Relation between aluminum concentrations in drinking water and Alzheimer's disease: an 8-year follow-up study.
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(20) HAL author manuscript. ½À CKHs^J]D4±½JD4JHIf]Jrµ#CEs^¢ \GMhfCKPRWIPpHINÌ¿ODGMR±½J]\G\GCEM>H<PRWOWKCE±½J Ã5fD4CEsGJDGCKP±½M>D NIJ][ÌJ]H²sGC¾P:PRf]fM>D4NICKHIF sGM%s^¢IJeU<O¡aiÜ4ÜGÜciäL:Ïóù=>nJf]M>HINmTÍ\4QIÇhÈ4Jfls^\¿VMR\GCEsGCE¯RJ.±½M>DsG¢IJ\4JefD4CEs^J]DGCKP̵ZJ]DGJeJuÑIPp[¶i CEHIJN(Ǻ(PÐ\GJ]HICKMRD HOJQID4M>WKM>FRCK\4seµ#¢OMfMRHOÙ<DG[ JNÿs^¢OJNICKPRF>HIMR\GCK\¶PpHIN/PR¿O¿IWKCEJNßs^¢IJ ?$@Ü ?X¹<U ²i ·UL$U$·yùGôfDGC»s^J]DGC¾P:±½M>DZ·U PRHIN%sG¢IJ:_PRfw¢OCKHI\4´hCV\Gf]M>DGJ±½M>D¯pPR\Gf]QIW¾PRDZNIJli [ JHs^CKPRùùs^MaNIMhfQI[ JHs:s^¢OJ NOC¾PRF>HOM>\GCE\MR±ZNOJ[ JHs^CKP PpHINÐC»s^\Jls^CKMRWKM>FRBº A¿ODGM>Ç<PpÇIWKJ M>Dr¿@M>\4\GCKÇOWKJ·U M>DrMRsG¢IJDrsºh¿@JMp±NIJ][ÌJ]H²sGC¾POÏ. inserm-00138528, version 1. / è % 1ï 0í è,ì32yèDC ) ì@ï10í è ·\4¿VJ]fCEÙIf%\4sGQINOº/Àá·-EY¡·ÃµZPR\\4s^PRD4sGJNßCEH/£Õ>Õ>¥as^M,JuÑOPR[ÌCEHIJÌsG¢IJ%D4JW¾PÛs^CKMRHni. \4¢ICK¿ÊÇ@J]sµ JJ]H(PRWKQI[ CKH²QI[æCEHÊNID4CKHI´²CKHOFµZPps^J]DePRHINÊ·yWK¼]¢IJCE[ÌJ]Dòó\UCK\4J PR\4J̱½M>Ds^¢IJ Á5PRg²QICKN \GQOÇhÈ4Jfls^\϶·$±s^JDCEH¯>J\ks^CEFPps^CEM>HMR±s^¢IJµZPpsGJD:NICK\ks^D4CKÇIQOsGCKM>HAHIJ]sµ M>DG´ÚTs^¢IJ \GPR[Ì¿OWKJ:µ¹PR\yNICE¯hCENIJNCKHs^M%ÅRÖÌNID4CKHI´²CEHIF̵ZPps^J]DPRD4J PR\]Ïy®¹µ M*\GQOD4¯>Jlºh\µZJ]DGJfPRDGD4CKJN M>QnsCKHë£Õ>ÕO£Ìs^M,[ J PR\4QIDGJÌ¿<_PRHONÊfM>HOfJHsGD^PpsGCKM>HI\ MR±$PRWKQO[ÌCEHhQO[Tf PpWKfCEQI[ T!PRHON F QOM>DGCEHIJÌCEHJPRfw¢µZPps^J]D \GQO¿I¿IWEºRT PRHINÐs^MA\ks^QINnºÐsG¢IJ̯pPRD4C¾PRÇICEWKC»sºAMR±Zs^¢IJÌ[ÌJPR\GQID4Jli [ JHs^\]Ï ®r¢IJ\4J:N<PpswP µ JD4J:NIJ\4fDGCEÇVJ]NaCKH*NIJlswPRCEWǺad>PRf]g²[ÌCEH%J]s R Ï ôáü ®r¢OJHPRWKWÚs^¢IJ D4J\GQOWEs^\MR±¹sG¢IJ fw¢IJ[ CKfPRWPRH<PRW»ºn\4J\.MR±¹NID4CKHI´²CEHIF µZPpsGJD*À½CKHIf]WKQINOCKHIFa\GCEWKCEf PÃfPRDGD4CKJN M>QnseǺs^¢OJ%\^PRHOCEswPpD4ºPRNI[ CKHICE\4s^DGPps^CEM>HÎÇVJlsµZJ]JH¨£Õ>ÕO£*PpHINþ£Õ>ÕRÝ,µ JD4J*fM>WEWKJ]f]s^J]NmÏ ®r¢IJ]DGJl±½M>DGJpT±½M>D JPRfw¢ßNIDGCEHI´²CKHIF µ¹PÛs^JD PRDGJPOT!µ J%fMR[Ì¿IQns^JNÿPaµZJ]CKF>¢sGJNß[ J PRHÊMp± PRWEWs^¢OJ.[ J PR\4QIDGJ]\MR±!J PRfw¢NIDGCEHI´²CKHIFeµZPps^J]Df]M>[Ì¿@M>HIJ]Hs Ïó®r¢IJµ JCEF>¢s^CEHIF sGMnMR´%CKHs^M Ë.
