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(1)ACTELION LTD AND SUBSIDIARIES. UNAUDITED CONSOLIDATED US GAAP FINANCIAL STATEMENTS FOR SEPTEMBER 30, 2012. Contents:. WorldReginfo - 6082548a-5beb-45fa-aa39-52928d835e8d. CONSOLIDATED INCOME STATEMENTS CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME CONSOLIDATED BALANCE SHEETS CONSOLIDATED STATEMENTS OF CASH FLOWS CONSOLIDATED STATEMENTS OF CHANGES IN SHAREHOLDERS' EQUITY.

(2) ACTELION LTD AND SUBSIDIARIES UNAUDITED CONSOLIDATED INCOME STATEMENTS. (in CHF thousands, except per share amounts). Three months ended September 30, 2012 2011. Nine months ended September 30, 2012 2011. Net revenue Product sales Contract revenue. 436,857 1,608. 400,115 1,656. 1,298,639 4,845. 1,290,249 81,439. 438,465. 401,771. 1,303,484. 1,371,688. Cost of sales Research and development Selling, general and administration Amortization of acquired intangible assets Litigation provisions. 49,455 102,145 147,192 9,883 -. 47,336 102,686 159,986 9,282 (55,017). 149,125 334,285 431,687 29,379 -. 149,012 331,415 517,419 29,215 430,188. Total operating expenses. 308,675. 264,273. 944,476. 1,457,249. Operating income (loss). 129,790. 137,498. 359,008. (85,561). Interest income Interest on litigation Interest expense on bonds Interest expense Impairment on financial assets Other financial income (expense), net. 423 (10,690) (3,010) (24) (5,266). 864 (7,519) (4,894) (525) (3,871) (27,121). 1,573 (31,234) (8,997) (478) (348) (1,908). 5,463 (13,345) (14,525) (1,636) (6,909) (22,326). Income (loss) before income tax expense. 111,223. 94,432. 317,616. (138,839). Income tax expense. (16,646). (12,871). (49,301). (41,867). Net income (loss). 94,577. 81,561. 268,315. (180,706). Basic net income per share Weighted-average number of common shares (in thousands). 0.82 116,018. 0.69 118,891. 2.30 116,699. (1.52) 119,167. Diluted net income per share Weighted-average number of common shares (in thousands). 0.80 118,338. 0.68 120,729. 2.26 118,529. (1.52) 119,167. 4,035 6,571 10,606. 8,815 12,178 20,993. 16,138 19,423 35,561. 26,469 37,642 64,111. Total net revenue Operating expenses. (1). Includes employee stock option costs as follows: Research and development Selling, general and administration Total stock-based compensation. WorldReginfo - 6082548a-5beb-45fa-aa39-52928d835e8d. (1).

(3) ACTELION LTD AND SUBSIDIARIES UNAUDITED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME. Net income (loss). 94,577. 81,561. Other comprehensive income (loss), net of tax Foreign currency translation adjustments Amortization of components of net periodic benefit costs Unrealized gain (loss) on marketable securities. 7,428 114 -. Other comprehensive income (loss), net of tax. 7,542. Comprehensive income (loss). 102,119. Nine months ended September 30, 2012 2011 268,315. (180,706). (2,931) 408 622. 93 342 -. (37,908) 1,227 (112). (1,901). 435. (36,793). 268,750. (217,499). 79,660. WorldReginfo - 6082548a-5beb-45fa-aa39-52928d835e8d. (in CHF thousands, except per share amounts). Three months ended September 30, 2012 2011.

(4) ACTELION LTD AND SUBSIDIARIES CONSOLIDATED BALANCE SHEETS. September 30, 2012 (unaudited). December 31, 2011 (audited). 950,455 200,747 2,792 474,008 57,318 19,961 6,879. 1,281,037 50,000 1,457 5,520 536,481 63,859 33,811 9,952. Total current assets. 1,712,160. 1,982,117. Restricted cash for litigation Property, plant and equipment, net Other non-current assets Intangible assets, net Goodwill Deferred tax assets, less current portion Total assets. 373,933 407,368 27,449 178,658 74,842 20,521 2,794,931. 424,659 23,385 204,267 74,940 22,710 2,732,078. Trade and other payables Accrued expenses Deferred revenue, current portion Other current liabilities. 126,096 349,050 3,008 17,948. 101,781 365,467 10,135 49,448. Total current liabilities. 496,102. 526,831. Deferred revenue, less current portion Other non-current liabilities Litigation provision Long-term financial debt Pension liability Deferred tax liabilities. 3,663 16,779 431,715 235,468 28,813 393. 4,843 18,014 404,696 235,578 31,271 391. 1,212,933. 1,221,624. Common shares (par value CHF 0.50 per share, authorized 180,998,245and 185,782,540 shares; issued 126,773,027 and 130,382,761 shares in 2012 and 2011 respectively) Additional paid-in capital Accumulated profit Treasury shares, at cost Accumulated other comprehensive income (loss). 63,387 942,045 1,394,813 (623,794) (194,453). 65,232 1,213,004 1,126,498 (699,392) (194,888). Total shareholders' equity Total liabilities and shareholders' equity. 1,581,998 2,794,931. 1,510,454 2,732,078. (in CHF thousands, except number of shares) Assets Current assets Cash and cash equivalents Short-term deposits Derivative instruments Marketable securities Trade and other receivables, net Inventories Other current assets Deferred tax assets, current portion. Liabilities and shareholders' equity. Total liabilities Shareholders' equity. WorldReginfo - 6082548a-5beb-45fa-aa39-52928d835e8d. Current liabilities.

