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B A Figure 6

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Proteome profiler 1-p38 2-ERK

A

NT Irinotecan Irinotecan Sorafenib

+sorafenib

1 2 1 2 1 2 1 2

NT Sorafenib Irinotecan

+Sorafenib Irinotecan

pp38 pERK Tub

B

pp38/Tubulin (arbitrary units)

0 1 2 3

NT Sorafenib Irinotecan

+Sorafenib Irinotecan

0 2 4 6 8

pERK/tubulin (arbitrary units)

NT Sorafenib Irinotecan

+Sorafenib Irinotecan

Figure 6

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