(21) HAL author manuscript. PRf]fM>QOH²s!s^¢IJrWEJHIFRsG¢MR±<sG¢IJr¿VJ]DGCEMnNMp±ÚQI\GJrMR±ÚJPRfw¢eµ¹PÛs^JD!\GQI¿I¿OWEºM¯RJDs^¢OJ¹¿IDGJl¯hCKM>QI\ £¥º>JPRDG\Àk£ÕRÖO£]iw£ Õ>ÕO£ Ã!PpHIN sG¢IJ$DGJWKPps^C»¯>J#fMRH²sGDGCEÇIQOs^CEM>H¶MR±mJPRfw¢×µZPps^J]D \4QI¿I¿IW»º>Ï ®r¢IJ ¿ID4J\4JHs\ks^QINnºaCK\rÇ<PR\4JN M>HAÅR¥¶PRDGJPR\r±½M>D¹µ#¢ICKfw¢ [ J PR\4QIDGJ][ÌJ]H²sG\rµZJ]DGJ.P¯pPRCEW¾PRÇOWKJRÏ $ 6 % 698áïG698H %(*I% 4 %(* éÍï18Âï. inserm-00138528, version 1. · XZM Ñ׿IDGMR¿VM>Dks^CEM>H<PRW<¢<Pp¼ PRD4N%[ÌMhNIJ]WÚµ#C»s^¢ÌNIJWKPºRJN*J]H²sGD4ºnù= rµ¹PR\Z¿VJ]D4±½M>D4[ÌJ]NÌs^M J]\4s^CE[×PÛs^JD4JW¾PÛs^CE¯RJ DGCE\G´²\ ÀÂL$LÃPpHINsGM$PRNÛÈ4QI\ksY±½MRDmfM¯pPRDGCKPps^J]\ÏY·F>J µZPR\ÍswPR´pJH PR\ms^¢IJ Ç<Pp\GCKf¹sGCK[ Jr\GfPRWKJrCEH¶sG¢IJ$PRH<PRW»ºh\GCK\]T\GM:s^¢<PÛs s^¢IJ#DGCE\G´Mp±NIJ][ÌJ]Hs^C¾PM>D'·U PpsPF>C»¯>J]H PRFRJf]M>QIWENÇ@J.[ MhNIJWEWKJNÏZo<M>Drs^¢OJ PRHIPRWEºh\GJ]\$µ J f]M>HI\4CKNIJ]DGJNM>HIW»º*\GQIDzÈ4Jf]sG\±½DGJ]J.Mp± NIJ][ÌJ]Hs^C¾P Pps¹J]H²sGD4º×CKHs^M sG¢IJfMR¢IM>D4sÏÜH P ¿ID4J]¯hCKM>QO\rPRH<PRW»ºh\GCK\4=ù ¹µZJMRÇI\GJ]D4¯>J]N sG¢<Pps sG¢IJ*¿IDGMR¿VM>Dks^CEM>H<PRW ¢<PR¼ PpDGNI\¶PR\4\GQI[ ¿OsGCKM>HßµZPR\e¯nCEM>W¾PÛs^JNб½M>DeF>JHONIJD]T \4M µ Jafw¢IM>\4J sGMe¿VJ]D4±½M>D4[-P\ks^D^PÛs^CEÙIJNaPRH<PpWEºh\GCE\ÏóJù ×®r¢IJ[ÌPRCEH×DGCE\G´¶±áPRf]sGM>DG\rQOHINIJDZfM>HI\4CKNIJ]D^PpsGCKM>H µ JD4J*PRWKQO[ÌCEHhQO[ PR\PAg²Q<PpH²sGCEs^Pps^C»¯>J̯pPRD4C¾PRÇOWKJ¶M>DPp\PAÇICEH<PRDkºÎ¯pPRD4C¾PRÇOWKJeµ#CEsG¢s^¢IJ sG¢IDGJ]\G¢IM>WENMR±¹¥OÏ»£Ì[ F¿@JD:WECEs^J]D:PRWKD4J PRNnº QI\GJ]NÊCKH ¿ID4J]¯hCKM>QO\ \4sGQINICEJ\KT L PRHON\GCEWKCEf P PR\ PßÇICEH<PRD4ºë¯pPRDGCKPRÇIWKJµ#CEs^¢ £>£RÏã¤>ËÊ[ F²ÞpW¶Às^¢IJ [ JNICKPRHþCKH M>QOD \GPR[ ¿IWKJ Ã×PR\*s^¢IJ f]QOs4i MR°!