(5) ACTELION LTD AND SUBSIDIARIES UNAUDITED CONSOLIDATED STATEMENTS OF CASH FLOWS. (in CHF thousands). Three months ended September 30, 2012 2011. Nine months ended September 30, 2012 2011. Cash flow from operating activities Net income (loss). 94,577. 81,561. 268,315. (180,706). Adjustments to reconcile net income to net cash provided from operating activities: Depreciation and amortization Stock-based compensation, incl. treasury shares to members of Board of Directors Excess tax benefits from share-based payment arrangements Deferred revenue (Gains) Losses on derivative instruments (Gains) Losses on marketable securities, incl. other-than-temporary impairment Interest expense on bonds Trade and other receivables Inventories Other assets Trade and other payables Other liabilities Changes in other operating cash flow items. 21,160 10,879 (160) (1,402) (7,020) 3,010 19,039 208 9,483 14,895 53,260 1,513. 20,399 20,942 (37) (1,465) 40,882 9,951 4,894 (14,593) (4,843) 6,225 (5,634) (8,143) 3,319. 61,911 36,136 (2,472) (4,647) (21,294) 1,309 8,997 61,191 6,541 18,488 25,247 19,049 (5,433). 61,589 66,217 (884) (80,904) 48,851 13,328 14,525 (66,361) (4,971) 14,777 (8,011) 427,025 1,343. 219,442. 153,458. 473,338. 305,818. Restricted cash for litigation Purchase of short-term and long-term deposits Proceeds from short-term and long-term deposits Purchase of property, plant and equipment Proceeds from marketable securities Purchase of intangible assets Purchase of other non-current assets Acquisition of a business, incl. deferred consideration payments. (50,000) 50,000 (9,181) (1,327) -. (15,752) 6,952 (910) -. (370,588) (400,747) 250,000 (29,032) 4,179 (4,131) (4,536) (18,200). (50,000) 150,000 (68,551) 9,298 (3,956) (18,375). Net cash flow provided by (used in) investing activities. (10,508). (9,710). (573,055). 18,416. Dividend payment Payments on capital leases Proceeds from exercise of stock options, net of expense Purchase of treasury shares Excess tax benefits from share-based payment arrangements. (15) 4,076 (63,237) 160. (20) 1,448 (38,355) 37. (93,686) (46) 15,433 (152,675) 2,472. (95,316) (62) 12,613 (76,053) 884. Net cash flow provided by (used in) financing activities. (59,016). (36,890). (228,502). (157,934). Net effect of exchange rates on cash and cash equivalents. (3,483). 9,233. (2,363). (7,948). (330,582). Net cash flow provided by (used in) operating activities Cash flow from investing activities. Cash flow from financing activities. 146,435. 116,091. 158,352. Cash and cash equivalents at beginning of period. 804,020. 1,238,206. 1,281,037. 1,195,945. Cash and cash equivalents at end of period. 950,455. 1,354,297. 950,455. 1,354,297. WorldReginfo - 6082548a-5beb-45fa-aa39-52928d835e8d. Net change in cash and cash equivalents.

(6) ACTELION LTD AND SUBSIDIARIES CONSOLIDATED STATEMENTS OF CHANGES IN SHAREHOLDERS' EQUITY. Additional (in CHF thousands, except number of shares). Common shares Shares. At January 1, 2011. 119,366,427. Amount 64,912. Accum. other. paid-in-. Accumulated. Treasury. comprehensive. Shareholders'. capital. profit. shares. income (loss). equity. 1,209,857. 1,272,817. (592,461). (159,921). 1,795,204. Comprehensive income (loss) net of tax: Net income (loss). (146,319). (146,319). Other comprehensive income (loss). (34,967). Comprehensive income (loss) Excess tax benefit and underrealization from share-based payment arrangement Exercise of stock options Transactions in treasury shares. (110) 639,776. 320. (2,888,083). Dividend payment 117,118,120. (110). 13,923. 14,243. (217). Stock-based compensation expense. At December 31, 2011 (audited). (34,967) (181,286). 65,232. (106,931). (107,148). 84,867. 84,867. (95,316). (95,316). 1,213,004. 1,126,498. (699,392). (194,888). 1,510,454. Comprehensive income (loss) net of tax: Net income (loss). 268,315. 268,315. Other comprehensive income (loss). 435. Comprehensive income (loss) Excess tax benefit and underrealization from share-based payment arrangement Transactions in treasury shares. 739,751. 370. (2,757,820). Stock-based compensation expense Cancellation treasury shares (share repurchase program). (2,197) 15,063. (63,128). (88,601). (151,729). 35,343 (2,215). Dividend payment At September 30, 2012 (unaudited). (2,197) 14,693. 35,343. (161,984). 164,199. -. (93,686) 115,100,051. 63,387. 942,045. (93,686) 1,394,813. (623,794). (194,453). 1,581,998. WorldReginfo - 6082548a-5beb-45fa-aa39-52928d835e8d. Exercise of stock options. 435 268,750.

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