HAL Id: inserm-00311471
https://www.hal.inserm.fr/inserm-00311471
Submitted on 18 Aug 2008
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Neurodevelopmental consequences of very preterm
births.
Christelle Roustit, Pierre Chauvin
To cite this version:
Christelle Roustit, Pierre Chauvin. Neurodevelopmental consequences of very preterm births.. The
Lancet, Elsevier, 2008, 372 (9633), pp.116. �10.1016/S0140-6736(08)61032-6�. �inserm-00311471�
✰✤✱✙✲✘✳✵✴✷✶✹✸☎✺✻✺✎✸✽✼✿✾✙❀✝✴✷✶❁✳❂✶✹❃❅❄❆✳✻✸✟✲✹✲✘✸✿✰✽✱❅❇☞❀❉❈❊✳✻❋ ●✵❍✓■✙❏ ✼▲❑▼❃✙◆❖❑P✼❘◗ ■❚❙✡❯✡❙ ❃✙✼✿✸✣✴✘✸☎❇✟✲❲❱✟✱❨❳✿✲✘✾❅❀❊❩❬✾❭❋✿✶❁✱✡✸ ■ ✾✡❱☎✳✻❇☎✺❭❪❬✸☞✶✹✸✟✲✘❫❨✳✻❋❊❇☎❋❴✶✘✴❵✾❭❛✖❜❬✸☎❇☎✺❝✶❞✱❬❇❡❋❅❢❣❜❨✸☎❇☎✺❝✶❁✱❊❱✩❇✟✲✘✸☎❃ ❄❵❇✟✲✘✳✭✴✘❃ ❙❉❤✐❯✒❥✮❦♠❧ ✲✘❇✟❋❅❱☎✸✙♥✡❇☎❋❅❢✂◆❬❋✡✳♦❈✌✸♣✲✜✴✘✳❝✶✹q✽❄r✳♦✸✟✲❞✲✘✸✿✸☞✶✝❑s❇✟✲❞✳✎✸✿✰t❀❊✲✉✳♦✸☎◗✈❄❵❇✟✲✘✳✭✴①✇✡❃✙❄❵❇✟✲❞✳✵✴✘❃ ❧ ✲✘❇✟❋❊❱✩✸✙② ③ q☎❇☞✶❁✲❞✳♦❱❴✸ ④⑤❇♣✲❞✲✘✾❊⑥❴❀✌✸ ❇✟❋✡❢ ❱☎✾✡✺✻✺✭✸✣❇✟⑦✙❀✌✸✣✴ ⑧✈❑▼❇♣✲✘❱☎✱ ⑨✐❃⑩❩ ⑨ ❥♣❶✙❷✜❸ ✲❲✸✟❩✡✾✡✲✈✶ ❢✙✳❹❛✹❛❞✸✟✲❲✸❡❋✣✶ ❋✡✸✟⑦❊❇☞✶❁✳❺❈✌✸ ❋✡✸✮❀❊✲✘✾❉❢✡✸✮❈❊✸☎✺✻✾✡❩❉❫❚✸☎❋❴✶✹❇☎✺✌❱☎✾❭❋❊✴✘✸☎⑥❴❀✌✸☎❋❊❱☎✸✣✴✤✾✡❛✒❈❊✸♣✲❲❻❬❩✡✲✘✸☞✶✹✸✟✲❞❫❽❼❊✳✻✲✷✶❁✱❉✴⑤✳✻❋❾❇ ❤ ◗✷❻❭✸☎❇✟✲①❛❁✾❉✺✭✺✻✾✙❿❬◗✈❀❊❩❚❱☎✾❭✱❅✾❭✲❁✶r❇♣❋✡❢❣✶❁✱✡✸ ✲✘✸❴✴❁❀✖✺❂✶❞✳✻❋✙⑦▼❀✝✴✘✸P✾✡❛♠✲✘✸☎✱❅❇✩❼❊✳✎✺✭✳❝✶✹❇✮✶❞✳✻✾✡❋➀❱☎❇✟✲✘✸✙②▲➁r✱✡✳✭✴✓✴✷✶✵❀✌❢✙❻▼✲➂✸❡❛❁✺✎✸☎❱☞✶✘✴★❇P❢✙❻✡❋❅❇❡❫❚✳✎❱P✾✡❛♠❩✡✲✘✾✡❛❁✾❅❀❊❋❅❢➃❱☎✱✡❇☎❋✙⑦❊✸✙✴➄✳✻❋ ✾✙❼✖✴✷✶✹✸✜✶❁✲❞✳✻❱❚❇☎❋✡❢➅❩❊❇☎✸✩❢❭✳✎❇☞✶❁✲✘✳✻❱❨❩✡✲✘❇☎❱☞✶❁✳✻❱✣✸❴✴❘✳❹❋ ❧ ✲✘❇☎❋✡❱☎✸❾✳✻❋➅✶❁✱❅✸➆✺♦❇☞✶✹✸ ❥♣➇✡➇✡❯ ✴❲❃✦❿♠✱✡✳✻❱☎✱➈✳✻❋❊❱☎✺❺❀✌❢✡✸☎❢➆✶❁✱❅✸❾❱✟✲✘✸✩❇☞✶❞✳♦✾❭❋➉✾❭❛ ✺✎✸✟❈❊✸☎✺ ●✹●❞● ❋✡✸☎✾✡❋✡❇✮✶✹❇✟✺✙❀✖❋✡✳❂✶✘✴①❇☎❋✡❢❨❇➊❋✡✸☎✾✡❋✡❇✮✶✹❇❡✺❊❱✩❇✟✲✘✸➊✲✘✸☎❛❁✸✟✲❞✲❲❇❡✺❊❋✡✸✮✶✵❿❨✾✡✲❞➋❣❼❭✸☞✶✵❿❨✸✩✸✟❋♠✱✡✾✖✴❞❩❊✳❝✶✹❇☎✺✵✴✮②➍➌ ❪❬✸❴✴❞❩❊✳❝✶✹✸❾✶❁✱✡✸➈✴✷❀❊❼✖✴✷✶✹❇♣❋❴✶✹✳✻❇☎✺▲❇☎❢✙❈❊❇☎❋✡❱✣✸❴✴✂✳❹❋➎✲✘✸✙✴❲✸☎❇✟✲✘❱☎✱➏✾❭❋➏❛❞✸✮✶✹❇✟✺t⑦✡✲❲✾❅❿❖✶❁✱➏❇✟❋✡❢➈✶❁✱✡✸➄❋✡✸☎✾✡❋✡❇☞✶✹❇☎✺⑤❇☎❢✡❇✟❩✙✶✹❇☞✶❁✳♦✾❭❋➈✶✹✾ ✸☞➐✐✶❁✲✘❇☞❀✡✶✹✸✟✲❞✳✻❋❅✸➑✺✎✳❹❛✹✸➒✶❁✱✡❇☞✶➓❢✙✲✘✾✙❈❊✸➔✶❁✱✡✳✭✴s❢❅❻❅❋❊❇❴❫❨✳✎❱☎❃★✶❁✱❅✸→❱☞❀❊✲❞✲❲✸✟❋❴✶▼✴✷✶✹❇✜✶✹✸❽✾✡❛s✴❲❱☎✳✭✸☎❋✣✶❞✳✻❛❞✳➉❱➒➋❉❋❅✾❅❿❬✺✻✸☎❢✙⑦✌✸➑✳✵✴ ✳✻❋✖✴✷❀✌❛❞❛❞✳✎❱☎✳✎✸❡❋✣✶✤❛❁✾✡✲▲✲✷❀❊✺✻✳✻❋✡⑦➈✾✙❀✡✶r✶❁✱✡✸♠✲✘✳✭✴❞➋➉✾❉❛t❼❅✲✘❇☎✳✻❋➈❢✡❇☎❫❚❇✟⑦✌✸➣❱☎✺✻✾✖✴✘✸☎✺✻❻➉❇❴✴✮✴✘✾❊❱☎✳✻❇☞✶✹✸☎❢❾❿❨✳❝✶❁✱❾✶❁✱❅✸➣✳✭❫❚❫❚❇☞✶✵❀❊✲❞✳❝✶❁❻✓✾❉❛ ✶❁✱✡✸❾❼✡✲❲❇❡✳✻❋➓❢❴❀❊✲✉✳✻❋✐⑦↔✳❝✶✘✴✂✸✩➐❭◗✈❀✡✶✹✸✟✲✘✾↔❢✡✸✮❈❊✸☎✺✻✾✡❩❉❫❨✸☎❋✣✶❖✳❹❋➈❈✌✸✟✲❁❻P❩✡✲❲✸☞✶✹✸✟✲❞❫↕❱☎✱✡✳✭✺✎❢✙✲✘✸☎❋✖②r➁r✱✡✸♣✲✘✸☎❛❁✾❭✲✘✸✩❃t✲✘✸❴✴❁❀✖✺❝✶✘✴✂❛✵✲✘✾❉❫ ❩✡✲✘✾➅✴✹❩❊✸☎❱☞✶❁✳❺❈❊✸❣✳✻❋✙❈✌✸✙✴✷✶✹✳❺⑦❊❇☞✶✹✳✻✾✡❋❉✴➙✴✷❀✌❱☎✱➄❇❴✴①④▲❇♣✲❞✲✘✾❊⑥❴❀✌✸❣❇✟❋❅❢❾❱✣✾✡✺❹✺✎✸☎❇♣⑦✙❀✌✸❅✴➜➛✒❇☎❋❅❢➄✾❴✶❁✱✡✸✟✲✜✴✹➝✽✴✘✱❅✾❅❀✌✺✻❢❾❼❊✸❣✳✻❋✣✶✹✸✟⑦✡✲✘❇☞✶✹✸☎❢ ✳✻❋➃❇➄✶✹✸❡✺♦✸☎✾❉✺✻✾✡⑦❉✳♦❱☎❇☎✺➊❩❊✸✟✲✜✴✹❩❊✸☎❱☞✶✹✳❺❈❊✸➞❼❭✸✟❻✡✾❊❋✡❢➟❫❚✸✟✲✘✸☎✺❺❻▼❋❊✸☎✾✡❋✡❇☞✶✹❇☎✺➙❱☎❇✟✲❲✸☎❃✽❛❁✾✡✲❣✶❁✱✡✸✣✴✘✸➠✳✻❋✙❈✌✸❴✴❁✶❞✳➡⑦❊❇☞✶❞✳♦✾❭❋✖✴✂❩✡✲✘✾❅❈❊✳✎❢✡✸ ✸❴✴➂✴✘✸☎❋❴✶✹✳✻❇☎✺✤❇♣✲❞⑦✙❀✖❫❚✸☎❋❴✶✘✴❘❛❁✾❭✲✿❩✡✲✘✸✮❈❊✸☎❋❴✶✹✳✻❋✙⑦➎❩✡✲✘✸➄❫❨❇☞✶✵❀❊✲❞✳❝✶❁❻❅❃➢❿✂✱✡✳✭❱☎✱➎✳✵✴❖❛❞✸☎❇✣✴✘✳♦❼✌✺✎✸➄✾❭❋✡✺✻❻➈❿❨✳❝✶✹✱➎❇➣✶✵❿✂✾❊◗✷❩✡✲✹✾❭❋✐⑦❊✸☎❢✡❃ ❼❊✳✻✾❉❫❚✸☎❢✡✳✎❱☎❇☎✺✖❇☎❋❅❢❬❩✖✴❞❻❭❱☎✱✡✾✖✴✘✾❊❱✟✳✎❇❡✺❊❇♣❩✡❩✡✲✘✾❉❇✩❱✟✱✖② ● ❋❅❢✡✸☎✸☎❢✡❃➤❿❬✾❭❫❬✸❡❋➥❇☎❋✡❢➦❩✡✲✘❇☎❱☞✶❁✳❂✶❞✳✻✾✡❋✡✸♣✲✜✴➎✴✘✱✡✾✙❀✖✺✻❢➔❼❭✸s✲❲✸❡❫❨✳✻❋❊❢✡✸☎❢➃✶❁✱✡❇☞✶✹❃♠❢✡✸✣✴❞❩✡✳❝✶✹✸➟❫❬✸☎❢❭✳✎❱☎❇☎✺❨❇✩❢❅❈❭❇❡❋❅❱☎✸✙✴✘❃➊✶❁✱✡✸ ❫❨✾✡✲❞❼❊✳✻❢P✾✙❀✡✶❖❱♣✾❭❫❬✸❅✴✂✾✡❛➊❩✡✲✘✸♣⑦❉❋❅❇❡❋❊❱✟❻❅❃✤✸✙✴❞❩❊✸✩❱❡✳✎❇☎✺✭✺✻❻➏❩✡✲✘✸➅❫❚❇☞✶✵❀❊✲❞✳❝✶❁❻❅❃✤❇✟✲✘✸➄❩❊❇✟✲✷✶❁✺❺❻➓✺✭✳✻❋✡➋❊✸☎❢➞✶✹✾P❩✖✴❁❻❊❱☎✱✡✾➟✴❲✾❉❱♣✳✻❇☎✺ ❢✡✸☞✶✹✸✟✲✹❫➣✳✻❋❊❇☎❋❴✶✘✴✹➧✤✴✷❀✌❱☎✱❨❇❴✴①❩✡✲✘✸♣⑦✡❋❊❇❡❋❅❱✟❻❚❢✡✸☎❋✡✳✭❇☎✺✌❇☎❋✡❢➣❩✡✲❲✸☎❱☎❇✟✲❞✳♦✾❅❀✝✴▲✴✘✾❊❱☎✳✻❇☎✺✒✴✘✳❝✶✵❀✌❇☞✶❁✳♦✾❭❋✖✴➜②✙➨❖❢❅❈❭❇☎❋✡❱☎✸✙✴①✳✻❋❾❋✡✸✩✾❭❋❅❇☞✶✹❇❴✺ ✳✻❋❴✶✹✸☎❋❉✴✘✳❺❈✌✸♠❱✩❇✟✲✘✸❣❫♠❀❆✴✷✶r❋❅✾❅✶❵❫❨❇✙✴❞➋❨✶❁✱✡✸❣❋❅✸❴✸✩❢❾❛❁✾❭✲✘❃✌✾❭✲r❼❊✸❣❫❚❇☎❢✡✸✿✶❁✾➣✶❁✱✡✸❖❢✡✸☞✶❁✲❞✳✻❫❚✸☎❋❴✶➢✾❭❛❁❃❭✶❁✱❅✸❣❫❚✸☎❇☎❋✖✴⑤❇☎❢✡✾❭❩✙✶✹✸✩❢ ✶❁✾⑩❢✡✸✮❈❊✸☎✺✻✾✡❩➩❩✡✲✘✳✻❫❾❇♣✲❲❻➫❩✦✴❞❻❭❱❡✱❅✾➭✴❲✾❉❱♣✳✭❇☎✺➃❩✡✲❲✸☞❈✌✸☎❋❴✶❁✳✻✾✡❋➩❫❚✸☎❇✙✴✷❀❊✲❲✸❴✴✘❃➃✸✣✴❞❩❊✸✣❱☎✳✭❇☎✺✻✺❹❻➯✴✘✳✻❋❊❱☎✸➲④⑤❇✟✲❞✲❲✾❉⑥❴❀✌✸➳❇✟❋✡❢ ❱☎✾✡✺✻✺✭✸✩❇✟⑦✙❀✝✸✣✴♣➛✽✴✷✶✵❀✌❢✙❻➎❛❁✾✙❀❊❋✡❢➅✶❁✱✡❇✮✶➊✺♦✾➭✴➂✴➊✶✹✾➠❛❁✾✡✺✻✺✻✾❅❿❬◗✈❀❊❩➈❿❬❇❴✴❖❫❨✾❭✲❲✸➄❱☎✾❭❫❨❫❨✾❊❋➠✳✻❋↔✴✘✾❊❱☎✳✻❇☎✺✭✺✻❻➎❢✡✳✵✴➂❇☎❢❅❈❭❇☎❋❴✶✹❇✟⑦❊✸☎❢ ❱✟✱✡✳✎✺✭❢✙✲❲✸❡❋✌② ❸ ④⑤❇✟✲❞✲✹✾❊⑥❴❀✌✸ ③ ❃✙➨✿❋❅❱✣✸❡✺✙❄❆➵✂❃❅❑s❇✟✲❞✲✘✸✮✶ ■ ❃✡✸➜✶❵❇✟✺✵② ❍ ✸☞❀❊✲✘✾❊❢✡✸☞❈❊✸☎✺✻✾✡❩❉❫❬✸❡❋✣✶✹❇☎✺❊❢❭✳✵✴✘❇✟❼❊✳✎✺✭✳❝✶✹✳✎✸❴✴①❇☎❋✡❢❾✴❞❩❊✸✩❱❡✳✎❇☎✺✌❱☎❇✟✲✘✸✿✾✡❛ ❤ ◗✷❻❅✸☎❇✟✲✘◗❞✾✡✺✻❢❨❱☎✱✡✳✭✺✎❢✙✲✘✸✟❋♠❼❭✾❭✲❞❋❖❼❊✸☎❛❁✾❭✲❲✸ ❶✡❶ ❿❬✸☎✸✟➋✖✴➢✾❭❛✝⑦❊✸❴✴❁✶✹❇☞✶✵✳✻✾❊❋❨⑧✈✶❁✱✡✸ ❏ ❄ ● ❄❆➨❖❳ ❏ ✴❁✶✵❀✌❢❴❻ ❷☞➸ ❇➤✺♦✾❭❋✐⑦❉✳❝✶✵❀✌❢✡✳✻❋✡❇☎✺ ❱☎✾✡✱✡✾✡✲✈✶❵✴✷✶✵❀✌❢❴❻✌②☞➺r➻✡➼❊➽☎➾❡➚ ❦❊❯✡❯ ⑨✡♥ ❶✡❙✒❥✐➸ ⑨ ❥♣❶❴➪❊❦❊❯ ② ➌ ■ ❿❣❻❅✸✟✲✒❄✝✼✂②✐➶➤✲❞⑦❊❇♣❋✡✳✈✴❲❇☞✶✹✳✻✾❭❋❬✾❭❛✝❩❊✸✟✲✘✳✻❋✡❇☞✶✹❇☎✺❝➹❁❋❅✸☎✾✡❋❊❇☞✶✹❇☎✺❊❱☎❇✟✲✘✸✙②➂➘✿➽✣➚♦➻✿➴✤➻❊➾♣➷❊➬❹➻✌➚♦➮⑤➱❊✃❞❐✡❐▲❒ ❥♣➇✡➇✡❶ ♥ ❶ ⑨ ❤✌➸✝❥✜➪①❥ ⑨✡② ➝✒❮❰✾✡✾❉❢ ❍✓■ ❃❅❑s❇✟✲❞✺✻✾✙❿ ❍ ❃❊✰✤✾➭✴✵✶✹✸✟✺♦✾❉✸✽Ï✂❃❊❳❣✳❺❼✝✴✘✾✡❋♠➨❖➁①❃❅❮➦✳✎✺✻➋❉✳✻❋✖✴✘✾✡❋❨➨➊✼✂② ❍ ✸☞❀❊✲✘✾✡✺✻✾✡⑦❉✳✻❱✿❇☎❋❅❢ ❢✡✸☞❈❭✸❡✺♦✾❭❩❊❫❚✸❡❋✣✶✹❇☎✺❊❢❭✳✵✴✘❇✟❼❊✳✎✺✭✳❝✶❁❻❚❇☎❛✭✶✹✸✟✲①✸☞➐✐✶❁✲✘✸✟❫❨✸☎✺❹❻❬❩✡✲✘✸☞✶✹✸✟✲❞❫❽❼❊✳✻✲✷✶❁✱✖② ❏ ❄ ● ✰t❀❊✲✘✸ ■ ✶✵❀✌❢❴❻❬❳➤✲❲✾❅❀❊❩✌②☞Ð↔Ñ▲➼✣Ò✝❒✙Ó✤Ô➀➾✟➷ ❦❊❯✡❯✡❯ ♥ ❶✙Õ❊❶✝➸✙❶✡❙ ⑨ ➪ ⑨ Õ ② ➧ ➨✿❋✡❱✣✸☎✺✙❄❆➵♠❃ ■ ❇☞❀❊✲✘✸☎✺✻◗❞✰t❀❊❼❊✳✻Ö✣✾❉✺✻✺✎✸❴✴✒❑▼×✮❃✙❪❨✳✙✼❘✸☎❋✙Ö✣✾❚❳❣✰▲❃❴❄❵❇✟❩❊✳✻✸✟✲✘❋✡✳✻➋ ❏ ❃ ③ ✲✘q☎❇✟✲✵✶❆❳❨② ■ ✾❉❱♣✳✻❇☎✺✖❢✡✳✻❛❞❛❆✸✟✲✘✸☎❋✡❱✣✸❴✴ ✾✡❛➭❈❭✸✟✲❞❻♠❩✡✲❲✸☞✶✹✸✟✲✘❫➒❼❊✳✻✲✷✶❁✱❨✳❹❋ ❏ ❀❊✲✘✾✡❩❊✸ ➸ ✳✻❋❴✶✹✸✟✲✘❇✩❱☞✶❁✳✻✾✡❋❣❿❨✳❝✶✹✱❨✾❴❼✖✴❁✶✹✸☞✶❁✲❞✳✻❱✿✱✡✳✵✴✷✶✹✾✡✲✷❻✌② ❏ ❀❊✲✹✾❭❩❅✾❭❩❨❳✿✲✹✾❅❀❊❩✌②✘➘❘Ø➀Ó
