Depuis la mise en place de l’étude en novembre 2018, 15 patients sur les 30 attendus ont été inclus. La phase d’inclusion est prévue pour 12 mois.
Cette étude me permet d’encadrer le travail de thèse d’exercice de Julie Dauenhauer dont la soutenance portant sur les résultats préliminaires est prévue en septembre 2019.
A terme, l’étude sera soumise pour publication dans Clinical Otolaryngology (Sigaps rang B, IF = 2,62) ou dans European Respiratory Journal (Sigaps rang A, IF = 7,12) selon la pertinence des résultats obtenus.
62
Bibliographie.
1. Hedman J, Kaprio J, Poussa T, Nieminen MM. Prevalence of asthma, aspirin intolerance, nasal polyposis and chronic obstructive pulmonary disease in a population-based study. Int J Epidemiol. 1999;28(4):717‑22.
2. Hosemann W, Göde U, Wagner W. Epidemiology, pathophysiology of nasal polyposis, and spectrum of endonasal sinus surgery. Am J Otolaryngol. 1994;15(2):85‑98.
3. Klossek JM, Neukirch F, Pribil C, Jankowski R, Serrano E, Chanal I, et al. Prevalence of nasal polyposis in France: a cross-sectional, case-control study. Allergy. 2005;60(2):233‑7.
4. Fokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I, Baroody F, et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2012. Rhinol Suppl. 2012;(23):3 p preceding table of contents, 1‑298.
5. Lildholdt T, Fogstrup J, Gammelgaard N, Kortholm B, Ulsoe C. Surgical versus medical treatment of nasal polyps. Acta Otolaryngol (Stockh). 1988;105(1‑2):140‑3.
6. Lund VJ, Mackay IS. Staging in rhinosinusitus. Rhinology. 1993;31(4):183‑4.
7. Settipane GA. Epidemiology of nasal polyps. Allergy Asthma Proc. 1996;17(5):231‑6.
8. Mortuaire G, Vandeville S, Chevalier D. Psychometric evaluation of the SinoNasal Outcome Test-16 for quality of life in chronic rhinosinusitis with nasal polyps. Eur Ann Otorhinolaryngol Head Neck Dis. 2010;127(3):91‑6.
9. Hessler JL, Piccirillo JF, Fang D, Vlahiotis A, Banerji A, Levitt RG, et al. Clinical outcomes of chronic rhinosinusitis in response to medical therapy: results of a prospective study. Am J Rhinol. févr 2007;21(1):10‑8.
10. Videler WJM, van Drunen CM, van der Meulen FW, Fokkens WJ. Radical surgery: effect on quality of life and pain in chronic rhinosinusitis. Otolaryngol--Head Neck Surg Off J Am Acad Otolaryngol-Head Neck Surg. 2007;136(2):261‑7.
11. Wabnitz DAM, Nair S, Wormald PJ. Correlation between preoperative symptom scores, quality- of-life questionnaires, and staging with computed tomography in patients with chronic rhinosinusitis. Am J Rhinol. 2005;19(1):91‑6.
12. Bousquet J, Van Cauwenberge P, Khaltaev N, Aria Workshop Group, World Health Organization. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol. 2001;108(5 Suppl):S147-334. 13. Larsen K. The clinical relationship of nasal polyps to asthma. Allergy Asthma Proc Off J Reg State
Allergy Soc. 1996;17(5):243‑9.
14. Bachert C, Gevaert P, Holtappels G, Johansson SG, van Cauwenberge P. Total and specific IgE in nasal polyps is related to local eosinophilic inflammation. J Allergy Clin Immunol. 2001;107(4):607‑14.
63 15. Kowalski ML, Pawliczak R, Wozniak J, Siuda K, Poniatowska M, Iwaszkiewicz J, et al. Differential metabolism of arachidonic acid in nasal polyp epithelial cells cultured from aspirin-sensitive and aspirin-tolerant patients. Am J Respir Crit Care Med. 2000;161(2 Pt 1):391‑8.
