), l’association entre le rejet et les évènements cardiovasculaires à savoir infarctus du myocarde, accident vasculaire cérébral, artérite des membres inférieurs. Cette étude prendra en compte l’ensemble des facteurs de risques et comorbidités cardiovasculaires colligées dans la base de données. Cette étude est actuellement en cours de réalisation et en cas de réponse positive, elle permettra pour la première fois dans un modèle humain et en population d’étayer l’hypothèse d’une association entre allo-anticorps et risque cardiovasculaire, ouvrant de larges implications dans le domaine de la transplantation mais également de la cardiologie et la pathologie vasculaire.
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Annexes
• Antibody-mediated vascular rejection of kidney allografts: a population-based study. The Lancet. 2013 Jan 26;381(9863):313-9
• Antibody-mediated vascular rejection from association to causation. The Lancet. 2013 (Editorial)
• Complement binding anti-HLA antibodies and kidney allograft survival. N Engl J Med. 2013 Sep 26;369(13):1215-26.
• C1q-Binding Antibodies in Kidney Transplantation
.
N Engl J Med. 2013 (Editorial)• Molecular Microscope Strategy To Improve Risk Stratification In Early Antibody-Mediated Kidney Allograft Rejection. JASN. 2014. In press.
• Early Recognition of Subclinical Rejection and Outcome of Kidney Allografts. The Lancet.