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Design evaluation and optimisation in crossover pharmacokinetic studies analysed by nonlinear mixed effects models

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Academic year: 2021

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Table I – Predicted and empirical standard error SE(β Cl ) for each design and value of β Cl .
Table II – Predicted powers (%) and observed powers (%) for each design and value of β Cl .
Table III – Population pharmacokinetic parameters of amoxicillin and and standard errors (SE) as well as relative standard errors (RSE) of parameter estimates by MONOLIX 2.4 for DAV1 study.
Table IV – Relative standard error (RSE; %) and standard error (SE) predicted by new extension ofMF for all the population parameters and criterion value according to each two-period crossover design of DAV2 study.
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