HAL Id: hal-01450873
https://hal.archives-ouvertes.fr/hal-01450873
Submitted on 31 Jan 2017HAL is a multi-disciplinary open access archive for the deposit and dissemination of sci-entific research documents, whether they are pub-lished or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.
L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
������ p53-����������������� � ������������� �������� ��������� �����
T.V. Shinkarenko, I.S. Shpon‘ka
To cite this version:
ɄɅȱɇȱɑɇȺ ɆȿȾɂɐɂɇȺ
ɆȿȾɂɑɇȱ ɉȿɊɋɉȿɄɌɂȼɂ
ɍȾɄ Ɍ.ȼ. ɒɢɧɤɚɪɟɧɤɨ, ȱ.ɋ. ɒɩɨɧɶɤɚ
Ⱥ
Ⱥ
ɇ
ɇ
Ⱥ
Ⱥ
Ʌ
Ʌ
ȱ
ȱ
Ɂ
Ɂ
3
3
ȱ
ȱ
Ɇ
Ɇ
ɍ
ɍ
ɇ
ɇ
Ɉ
Ɉ
Ɋ
Ɋ
ȿ
ȿ
Ⱥ
Ⱥ
Ʉ
Ʉ
Ɍ
Ɍ
ɂ
ɂ
ȼ
ȼ
ɇ
ɇ
Ɉ
Ɉ
ɋ
ɋ
Ɍ
Ɍ
ȱ
ȱ
ȼ
ȼ
Ⱥ
Ⱥ
ɋ
ɋ
Ɍ
Ɍ
Ɋ
Ɋ
Ɉ
Ɉ
ɐ
ɐ
ɂ
ɂ
Ɍ
Ɍ
Ⱥ
Ⱥ
Ɋ
Ɋ
ɇ
ɇ
ɂ
ɂ
ɏ
ɏ
ɉ
ɉ
ɍ
ɍ
ɏ
ɏ
Ʌ
Ʌ
ɂ
ɂ
ɇ
ɇ
Ⱥ
Ⱥ
ɏ
ɏ
Ƚ
Ƚ
Ɉ
Ɉ
Ʌ
Ʌ
Ɉ
Ɉ
ȼ
ȼ
ɇ
ɇ
Ɉ
Ɉ
Ƚ
Ƚ
Ɉ
Ɉ
Ɇ
Ɇ
Ɉ
Ɉ
Ɂ
Ɂ
Ʉ
Ʉ
ɍ
ɍ
ȾɁ «Ⱦɧɿɩɪɨɩɟɬɪɨɜɫɶɤɚ ɦɟɞɢɱɧɚ ɚɤɚɞɟɦɿɹ ɆɈɁ ɍɤɪɚʀɧɢ» ɤɚɮɟɞɪɚ ɩɚɬɨɥɨɝɿɱɧɨʀ ɚɧɚɬɨɦɿʀ ɿ ɫɭɞɨɜɨʀ ɦɟɞɢɰɢɧɢ (ɡɚɜ. – ɞ. ɦɟɞ. ɧ., ɩɪɨɮ. ȱ.ɋ. ɒɩɨɧɶɤɚ) ɜɭɥ. Ⱦɡɟɪɠɢɧɫɶɤɨɝɨ, 9, Ⱦɧɿɩɪɨ, 49044, ɍɤɪɚʀɧɚ
SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine» Department of Pathological Anatomy and Forensic Medicine
Dzerzhinsky str., 9, Dnipro, 49044, Ukraine e-mail: Timash3061990@gmail.com
Ʉɥɸɱɨɜɿɫɥɨɜɚ ɩɭɯɥɢɧɚ ɝɨɥɨɜɧɨɝɨ ɦɨɡɤɭ, ɿɦɭɧɨɝɿɫɬɨɯɿɦɿɹ, ɞɿɚɝɧɨɫɬɢɤɚ, p53, Ki-67 .H\ZRUGV brain tumor, immunohistochemistry, diagnostics, p53, Ki-67
16/ Ɍɨɦ XXȱ / 4
ɋ
ɋ
ɉ
ɉ
ɂ
ɂ
ɋ
ɋ
Ɉ
Ɉ
Ʉ
Ʉ
Ʌ
Ʌ
ȱ
ȱ
Ɍ
Ɍ
ȿ
ȿ
Ɋ
Ɋ
Ⱥ
Ⱥ
Ɍ
Ɍ
ɍ
ɍ
Ɋ
Ɋ
ɂ
ɂ
Ⱥɧɬɨɦɨɧɨɜ Ɇɘ Ɇɚɬɟɦɚɬɢɱɟɫɤɚɹ ɨɛɪɨɛɨɬɤɚ ɢɚɧɚɥɢɡɦɟɞɢɤɨɛɢɨɥɨɝɢɱɟɫɤɢɯɞɚɧɧɹɯɆɘȺɧɬɨ ɦɨɧɨɜ±Ʉɢɟɜ±ɫ ɉɨɫɥɚɜɫɶɤɚɈȼɆɟɬɨɞɨɥɨɝɿɹɜɢɤɨɪɢɫɬɚɧɧɹɩɪɨ ɝɪɚɦɧɨɝɨɡɚɛɟɡɩɟɱɟɧɧɹɞɥɹɚɧɚɥɿɡɭɰɢɮɪɨɜɢɯɦɿɤɪɨɮɨɬɨ ɝɪɚɮɿɣɧɚɛɚɡɿɤɭɪɫɭɩɚɬɨɦɨɪɮɨɥɨɝɿʀɡɦɟɬɨɸɩɿɞɜɢɳɟɧ ɧɹ ɩɪɨɮɟɫɿɣɧɨɝɨ ɪɿɜɧɹ ɫɬɭɞɟɧɬɿɜ ɿ ɧɚɭɤɨɜɰɿɜ Ɉȼɉɨ ɫɥɚɜɫɶɤɚ0RUSKRORJLDɌʋɋ
