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CHAPITRE III : Obtention de la structure -hydroxy-6-methyl-3-(1-p- tolyl-1H-pyrazol-3-yl)-pyran-2-one

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Introduction………..…01

CHAPITRE I : Mise au point bibliographique

I-1 - Principaux modes de synthèse des Pyrazoles……..………..……….……...04

I-2 - Synthèse de quelques pyrazoles à partir de l’acide déhydroacétique...08

CHAPITRE II : Propriétés biologiques et/ou thérapeutiques des structures pyrazoles

II-1-Intérêts biologiques des pyrazoles ………..………12

II-2- Indications principales et caractère multifonctionnel des pyrazoles ……16

II-3- Accès aux 4-aryl THP pyrazoles…………..………...……17

CHAPITRE III : Obtention de la structure -hydroxy-6-methyl-3-(1-p- tolyl-1H-pyrazol-3-yl)-pyran-2-one

III-1-Préparation de Composé 1 ……….……..…..20

III-2-Préparation de Composé 2 ……….…21

III-3- Analyse spectroscopique ………..……….………22

III-4-Discussion sur le mécanisme de la réaction ……….……….…24

PARTIE EXPERIMENTALE.……….……… ..…25

Conclusion……….………..…30 Bibliographie

SOMMAIRE

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