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Cancer control tools to

support costing cancer plans and benefit packages

Dr Melanie Bertram Dr Elena Fidarova Dr Cindy Gauvreau

Dr Scott Howard Dr. André Ilbawi Dr Ben Anderson

Dr Felipe Roitberg

Dr Sandra Luna-Fineman Dr Filip Meheus

Dr Roberta Ortiz Dr. Dario Trapani

Mr. Rory Watts

(2)

Context of WHO Cancer Priority Setting Tools

WHA70.12

2

Recalling also

United Nations Gen eral Assem

bly resolution 66/2 (2011

) on the

Political Declaration

of the High-level Meeting of the Gen

eral Assem bly on

the Prev ention

and Control of Non-communi

cable Diseases, which inc

ludes a ro ad map of

nationa l com

mitments from Heads of State and Governm

ent to address cancer and oth

er noncommuni cable dise

ases;

Recalling fur ther resolution

WHA66.10 (2013 ) endorsing the glob

al action plan for the prevention

and control of nonco mmuni

cable dise ases 2013

–2020, which provides guidance on how Member States can realize the co

mmitments they mad e in the Po

litical Declaration of the High-level Meeting

of the Gen eral

Assem bly on

the Prev ention an

d Cont rol of

Non-communi cable Dise

ases, includi

ng those related

to addr essing

cancer;

Recalling in addition

United Nations Gen eral Assembly res

olution 68/300

(2014) on the Outcome documen

t of the high-level m eeting

of the Gen eral Assembly on

the com prehensi

ve review and assessment of the prog

ress achiev ed in

the prevention and control of

non-communi cable dise

ases, which

sets out the continue d and incr

eased

commitments that are essential

in order to realize the road map of co

mmitmen ts to addr

ess cancer and othe r noncommunicabl

e diseases included in the Political Declaration

of the High-level Meeting of the Gen

eral Assem bly on

the Prev ention

and Control of Non-communi

cable Di seases

, including four time-bound national commitments for 2015 an

d 2016;

Mindful of the ex isting

moni toring tool that WHO

is usi ng to track

the extent to which

its 194 Me

mber Stat es are implem

enting these four time-bound

commitm ents to address can

cer an d other nonco

mmuni cable dise

ases, in acc ordan

ce with the techni

cal note1 pub lished

by W HO on

1 May 2015 pursuan

t to decision EB136(13) (2015

);

Mindful also of the W

HO Fram ework Conv

ention on Tobacc o Cont

rol;

Also mindf ul of

the Sust ainable Developm

ent Goals of the 2030 Agenda for Sustainable Developm

ent, sp ecifically Goal 3 (Ensur

e healthy lives and prom

ote wel l-being for

all at all ages) with its ta

rget 3.4 to reduce, by

2030, prem ature mor

tality from noncommuni

cable diseases by one th

ird, and target 3.8 on achieving

universal hea lth coverage;

Appreciating the efforts made by Me

mber States2 and inter

national pa rtners in

recent years to prevent an

d cont rol cancer, but

mindf ul of the nee

d for further action;

Reaffirming the global strategy and plan of action on pub

lic health, innov ation

and intellectual prope

rty;

Reaffirm ing also

the rights of Mem ber Sta

tes to the full use of the flex

ibilities in the WTO Agreemen

t on Trade -related Aspects of the

Intellectual Pro perty Rights (TRIPS) to

increase access to affordable, sa

fe, effective and qua lity m

edicines, noting that, inter alia, intellectua

l property rights are an impor

tant incent ive in the

developm ent of new

health prod ucts,

1 Available

at http://www.who.int/nmh/events/2015/technical-note-en.pdf?u

a=1 (accessed 19 May 2017).

2 And, where applicable, regional econom

ic integ ration organizations.

