Coupling the Cell cycle and the Circadian Cycle
Texte intégral
(2) INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET EN AUTOMATIQUE. Coupling the Cell cycle and the Circadian Cycle Laurence Calzone — Sylvain Soliman. N° 5835 February 2006. N 0249-6399. ISRN INRIA/RR--5835--FR+ENG. Thèmes SYM et BIO. apport de recherche.
(3)
(4)
(5) !"
(6) #$" '% &)(!*,+.-!/0+213&)465078-!+ 9;:=< 4?>@&)A6- : 7)46A6BC&)DFEHG,I3J,K'L.MONPJ
(7) QSR"TVUXWYL[Z\K]QVG,I^J_KK]Z[Ia`@b0cedgf.hHJ,KFJ
(8) Q'L\Z[K]QVG,I3J,K`Hdibjcibjk0dif.hHJ_K lnmVbjopJ Qrqbjs.QVmutvdis.QVJ_K w'tjxHx)bjmVQyHJzmVJ_{uEHJ
(9) mu{uEHJ|s)};~jj.~WHJ
(10) `mVhtjmVZ vj0OW_~axtjkjJ_K ∗. ∗. ,
(11) Hjj q"tvs{
(12) J
(13) mQmVJ_tQI^J,s.QK`t0K]J_yObjsOQEHJntjyHI^disHdgKpQmtvQVdibjsObv\I3J,yHdi{
(14) desHJ_KtvQy\de)J,mVJ,s.QQVdiI3J,Kbj QEHJ'yHtZE@tjJ"`@J,J
(15) sK]EbsQbz`@JI3bjmJ"J { diJ
(16) s.Qntvk.tvdisK]Q!Itjcedikjs3{ J,cecgK;tvsy^ciJ,KK;yHtvItjkjdisHkSQb"tjmyK EJ,tvceQVE[Zb0sHJ,K, DFEHJ_K]JmJ,KVhHceQKOI3dek0E.Q`@JmJ
(17) cgtQJ,yQVb¡QVEJmVJ_{ J
(18) s.Qy\dgK{ bjJ,mVZ¡bj"cides¢[K`@J
(19) QpJ,J
(20) s£QVEHJ {
(21) demu{
(22) t0y\dgtvs{ cib\{u¢ { bjs.QmVb0ceciJ,y¥`[ZQVEJcidek0E0Q ¦yHtjmV¢¡{ Z\{
(23) ceJabvntytZ\§ tvsy¡QEHJ3{ J
(24) cic!{ Z\{ ciJj O¨'b"J
(25) 0J
(26) m deOI3tjs[Z©I3b[yHJ
(27) cgK¤ EtjJ`)J
(28) J
(29) sªy\J,jJ,ceb0x@J_y©Qb©y\J,K{ mde`)J¡`@bjQVE«bv¬QVEJ,KVJ¡{
(30) Z\{ ciJ,K Qb£b0hHm¢[sHbciJ,y\k0J sbjsHJaEtjK¬y\J,K{ mdi`@J_ytmJ,tjcdis.QVJ,mt0{ QVdibjs¥`)J Qp"J
(31) J,sQEHJ
(32) I¡ z£JadicecQmVZQVbJ,K]Qtj`HcidiKVEtmJ
(33) cgtQdeb0stQ tI3bjciJ,{
(34) hHcgtvmzciJ
(35) jJ,c®tvsy2"Jdecic;QVEJ
(36) sKpQhy\ZQVEHJ{
(37) bjsy\deQVdibjs@KObvFJ
(38) s.QVmutvdisHI3J
(39) s.Qzdes¯x)J
(40) mdeb\y2bv"QVEHJ_K]J {
(41) Z\{ ciJ,KdeQVE¥QEHJI3b\y\J
(42) cidisHkJ
(43) s[[dimVb0sHI3J
(44) s.Q'RTVUzq"¨r°SN @T±s¥bvQEHJ
(45) mrb0myHK "JzdecicKVJ,tjm{uE¡EHb²tvs@y EJ
(46) mJ¬dis¡QVEJzxtvmutvI3J QJ
(47) mKVxtj{
(48) Jzbv!bjhHmI3b\y\J
(49) cQVEHJOQp"b{ Z\{ ciJ,KFk0J QSKVZ[s{uEHmbjsHdi³
(50) J_y ;DFEHdiKQVJ,{uEsHdi{,tvc mJ
(51) x)bjmVQ®dicec)des@K]dgKpQbjs3QVEJr{ b0sy\deQVdibjsKnbvJ
(52) s.QmtjdesHI3J,s0Qbv8QVEHJ¬{ J,cec){ Z\{ ciJ'`[ZQEHJr{
(53) demu{
(54) t0y\dgtvs{ Z\{ ciJ[dit t3{
(55) bjI3I3bjsxHmVbjQVJ,des¢[dest0K]JOª´®´Sj µ¥¶.·8¸¹º »j qJ,cec{ Z\{ ciJ {
(56) demu{
(57) t0y\ditjs{
(58) ceb\{u¢ ItQVEJ
(59) ItQdi{,tvcI3b\y\J
(60) c J
(61) s.QmtjdesHI3J,s0Q. ∗. ¼@½¿¾uÀ?Á±Â!Ã8¾ Ä
(62) Â?½6ÅuÆÇÄ Â?Á]ÈÉ'Ê ËpÌÍ\ÎiÏÐpÑ,ÒVÓuÔ
(63) ËpÌÍ Õ_Ð±Ô ÑÐ]Ë\ÎgÖ Ñ. Unité de recherche INRIA Rocquencourt.
(64) ¡ P 3"
(65) " !"
(66) J,K!J
(67) [x
(68) mdiJ
(69) s{
(70) J,Km _{ J,s0QJ,KI3bjs.QVmJ
(71) s.Q;f0hJ"ciJ"QVmutvdeQVJ,I^J,s.Q!y\J_K;{
(72) tjs{ J,mKxtvm;y\J_K;{uEHdiI^dib QE
(73) mutvxdeJ_Knx)J
(74) h\Q QmVJ¬K]J,sKVde`HciJ
(75) I3J,s0QFxHcihK"J {
(76) t0{ JrJ QFI^b0des@K®QmtjhHItQVdgKtvs.QKVd)ciJ,K"{ Z.QbvQVb \dgf.hHJ,K"K]b0s.Q t0y\I3desdiK]QVm ,K y\de ,mVJ,s.QKI^b0I3J
(77) s.QKy\JrcgtFopb0hHmVs
(78) Jj nqJ
(79) Q]QVJ¬{ b0sKpQutQutQVdibjsJ_KpQ I3J QVQVmJSJ,sxtvmutvciciG
(80) ciJ t0J,{cit£y ,{
(81) bjhH0J
(82) mVQVJm _{ J,s0QJyHJcideJ,sK3J
(83) s.QmVJc EHb0mVcibjk0J{ dimu{
(84) tjyHdeJ,sHsHJ { b0s.QVm jc
(85) Jx@tvm3c tvceQVJ,mVs@tvs{
(86) J cihHI3diG
(87) mJ¦b0`K{ hHmd Q _§FJ
(88) Q¬ciJ3{ Z\{ ciJ^{
(89) J
(90) cicehcitjdemJj qJ
(91) x)J
(92) s@yHtvs.Q KVd!y\J,K¬I3b\y\G
(93) ¤ ciJ,KOy\J3{ J_Kry\J,h { Z\{
(94) ceJ_KSb0s0Q y po Q ¡y ,jJ
(95) cibjx!x _K tjh{ hHsCsHJy ,{ mdeQ^m
(96) J,ceciJ
(97) I3J
(98) s.Q sHbjQVmJ{
(99) bjsHstjdiKKtvs{
(100) J "c dis.QVJ
(101) mutj{ QVdibjsJ,s0QmVJ J,h $ #SbjhK3xHmbjx)b0KVbjs@Ka%y Qutv`Hcidim^hsHJQVJ
(102) ciciJmJ
(103) cgtQdeb0sCtjh sHdijJ_tvh I3b0&c _{ hHcgtvdimVJxHhHdg'K Qhy\dibjsK^ciJ,K {
(104) bjsyHd Qdeb0sKO%y J,s.QVmutvdisHJ
(105) I3J
(106) s.QzJ
(107) s£x
(108) mdeb\y\J3y\h{ Z\{ ciJ3{ J
(109) cicihHcitjdemJj ^´®s¯%y tvh\QmVJ_K¬QVJ
(110) mI3J,K sHbjh@Kztvciceb0sK 3"c tvdgy\Jy\Jz"c J,s.[dimVb0sHsHJ,I^J,s.QSy\JzI3b[y
(111) cidiKtQdeb0s¡R"TVUzq"¨r°SN mJ,{uEJ
(112) mu{uEHJ
(113) myHtjsK"c J_K]xt0{ Jzy\J_K'xtjmt I3G
(114) QVmJ,KciJ,KSm ,kjdibjsKy\JaK]Z[s{uEHmbjsdiKtQdeb0sy\J_KSy\J,h ¥{ Z\{ ciJ,K, qJmtjxHx@b0m]QSKVJz b\{
(115) tjcedgKVJzJ
(116) s¥xtjm]Qdi{
(117) hHcediJ
(118) m KVhHm®ciJ,K{ b0sy\deQVdibjsK%y J,s.QVmutvdisHJ
(119) I3J
(120) s.Qny\h{ Z\{ ciJ'{ J,cecihHcgtvdimVJxtjmnciJS{ Z\{
(121) ceJ'{
(122) demu{
(123) t0y\deJ,(s ¬QVmutjJ,mK!cgtz¢[des@tjKVJ ª´n´'j )º _ ¸ + * qZ\{
(124) ceJ{
(125) J
(126) cicehHcgtvdimJ EHb0mVcibjk0J¬{
(127) demu{
(128) t0y\diJ
(129) sHsHJ I3b\y
(130) cidiKtQdeb0s¡I3tvQVE ,ItQVdgf.hHJ J
(131) s.QVmutvdisH,J I3J,s0Q.