16. Misso NLA, Thompson PJ. Oxidative stress and antioxidant deficiencies in asthma: potential modification by diet. Redox Rep Commun Free Radic Res. 2005;10(5):247‑55.
17. Xiao C, Puddicombe SM, Field S, Haywood J, Broughton-Head V, Puxeddu I, et al. Defective epithelial barrier function in asthma. J Allergy Clin Immunol. 2011;128(3):549-556.e1-12. 18. Rugina M, Serrano E, Klossek JM, Crampette L, Stoll D, Bebear JP, et al. Epidemiological and
clinical aspects of nasal polyposis in France; the ORLI group experience. Rhinology. 2002;40(2):75‑9.
19. Van Zele T, Gevaert P, Watelet J-B, Claeys G, Holtappels G, Claeys C, et al. Staphylococcus aureus colonization and IgE antibody formation to enterotoxins is increased in nasal polyposis. J Allergy Clin Immunol. 2004;114(4):981‑3.
20. Braun H, Buzina W, Freudenschuss K, Beham A, Stammberger H. « Eosinophilic fungal rhinosinusitis »: a common disorder in Europe? The Laryngoscope. 2003;113(2):264‑9.
21. Shin S-H, Lee Y-H, Jeon C-H. Protease-dependent activation of nasal polyp epithelial cells by airborne fungi leads to migration of eosinophils and neutrophils. Acta Otolaryngol (Stockh). 2006;126(12):1286‑94.
22. Bachert C, Zhang N, Patou J, van Zele T, Gevaert P. Role of staphylococcal superantigens in upper airway disease. Curr Opin Allergy Clin Immunol. 2008;8(1):34‑8.
23. Beck LA, Stellato C, Beall LD, Schall TJ, Leopold D, Bickel CA, et al. Detection of the chemokine RANTES and endothelial adhesion molecules in nasal polyps. J Allergy Clin Immunol. 1996;98(4):766‑80.
24. Pods R, Ross D, van Hülst S, Rudack C, Maune S. RANTES, eotaxin and eotaxin-2 expression and production in patients with aspirin triad. Allergy. 2003;58(11):1165‑70.
25. Roongrotwattanasiri K, Pawankar R, Kimura S, Mori S, Nonaka M, Yagi T. Decreased Expression of FOXP3 in Nasal Polyposis. Allergy Asthma Immunol Res. 2012;4(1):24‑30.
26. Shaw JL, Fakhri S, Citardi MJ, Porter PC, Corry DB, Kheradmand F, et al. IL-33-responsive innate lymphoid cells are an important source of IL-13 in chronic rhinosinusitis with nasal polyps. Am J Respir Crit Care Med. 2013;188(4):432‑9.
27. Sun D-I, Joo Y-H, Auo H-J, Kang J-M. Clinical significance of eosinophilic cationic protein levels in nasal secretions of patients with nasal polyposis. Eur Arch Oto-Rhino-Laryngol Off J Eur Fed Oto-Rhino-Laryngol Soc EUFOS Affil Ger Soc Oto-Rhino-Laryngol - Head Neck Surg. 2009;266(7):981‑6.
28. Bachert C, Wagenmann M, Hauser U, Rudack C. IL-5 synthesis is upregulated in human nasal polyp tissue. J Allergy Clin Immunol. 1997;99(6 Pt 1):837‑42.
64 29. Van Crombruggen K, Zhang N, Gevaert P, Tomassen P, Bachert C. Pathogenesis of chronic
rhinosinusitis: inflammation. J Allergy Clin Immunol. 2011;128(4):728‑32.
30. Akdis CA, Bachert C, Cingi C, Dykewicz MS, Hellings PW, Naclerio RM, et al. Endotypes and phenotypes of chronic rhinosinusitis: a PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology. J Allergy Clin Immunol. 2013;131(6):1479‑90.
31. Polzehl D, Moeller P, Riechelmann H, Perner S. Distinct features of chronic rhinosinusitis with and without nasal polyps. Allergy. 2006;61(11):1275‑9.