SEVENTIETH WORLD HEALTH ASSEMBLY

WHA70.12

Agenda item 15.6

31 May 2017

Canc er pre ventio n and contr ol in t he co ntext of an int egrat ed ap proac h

The Seventieth World Health Assembly,

Having considered the report on cancer prevention and control in the context of an integrated approach;1

Acknowledging that, in 2012, cancer was the second leading cause of death in the world with 8.2 million cancer-related deaths, the majority of which occurred in low- and middle-income

countries;

Recognizing that cancer is a leading cause of morbidity globally and a growing public health concern, with the annual number of new cancer cases projected to increase from 14.1 million in 2012

to 21.6 million by 2030;

Aware that certain population groups experience inequalities in risk factor exposure and in access to screening, early diagnosis and timely and appropriate treatment, and that they also experience poorer outcomes for cancer; and recognizing that different cancer control strategies are

required for specific groups of cancer patients, such as children and adolescents;

Noting that risk reduction has the potential to prevent around half of all cancers;

Aware that early diagnosis and prompt and appropriate treatment, including pain relief and palliative care, can reduce mortality and improve the outcomes and quality of life of cancer patients;

Recognizing with appreciation the introduction of new pharmaceutical products based on investment in innovation for cancer treatment in recent years, and noting with great concern the

increasing cost to health systems and patients;

Emphasizing the importance of addressing barriers in access to safe, quality, effective and affordable medicines, medical products and appropriate technology for cancer prevention, detection, screening diagnosis and treatment, including surgery, by strengthening national health systems and international cooperation, including human resources, with the ultimate aim of enhancing access for

patients, including through increasing the capacity of the health systems to provide such access;

Recalling resolution WHA58.22 (2005) on cancer prevention and control;

1 Document A70/32.

• Develop resource-stratified tool kits to establish and implement comprehensive programmes… leveraging work of other organizations

OP1

• Collect, synthesize and disseminate evidence on the most cost-effective interventions…and to make an

investment case for cancer

OP2

• Strengthen the capacity of the Secretariat to support implementation of cost-

effective interventions and country- adapted models…

OP3

(2) Member State Mandate

Set priorities / define UHC benefit package

>90% inefficiency in expenditure, breast ca

not included in UHC

Anticipates budget needs (eg, costs)

Only 10% MS cost cancer plans

Determines health system requirements

(eg, workforce)

>70% LMIC lack cancer system capacity

Generate business plan

No platform for national cancer business plans

(1) Meeting

Government Needs

(3)

Figure: Financial catastrophe due to the costs of

cancer treatment Source: Jan et al. 2018. Lancet 391(10134):2047-2058; Rajpal et al. 2018. PLoS ONE 13(2):

e0193320; Hoang 2017, BioMed Res Int, https://doi.org/10.1155/2017/9350147

• Large out-of-pocket spending puts a heavy burden on families, especially the poor; risk of

impoverishment due to catastrophic health spending.

• In many countries, patients bear the cost for

diagnosis and treatment of cancer and for those that can’t bear the cost they forgo treatment.

China 21%

Myanmar

India 50%

60%

Vietnam

57% Philippines Thailand 56%

24%

Indonesia 44%

Malaysia 45%

Iran 68%

Financial burden of cancer to households

(4)

Context of WHO Cancer Priority Setting Tools

WHA70.12

2

Recalling also

United Nations Gen

eral Assem

bly resolution 66/2 (2011

) on the

Political Declaration

of the High-lev el Me

eting of th

e Gen eral Assem

bly on the Prev

ention and C

ontrol of Non-communi

cable Diseases , which inc

ludes a road map of

nationa l com

mitments from Heads

of State and Gov

ernment to addr ess cancer an

d oth er noncom

municabl e diseases;

Recalling fur

ther resol ution

WHA66.10 (2013 ) endor

sing the glob al action

plan for the prevention

and co ntrol of nonco

mmuni cable

diseases 2013 –2020, which

provides guidan ce on how Member Stat

es can rea lize

the co mmitmen

ts they mad e in the Po

litical Dec laration

of the High-level Meeting

of the Gen eral Assem

bly on the Prev

ention an d Cont

rol of Non-com

municabl e Dise

ases, includi

ng those related

to addr essing

cancer;

Recalling in

addition United

Nations General

Assembly res olution

68/300 (2014)

on the Outcom

e documen

t of the high-level m eeting

of the Gen eral Assem

bly on the com

prehensi ve review and assessm

ent of the progress achiev

ed in the prevention

and control of non-communi

cable dise ases, which

sets out the continue d and increased

commitments that are ess

ential in order to

realize the road map of co

mmitments to

address cancer and other non

communi cable dise

ases included in the Political Declaration

of the High-level Me

eting of the Gen

eral Assem bly on

the Prev ention

and C ontro

l of Non-com

municable Di seases

, including fou r tim

e-bound national commitments

for 2015 an d 2016;