Ï,ÓÐJaPRNÛÈ4QO\4s^J]Nʱ½M>D¿@MRs^J]Hs^C¾PpW f]M>HO±½M>QIHONIJD4M\ A%J]NIQIf PÛs^CKMRH<PRWWKJ]¯RJW:Àµ#CEsG¢Ê¯n\ µ#C»s^¢IM>Qns Pÿ¿ODGCK[ÌPRDkº \4fw¢IMnMRWNOCK¿IWEM>[×P>ÃlTóùûµ#CKHOJÎf]M>HI\4QI[Ì¿ns^CKMRH7À½HIM>Hni NIDGCEHI´RJ]DG\aM>D [ CKWEN×NID4CKHI´pJDG\r¯h\r[ MnNIJ]D^PpsGJM>Dr¢IJP ¯hº%NIDGCEHI´RJ]DG\wÃäùüPpHINa¿IW¾PRf]JMR±YDGJ]\GCKNOJHIf]J×À½DGQIDGPRW ¯h\QIDGÇ<PpHÚÃlÏÌ·NÛÈ4QI\ks^[ JHs±½M>D:Ç<PR\GJ]WKCEHIJ¶fM>F>HOCEs^C»¯>J¶\4s^Pps^QO\.[ J PR\4QIDGJ]NǺs^¢OJ%¡CEHIC É.
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(28) HAL author manuscript inserm-00138528, version 1. CEHIFN<PRCEWEº[ CKHIJ]D^PRW²µ¹PÛs^JD'Pp\HIM>Hni JlÑn¿@M>\GJ]NmñhsG¢IJrJ]°VJfls'MR±VPRWKQO[ÌCEHhQO[ \4s^CEWKWhDGJ][×PRCEHIJN QIHOfw¢<PRHIF>J]N¨PRHINþµ¹Pp\*\4s^CEWKW#\GCEF>HIC»Ù<f PRHsGWEºëPR\G\4Mnf]C¾PpsGJN/µ#C»s^¢þNIJ][ÌJ]H²sGC¾P ÀáLyL?ÄOÏÔÄO£>T ¿Úâ¥OÏÔ¥RݲÃuÏ nJl¯>JDGPRWCKH¯>J]\4sGCKFPpsGM>DG\r¢IP¯RJ.NOJ\Gf]DGCEÇVJ]N sG¢<Ppsrs^¢OJ¿I_ Mp±!NID4CKHI´²CEHIFµ¹PÛs^JD#f]M>QIWKN Pp°VJflss^¢IJ¶\4M>WKQIÇOCKWKC»sº MR±¹PpWKQI[ CKHICEQI[eifMR[Ì¿@M>HIJ]H²sG\ñó=ù :CEsCE\¿IW¾PRQO\GCKÇOWKJ sG¢<Ppss^¢OJ ÇOC»i M>WEM>F>CEf PRWP ¯pPRCKWKPRÇICEWKCEsº×MR± PRWKQO[ÌCEHICKQI[-CK\¢OCKF>¢IJ]D±½M>DyWKMµ s^¢<PpH,±½M>D¢ICEF>¢,¿<_TVµ#¢ICEfw¢ [ J PRHO\'sG¢<Pps¢ICEF>¢Ì¿I_ µ M>QIWENÌÇ@JPp\G\GMhfCKPps^J]N µ#C»s^¢ WKMµ/f]M>HIf]JHs^DGPps^CEM>HI\MR±mÇICEMP ¯pPRCKW i PRÇOWKJrPRWEQI[ CKHICEQI[Ï®r¢IJ\4JyD4J\GQOWEs^\5µZJ]DGJ#HIMRs f]M>HOÙ<D4[ÌJ]N¶CKHeM>QID!