(132)
(133)
(134) !!"
(135) #$$% & '. . a =!n q"tjs{ J,m"{uEmVb0sHbvQEHJ
(136) mutvxHdiJ,KtvmJSI3bjmJrtjsyI^b0mVJrhKVJ,ydis¡{
(137) tvs@{ J
(138) mQVmJ,tvQVI3J
(139) s.QuK `t0K]J_ybjsQVEHJOtjyHI^dis dgK]QVmutQVdibjsbv=I3J_y\di{
(140) desJ,KtQ'y\de8J
(141) mJ
(142) s.QQdeI3J_KFbv=QEHJzyHtZj ;DFEHJ,ZEtjJ¬`)J
(143) J
(144) s¡KVEHbsQb^`)JO`@bjQVEI3bjmJ J
(145) { diJ
(146) s.Qtvk0tjdes@KpQ¬I3tjcedikjs£{ J,cecgKztvsy2ciJ,KK¬ytvItvk0desHkQVbFtvmuyHKrEHJ,tjc QE.Z¥b0sHJ,K* ,+ 3DFEHJ,KVJ3mVJ_K]hHceQK I3dikjE.Q`)JmJ
(147) cgtQJ,y£Qb¥QVEHJmJ,{ J,s.Qay\dgKV{
(148) bjJ
(149) mZbj'cedisH¢\K`)J Qp"J
(150) J,s¯QVEHJ¡{ dimu{
(151) tjyHditjs¯{
(152) ceb\{u¢ ¤ {
(153) bjs.QVmbjciceJ_y `[Z2QVEHJcedikjE.Q ¦vyHtvm¢2{
(154) Z\{ ciJbvSt¥yHtZH§ tjsy£QVEHJ{ J
(155) cicF{ Z\{ ci-J */. , +6 ¨SbJ,jJ
(156) m de'Itvs[ZI3b\y\J,ciK E@tjJO`@J,J
(157) sy\J,jJ,ceb0x@J_yQby\J,K{ mdi`@J`)bvQE¥bvQVEHJ_K]Ja{ Z\{ ciJ,K sHb0sHJzEtjKSy\J,K{ mde`)J,y¡t3mJ,tjcdes.QJ
(158) mutj{ Qdeb0s `)J Qp"J
(159) J,sQVEHJ,I RFtjKVJ,yb0s¡QVEHJ{
(160) bjhHxcedisHkbv!Qp"b3s.hI^J,mVdg{
(161) tjcI3b\y\J
(162) cgK bjsHJ bjmQEHJ{ dimu{
(163) tjyHditjs{
(164) Z[{
(165) ceJ yHdemJ,{ QVciZatjytvx\QJ,ya mVb00 I *Ç~ + tvs@ytrk0J
(166) sHJ,mVdg{FbjsJ b0m;QVEJS{ J,cec{
(167) Z\{ ciJ disK]xdemJ,y^`[Z * 1+@tjsyaQVEHJ,sI3b[yHd 2 J,y^QVb 2 Qnbjhm®sHJ
(168) J_yHKu§ J'dicicHQVmZaQVbJ_KpQutv`HcidiKVEtzmJ
(169) cgtQVdibjstvQtO`Hdi¤ b I^b0ceJ_{ hHcgtvm;ciJ
(170) 0J
(171) c6 DFEJ
(172) s hKVdesHk QEHJzI3b\y\J
(173) cideskJ
(174) s[[dembjsHI3J,s0QR"TVUzq"¨S°r3 N * +="J¬dicic=KpQhy\ZQVEHJ{
(175) bjsy\deQVdibjs@Kbv!J
(176) s.QVmutvdisHI3J
(177) s.Qdis x)J
(178) mdib[ybjQEHJ,KVJ{ Z\{ ciJ,K dis¥bvQEHJ
(179) m"bjmuyHK EHb tjsyEHJ
(180) mJzdisQEHJxtjmtjI3J QVJ,m'K]x@tj{ JObjb0hHm'I3b\y\J
(181) c QEHJrQpb^{ Z\{ ciJ,K"kjJ
(182) Q"KVZ[s{uEHmbjsHdi³
(183) J_y DFEbjhHk0EK]b0I3JrbjQVEHJ,mcides¢[K"Et0JSmJ,{
(184) J
(185) s.QVciZ3`@J,J
(186) sE[Z[x)bvQVEJ,KVde³,J,y QEHdgK^QVJ,{uEsHdi{,tvcFmJ
(187) x)bjmVQadicecdisKVdiK]Qbjs©QEHJ¥{ b0sy\deQVdibjsK^bvrJ
(188) s.QVmutvdisHI3J
(189) s.Q3bvSQEHJ¥{ J,cec{ Z\{
(190) ceJ`[ZQVEHJ {
(191) demu{
(192) t0y\dgtvs{
(193) Z\{ ciJ¬[dgt3t^{
(194) bjI3I3bjsxHmbvQVJ,des¡¢[distjKVJrª´n´'j (. ). 4564. 798;:8<8;:>=6?6:@BAC?EDFA :>GH?E:>@IAJKAC=6L. 45WV. XZYK[\L]DF?^8;L_@a`:>=SLCbc?^GcL_@HA Ledf-=6?6@QgKhji\LC`klL]Lm@n`ocLpAC?6DFA :>GQ?E:>@n:>@HGqA L_=^= AJcAC=6L_h r*/.,+ ,. T±sªItjs.Z bjmk0tjsHdgK]IK KVx@b0s.QtvsJ
(195) bjh@Kb0K{ dicecgtQdeb0sKdeQVE t©x@J,mVdib\yª{ cib0KVJ¡QVb MEHbjhmKE@tjJ`)J
(196) J,s b0`KVJ
(197) mjJ,y "°${
(198) bjI3xHciJ, ¡sHJ Qp"bjm¢bj;xHmVbjQVJ,desK KVJ
(199) s@K]deQVdijJOQbcedikjE.Q dgK'b0mVk.tvsHdi³
(200) J_yQbItvdis0Qutvdis¡QVEHJ_K]J b.KV{
(201) decicgtQVdibjs@KatvQaQEHdiK3x)J
(202) mdib[y T±s I3tjI3I3tjcedgtvs { J,cecgK Qpb£Itopbjm^xHmbvQJ
(203) disK3tvmJQmtjsKV{
(204) mVdi`)J,y©disCt {
(205) demu{
(206) t0y\dgtvsOItvsHsHJ,m Oq NUzOq P tvs@yzR"NQ° N®nEHdi{uEz`desyzQVb b0mVI²tEHJ
(207) QVJ
(208) mb\y\diI^J,m=mJ,KVx@b0sKVde`HciJ! bjm=QVEHJ QmtjsK{ mdex\Qdeb0sbj F# ¤ x@J,mVdib\y§Ftvs@y #R ¤ {
(209) mVZ[x\Qb[{uEmVb0I^J§ nDFEJOQpbsHJ,ceZ 6 bjmI3J,yxHmVbjQVJ,desK"QEHJ
(210) s `desytvsyt0KSKVb[bjstjKSQVEJatj{ QVdi[d QpZbv;QEHJ^{
(211) bjI3xHciJ, ¡mVJ_tj{uEHJ_K'tQEHmJ,KVEHbjcgy l®´nwr¦0q"w=M tjKKVb[{
(212) ditvQVJ_K deQVEQVEJO{
(213) bjI3xHci,J Oq N!UzOq P¦RFNQ° Nn'QbadisHEHdi`HdeQ'd QuK"t0{ Qde[deQpZtvsyQVEHJ,mVJ
(214) bjmJSQEHJ¬QVmutvsK{ mdix\QVdibjsbj QEHJQp"bxHmbvQJ
(215) disK;l®´nwXtvsyq"wM^ 0HmbjI QVEdiKnsHJ
(216) k.tQVdijJF J,J,y\`@tj{u¢^ceb[bjx b0K{ dicicitvQVdibjsK®tjmVJ`)bjmstvs@y Itjdes.QtjdesJ,y !° I3b\y\J
(217) c)xHmbjx)b0KVJ,y3`[SZ NJ
(218) cibjhxtvsy T¬b0ciyH`@J
(219) QVJ
(220) mbjsItjI^Itjcedgtvs{
(221) J
(222) cic@{ Z\{
(223) ceJ¬y\J,K{ mde`)J,K dis¡I3bjmJ¬y\J
(224) QtjdecQEHJzsHJ,k0tQde0JS J,J,y\`@tj{u¢cib[bjxKFdis[jbjcijJ_ydisQVEHdgKI3J,{uEtjsHdgK]U I *Ç~ + NtQKVhHbtjsy{ b0ceciJ,tjkjhHJ_K b0`K]J,mV0J,ymJ
(225) kjJ,sHJ
(226) mutQdesk^cidijJ
(227) m¬{ J,cecgKStjsy¡I3J,tjKVhHmJ,yQVEJJ \xHmJ,KKVdeb0sbj xmVbjQVJ
