[PDF] Top 20 A broadly neutralizing human monoclonal antibody is effective against H7N9
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A broadly neutralizing human monoclonal antibody is effective against H7N9
... for a mAb for use as treatment combined with oseltamivir or zanamivir for severe influenza ...of a neutralizing mAb that could provide a therapeutic adjunct for diverse strains that are both ... Voir le document complet
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Structural Basis for Broad HIV-1 Neutralization by a Novel MPER-Specific Human Broadly Neutralizing Antibody
... lymphocytes is an effector function held by some but not all bnAbs. Antibody- dependent cellular cytotoxicity (ADCC) is mediated through the binding of the Fc portion of the antibody to Fc ... Voir le document complet
25
Peptide-Based Vaccination for Antibody Responses Against HIV
... HIV-1 is responsible for a global pandemic of 35 million people and continues to spread at a rate of >2 million new ...It is widely acknowledged that a protective vaccine would be ... Voir le document complet
12
IgA dominates the early neutralizing antibody response to SARS-CoV-2
... which is more likely to occur in damaged lung tissue (31, 32). A clonal relationship has been shown between serum and mucosal antigen-specific IgA ...it is possible that plasma IgA antibodies could ... Voir le document complet
15
A neutralizing monoclonal antibody (mAb A24) directed against the transferrin receptor induces apoptosis of tumor T lymphocytes from ATL patients
... (ATL) is an aggressive lymphoid proliferative disease that exists under diverse clinical forms ranging from chronic to ...cells, human T-cell lymphotropic virus type 1 (HTLV-1) infected cells constitutively ... Voir le document complet
2
Structural Basis for Broad HIV-1 Neutralization by the MPER-Specific Human Broadly Neutralizing Antibody LN01
... Among a cohort of chronically HIV-1-infected patients, naı¨ve to antiretroviral therapy, we identified a patient (SA003) who showed high level of serum bnAbs, as assessed on a panel of 9 HIV-1 ... Voir le document complet
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Enhanced Neutralizing Antibody Titers and Th1 Polarization from a Novel Escherichia coli Derived Pandemic Influenza Vaccine
... robust antibody responses in many vaccines, is a Th2-polarizing ...both a Th1-type cytokine response, and inducing an antibody response dominated by ...protective antibody, with ... Voir le document complet
11
Boosting regulatory T-cell function with the humanized CD4-specific humanized monoclonal antibody Tregalizumab (BT-061)
... Figure 1 Tregalizumab (BT-061) activates Treg in vitro. Tregalizumab binds the extracellular domain 2 (D 2 ) of the CD4 molecule. Treg suppression activity is then enhanced, possibly through increased LAP ... Voir le document complet
2
Single-domain antibodies represent novel alternatives to monoclonal antibodies as targeting agents against the human papillomavirus 16 E6 protein
... 21 monoclonal antibodies (mAbs) benefit from greater therapeutic specificity and longer intracellular half-lives than siRNA [ 22 ...elicited a notable restoration of p53 protein levels [ 20 , 26 ] and that ... Voir le document complet
22
Targeting and killing glioblastoma with monoclonal antibody to O-acetyl GD2 ganglioside
... using a MTT assay (Figure 3, left column panels). We included a control antibody to ensure that the observed results were antigen ...control antibody- treated cells (Figure ...the ... Voir le document complet
15
The biochemical dynamics of monoclonal antibody production in high density perfused fermentors
... The amino acid-to-protein mass balance fails to close under conditions favoring high IgG secretion. At the high cell densities examined at steady-state, when the IgG[r] ... Voir le document complet
218
Targeting the Human T-Cell Inducible COStimulator Molecule with a Monoclonal Antibody Prevents Graft-vs-Host Disease and Preserves Graft vs Leukemia in a Xenograft Murine Model
... (GVHD) is a major complication of allogeneic bone marrow transplantation (BMT), used to treat hematological ...response is often necessary to eliminate residual malignant cells, an effect referred to ... Voir le document complet
11
Targeting the Human T-Cell Inducible COStimulator Molecule with a Monoclonal Antibody Prevents Graft-vs-Host Disease and Preserves Graft vs Leukemia in a Xenograft Murine Model
... (GVHD) is a major complication of allogeneic bone marrow transplantation (BMT), used to treat hematological ...response is often necessary to eliminate residual malignant cells, an effect referred to ... Voir le document complet
11
Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics
... or a biosimilar to a reference pro- duct) is highly ...as a reference database for mAb NMR studies in development, quality control, and post-licensure supervi- sion of the ...into a ... Voir le document complet
15
Comparison of conjugation procedures for the preparation of monoclonal antibody-enzyme conjugates
... As far as global conjugate activity was concerned, Nakane's technique (tested on three antibodies) provided slightly more efficient conjugates in terms of initial IgG input, while Tijssen's conditions proved superior in ... Voir le document complet
10
Prescribed regimen is effective.
... We don’t understand how a signed consent form is of value as regards its authenticity. We believe journals should place more trust in authors’ attestation of consent. Forms could be archived in the ... Voir le document complet
4
Straightforward selection of broadly neutralizing single-domain antibodies targeting the conserved CD4 and co-receptor binding sites of HIV-1 gp120
... to a CD4 mimic, as immunogens in llamas, we selected a panel of broadly neutralizing single-domain antibodies that bind either to the CD4 or to the co-receptor binding sites (CD4BS and CoRBS, ... Voir le document complet
2
Humanisation of a claudin-1-specific monoclonal antibody for clinical prevention and cure of HCV infection without escape
... PHH is indeed possible via CLDN6 (even at low expression levels), we expected that addition of a CLDN6-speci fic antibody would enhance the antiviral potency of ...used a previously described ... Voir le document complet
11
A novel monoclonal anti-CD81 antibody produced by genetic immunization efficiently inhibits Hepatitis C virus cell-cell transmission.
... the antibody-producing ...to human CD81 expressed on the cell surface of CHO cells transfected with ...JS81 antibody was obtained from BD ...CBH23, a kind gift from S.K.H. Foung) mAbs and ... Voir le document complet
12
Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: a review of the rationale and clinical evidence.
... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ... Voir le document complet
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