Mindful of the ex isting

moni toring tool

that WHO is usi

ng to track the exten

t to which its 194 Me

mber Stat es are

implem enting the

se four time-bound

commitments to ad dress can

cer an d other nonco

mmuni cable dise

ases, in accordan

ce with the techni

cal note1 pub lished

by W HO on

1 May 2015 pursuan

t to decision EB136 (13) (2015

);

Mindful also of the W

HO Framewo rk Conv

ention on Tobacc o Cont

rol;

Also mindf

ul of the Sust

ainable Developm ent Goals

of the 2030 Agenda for

Sustainable Developm

ent, sp ecifically G

oal 3 (Ensur e healthy lives

and prom ote wel

l-bei ng for

all a t all ages) with its ta

rget 3.4 to reduce, by

2030, prem ature mor

tality from nonco

mmuni cable dise

ases by o ne third, and tar

get 3 .8 on ach

ieving universal hea

lth coverage;

Appreciating th e efforts m

ade by Me mber States2

and internationa l partners in

recent yea rs to prevent an

d control ca ncer, but

mindf ul of the nee

d for further action;

Reaffirm ing th

e glob

al strategy and plan of

action on pub lic hea

lth, innov ation

and intellectual prope

rty;

Reaffirm ing also

the rights of Mem

ber Sta tes to

the full use of th

e flex ibilities in

the WTO Agreemen

t on Trade

-related Aspec ts of the Intel

lectual Pro

perty Rights (TRIPS

) to increase access to

affordable, sa fe, ef

fective and qua lity m

edicines, noting that, int

er alia, intellectua

l prop erty right

s are an impor

tant incent ive in the

developm ent of new

health prod ucts,

1 Available at http://www

.who.int/nmh/ev ents/2

015/techn ical-n

ote-en .pdf?u

a=1 (access ed 19

May 2017).

2 And, where applicable, re

gional econom ic integ

ration organiza tions.

SEVENTIETH WORLD HEALTH ASSEMBLY

WHA70.12

Agenda item 15.6

31 May 2017

Canc er pre ventio n and contr ol in t he co ntext of an int egrat ed ap proac h

The Seventieth World Health Assembly,

Having considered the report on cancer prevention and control in the context of an integrated approach;1

Acknowledging that, in 2012, cancer was the second leading cause of death in the world with 8.2 million cancer-related deaths, the majority of which occurred in low- and middle-income

countries;

Recognizing that cancer is a leading cause of morbidity globally and a growing public health concern, with the annual number of new cancer cases projected to increase from 14.1 million in 2012

to 21.6 million by 2030;

Aware that certain population groups experience inequalities in risk factor exposure and in access to screening, early diagnosis and timely and appropriate treatment, and that they also experience poorer outcomes for cancer; and recognizing that different cancer control strategies are

required for specific groups of cancer patients, such as children and adolescents;

Noting that risk reduction has the potential to prevent around half of all cancers;

Aware that early diagnosis and prompt and appropriate treatment, including pain relief and palliative care, can reduce mortality and improve the outcomes and quality of life of cancer patients;

Recognizing with appreciation the introduction of new pharmaceutical products based on investment in innovation for cancer treatment in recent years, and noting with great concern the

increasing cost to health systems and patients;

Emphasizing the importance of addressing barriers in access to safe, quality, effective and affordable medicines, medical products and appropriate technology for cancer prevention, detection, screening diagnosis and treatment, including surgery, by strengthening national health systems and

international cooperation, including hum

an resources, with the ultimate aim of enhancing access for

patients, including through increasing the capacity of the health systems to provide such access;

Recalling resolution WHA58.22 (2005) on cancer prevention and control;

1 Document A70/32.

• Develop resource-stratified tool kits to establish and implement comprehensive programmes… leveraging work of other organizations

OP1

• Collect, synthesize and disseminate evidence on the most cost-effective interventions…and to make an

investment case for cancer

OP2

• Strengthen the capacity of the Secretariat to support implementation of cost-

effective interventions and country- adapted models…

OP3

(2) Member State Mandate

(1) Meeting

Government Needs

(5)

Tool Functionality

Inputs Current service analysis

Select package,

scale-up Outputs

Dialogue Decision

Data

Assessment tool

IARC, WHO, IAEA database

country situational analysis

(6)

Data Synthesis

and Models Output

Assessment tool (imPACT)

IDCCP (cervical cancer)