(228) disKzdis[jb0ce0J,y2des¯QEHJ{ J,cec"{ Z\{ ciJI3J,{uEtjsHdgK]I tQy\de8J
(229) mJ
(230) s.QEHb0hHmKbvFQVEHJyHtZ J,KVx@J_{ dgtvciceZ2QVEHJ ª´n´'z¢[dest0K]JOtvs@ydeQK"QutvmkjJ Q QVEHJz{ Z\{
(231) cedis ±y\J
(232) x)J
(233) syHJ
(234) s.Q'¢[dest0K]J st ®DFEHJOª´®´Sz¢.dist0K]JzKVJ
(235) J
(236) IKQVb `)JSk0b[b[yt{
(237) tjsy\dgyHtQJQVbaJ,K]Qtj`HcedgKVEtcides¢^`)J Qp"J
(238) J,sQVEJ¬{
(239) J
(240) cic)tjsy{ dimu{
(241) tjyHditjs{ Z\{ ciJ,Ky\hHmdesHkQVEHJ\Tz NPQmtjsK]deQVdibjs ¤ K]J,JzsH,J [QrKVJ,{ QVdibjs bjm'I3b0mVJy\J
(242) QtjdecgK§ nT±syHJ
(243) J,y IhHQtQdeb0sKbj!{
(244) demu{
(245) t0y\ditjsk0J
(246) sHJ_KEt0J tyHdemJ,{ QSdeI3xt0{ QSb0vs u sxw I3w #S°tjsyxHmbvQVJ,des¥x@tQ]QJ
(247) msK, Fbjm'
(248) J HtvI3xHciJ tyHJ 2 {
(249) deJ,s0Q #R Iah\Qtjs0Q J
(250) \EHde`d QuKzEHdikjE£ceJ,jJ
(251) cgKObvr u sxw Iw #r° QVEmVb0hHkjEHb0h\QOmVJ,kjJ
(252) sJ
(253) mutQVdibjys */.+ K]hHk0kjJ_KpQdesHkQEtQª´®´SdiK mJ
(254) k0hHcgtQVJ_yz`[ZK]b0I3J{ b0I3x@b0sHJ
(255) s.QKbvQVEHJ{ dimu{
(256) tjyHditjs{ Z\{ ciJj DFEHJF{uEtvsHk0Jndis3q qF St0{ Qde[deQpZzI^dikjE.Q!`@J t3{
(257) bjsKVJ,f.hHJ,s{ J¬bvQVEHJ{uEtjsHkjJ¬disª´®´Sj nDFEHSJ u sw kjJ
(258) sJ¬xmVb0I^bjQVJ,m"dgKF`)J
(259) cideJ,jJ,yQVb3`)Jtj{ QVditvQVJ_y `[ZQEHJ{ b0I3xHce
(260) J ¡Oq NUzOq P¦vRFNQ° Nn¬tjsydisHEHdi`HdeQVJ_y`[Z¥q"w=M^ Ä. zmz {F|R}R~R|.
(261) x S C M. dek0hHmJ^>NdisH¢[desHk3QEHJ{ dimu{
(262) tjyHditjstvs@yQEHJ{ J,cec={
(263) Z\{ ciJ,KF[dit^ª´®´S DFEHJ,mVJatvmJbv®{ b0hHmuK]JzbjQVEHJ,mScidesH¢\KS`.ZEHdg{uE¥QVEJ{ dim{,tjy\dgtvs¡mE[Z0QEHI deshHJ
(264) s@{ J,K'QVEHJ^{ J,cec{ Z\{ ciJj T QFEt0Kn`)J
(265) J,s bjm"desK]Qtjs{ J mVJ,x@b0m]QJ,y3QEtQFl®´nwS mJ
(266) kjhcitvQVJ,K®QVEHJrQVmutvs@KV{
(267) mVdix\QVdibjsbj tvsydest I3b\y\J,mtvQVJFtZQEtQ¬bv S
(268) t * M+ cidesH¢\K'QVEHmbjhHk0E W ¤ QdeI3J,ceJ_KVKu§'tjmVJtjciKVbE[Z.x)bvQEHJ,KVdi³
(269) J,y *e , +6 ¨SbJ,jJ,m QEHJxHmJ,{
(270) diKVJzI3J,{uEtjsHdgK]IKdis[jbjcijJ_y¡tvmJKpQdecicsbvQr{
(271) bjI3xHciJ QVJ,ceZ{ ciJ,tjmrtvs@ymJ,f.hHdimJtjJ,mVZ yHJ QtjdeciJ,y3y\J_KV{
(272) mVdix\Qdeb0sabj@QEHJS{ J,cec@{ Z\{ ciJ dis{
(273) cehyHdesHk #S° ytvItvk0JmVJ_K]x)bjsKVJ xHmVJ_{ dgK]JF´ `)b amJ
(274) cgtQVJ_y QmtjsK{ mdex\Qdeb0sI3J,{uEtjsHdg{
(275) K yHdiK]QVdis{ Qdeb0s`)J Qp"J
(276) J,sl®´nw l®´wS tjsyln´nw' J Q{j zT±sQEHdiKOmJ
(277) x)bjmVQ "J'dicec@QVE[hKmJ,K]QVmdi{ QnbjhHm"KpQhy\Z^QVbQVEHJ¬cedisH¢3J,K]Qtj`HcidiKVEHJ,y^QEHmbjhHk0Eª´®´' EHdg{uEdicec8tvcicibChKnQVb mJ
(278) ciZb0stK]diI3xHciJ
(279) mStjsy¡I3bjmJzkjJ
(280) sJ
(281) mdi{OI3b\y\J
(282) cbv!QVEJ{ J,cec{ Z\{ ciJ b\{
(283) hK]J_y¡bjs¥I3deQVb0KVdgK
(284) F°SKry\J QutvdiceJ_y disQVEHJyHdiK{ hKKVdeb0s t3I^b0mVJO{ b0I3xHceJ
(285) QVJzI3b\y\J
(286) cdgK'{
(287) hHmVmJ
(288) s.QceZhHs@y\J
(289) mSK]QVh@y\Zj 45. 79h?68;[H=^? HLmGL_@QL]DF?^A A L_=^= AJcAC=EL. FD EJa{ J,cec;{
(290) Z[{
(291) ceJabvnKVbjItQdi{a{ J,cecgKSdgKO{ b0I^x)b0KVJ,y¡bj® bjhmrxHE@tjKVJ,K #r°mJ
(292) xHcidg{
(293) tQdeb0s ¤ LxHEt0K]J§'tvs@y {uEmVb0I^b.K]b0I3JK]J,kjmJ
(294) k.tQVdibjs NxHEtjKVJ_§aKVJ
(295) xtjmtvQVJ,y `[Z¯Qpb£k0tjx xHEt0K]J_K T^¥tvsy'Tz j§ bjm3bjhHm xhHmVx)b0KVJ QEHJI3b\y\J
(296) cy\J,K{ mde¤`desHkt3k0J
(297) sHJ,mVdg{O{ J
(298) cic={
(299) Z[{
(300) ceJOdicec= b\{ hKb0sQEHJ Tz¤ N QVmutvsKVdeQVdibjs¡y\hHmdesHk Edi{uEQVEJzxHmVbjQVJ,des¡ª´®´'xHcitZ\Kt3KVdek0sHd 2 {
(301) tvs.QmbjciJj nDFEHJ{
(302) J
(303) cic={ Z\{
(304) ceJOdicec=QVE[hK`)Jy\di.dgy\J_ydis¡Qp"b yHd 8J
(305) mJ
(306) s.QxHEt0K]J_K QEHJ T^, pL ETz atjsyNPxEtjKVJ,K, °"QQVEHJn{
(307) J
(308) s.QVJ,m=bj.QEHJn{
(309) J
(310) cic0{ Z\{
(311) ceJ®mJ
(312) k0hHcgtQVdibjs QEHJ
(313) mJ;diKtkjmbjhx¬bj\xHmVbjQVJ,desK QVEHJ"{ Z\{ cides y\J,x@J,sy\J,s0Q ¢[distjKVJ,K, SDFEHJ^{ Z\{ cidis yHJ
(314) x)J
(315) sy\J,s.Qr¢[des@tjKVJ,KStjmVJa{ bjI3x)b0KVJ,y¥bj;QpbK]hH`hHsHdeQK t¢.dist0K]J $%t tvsyt {
(316) Z\{ cidesx@tvmVQVsHJ,mEHdg{uEayHJ QVJ,mVI3disHJ,K=QVEJ"KVx@J_{ d 2 { deQpZzbvQVEHJF{ b0I^xce
(317) J 8 DFEHJFtj{ Qde[deQpZObvHQEHJ"{
(318) bjI3xHci,J \J,K. "z.
