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Circadian rhythm of water diuresis and salt excretion in treatment naïve children with nocturnal polyuria and the influence on desmopressin response

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(1)

CIRCADIAN RHYTHM OF WATER DIURESIS AND SALT EXCRETION IN TREATMENT NAÏVE

CHILDREN WITH NOCTURNAL POLYURIA AND THE INFLUENCE ON DESMOPRESSIN RESPONSE

(SECONDARY ANALYSIS OF THE SLEEP STUDY)

S. Karamaria, L. Dossche, A. Raes, R. Mauel, E. Van Laecke, C. Van Herzeele, J. Vande Walle

(2)

MATERIAL AND METHODS

2

̶ Post-hoc analysis of the SLEEP study (Van Herzeele et al 2016)

̶ 30 children

̶ MNE: > 5/7 wet nights

̶ Nocturnal polyuria (>100% of EBC for age) Baseline

• History

• Voiding diary

• Polysomnography (PLMS,

arousability, arousal index, FUSP)

• 24hour urine concentration profile (volume, creatinine, Na, K, Cl)

Month 6

• History

• Voiding diary

• Polysomnography (PLMS,

arousability, arousal index, FUSP)

• 24hour urine concentration profile (volume, creatinine, Na, K, Cl)

Desmopressin MELT

Dr. Frederic Paulsen Chair

IWT-SBO 130033

Circadian rhythm of water diuresis and salt excretion in treatment naïve children with nocturnal polyuria and the influence

desmopressin response

(3)

RESULTS

(4)

RESULTS

4

Dr. Frederic Paulsen Chair

IWT-SBO 130033

Circadian rhythm of water diuresis and salt excretion in treatment naïve children with nocturnal polyuria and the influence

desmopressin response

(5)

RESULTS

(6)

CONCLUSION

6

Treatment naïve patients with Enuresis and Nocturnal Polyuria

̶ Before desmopressin:

• ↑ diuresis

• ↓ osmolality

• ↑ osmotic excretion

• FUSP < 4hours

̶ After desmopressin:

• ↓ enuretic episodes

• ↓ nocturnal polyuria

• ↓ water diuresis

• ↓ Na excretion  cannot be attributed to desmopressin

 credited to better sleep during lower filling volumes

Dr. Frederic Paulsen Chair

IWT-SBO 130033

Circadian rhythm of water diuresis and salt excretion in treatment naïve children with nocturnal polyuria and the influence

desmopressin response

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