\4s^QONOº@ñnHIJl¯>J]D4s^¢OJWKJ]\G\]T Õ>ÖnÏãtÅ sØMR±Ys^¢IJ:[ J PR\4QIDGJ]\$Mp±¿<_¸µ JD4J.¢ICEF>¢IJ]D¹s^¢<PRHAÅaÀáDGPRHIF>]J A ÉnÏÆÄO£liäÖOÏóÝ>ݲÃuÏ nQIDk±áPRfJ#µZPps^J]DG\ÀáW¾Pp´RJ\M>D'DGC»¯>J]DG\wÃ'PRD4J$Mp±s^JH¶s^D4J PpsGJN µ#CEs^¢ÌPRWEQI[ÌCEH²QI[ \4QIWK¿O¢<Pps^J sGMCEHINIQIf]J F Mnf]QIW¾PÛs^CKMRH¶PRHIN DGJ[ M¯>J#M>D4FPRHICEf#PRHIN MRs^¢IJ]D'fM>HswPp[ÌCEH<PRHs^\]Ï!ÜHINIJ]JNmThCKH sG¢IJy¿IPRDGCE\G¢IJ]\ZCKH¶s^¢OCK\\4s^QONOº>Ths^¢IJ$[ÌJ]NIC¾PpHÌMR±ÍPRWKQI[ CKH²QI[ fM>HOfJHsGD^PpsGCKM>H µ¹PR\ ¢ICKFR¢IJD CEH \4QID4±áPpfJµ¹PÛs^JD4\yf]M>[ ¿<PRDGJ]N*µ#CEs^¢aQIHONIJD4F>DGM>QOHINµZPps^J]DG\ ÀÂ¥OÏÔ¥¤RÄ ¯h\y¥OÏÔ¥>¥>Ée[ÌFÞpWÃuÏ _$M µ J]¯RJD]THIMÌJWKJl¯pPps^J]NACKHOfCKNOJHIf]J.MR±!NIJ[ JHsGC¾P µZPR\$±½M>QIHINa±½M>D$\GQIÇhÈ4J]f]sG\WKC»¯nCEHIFeCKH PRD4J PR\#\4QI¿I¿IWECKJNaǺ*\4QID4±áPRf]JµZPpsGJDG\]Ï nCEF>HICEÙIf PRHsyPR[ M>QIHs^\#MR±PRWKQI[ CKHOCKQI[³[×P ºaPpWK\GM Ç@J.\4QI¿I¿IWECKJNa±½DGMR[ PRWKQO[ÌCEHICKQI[ f]MnM>´²CEHIFÐQO\4s^J]HI\GCEWK\]Ï/ÓJ¿VJ]D4±½M>D4[ÌJ]N PRH PRNINIC»s^CEM>H<PRWrPpH<PRWEºh\4CK\ CKHIf]WKQINICEHIFs^¢IJQI\GJ MR±PpWKQI[ CKHICEQI[f]MnM>´µZPRDGJ¶Pp\PRHJlÑn¿IWKPRH<PpsGM>D4º ¯pPRDGCKPRÇIWEJRT@ÇIQOsHIM*CEH F QIJ]HIfJ M>H,s^¢IJ D4CK\G´ MR±NIJ][ÌJ]Hs^C¾PʵZPR\ M>ÇI\GJ]D4¯RJN³ÀÂ_yL £>ÏÔ¥RÝIT¿<â:¥nÏÆÖ>ÉnTDGJ]\GQIW»s^\aÇ<PR\4JN¸MRH £>TÆËRÖ>É £Ä.