(319)
(320)
(321) !!"
(322) #$$% & '. ~. ciJ,t0yHK"QVby\de8J
(323) mJ
(324) s.QStj{ QVdibjsK"disQEHJ{ J,cec{ Z\{ ciJj !T±sy\J,J,y tj{
(325) {
(326) bjmuy\disHkQb^QVEHJ{
(327) Z[{
(328) cedis QEHJ{ b0I^xceJ
(329) {
(330) tjs QmVdikjk0J
(331) m #S°²mJ
(332) xHcidi{,tQdeb0s bjmJ,s0QmVZdes.QVb3I3deQVb0KVdgK J
(333) Q{3
(334) , DFEHJrItopbjmbjsHJSdiK"tR?QpZ[x)JS{ Z\{
(335) cedis ;DFEHJr{
(336) bjI3xHciJ, q qF .¦{
(337) Z[{
(338) cedisR tvxHx)J,tjmKndesQpbO b0mVIK tjs t0{ Qde0Jz bjmI {
(339) tvciciJ,yN¥l ¤ b0m¬N xHEt0K]Jal®mbjI3bvQdesHktj{ QVb0mu§ tjsytjsdes@tj{ Qde0J b0mVI mJ J
(340) mmJ,yQVb t0KnxmVJ_N¥ln" \DFEHJ
(341) mJ¬tjmVJ¬K]J,jJ,mtjcFtZ[K®QVb^mVJ,kjhHcgtQJSdeQKFtj{ QVdi[d QpZ0 ®UrsJSbv=QVEHJ,I des[jb0ce0J,K®QVEHJO¢[des@tjKVJ ª´n´'tjsy£QVEHJxHEHb.K]xHE@tQt0K]Jq qF j~H N¥ln²dgKxHEb0KVxHEHbjmZ[citvQVJ_y£tjsy¯distj{ QVditvQVJ_y`[Z2ª´®´S tjsy3y\J
(342) xEHb0KVxHEHb0mVZ[cgtQVJ_yatjsytj{ QVditQVJ_y^`.Zq qF 0~\ !R"bvQVE3QEHJ'¢[distjKVJ'tvsy^xHEb0KVxHEtQutjKVJtj{ Qde[deQVdiJ,K tjmVJrQVEJ
(343) IK]J,ce0J,KFmJ
(344) k0hHcitvQVJ_y`[ZN¥l mVJ_K]x)J,{ QVdijJ,ceZdistj{ QVditQVJ_y¡tvsytj{ QVditvQVJ_y`[ZQEHJ{ b0I3xHce
(345) J DFEHJxHmbvQVJ,des@K{uEHb.K]J,sOQVbrdeciceh@KpQmtvQVJ®QEHJ{
(346) J
(347) cic.{
(348) Z\{ ciJnxHmJ,KVJ
(349) s.QVJ_yOdesQVEHdgKmVJ,x@b0m]QtjmVJ"N¥ln xHmJ,N¥ln QEHJy\J,kjmutjyHtvQVdibjs¿t0{ QbjmbvQVEJ{ Z\{ cidisK °Sl"q QEHJª´®´S¢[dest0K]JztjsyQVEHJaq qF j~axHEHb.K]xEtQutjKVJ dek0hHmVJ¬,§ ´ntjmVciZzdisQVEJF{
(350) Z\{ ciJ N¥lndiK¢jJ,x\Q!dest0{ Qde0J`)J,{,tvhKVJnQEHJF{ Z\{ cidesadiKsHbjQ®K]Z[s.QVEHJ_K]di³
(351) J_ytvs@y ª¤ ´n´'FdiK!xHmJ,KVJ
(352) s.Q_ °SKQEHJ{ Z\{ cidisdgK;K]cibceZzKVZ[s0QEHJ,KVdi³
(353) J,y N¥lnt0{ QdetQJ,K!tvs@ymJ,tj{uEJ,KtSQEHmJ,KVEHbjcgy QEtQ"`@bjQVEdest0{ QdetQJ,Knª´®´'Otvsyt0{ QdetQJ,Kq qF 0~OEHdg{uEItvdis.QtvdisKN¥ln¯disdeQK"tj{ Qde0JSK]QtQJj DFEJ2{ J,cecrJ
(354) s.QVJ,mKI3d Qb0KVdiK, ªdeQVE tCK]EbjmVQy\J
(355) cgtZ °Sl"q dgKt0{ QVditQJ,y tjsy y\J,kjmutjy\J_K3QVEHJ£{ Z\{ cidis {
(356) bjI3x)bjsHJ,s0Qbj'N¥ln" DFEHJ{ J
(357) cic®
(358) J [deQKI3d Qb0KVdiKtjsy£mVJ,x@J_tQuKzd QuK{
(359) Z[{
(360) ceJ0 DFEJI^b\y\J,cndgK{
(361) bjI3x@b.K]J_y bj=Qp"b3x@b.K]deQVdijJr J
(362) J_y\`tj{u¢ceb[bjx@K ¤ q qF j~^tj{ QVditvQVJ_K"Nln©EHdg{uE¡desQVhmVs¥tj{ QVditQVJ_K'q qF 0~ tvs@y ª´n´'distj{ QVditvQVJ_KN¥ln EHdg{uE dis«QVhmVs«distj{ QVditvQVJ_Kª´®´'§tvs@y t¯sJ
(363) k0tvQVdijJ J
(364) J_y\`t0{u¢©ceb[b0x N¥ln tj{ QVditQVJ_K°Sl"q QVEHmbjhkjE tvsªdis.QVJ,mVI3J,yHditjmVZCJ
(365) sH³,Z.I3J tvsyª°Sl"q y\J,kjmutjy\J_K^QVEHJ£{ Z\{ cidis {
(366) ¤ bjI3x)bjsHJ,s0QbjQEHJz{ bjI3xHci,J ¡N¥ln;§ ¤ dikjhHmJ j§ . dek0hHmJz ;D=J,I^x)bjmutvcKVdiIhHcgtQdeb0sbjt^kjJ,sHJ
(367) mdi{O{
(368) J
(369) cic{ Z\{ ciJ Ä. zmz {F|R}R~R|.