32. Soler ZM, Sauer DA, Mace J, Smith TL. Relationship between clinical measures and histopathologic findings in chronic rhinosinusitis. Otolaryngol--Head Neck Surg Off J Am Acad Otolaryngol-Head Neck Surg. 2009;141(4):454‑61.
33. Couto LGF, Fernades AM, Brandão DF, Santi Neto D de, Valera FCP, Anselmo-Lima WT. Histological aspects of rhinosinusal polyps. Braz J Otorhinolaryngol. 2008;74(2):207‑12.
34. Bachert C, Zhang N. Chronic rhinosinusitis and asthma: novel understanding of the role of IgE « above atopy ». J Intern Med. 2012;272(2):133‑43.
35. Bachert C, Zhang N, Holtappels G, De Lobel L, van Cauwenberge P, Liu S, et al. Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma. J Allergy Clin Immunol. 2010;126(5):962‑8, 968.e1-6.
36. Zhang N, Van Zele T, Perez-Novo C, Van Bruaene N, Holtappels G, DeRuyck N, et al. Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease. J Allergy Clin Immunol. 2008;122(5):961‑8.
37. Pinto JM, Mehta N, DiTineo M, Wang J, Baroody FM, Naclerio RM. A randomized, double-blind, placebo-controlled trial of anti-IgE for chronic rhinosinusitis. Rhinology. 2010;48(3):318‑24. 38. Gevaert P, Calus L, Van Zele T, Blomme K, De Ruyck N, Bauters W, et al. Omalizumab is effective
in allergic and nonallergic patients with nasal polyps and asthma. J Allergy Clin Immunol. janv 2013;131(1):110-116.e1.
39. Gevaert P, Lang-Loidolt D, Lackner A, Stammberger H, Staudinger H, Van Zele T, et al. Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps. J Allergy Clin Immunol. 2006;118(5):1133‑41.
40. Gevaert P, Van Bruaene N, Cattaert T, Van Steen K, Van Zele T, Acke F, et al. Mepolizumab, a humanized anti-IL-5 mAb, as a treatment option for severe nasal polyposis. J Allergy Clin Immunol. 2011;128(5):989-995.e1-8.
41. Van Bruaene N, Bachert C. Tissue remodeling in chronic rhinosinusitis. Curr Opin Allergy Clin Immunol. 2011;11(1):8‑11.
42. Shimbara A, Christodoulopoulos P, Soussi-Gounni A, Olivenstein R, Nakamura Y, Levitt RC, et al. IL-9 and its receptor in allergic and nonallergic lung disease: increased expression in asthma. J Allergy Clin Immunol. 2000;105(1 Pt 1):108‑15.
65 43. Gounni AS, Gregory B, Nutku E, Aris F, Latifa K, Minshall E, et al. Interleukin-9 enhances interleukin-5 receptor expression, differentiation, and survival of human eosinophils. Blood. 15 2000;96(6):2163‑71.
44. Peterson S, Poposki JA, Nagarkar DR, Chustz RT, Peters AT, Suh LA, et al. Increased expression of CC chemokine ligand 18 in patients with chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2012;129(1):119-127.e1-9.
45. Stone KD, Prussin C, Metcalfe DD. IgE, mast cells, basophils, and eosinophils. J Allergy Clin Immunol. 2010;125(2 Suppl 2):S73-80.
46. Patou J, Gevaert P, Van Zele T, Holtappels G, van Cauwenberge P, Bachert C. Staphylococcus aureus enterotoxin B, protein A, and lipoteichoic acid stimulations in nasal polyps. J Allergy Clin Immunol. 2008;121(1):110‑5.
47. Pawankar R, Lee KH, Nonaka M, Takizawa R. Role of mast cells and basophils in chronic rhinosinusitis. Clin Allergy Immunol. 2007;20:93‑101.
48. Xue L, Gyles SL, Wettey FR, Gazi L, Townsend E, Hunter MG, et al. Prostaglandin D2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cells. J Immunol Baltim Md 1950. 15 2005;175(10):6531‑6.
