Quercetin induces insulin secretion by direct activation of L-type calcium channels in pancreatic beta cells

Chronic fructose exposure potentiates GSIS in human islets through extracellular ATP signaling mediated by pannexin1 channels and P2Y1 receptors. Isolated human islets

In intact INS-1 cells stimulated with methyl succinate, the blunted in- sulin secretion correlated with an inhibited increase in [Ca 21 ] m upon a second exposure.. In contrast,

In the pancreatic /3-celi, mitochondrial metaboiism plays a pivotai role in the generation of signais coupling glucose recognition to insulin secretion [11,27,30,35].. Metabolism

Our results show that the defec- tive glucose-induced insulin secretion observed after H 2 O 2 treatment correlates with altered mitochondrial activation seen as a loss of

Irrespective of the glutamate levels measured in glucose- stimulated cells, the principal observation is that glutamate directly stimulates insulin exocytosis in permeabilised cells

F IG. Induction of WT-HNF1␣ and DN-HNF1␣ regulates the HNF1␣ mRNA expression and HNF1␣ promoter luciferase activity through altered HNF4 ␣ binding. A, for EMSA, the

Cells overexpressing GAD follow- ing AdCA-GAD65 infection and stimulation with high glucose could therefore theoretically release significant amounts of GABA with a possible

Comparision of Redox Conditions in Ad-GlpK-treated Cells Incubated with Glucose, Glycerol, DHA, or Pyruvate—In INS1-E cells with glycerol kinase expression, both DHA and