(370) . x S C . DFEHJO`Hdib\{uEHJ
(371) I3dg{
(372) tjc)mJ,t0{ Qdeb0sKFy\J,K{ mde`desHkaQVEJOKVZ\KpQJ
(373) I tjmVJrmVdeQ]QJ
(374) sdesQVEJRTVUzq"¨r°SNPJ
(375) s[[dembjs 3I J,s0Qr* + mbjI EHdg{uEsbjsHcidesJ,tvm"bjmuy\distvmZy\de)J,mVJ,s0Qditjc8J,f.htQdeb0sKFtvmJry\J_y\h{
(376) J,y ¤ Dtv`HciJa§®deQVE QEHJ¡{ bjmmJ,KVx@b0sy\disHkxtjmtjI^J
(377) QVJ,mK ¤ Dtv`HciJ¡ j§zQEtQy\J,K{ mdi`@JQVEHJ¡t b0mVJ,I3J
(378) s.QVdibjsHJ_y`)J
(379) Et[dibjm_ £DFEHJ x@tvmutvI3J QJ
(380) muKtjmVJ{uEHb.K]J,sK]h{uE^QEtQ;QEHJS{ Z\{
(381) ceJFEt0K®tvstvhHQVbjsbjI3bjhK!x)J
(382) mdib[y^bj)b.KV{
(383) decicitvQVdibjsK!bj 0 \ MjE d[preM P F ] dt. = ksmpf + kimpf · [W ee1] · [M P F ] − kampf · [C25P ] · [preM P F ] −kdmpf · [AP C] · [preM P F ] − kdmpf p · [preM P F ]. d[M P F ] dt d[C25] dt d[C25P ] dt d[W ee1] dt. d[W ee1P ] dt d[AP C] dt d[X] dt d[W ee1m] dt d[AP Ci] dt. = = =. = =. −kdmpf · [AP C] · [M P F ] − kdmpf p · [M P F ] V ic · [C25P ] V apc + V ac · [M P F ] · [C25] + ks25 − kd25 · [C25] − Kic25 + [C25P ] Kac25 + [C25] V apc + V ac · [M P F ] · [C25] V ic · [C25P ] − kd25 · [C25P ] − Kac25 + [C25] Kic25 + [C25P ] V iw · [W ee1P ] + kswee · [W ee1m] Kiw + [W ee1P ] V apw + V aw · [M P F ] · [W ee1] −kdwee · [W ee1] − Kaw + [W ee1] V apw + V aw · [M P F ] · [W ee1] V iw · [W ee1P ] − kdwee · [W ee1P ] − Kaw + [W ee1] Kiw + [W ee1P ] kaapcp + kaapc · [X] · [AP Ci] kiapc · [AP C] − Kapc + [AP Ci] Kapc + [AP C]. = ksx · [M P F ] − kdx · [X] = =. ksweemp + ksweem · [BN ] − kdweem · [W ee1m] Kweem + kwpcn · [P CN ] kiapc · [AP C] kaapcp + kaapc · [X] · [AP Ci] − Kapc + [AP C] Kapc + [AP Ci]. Dtv`HciJ !´nf.htvQVdibjsKFbjQEHJ{ J,cec{
(384) Z\{ ciJzI^b\y\J,c. . VK564. = kampf · [C25P ] · [preM P F ] − kimpf · [W ee1] · [M P F ]. ?6@Qg ?^@. `ocL `kld<AJcAC=EL_h. DFEJQpbzI3b\y\J,ciKy\J,K{ mde`desHkQVEHJS{
(385) J
(386) cic)tjsy{ dimu{
(387) tjyHditjs^{
(388) Z[{
(389) ceJ_KntjmVJcides¢jJ,y^QEHmbjhHk0E3QVEHJQmtjsK{ mdex\Qdeb0s bj;ª´®´'j °SsJ,f.htvQVdibjs bjm u sw Iw #r° {
(390) tvciciJ,y2J,Jj,I dgK'tjyHyHJ,yQVbQVEHJKVJ Qrbv;J,f.htvQVdibjsKbj . "z.
(391)
(392)
(393) !!"
(394) #$$% & '. . H ~ H . Q t u s % . u s. . . H Ç & 00~ H j u s ~ Dtv`HciJ !l;tvmutvI3J QJ
(395) muK
(396) c t u s . H i . H Ç j~. Q &
(397) u s u u s
(398). .. e H i ~ H j.~ H Ç . c %
(399) u &$F u u $
(400).
(401) c
(402) u .
(403). . s u F . . ~ H H ~. QEHJz{ J,cec{ Z\{
(404) ceJOdisDtv`HciJ3v ;T±sQEHJOI3b[yHJ
(405) c8bvQVEHJz{ J,cec{
(406) Z\{ ciJ¬tjceb0sHJ u sxw Iw #r°²"t0Kt^xtjmtjI^J
(407) QVJ,m J_f.htvc8Qb0 ;T±sQEHJ{ b0hHxHciJ,yI3b\y\J
(408) c QVEHJzJ_f.htQdeb0s b0m2J,Jj
(409) I diKt0K" bjciceb'K ksweemp + ksweem · [BN ] d[W ee1m] = − kdweem · [W ee1m] dt Kweem + kwpcn · [P CN ]. EJ
(410) mJ|QVEHJ xHmb[yHh{ Qdeb0s bv©£J
(411) J0
(412) I diK t hHs@{ QVdibjs bvQVEJs[h{ ciJ,tjm b0mVI bvQEHJ {
(413) bjI3xHciJ, RFNH° N®¦jOq NUzqOP ¤ R#r§'tvsyQEHJhHsHxEHb0KVxHEHb0mVZ[cgtQVJ_ys.h@{ ciJ,tvm' bjmI bv!QEHJ{ b0I3xHceJ
(414) ln´nwr¦jq"wM l"q #r§ #'bjQVJ^QVEtvQOtIhHQtQdeb0sbj #R t8J,{ QK¬sHJ
(415) k.tQde0J
(416) ciZRFN°HN®¦0qONUzqOP tjsy`[Z¡J, [QVJ,sKVdeb0s Q¤ EHJIw #r° bj u sxw ¯DFEJsHJ,k0tQde0JJ 8J,{ QabjSl"q # ¤ s[h{ ciJ,tjmal®´wr¦jq"wM desQEHJI^b\y\J,cg§y\b[J,K sbvQsJ
(417) J,y QbCtjxHx@J_tvmdesªQEHJJ_f.htQdeb0s K]dis{ J2d Q¡tvcimVJ_tjy\ZCEtjKtvsªdis hJ
(418) s{
(419) Jbjs QVEHJ£tj{ Qde[deQpZCbj RFNH° N®¦jOq NUzOq P3 .¨'b"J
(420) 0J
(421) m "J¬{uEb.b.K]JSQVb^des@{ cihy\JOd QdisQEHJOJ,f.htvQVdibjstjs.Z[FtZ^QVb^desKVdgKpQFbjsQVEHJ sJ
(422) k0tvQVdijJ¬J 8J,{ QFbj®q"wM^ HDFEHJy\J
(423) k0mt0yHtQdeb0sbvO u sxw Iw #r°²diK{
(424) bjsKVdiyHJ
(425) mJ,yQVb3`@JOcidesJ,tvmEJ
(426) mJj ;°SK b0mSª´®´SxHmbvQJ
(427) dis deQKrxHmb[yHh{ Qdeb0s¥diKSxHmVb0x@b0m]Qdeb0stvcQVbQEHJtvI3b0hHs.QSbvc u sw Iw #S°xHmJ,KVJ
(428) s.QSdis QEHJF{ J
(429) cic[tvsyzdeQK!y\J,kjmutjyHtvQVdibjsOdgKt0KVKVhHI3J,yOQbS`)JcidisHJ,tjm, DFEHJnxHEb0KVxHEHbjmZ[citvQVdibjs)¦vy\J
(430) xEHb0KVxHEHb0mVZ[cgtQVdibjs QJ
(431) mIKtvmJ¬sbvQI3b[yHd 2 J_y mVb0I QVEHJzxmVJ,.dibjh@KFI^b\y\J,c d[W ee1] dt. =. V iw · [W ee1P ] + kswee · [W ee1m] Kiw + [W ee1P ] V apw + V aw · [M P F ] · [W ee1] −kdwee · [W ee1] − Kaw + [W ee1]. Urs{
(432) J3QVEHJJ_f.htQdeb0sKztvmJ3mVdeQ]QJ
(433) s QVEHJx@tvmutvI3J QJ
(434) mztvcihHJ,KOsJ
(435) J,y£Qb¡`@J{uEb0KVJ
(436) s¯{
(437) tvmJ hceciZtvs@y QEHJ,KVJr{uEbjdg{ J,KtvxHx)J,tjm®Qb`)JSciJ,KKnb0`.[dibjhK®QVEtjsJ, \x)J,{ QVJ,y ;L\J
(438) jJ,mtjctvcihHJ_Kn"J
(439) mJQVmdiJ,y3 b0m®QVEJrsHJ, x@tvmutvI3J QJ
(440) muK ¤ u s u $ \u s tvs@y u F §tvcibjsHk3deQVEQVEJbjsHJ_KFQVE@tQ'"J
(441) mJ¬mJ
(442) cgtQJ,yQVb ª´n´' ¤ u s u s tvs@y Q §atvsy¯y\dijJ,mKVJ3`@J,Et[deb0mKO"J
(443) mJ3bj`\QutvdisHJ,y DFEHJ hHcicnI3b\y\J,cndis R"TVUzq"¨r°SN K]Z[s.Qt diKFk0de0J
(444) sdes¥tjxHx@J,sy\d& VK5WV. ld. @QGH? `?Ed @Hh dfLm@ ` D:>?^@Q8;L_@a`. Db 2 sy tvcihHJ,K^ b0mEHdg{uE J,s.QVmutvdisHI3J
(445) s.Qb[{,{ hHmuK QVEJ¥xtvmutvI3J QJ
(446) mKVxtj{
(447) J b0mJ,t0{uECxtjmtjI3J QVJ,m3diK J
(448) \xHceb0mVJ_y DFEHJ2tvcihHJ,KbvzQVEmVJ,JxtjmtjI^J
(449) QVJ,mKtjxHx)J,tvmJ,y Qb©`)J2I3bjmJKVdek0sHd 2 {
(450) tjs0QQVEtjs bvQEHJ
(451) muK u s u s tjsy Q rDFEHJzQp"bxtvmutvI3J
(452) QVJ
(453) muK u s tjsy u s `@bjQVE{
(454) bjs.QVmbjcQEHJciJ
(455) 0J
(456) c=bj Ä. zmz {F|R}R~R|.