$SRSWRVLV WKHUDS\ LQ FDQFHU WKH ILUVW VLQJOHPR OHFXOH FRDFWLYDWLQJ S DQG WKH WUDQVORFDWRU SURWHLQ LQ JOLREODVWRPD6'DQLHOH67DOLDQL('D3R]]R>HWDO@ 6FLHQWLILFUHSRUWV±±Ɍ
([SUHVVLRQ RI S HSLGHUPDO JURZWK IDFWRU UHFHS WRU.LDQG2PHWK\OJXDQLQH'1$PHWK\OWUDQVIHUDVHLQ KXPDQ JOLRPDV ; +X : 0LDR < =RX >HW DO@ 2QFRORJ\OHWWHUV±±9RO1±3
*DQJXO\$/L)UDXPHQL6\QGURPH$*DQJXO\ =&KHQ 0ROHFXODU 3DWKRORJ\ LQ &OLQLFDO 3UDFWLFH ± 6ZLW]HUODQG 6SULQJHU ,QWHUQDWLRQDO 3XEOLVKLQJ ± ɋ
.UXLVZLMN)SLQVXUYLYDOGHDWKDQGPHWDEROLF KHDOWK D OLIHJXDUG ZLWK D OLFHQFH WR NLOO ) .UXLVZLMN &)/DEXVFKDJQH.+9RXVGHQ1DWXUH5HYLHZV0ROH FXODU&HOO%LRORJ\±±9RO1±3 /HUR\%73PXWDWLRQVLQKXPDQFDQFHUGDWD EDVHUHDVVHVVPHQWDQGSURVSHFWVIRUWKHQH[WGHFDGH% /HUR\ 0 $QGHUVRQ 7 6RXVVL +XPDQ 0XWDWLRQ ± ±9RO1±3
1XFOHDU LQWHUDFWRU RI $5) DQG 0GP UHJXODWHV PXOWLSOHSDWKZD\VWRDFWLYDWHS605HHG-+DJHQ 9 6 7RPSNLQV >HW DO@ &HOO &\FOH ± ± 9RO 1±3 5HYLVLWLQJ 73 PXWDWLRQV DQG LPPXQRKLVWR FKHPLVWU\±DFRPSDUDWLYHVWXG\LQGLIIXVHJOLRPDV +7DNDPL$<RVKLGD6)XNXVKLPD>HWDO@%UDLQ3D WKRORJ\±±9RO1±3 7DQERRQ - 7KH 'LDJQRVWLF XVH RI LPPXQRKLVWR FKHPLFDO VXUURJDWHV IRU VLJQDWXUH PROHFXODU JHQHWLF DOWHUDWLRQVLQJOLRPDV-7DQERRQ($:LOOLDPV'1 /RXLV-1HXURSDWKRO ([SHULP1HXURORJ\±± 9RO1±3
7UDQVFULSWLRQDO FRQWURO RI KXPDQ SUHJXODWHG JHQHV75LOH\(6RQWDJ3&KHQ>HWDO@1DWXUH5H YLHZV 0ROHFXODU &HOO %LRORJ\ ± ± 9RO 1 ± 3
:+2 &ODVVLILFDWLRQ RI WXPRXUV RI WKH FHQWUDO QHUYRXV V\VWHP '1/RXLV +2KJDNL 2':LHVWOHU >HWDO@±ɟɢɡɞ±/\RQ,$5&±ɪ
5
5
(
(
)
)
(
(
5
5
(
(
1
1
&
&
(
(
6
6