WHO GICC (childhood cancer) WHO Health workforce

strategy

Partners’ data / assessment tools

IAEA Radiotherapy

Qualitative review

Report

WHO, IARC OneHealth Tool for Cancer

Policy dialogue Operational planning

Investment case

WHO Workforce tool for cancer

Registries (IARC)

Database of current capacity (previous missions)

Harmonized Dataset

Costing tool (as appropriate)

PRIME HPV vaccination

Screening programme review

IPCHS patient perspectives

National Facility Patient

Partners’ approach

Quality assurance / quality improvement

Synthesized findings and recommend-

ations Inputs

Harmonized Assessment Tool

(7)

Tool Functionality

Inputs Current service analysis

Select package,

scale-up Outputs

Assessment tool

IARC, WHO, IAEA database country situational analysis

User select, scale-up 14 cancers

>150 interventions

Country Snapshot

Service provision, Unmet need Quality, coverage

Impact

System requirement Scale-up

Total costs

Data Dialogue Decision

(8)

Country Case Study

Current situation:

Advanced stage of

presentation (>50% stage III/IV)

Potential annual saving $USD 50,000

500+ lives saved

100 105 110 115 120 125 130

Current (late stage) New scenario (early stage)

Mill io n ( lo cal curr ency) Liv e s Sa ve d

Data Dialogue Decision

Screening

• ~ $1-2 mil per year

•  MG from 3 to 50

•  radiologist 3 FTE & path

Impact: 200-500 lives saved

Early Diagnosis

• ~ $250,000 per year

• Awareness, PC training, referral, navigator

Impact: 200-400 lives saved

Government invested in early diagnosis programme + cervical

cancer screening

(9)

Country Case Study

Current situation:

Advanced stage of

presentation (>50% stage III/IV)

Potential annual saving $USD 50,000

500+ lives saved

100 105 110 115 120 125 130

Current (late stage) New scenario (early stage)

Mill io n ( lo cal curr ency) Liv e s Sa ve d

Data Dialogue Decision

Screening

• ~ $1-2 mil per year

•  MG from 3 to 50

•  radiologist 3 FTE & path

Impact: 200-500 lives saved

Early Diagnosis

• ~ $250,000 per year

• Awareness, PC training, referral, navigator

Impact: 200-400 lives saved

Government invested in early diagnosis programme + cervical

cancer screening

(10)

Country Case Study

0 50 100 150 200 250

Current Scenario Price negotiation

Mil lio ns ( lo cal c ur rency )

Total costs Medicine costs

Item Global

ref price

Price paid by country

%

difference

5-FU 2.40 5.71 138%

Cisplatin 6.05 22.14 266%

Filgastrim 4.50 54.29 1106%

Irinotecan 4.66 220.53 4637%

Paclitaxel 11.08 107.14 867%

Tamoxifen 0.11 0.08 -33%

Data Dialogue Decision

Potential annual

saving

$USD 500,000

Government requested WHO

support procurement Current situation:

Medicine costs

1-50x higher

(11)

Defining value of cancer control

Protect from financial risk of cancer

Increased earning capacity

Increased life expectancy People

become healthier More money

for health

Reduced health care expenditure Increased

workforce participation Boost in

GDP

Source: WHO (2018) Saving lives, spending less. WHO/NMH/NVI/18.8

(12)

12

WHO Cancer Initiatives

(13)

Breast cancer programme planning

>60% stage I + II Time to initiate treatment <60 days Treatment coverage

90% by 2030 0

50,000 100,000 150,000 200,000

2021 2022 2023 2024 2025 2026 2027 2028 2029 2030

Annual Breast cancer lives saved

$US 1.20 per capita

(14)

How can the tool support you?

✓ Promote data for decision-making

✓ Generate data on programme impact (implement’n research)

Data Dialogue

Decision Research

✓ Facilitates dialogue on priority settings

✓ Supports discussion on health system planning

✓ Promotes budget planning

✓ Enables multi-sectoral dialogue with partners, donors

✓ Advances health sciences research

✓ Produces scenarios to establish best practice

(15)

Thank you

WHO/IARC Costing and Planning Tool Group:

Dr Ben Anderson Dr Melanie Bertram Dr Elena Fidarova Dr Cindy Gauvreau Dr Scott Howard Dr. André Ilbawi

Dr Sandra Luna-Fineman Dr Filip Meheus

Dr Roberta Ortiz Dr Felipe Roitberg Dr. Dario Trapani Mr. Rory Watts

UN experts and collaborators:

Dr Adriana Velazquez-Berumen Dr María del Rosario Perez

Dr Rania Kawar Dr Mathieu Boniol Dr Cherian Varghese Dr. Freddie Bray

Dr. Isabelle Soerjomataram, Dr. May Abdul-Wahab

Dr Eduardo Zubizarreta Dr Alfredo Polo Rubio Dr Catherine Lam

Dr Rei Haruyama

>100s of international experts

>50 international organization

(including ESMO, NCI, ICCP, St Jude)

(16)

Key messages

Government commitment to cancer care action and integration into UHC Implement value for money solutions

Prioritize important programmes and policies Ensure financial protection

Health systems approach – facilities and human resources at the health of planning

Invest in data systems. We cannot monitor what we cannot measure.

(17)

Tool Application and Adaptability

Cancer &

COVID model

Define problem

Input data

Generate result Implement

Fear to access health care

Limited diagnostic

services

Insufficient staff Geographic

barriers (transport)

Products not available Alter care to

limit risks Service interruption

Death from COVID

Delays in diagnosis

Treatment services not

accessible

Optimal treatment not available

Treatment abandoned

Systematic Review Survey data (WHO, partners)

Systematic Review Survey data (WHO, partners) Mitigation Strategy

Results pending (Feb 2021)

Telemedicine Role delegation Supply chain

manage Triage patients

(18)

Why Develop Priority Setting Tool?

Provide funding “why”

(3) Supporting Stakeholders

By linking data to decision-making

Direct productivity

Full social value

How much?

In what?

What benefit?

Data IARC data and

research

Dialogue WHO policy dialogue

Decision

(19)

Tool Input Structure (1 of 4)

(20)

Tool Input Structure (2 of 4)

(21)

Tool Input Structure (3 of 4)

(22)

Tool Input Structure (4 of 4)

(23)

Sample Scenarios: Significant Findings

Tobacco control

• Maximal prevention

• 1000-2000+ cases per year

• Beginning in ~2040 and extending beyond

(oral cancer not included)

• Cost estimate:

• $150,000 for legislative/regulatory programme

• $100,000 for awareness/cessation programme

Reducing Harmful Use of Alcohol

• Maximal prevention

• 1000 cases per year

• Beginning in ~2040 and extending beyond

• Cost estimate:

• $100,000 for legislative/regulatory programme

• $140,000 for public health

outreach

(24)

Low Quality Care

• Cost

• 5-10%  per cancer intervention

• Overall cost: $100,000

• Impact

TBD – initial focus on childhood cancer

• ? 20-30% treatment abandonment

• ~10% loss of healthy life-years gained

Increase salaries to UMIC level

• 4-5x  salaries

• E.g. physician $15,000 / yr;

nurse $7,500 /yr

• HR costs  $3mil / yr;

now ~45% of total costs

No associated change in outcomes

? Attrition rates

? Quality / performance

Sample Scenarios: Significant Findings

(25)

Sample Scenarios: Significant Findings

New Radiotherapy Machine

• Marginal value depends on # of existing

machines & optimal use

• If 2 machines exist:

• Adding #3, saves ~5-10 lives

(26)

What would you do?

Breast cancer

screening programme

• Cost:

• Approx $1-2 mil per year

•  Mammography machines from 3 to 50

•  radiologist by 3 FTE &

pathologists (minor)

• Impact

• 200-500 lives saved

Breast cancer early diagnosis

• Cost:

• Approx $250,000 per year

Elements: awareness programme, PHC training, referral & patient navigator

• Minor health system needs

• Impact

• 30% downstaging

• 200-400 lives saved

(27)

↑ Service coverage

↑Quality (diagnosis

& treat)

↑Treatment complexity Downstage

(earlier diagnosis)

↑ Service coverage as part of UHC is priority to

↑ outcomes

Early diagnosis should be prioritized over screening

(except cervical)

Prioritized response

(28)

↑ Service coverage

↑Quality (diagnosis

& treat)

↑Treatment complexity Downstage

(earlier diagnosis)

Unable to access care

Untreated (delays) Untreated (abandon)

Substandard treatment

Undiagnosed (delays) Deadly interplay: cancer patients at

higher risk of COVID-related deaths

Building capacity →

Resilient systems against COVID

(29)

29

COVID-19 impact on cancer: WHO systematic review

(30)

30

But, cancer generally not covered in COVID response plans:

The clock is ticking and people are dying.

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