(457) . x S C . QEHJª´®´SxHmbvQJ
(458) distvsy¡KVEHb KVh{uEKVdeI3dicitjmVdeQVdiJ,KQVEtvQrdis¡QVEHJz b0cecibdisHky\dgKV{
(459) hKVKVdibjs JzdicecbjsHciZ mJ
(460) x)bjmVQbjs u s nDFEHJOxtvmutvI3J
(461) QVJ
(462) mFtvcihHJ_K'tvmJrtjmVdiJ,ydes¥t3k0de0J
(463) sdis.QVJ,mVtvctjsymVJ,jJ_tvcy\bjItjdesKFbj J,s.QVmutvdisHI3J
(464) s.QnmJ
(465) x)bjmVQVJ,y3disdikjhHmJr\ ;DFEHJrxtvmutvI3J
(466) QVJ
(467) muK®tjmVJ'xcebjQ]QVJ_yt0KntO hHs@{ QVdibjsbvQEHJSx)J
(468) mdeb\ybj QEHmJ
(469) J®xHmbvQJ
(470) disK8QEtQt0{
(471) {
(472) bjhHs.Q bjm=QVEHJn`@J,Et[deb0mbv[QVEJ;Qpb'{
(473) Z\{ ciJ,K R # ¤ RFNQ° Nn¦jOq N!UzOq P©s[h{
(474) ceJ_tvm § b0m"QVEHJ{
(475) demu{
(476) t0y\ditjs{ Z\{
(477) ceJ N¥ln b0mFQVEHJz{
(478) J
(479) cic{ Z\{ ciJ tjsyQEHJ
(480) dimFcedisH¢ ª´®´Sj ®Hb0mceb tjcehJ,KFbvQVEHJ x@tvmutvI3J QJ
(481) muK ¤ mJ
(482) kjdibjs§ N¥ln«tvs@y¥R #EtjJzdisy\J,x@J,sy\J,s0Q¬x@J,mVdib\yHK'bj®b0K{ dicecgtQdeb0sKbj® 0 \ MjE¥tvs@y jH 0~vEmJ,KVx@J_{ QVdijJ,ceZatvsy^sHbKVhK]QtvdisHJ_yab.KV{
(483) decicgtQVdibjs@K;tvmJ"b0`KVJ
(484) mjJ,y bjm®ª´n´'j ;DFEHJmJ,t0K]b0s b0m;QVEHJ x)J
(485) mVQVhmV`tvQVdibjsdes¡ª´®´'zb.KV{
(486) decicgtQVdibjs@KndisQVEHdgKFmVJ,kjdibjsdiK"QEtQª´®´'zmJ,{
(487) J
(488) dijJ_K"KVdiIhHceQtjsHJ
(489) b0hK]ciZ3Qp"b dis hJ
(490) s{
(491) J,K 8 mVb0I QEHJ{
(492) demu{
(493) t0y\ditjsz{ Z\{ ciJ;QVE@tQ{
(494) bjs.QVmbjcgK)QVEJ®QVmutvs@KV{
(495) mVdix\QVdibjsObj.QEHJnxmVbjQVJ
(496) diszI3J,y\dgtQJ,yO`[Z QEHJS{
(497) demu{
(498) t0y\ditjsQmtjsK{ mdex\Qdeb0s¿t0{ QbjmuK;R"NQ° N®¦jOq N!UzOq P tvsy3ln´nwr¦jq"wM 0tvs@y mbjIQVEHJr{ J
(499) cic{
(500) Z[{
(501) ceJ QEtQ{
(502) bjs.QVmbjcgKrQVEHJt0{ QVdi[d QpZ¥bjnQEHJxHmbvQVJ,des£[ditxHEb0KVxHEHbjmZ[citvQVdibjs`[ZNln" ª´®´'dgKOxHmb[yHh{ J_y `h\QtjK^K]b[bjs tjK^N¥ln$t0{ QdetQJ,K deQ3dgK^des@tj{ QdetvQVJ,y `@J_{
(503) tjhK]Jª´®´'¡Et0Ksb2b0m^cideQ]QVciJ¡J 8J,{ Q^b0s Nln©tj{ QVditQVdibjstvsyN¥lndisHEHdi`HdeQKFª´®´SzxHmVbjQVJ,des ;DFEHJrQp"badis hHJ,s{ J_K"bjx)J
(504) mutQVJ¬bjsª´®´'ztQ yHd 8J
(505) mJ
(506) s.QFQVdiI3J,K't0K"QVEHJ,Z`)bvQVE¡Et0J¬yHd 8J
(507) mJ
(508) s.Q'x)J
(509) mdeb\yHK x@J,m]QhHm`Hdesk^ª´n´'x)J
(510) mdeb\y bjmndis.QVJ,mVI3J,yHditvQVJ'tvcihHJ_K®bv8QEHJ'xtjmtjI^J
(511) QVJ,mK mVJ,kjdibjs j§ ª´n´'rK]Qtjm]QuK!QVbaxHcitZ^tzI3bjmJ'K]dikjsd dg{
(512) tjs.Q®mVb0ceJdis3QVEHJr{ J
(513) cic{
(514) Z[{
(515) ceJ`[Z^desEHde`d QdesHkaN¥ln£tj¤ { Qde[deQpZ tvsyt0K®tOmVJ_K]hc Q y\dgKpQhHm`HdeskN¥ln£b0K{ dic cgtQdeb0sK, ;T Q'diKb0sHciZEHJ
(516) s¡QEHJzxtjmtjI^J
(517) QVJ,mK"mJ,tj{uE¡t^EHdikjE¡tvcihHJ J,d QEHJ
(518) m Q j Ç ^bjm u s M[§ QEtQ¬QVEJ^b.KV{
(519) decicgtQVdibjs@KSbjN¥lnª`)J,{
(520) bjI3J3KpQutv`HciJ^tjk0tjdes`h\Qzd QE2¤ tx@J,mVdib\yKVdeI3dicitjmrQbQEtQObvQVEHJ {
(521) demu{
(522) t0y\dgtvs{ Z\{ ciJ ¤ mVJ,kjdibjs0§!mJ
(523) 0J,tjcedisHkOQVEJSJ
(524) s.QmtjdesHI3J,s0Q®bjQVEHJr{ J
(525) cic8{ Z\{ ciJQVEmVb0hHkjE3ª´®´'¬tj{ QVdi.deQpZ ¤ QVEHmbjhkjE Q §Fb0mxHmbvQVJ,desciJ
(526) jJ,c ¤ QEHmVb0hHkjE u s § kimpf. kswee. 25. 15 10. 1. 2. 3. 5. MPF BN Wee1. 20. Period. 20. Period. 25. MPF BN Wee1. 15 10. 1. 2. 3. 5. 0. 0 0. 0.2 0.4 0.6 0.8. 1. 1.2 1.4 1.6. 0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1. dikjhHmJ'l®cibvQ"bv8QVEHJrx@J,mVdib\ytjK®tz hHs{ Qdeb0sbv8QEHJSxtjmtjI3J QVJ,m Q mVb0I FQVb0 ztjsy u s mbjI H HOQbj DFEHJaK]Z\K]QVJ
(527) I KVEHb'KJ
(528) s.QmtjdesHI3J,s0QS bjmStjcehHJ_KSKVhHx)J
(529) mdeb0mQVb0 a b0m c tvs@y¥H M b0m u s Hbjmzb0hHmzxHhHmx)b0KVJ,K { b0sKpQutvs.QOx@J,mVdib\yHKztvmJy\J 2 sJ,y¯tjK¬ b0cecib'K rQVEJcit0KpQj3x)J,tj¢[KObj QEHJ3K]diIhHcgtQdeb0sb0J
(530) mz~vjQVdiI3JahHsd QuKzK]EHb|sbI3b0mVJQVEtjs 4% yHd 8J
(531) mJ
(532) s{
(533) JadisQEHJ
(534) dimzIt \diI3ttvsy QEHJ'ciJ
(535) sHkjQVEbj8QVEHJ'x)J
(536) mdib[yK
(537) ;N¥ln¯K]Qtjm]QuK;d QEtvstjh\QVb0sHbjI3b0hK;x)J
(538) mdeb\y3bv= 0 \ MjEtvsyR # tx@J,mVdib\y bjS vH 0~vE ¥°SK Q tvsy u $ dis{ mJ,t0K]J Nln b0K{ dicecgtQdeb0sK ¤ t0{
(539) {
(540) bjhHs.QVdisHk¥ b0ma{
(541) J
(542) cic{ Z\{
(543) ceJ§zcib0KVJ K]Qtj`HdicedeQpZ£tjsytvmJJ,s0QmtjdesJ,y tvcibjsHk¥deQVE ª´®´' b0mEHdikjEJ
(544) mtjcehHJ_KbjQVEHJx@tvmutvI3J QJ
(545) mdeQVE t x)J
(546) mdib[ybv® v .~E "z.