$QWRPRQRY 0 >0DWKHPDWLFDO SURFHVVLQJ DQG DQDO\VLV RI PHGLFDO DQG ELRORJLFDO GDWD@ .\LY )0' 5XVVLDQ
3RVODYVND29>0HWKRGRORJ\IRUWKHXVHRIVRIW ZDUHIRUWKHDQDO\VLVRIGLJLWDOPLFURJUDSKVRQWKHEDVHRI SDWKRPRUSKRORJ\ FRXUVH LQ RUGHU WR LQFUHDVH WKH SURIHV VLRQDO OHYHO RI VWXGHQWV DQG VFLHQWLVWV@ 0RUSKRORJLD 8NUDLQLDQ
'DQLHOH67DOLDQL6'D3R]]R(HWDO$SRSWRVLV WKHUDS\ LQ FDQFHU WKH ILUVW VLQJOHPROHFXOH FRDFWLYDWLQJ S DQG WKH WUDQVORFDWRU SURWHLQ LQ JOLREODVWRPD 6FLHQ WLILFUHSRUWV$SUGRLVUHS
+X;0LDR:=RX<HWDO([SUHVVLRQRIS HSLGHUPDO JURZWK IDFWRU UHFHSWRU .L DQG 2PHWK\O JXDQLQH'1$PHWK\OWUDQVIHUDVHLQKXPDQJOLRPDV2QFROR J\OHWWHUV-XOGRLRO
*DQJXO\ $ &KHQ = /L)UDXPHQL 6\QGURPH ,Q0ROHFXODU3DWKRORJ\LQ&OLQLFDO3UDFWLFHSS 6SULQJHU,QWHUQDWLRQDO3XEOLVKLQJ
.UXLVZLMN ) /DEXVFKDJQH &) 9RXVGHQ .+ S LQ VXUYLYDO GHDWK DQG PHWDEROLF KHDOWK D OLIHJXDUG ZLWK D OLFHQFH WR NLOO 1DWXUH UHYLHZV 0ROHFXODU FHOO ELRORJ\ -XO GRLQUP /HUR\%$QGHUVRQ06RXVVL773PXWDWLRQV LQKXPDQFDQFHUGDWDEDVHUHDVVHVVPHQWDQGSURVSHFWVIRU WKHQH[WGHFDGH+XPDQPXWDWLRQ-XQ GRLKXPX 5HHG 60 +DJHQ - 7RPSNLQV 96 HW DO 1XFOHDU LQWHUDFWRURI$5)DQG0GPUHJXODWHVPXOWLSOHSDWKZD\V WR DFWLYDWH S &HOO F\FOH $SU GRLFF
7DNDPL + <RVKLGD $ )XNXVKLPD 6 HW DO 5H YLVLWLQJ 73 PXWDWLRQV DQG LPPXQRKLVWRFKHPLVWU\ ± D FRPSDUDWLYH VWXG\ LQ GLIIXVH JOLRPDV %UDLQ 3DWKR ORJ\0D\GRLESD
7DQERRQ - :LOOLDPV ($ /RXLV '1 7KH 'LDJ QRVWLF XVH RI LPPXQRKLVWRFKHPLFDO VXUURJDWHV IRU VLJQD WXUH PROHFXODU JHQHWLF DOWHUDWLRQV LQ JOLRPDV -RXUQDO RI 1HXURSDWKRORJ\ ([SHULPHQWDO 1HXURORJ\ -DQ GRLMQHQQOY
5LOH\76RQWDJ(&KHQ3/HYLQH$7UDQVFULS WLRQDO FRQWURO RI KXPDQ SUHJXODWHG JHQHV 1DWXUH UH YLHZV 0ROHFXODU FHOO ELRORJ\ 0D\ GRLQUP