CHAPTER 3 SYSTEM CONCEPTS
4.2 DEVICE ASSIGNMENTS
A partir dos estudos realizados neste trabalho foi possível concluir que:
1. Carboximetil-κ-carragenana com graus de substituição (DS) de 0,8 a 1,6 foram obtidas com sucesso a partir da reação de carboximetilação da κ-carragenana (KC);
2. A carboximetilação da KC aumenta as atividades biológicas tais como: compatibilidade com o suor e a umidade característicos dos corpos humanos, absorção e retenção de umidade, atividade antioxidante e atividade antibacteriana.
3. CMKC com DS entre 1,0 e 1,2 apresentam os melhores resultados de acordo com os testes realizados para a aplicação em um biomaterial;
4. Nanofibras de misturas poliméricas de PVA com CMKC (DS 1,1) em diferentes proporções podem ser produzidas a partir da técnica de electrospinning e reticuladas por processo térmico;
5. A incorporação de CMKC 1,1 aumenta a citocompatibilidade, adesão e crescimento celular, bem como favorece a diferenciação osteogênica de células ADSC P3;
6. Nanofibras com maior incorporação de CMKC promovem uma maior adesão e ativação plaquetária, adsorção de fibrinogênio e demonstram alto percentual de coagulação; 7. A incorporação de CMKC as nanofibras confere maior atividade antibacteriana contra
bactérias gram-positivas e gram-negativas;
8. Foram produzidas nanofibras biocompatíveis sem a geração de resíduos tóxicos no processo;
9. As nanofibras produzidas são fortes candidatas para a aplicação de curativos para ferimentos.
96
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