(547)
(548)
(549) !!"
(550) #$$% & ' 1. DFEHJzKtvI3JSb0`KVJ
(551) mtvQVdibjsK"{
(552) tjs`)J¬It0y\Jr`[Zcib[bj¢[deskatQ"QVEJrQmtvopJ,{ QVbjmdiJ,K®bjN¥ln tjKFtz hHs@{ QVdibjs jb ®R # ¤ dikjhHmJ Mjt.§'tjsy¡bvnN¥lªtjKSt hHs{ Qdeb0sbv®`)bvQER#tjsy¡ª´®´' ¤ dikjhHmJ Mj`)§F bjmSQVEHmJ
(553) J yHd 8J
(554) mJ
(555) s.Q®tvcihHJ,Knbv Q Qutv¢0J
(556) s3des3QEHJQEHmVJ,J'mJ
(557) kjdibjs@K
(558) ;UrsHceZaEHJ
(559) sJ,s.QVmutvdisHI3J
(560) s.Q®b\{
(561) { hmK y\b[J,K®QVEHJ QmtvopJ,{ QVbjmZ¡ bjcicibt¥K]disHk0ceJ3xtvQVE£mVJ,jJ,tjcedisHk¡tcediI3d Qa{
(562) Z\{ ciJj HmbjI QEHJ,KVJbj`@K]J,mVtQdeb0sK d Q{,tvs¯`@J {
(563) bjs 2 mVI3J,y¥QVEtvQrQEHJ^{
(564) bjs{
(565) J
(566) s.QVmutQdeb0s¥bjmSQVEHJ3tj{ QVdi.deQpZ¥bv®ª´n´'K]J,J
(567) IK'Qb`)J^yHJ QVJ,mVI3distvs.QOdesQVEHJ J,s.QVmutvdisHI3J
(568) s.Qbv=QEHJ{ J,cec{ Z\{ ciJO`.ZQVEHJ{
(569) demu{
(570) t0y\ditjs{
(571) Z[{
(572) ceJ0 . dikjhHmKJ M t.§® xHcibvQuK®bj)QmtvopJ,{ QVbjmdiJ,K!bvR# t0K®t¬ hHs{ QVdibjsbjNln" `@§; xcebjQK®bj@QmtvopJ,{ QVb mdiJ,Kbj!R#$¤ t0Kt^ hHs{ Qdeb0s¥bv®N¥ln tvs@yª´n´'j °SK Q dis{ mJ,t0K]J_K QV¤ EHJOQmtvopJ,{ QbjmdeJ_KtvxHxmVb.tj{uE tKpQutv`HciJb.KV{
(573) decicgtQVb0mVZmJ
(574) kjdiI3Jj OHb0m c j Ç~ R# tvsyNln KVEHb$tK]Qtj`HceJQVmutopJ_{ QVb0mVZ¡tvmbjhsy tKpQutv`HciJcideI3deQO{
(575) Z\{ ciJ`Hh\QOdeQVE2tjstvs.QVdixHEt0K]dg{`)J
(576) E@t.dibjhm, Sbjm Q atjsy c H QVEHJ {
(577) J
(578) cic{ Z\{ ciJ ¤ dicicehK]QVmutQJ,y`[ZN¥ln;§FdgKsHbjQFJ,s.QVmutvdisHJ,y`[ZQVEHJ{
(579) demu{
(580) t0y\dgtvs{
(581) Z\{ ciJ ¤ dicecihK]QVmutQVJ_y`[ZR#¬§ ¨SbJ,jJ
(582) m QVEHJK]QVhy\Z¥bj c QVEHJ3xtjmtjI3J QVJ,mr{
(583) bjs.QVmbjcicedisHkQVEHJ3tj{ QVdi.deQpZ¡bvnª´n´'3bjs2Nln dist0{ QVditQdeb0s KVEHb'KQEtQ3QEHJ¡J
(584) s.QVmutvdisHI3J
(585) s.Q^yHb.J_K^sHbvQKVbjciJ
(586) ciZ¯yHJ
(587) x)J
(588) syCbjs QVEHJ¡tvcihHJbvSQEHJ¡xt mutvI3J
(589) QVJ
(590) m`h\QSI3bjmJzxtvmVQVdg{ hcitjmVciZbjsQEHJmutQVdib c ¦ Q KVdes@{ Jz`)bvQVE2q qF j~3tjsy¡ª´®´'atvmJ dis[jb0ce0J,ydisQVEHJzx)b0KVd Qde0JS J,J,y\`@tj{u¢cib[bjxK"QEtQ'tj{ QVditQVJzN¥l tvs@yQEHJ
(591) mJ b0mVJOmJ,KVx@b0sK]di`HciJS b0mFQVEHJ Tz N QmtjsKVd Qdeb0s ¥D=b2des[jJ_KpQdek.tQJ3QVEHdgKy\h@tvc"J 8J,{ Q QVEHJcediI3d Q^bv'J
(592) s.QmtjdesHI3J,s0QadiKI^J_tjKVhHmJ,ytjK QEHJQp"bx@tvmutvI3J QJ
(593) muK Q tvsy
(594) c tvmJtvmdiJ,y©KVdeIahHceQtvsJ
(595) bjh@K]ciZj £° cidesHJ_tvma hHs{ QVdibjs©bj'QVEHJ b0mVI kampf = 2.44832 · kimpf + 2.0071 diK¬bj`HQtvdisHJ_y QVEJ^mJ
(596) k0deb0s`)J
(597) cib|QVEHJ3cidesJ^`)J
(598) disHkQVEJ J,s.QVmutvdisHI3J
(599) s.QmVJ,kjdibjs ¤ dek0hHmVJ~0§ Ä. zmz {F|R}R~R|.
