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Human plasma levels of vitamin E and carotenoids are associated with genetic polymorphisms in several genes involved in lipid metabolism

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HAL Id: hal-02655150

https://hal.inrae.fr/hal-02655150

Submitted on 29 May 2020

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Human plasma levels of vitamin E and carotenoids are

associated with genetic polymorphisms in several genes

involved in lipid metabolism

Patrick Borel, Myriam Moussa, Emmanuelle Reboul, Bernard Lyan, Catherine

Defoort, Richard Planells, Stéphanie Vincent, Michel Darmon, Henri

Portugal, Denis Lairon

To cite this version:

Patrick Borel, Myriam Moussa, Emmanuelle Reboul, Bernard Lyan, Catherine Defoort, et al.. Human plasma levels of vitamin E and carotenoids are associated with genetic polymorphisms in several genes involved in lipid metabolism. Annals of Nutrition and Metabolism, Karger, 2007, 51, pp.19. �hal-02655150�

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Comment citer ce document :

Borel, P., Moussa, M., Reboul, E., Lyan, B., Defoort, C., Planells, R., Vincent, S., Darmon, M., Portugal, H., Lairon, D. (2007). Human plasma levels of vitamin E and carotenoids are associated with genetic polymorphisms in several genes involved in lipid metabolism. Annals of

Nutrition and Metabolism, 51, 19.

Version définitive du manuscrit publié dans / Final version of the manuscript published in : Annals of Nutrition and Metabolism, 2007, no.51, supplement 1

Manuscrit d’auteur / Author manuscript

Manuscrit d’auteur / Author manuscript Manuscrit

d’auteur / Author manuscript

Human plasma levels of vitamin E and carotenoids are associated with genetic polymorphisms in several genes involved in lipid metabolism

Patrick Borel 1, Myriam Moussa 1, Emmanuelle Reboul 1, Bernard Lyan 2, Catherine Defoort

1

, Richard Plannels 1, Stéphanie Vincent 1, Michel Darmon 1, Henri Portugal 1, and Denis

Lairon 1

1

INSERM, U476 « Nutrition Humaine et Lipides », Marseille, F-13385 France; INRA,

UMR1260, Marseille, F-13385 France; Univ Méditerranée Aix-Marseille 2, Faculté de

Médecine, IPHM-IFR 125, Marseille, F-13385 France.

2

INRA, UMR1019 « Nutrition Humaine », Saint-Genes-Champanelle, F-63122 France.

Vitamin E and carotenoids are fat-soluble micronutrients carried by plasma lipoproteins.

Their plasma concentration is governed by several known factors (dietary intake,

bioavailability…) including genetic factors. Scarce data are available on this topic. We

hypothesized that genes involved in lipid metabolism are, directly or undirectly, implicated in

the intestinal uptake, intracellular trafficking and lipoprotein distribution of these

microconstituents, and consequently can regulate their plasma concentration. We therefore

assessed whether key genes involved in lipid metabolism were related to the plasma status of

these micronutrients. Fasting plasma vitamin E (alpha and gamma-tocopherol) and

carotenoids (alpha and beta-carotene, lutein, lycopene, beta-cryptoxanthin and zeaxanthin)

concentrations were measured by HPLC in 169 male and female volunteers involved in the

Medi-RIVAGE study. Genotyping of several genes involved in lipid metabolism was carried

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Version postprint

Comment citer ce document :

Borel, P., Moussa, M., Reboul, E., Lyan, B., Defoort, C., Planells, R., Vincent, S., Darmon, M., Portugal, H., Lairon, D. (2007). Human plasma levels of vitamin E and carotenoids are associated with genetic polymorphisms in several genes involved in lipid metabolism. Annals of

Nutrition and Metabolism, 51, 19.

Manuscrit d’auteur / Author manuscript

Manuscrit d’auteur / Author manuscript Manuscrit

d’auteur / Author manuscript

lipase (HL), lipoprotein lipase (LPL), intestinal fatty acid binding protein (I-FABP),

microsomial triglyceride transfer protein (MTP), and scavenger-receptor class B type I

(SR-BI). Results showed that plasma alpha-tocopherol was significantly (p<0.05) associated with

Apo-AIV, Apo-CIII, Apo-E, CETP and SR-BI genotypes. Gamma-tocopherol was associated

with Apo-AIV, HL and SR-BI. Alpha-carotene was associated with HL and SR-BI,

carotene with Apo-B, HL and SR-BI, lycopene with apo-AIV, apo-B and I-FABP,

beta-cryptoxanthin with SR-BI. No association was found between either lutein or zeaxanthin and

the studied SNPs. These results show that several genes involved in lipid metabolism are

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