(29) HAL author manuscript inserm-00138528, version 1. ¿<PpD4s^CEfCE¿<PRHs^\¹µ#¢IM ¢<PRN PRHO\4µ JDGJ]NAs^¢OCK\rg²QIJ\ks^CEM>HAPÛsrs^¢IJÄÛicº>J PpD#±½MRWKWKMµ¹i QI¿ÚÃlÏ u QIDeDGJ]\GQIW»s^\ef]M>HOÙ<D4[ s^¢IJ*\4CKF>HOCEÙ<fPRHs¶PR\G\4Mnf]C¾PpsGCKM>HMR±·Uµ#CEs^¢ÿJuÑO¿@M>\4QIDGJ*s^M PRWEQI[ CKH²QI[ ¿ID4J]¯hCKMRQI\GW»ºëD4J¿@M>D4sGJNþCEH J¿OCKNIJ][ÌCEM>WKM>FRCKf PpWZ\4sGQINICEJ\Ï Lv?yJl¯>J]D4s^¢OJWKJ]\G\]T sµ M DGJf]JHs \4sGQINICKJ]\±áPRCKWEJNsGM,Ù<HIN(P,DGJ]W¾PpsGCKM>HO\G¢ICE¿µ#CEsG¢ÿPRWKQI[ CKH²QI[ CEHßNIDGCEHI´²CKHIF µZPps^J]DÏõ ô
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(34) "$ HAL author manuscript. £XZM>D4NIJDO'_.TXOPpQIHINIJ]DG\Ø·¡ÐTX²s^DGC»sGsG[×Pps4s^J]D Ó d1Jls³PRWcÏÊj:J]HIJ÷NIM>\4J?Mp± PR¿@M>WKCE¿VMR¿IDGMRsGJCEHO sºh¿VJÝ×PpWKWKJ]WKJPpHINsG¢IJ.D4CK\4´%MR±·yWK¼]¢IJCE[ÌJ]Dòó\$NOCK\GJPR\GJCKHaWKPps^J M>HI\4J]s#±áPR[ CKWECKJ\]Ïnf]CKJHOfJ £Õ>Õ>ÄOñƤRÉO£hAÆÕ¤h£]iäÕ¤RËnÏ. inserm-00138528, version 1. ¤(¡fMEYPpfw¢IW¾PRHÎULrXÏ·WKQO[ÌCEHICKQI[?PRHON sG¢IJeDGCE\G´ ±½M>D·WE¼¢IJ]CK[ JDòó\NICE\GJPR\GJpÏnO Hni ¯hCKD4M>HI[ J]s^D4CKf]\£Õ>ÕËnñÔÉSAƤRÄ>ÄÛiä¤>Å>ËnÏ Ä(_yQIPRHIF} eT_yJ]DG[ÌPRHΡ,¡ÐT`EÍCEQ dOTo:PpsG\GJ]sGM>\:X¹UT@Ó CKWKWE\¡LToOP ¯>M>Dkº dOÏo?$JQni DGMpÙ<ÇIDGCEWKWKPRD4ºþWEJ\4CKM>HI\ CKH¸JlÑn¿VJ]DGCE[ÌJ]H²s^PRW.PRWKQI[ CKHOCKQI[eiCEHINIQIf]JNþJHOfJ¿O¢<PRWKMR¿<Pps^¢º PRHIN ·yWK¼¢OJCK[ JD]òÔ\×NICK\4J PR\4J\G¢<PRD4JCK[ [QIHIMRDGJ Ppf]s^C»¯hCEsºß±½M>D*Pp[ ºhWKM>CEN ¿ID4JfQODG\GMRD ¿ID4MRs^J]CKHmT ·?Ç@J]s^POT¹PpWK¿I¢<Pߣ]iPRHs^CEfw¢²ºh[ MRs^Dkºh¿I\GCEH PRHON QIÇICEg²QICEsºi¿ODGMRsGJCKHÿf]M>HÛÈ4Qni FPpsGJ\]Ï,öZDGPRCKHaL#J\:£Õ>Õ>ÅnñãÅRÅn£tAƤn£ÄÛiä¤>¤R¥OÏ Ý XZQIfPRDGJ]WKW¾P.XTn¡M>Hs^MRWKCKQÌXTh_yJ]DG[ JHIJ]F>CKWENIM.XëJ]sZPRWÂϲXZ¢IDGMRHICKf$JlÑn¿@M>\GQID4JysGM PRWEQni £Å.
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