(600) _. x S C . dikjhHmJ~ zR"TVUzq"¨S°rN 6k0J
(601) sHJ,mtvQVJ_yxHcibvQzbv"QVEJ^J,s.QVmutvdisHI3J
(602) s.Qzdes¯x)J
(603) mdeb\y2bv"QVEHJ{
(604) J
(605) cic®{ Z\{ ciJ3`.ZQVEHJ {
(606) demu{
(607) t0y\dgtvs{
(608) Z[{
(609) ceJ^ b0mOyHd 8J
(610) mJ
(611) s.QztvcihHJ,K¬bv Q t0{ Qdeb0s2bjnª´®´'b0s£N¥l!§¬tjsy Q t0{ Qdeb0s bjzq qF j~2bjs«N¥ln;§ DFEHJ¡cideI3deQbvrJ,s.QVmutvdisHI3¤ J
(612) s.Q{ bjI3xHhHQVJ,y `[Z R"TVUzq"¨S°rN ¤ mVJ_yC{
(613) mVb.KV¤ KVJ,Ku§diK dis.QVJ,mVx)bjcgtQJ,y`.ZQVEHJzcidesJ,tvmF hs{ Qdeb0s kampf = 2.44832 · kimpf + 2.0071 ¤ KVbjcidiycedisHJ§ , T±s£QEHdiKmVJ,x@b0m]Q "J^E@tjJ{ b0sK]dgy\J,mVJ_yQEHJJ
(614) s.QVmutvdisHI3J
(615) s.Qzbv"QVEJ{ J
(616) cicntjsy¯{ dim{,tjy\dgtvs¯{ Z\{ ciJ,KztvQzQVEHJ Tz N QVmutvs@K]deQVdibjsaQVEHmbjhkjE^QVEHJª´n´''¢[des@tjKVJ"xmVbjQVJ
(617) dis3tvsy3y\J 2 sHJ,yaQEHJSKVx@J_{ d 2 {{ b0sy\deQVdibjsK!hHs@y\J
(618) m Edi{uEzQEHdgK=J,s0QmtjdesI^J,s.Qb\{
(619) {
(620) hHmK, £JE@tjJ®KVEHbsEHJ,mVJ;QEtQ!ª´®´'FKVEtvmJ,K8Qp"bS¢[disyHKbvHdis hHJ,s{ J mbjI `)bvQE¥QVEHJ3{ dimu{
(621) tjyHditjstvsy¡QEHJ3{ J
(622) cic!{ Z\{ ciJ,K, zUrsbjsHJaEtvsy
(623) J \x@J,mVdiI3J
(624) s.QtjcyHtvQtKVhHk0kjJ,K]QSQEtQ {
(625) demu{
(626) t0y\dgtvsk0J
(627) sHJ_K!I3J,y\dgtQJª´®´'QmtjsKV{
(628) mVdix\Qdeb0satvs@yab0sQEHJ'bjQVEHJ,m;Etvsy d QdiK!`)J
(629) cideJ,jJ_yQEtQnNln mJ
(630) k0hHcgtQVJ_KSª´n´'tj{ QVdi.deQpZ¥`[ZxHEHb.K]xEHbjmZ[citvQVdisHktjsydistj{ QVditQVdisHk¡deQ, 3DFEHJ
(631) mJ b0mVJ QVEHJ^QVdiI3deskbj QEHJ Tz ±N QVmutvsKVd Qdeb0syHJ
(632) x)J
(633) syHK'sHbvQ'b0sHceZbjsQVEHJzciJ
(634) 0J
(635) cbjª´®´SxHmbvQVJ,des`Hh\QStjciKVb3bjsQVEHJatj{ Qdeb0s bjª´®´Sbjs¡N¥lnCtjKFbjxx@b.K]J_yQb3QVEtvQ'bv;q qF j~H T±sCQVEHJI3b\y\J
(636) cxHmJ,KVJ
(637) s.QJ,yEHJ,mVJ KVdes{
(638) JQVEHJ b\{ hK3dgK^bjs©QEH-J Tz ±N QVmutvs@K]deQVdibjs QVEHJ¥{ b0hHxHcidesk bjnQEHJ^Qpb¥{ Z\{
(639) ceJ_Krb0sHciZtj{,{ bjhs0QuKr bjm¬QVEHJJ,s.QVmutvdisHI3J
(640) s.Q¬bjx)J
(641) mdeb\y2`Hh\QsHbjQzbvxEtjKVJj 3¨'b"J
(642) 0J
(643) m J,jJ,sQEHbjhHk0EQhHI3bjm{
(644) J
(645) ciciKz¢0J
(646) J,x£tx)J
(647) mdeb\y2bv' MjE QVEHJ,Z2tjmVJ^`@J,cediJ
(648) 0J,y2QVb¥KVEHb t¡KVEHde QbvxEtjKVJj R"J_{
(649) tvh@K]JObvQVEJK]diI3xHcidi{
(650) d QpZbv!bjhHmr{ J
(651) cic={
(652) Z[{
(653) ceJzmJ
(654) xmVJ_K]J,s0QutQdeb0s QVEHdgKSKVEHde Qr{
(655) tjsHsHbjQ'`@JdicicehK]QVmutQJ,ydis QEHdgKOI^b\y\J,c? ^T±s2QVEHJ^ h\QhHmVJ tI3bjmJa{ b0I3xHceJ
(656) QVJ3I3b\y\J
(657) c;bjnQVEJa b0hHmzxHEt0K]J_K¬bv®QEHJ{ J
(658) cic®{ Z\{
(659) ceJ3dicec t0{
(660) {
(661) bjhHs.Q b0mQEHJxHE@tjKVJKVEHd QuKatjsyxHmb[diyHJt`)J QVQVJ
(662) m3tvs@tvciZ[KVdgKbvQEHJJ
(663) s.QVmutvdisHI3J
(664) s.Qa{
(665) bjsy\deQVdibjs@K
(666) L\h{uEtI3b\y\J,c)"bjhciytjcecib«hKQVb^K]diIhHcgtQJS`)bvQEEHJ_tvceQVE[Ztvsy{,tvs{
(667) J
(668) mbjhK{ J,cecgKtjsydis{ cihy\J¬cidesH¢\K Qb¬QVEHJ{ dimu{
(669) tjyHditjsa{ Z\{
(670) ceJFdis.0bjci[desHk S
(671) t b0m EHdg{uEaI3dikjE.Q;`@Jt¬kjb[b\y^{
(672) tvs@y\diytQVJ bjm;¢0J
(673) J,xHdesk QEHJzx)J
(674) mdeb\ybv;{
(675) tvs@{ J
(676) mbjh@K"{
(677) J
(678) ciciK{
(679) ceb.K]J¬Qb MjE£ . "z.
(680) 0.
(681)
(682) !!"
(683) #$$% & '. K564. locL_D:[\LK`?6A [\L]DFh [\L_A`? baL_h. °rK"x@b0des.QVJ_yb0h\QF`.Z3QEHJOmVJ_{ J,s0QFmJ,KVJ,tvmu{uEtv`)bjhHQF{,tvs{
(684) J
(685) mF{uEHmVb0sHbvQEHJ
(686) mutvxdeJ_K { dim{,tjy\dgtvsmE[Z.QVEHIKF{
(687) tjs E@tjJt0J
(688) mZCK]QVmbjsHkJ
(689) )J_{ Qb0sªQVEJ¥QVb \dg{ deQpZ tjsy QVEHJ2J {
(690) t0{ Z bvtvs.Qd 6QVhHI3b0my\mhHk0K * +6 UrsHJ x)b0KKVde`HciJ
(691) J \xHcitjstQdeb0s¥diKSQVE@tQSQEHJ^J 8J,{ QObvntjs.QVd& {,tvs{
(692) J
(693) mSy\mhHk.K'bjs2t ¤ EJ,tvceQVE[Z¡bjmSQVhHI3b0mVb0hK§S{ J,cec dgK"y\J
(694) x)J
(695) syHJ
(696) s.QbjsQEHJrxEtjKVJSbjQVEHJO{ J,cec8{ Z\{
(697) ceJrdesEHdi{uEQVEtvQF{
(698) J
(699) cic@cidiJ,K, !¨SJ,tjc QE.Z3QdiKKVhHJ,KmVJ,ItvdisHdesk I3b.KpQceZ3K]Z[s{uEmVb0sHde³,J,y3`[ZaQVEHJ¬{ bjhxHcedisHkyHJ,K{ mde`)J,ytj`@b0J d Q"diKx@b.KVKVdi`HceJ'QVbayHmt0KpQdi{,tvciceZamVJ_y\h{ JSQVEHJ Qb \di{
(700) d QpZ`[ZdisopJ_{ QVdisHkQVEHJ^tvs.QVdeQVhI^b0m¬yHmVhHk.K'EHJ,s¥QVEJ
(701) Z¥EtjmVI tjKS J
(702) |EHJ_tvceQVE[Z¥{ J,cecgKrt0K'x)b0KK]di`HciJj UrsCQVEJ¥bvQVEJ
(703) mEtjsy QVhHI3b0mVb0hK3{ J
(704) cicStjmVJ¡J
(705) deQVEJ
(706) mxHEt0K]
Documents relatifs
C'est aussi le résidant pas chez leurs parents fréquentent deux fois parativement à la province, les étudiants de Nanterre ne lement ce moindre attachement à la ville
In this paper, we study the performance of an enhanced channel estimation technique combining estimation using an autocorrelation based method and the Expectation-
Selon Laeven et Valencia (2012) , le coût budgétaire de la crise bancaire s’est respectivement élevé à 44 et 41 points de PIB en Islande et en Irlande, ce qui place ces deux
Dans ce travail, nous comparerons les entreprises coopératives, détenues par leurs membres, dont le produit risqué est la ressource critique apportée et dont l’objectif est
À cet effet, un nombre considérable de recherches démontre cliniquement que les enfants de parents souffrant de problème de santé mentale sont plus à risque d’un retard dans leur
usual route to school and provide us with some details about their travel routine (e.g., schedule, mode of transportation, people accompanying them, etc.); 3) recent interventions
La question de l’extension des limites de Paris jusqu’à cette ligne avait été discutée mais ne fut tranchée que par un décret impérial du 9 janvier 1859 qui décidait de