49. Weathington NM, van Houwelingen AH, Noerager BD, Jackson PL, Kraneveld AD, Galin FS, et al. A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation. Nat Med. 2006;12(3):317‑23.
50. Van Zele T, Coppieters F, Gevaert P, Holtappels G, Van Cauwenberge P, Bachert C. Local complement activation in nasal polyposis. The Laryngoscope. 2009;119(9):1753‑8.
51. Liang X, Lin T, Sun G, Beasley-Topliffe L, Cavaillon J-M, Warren HS. Hemopexin down-regulates LPS-induced proinflammatory cytokines from macrophages. J Leukoc Biol. 2009;86(2):229‑35. 52. Philippot Q, Deslée G, Adair-Kirk TL, Woods JC, Byers D, Conradi S, et al. Increased iron
sequestration in alveolar macrophages in chronic obstructive pulmonary disease. PloS One. 2014;9(5):e96285.
53. Nadolska B, Frączek M, Kręcicki T, Kocięba M, Zimecki M. Lactoferrin inhibits the growth of nasal polyp fibroblasts. Pharmacol Rep PR. 2010;62(6):1139‑47.
54. Borth W. Alpha 2-macroglobulin, a multifunctional binding protein with targeting characteristics. FASEB J Off Publ Fed Am Soc Exp Biol. 1992;6(15):3345‑53.
55. Furlaneto CJ, Ribeiro FP, Hatanaka E, Souza GM, Cassatella MA, Campa A. Apolipoproteins A-I and A-II downregulate neutrophil functions. Lipids. 2002;37(9):925‑8.
56. Van Roey GA, Vanison CC, Wu J, Huang JH, Suh LA, Carter RG, et al. Classical complement pathway activation in the nasal tissue of patients with chronic rhinosinusitis. J Allergy Clin Immunol. 2017;140(1):89-100.e2.
66 57. Mulligan JK, Patel K, Williamson T, Reaves N, Carroll W, Stephenson SE, et al. C3a receptor antagonism as a novel therapeutic target for chronic rhinosinusitis. Mucosal Immunol. 2018;11(5):1375‑85.
58. Dalziel K, Stein K, Round A, Garside R, Royle P. Systematic review of endoscopic sinus surgery for nasal polyps. Health Technol Assess Winch Engl. 2003;7(17):iii, 1‑159.
59. Attems J, Walker L, Jellinger KA. Olfactory bulb involvement in neurodegenerative diseases. Acta Neuropathol (Berl). 2014;127(4):459‑75.
60. Rolet A, Magnin E, Millot JL, Berger E, Vidal C, Sileman G, et al. Olfactory dysfunction in multiple sclerosis: evidence of a decrease in different aspects of olfactory function. Eur Neurol. 2013;69(3):166‑70.
61. Oakley GM, Harvey RJ, Lund VJ. The Role of Macrolides in Chronic Rhinosinusitis (CRSsNP and CRSwNP). Curr Allergy Asthma Rep. 2017;17(5):30.
62. Videler WJ, Badia L, Harvey RJ, Gane S, Georgalas C, van der Meulen FW, et al. Lack of efficacy of long-term, low-dose azithromycin in chronic rhinosinusitis: a randomized controlled trial. Allergy. 2011;66(11):1457‑68.
63. Piagkou M, Demesticha T, Troupis T, Vlasis K, Skandalakis P, Makri A, et al. The pterygopalatine ganglion and its role in various pain syndromes: from anatomy to clinical practice. Pain Pract Off J World Inst Pain. 2012;12(5):399‑412.
64. Windsor RE, Jahnke S. Sphenopalatine ganglion blockade: a review and proposed modification of the transnasal technique. Pain Physician. 2004;7(2):283‑6.
65. Hwang J-H, Liu C-M, Liu T-C, Hsu M-C. Sphenopalatine ganglion block before removal of nasal packing. The Laryngoscope. 2003;113(8):1423‑4.
66. Cho D-Y, Drover DR, Nekhendzy V, Butwick AJ, Collins J, Hwang PH. The effectiveness of preemptive sphenopalatine ganglion block on postoperative pain and functional outcomes after functional endoscopic sinus surgery. Int Forum Allergy Rhinol. 2011;1(3):212‑8.
67. Friedman M, Venkatesan TK, Lang D, Caldarelli DD. Bupivacaine for postoperative analgesia following endoscopic sinus surgery. The Laryngoscope. 1996;106(11):1382‑5.
68. Kesimci E, Öztürk L, Bercin S, Kırış M, Eldem A, Kanbak O. Role of sphenopalatine ganglion block for postoperative analgesia after functional endoscopic sinus surgery. Eur Arch Oto-Rhino- Laryngol Off J Eur Fed Oto-Rhino-Laryngol Soc EUFOS Affil Ger Soc Oto-Rhino-Laryngol - Head Neck Surg. 2012;269(1):165‑9.
69. Zink W, Graf BM. The toxicity of local anesthetics: the place of ropivacaine and levobupivacaine. Curr Opin Anaesthesiol. 2008;21(5):645‑50.
70. Horn EP, Schroeder F, Wilhelm S, Wappler F, Sessler DI, Uebe B, et al. Wound infiltration and drain lavage with ropivacaine after major shoulder surgery. Anesth Analg. 1999;89(6):1461‑6.
67 71. Jung G, Kim BS, Shin K-B, Park K-B, Kim SY, Song SO. The optimal volume of 0.2% ropivacaine required for an ultrasound-guided stellate ganglion block. Korean J Anesthesiol. 2011;60(3):179‑84.
72. Frank DO, Kimbell JS, Pawar S, Rhee JS. Effects of anatomy and particle size on nasal sprays and nebulizers. Otolaryngol--Head Neck Surg Off J Am Acad Otolaryngol-Head Neck Surg. 2012;146(2):313‑9.
73. Möller W, Schuschnig U, Celik G, Münzing W, Bartenstein P, Häussinger K, et al. Topical drug delivery in chronic rhinosinusitis patients before and after sinus surgery using pulsating aerosols. PloS One. 2013;8(9):e74991.
74. Reychler G, Colbrant C, Huart C, Le Guellec S, Vecellio L, Liistro G, et al. Effect of three-drug delivery modalities on olfactory function in chronic sinusitis. The Laryngoscope. 2015;125(3):549‑55.
75. Allen DB. Systemic effects of intranasal steroids: an endocrinologist’s perspective. J Allergy Clin Immunol. 2000;106(4 Suppl):S179-190.
76. Fitzpatrick MF, McLean H, Urton AM, Tan A, O’Donnell D, Driver HS. Effect of nasal or oral breathing route on upper airway resistance during sleep. Eur Respir J. 2003;22(5):827‑32. 77. Meen EK, Chandra RK. The role of the nose in sleep-disordered breathing. Am J Rhinol Allergy.
2013;27(3):213‑20.
78. Takahashi R, Ohbuchi T, Hohchi N, Takeuchi S, Ohkubo J, Ikezaki S, et al. [Effect of septoplasty and turbinectomy on obstructive sleep apnea syndrome]. Nihon Jibiinkoka Gakkai Kaiho. 2013;116(7):789‑92.
79. Värendh M, Johannisson A, Hrubos-Strøm H, Andersson M. Sleep quality improves with endoscopic sinus surgery in patients with chronic rhinosinusitis and nasal polyposis. Rhinology. 2017;55(1):45‑52.
68
Publications et communications.
Ma capacité à concevoir et diriger des travaux de recherche est attestée par les tableaux suivants qui résument mes publications. Je suis premier ou dernier auteur dans 52% des travaux publiés avec référencement.
Depuis ma thèse d’université en 2015, mon score SIGAPS a augmenté de 46% (+ 243pts) témoignant d’une dynamique positive de productions.
I. Nombre de publications par année et par catégorie :