Article
Reference
COVID-19 Symptoms: Longitudinal Evolution and Persistence in Outpatient Settings
NEHME, Mayssam, et al. & COVICARE TEAM
Abstract
Background: Coronavirus disease 2019 (COVID-19) has spread, causing a worldwide pandemic, and prolonged effects are emerging (1, 2). The term “long COVID” describes illness in persons who continue to report lasting effects after infection (3, 4). To date, little information exists about outpatient settings in this novel disease where 81% of cases are reportedly on the mild end of the spectrum (5). Informing patients and physicians about COVID-19 symptom evolution may help them recognize the time course of the disease, legitimize patients' concerns, and reassure them when possible. Messages around potentially persisting symptoms could also assist in reinforcing public health measures to avoid the spread of infection. Objective: To describe COVID-19 symptom evolution and persistence in an outpatient setting in Geneva, Switzerland, from day 1 through day 30 to 45 after diagnosis.
NEHME, Mayssam, et al . & COVICARE TEAM. COVID-19 Symptoms: Longitudinal Evolution and Persistence in Outpatient Settings. Annals of Internal Medicine , 2020, vol. 174, no. 5, p.
723-725
DOI : 10.7326/M20-5926 PMID : 33284676
Available at:
http://archive-ouverte.unige.ch/unige:155430
Disclaimer: layout of this document may differ from the published version.
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© 2020 American College of Physicians
Supplementary Material*
Nehme M, Braillard O, Alcoba G, et al. COVID‐19 symptoms: longitudinal evolution and persistence in outpatient settings. Ann Intern Med. 8 December 2020. [Epub ahead of print].
doi:10.7326/M20‐5926
Supplement. Survey Data Collected
* This supplementary material was provided by the authors to give readers further details on their article. The material was reviewed but not copyedited.
Supplement. Survey data collected Record ID
Date
Unreachable Yes/No
Date of test Testing center
Hospitalization Yes/No
Date of hospitalization Date of symptoms onset
Risk factors (Yes/No, multiple options possible) Cardiovascular disease Hypertension
Diabetes
Chronic respiratory disease Cancer
Immunosuppression Other chronic disease Pregnancy
Symptoms (Yes/No, multiple options possible) Cough Dyspnea Fever (T >38C) Fatigue
Myalgias, arthralgias Headache
Rhinorrhea Odynodysphagia Anosmia/agueusia Abdominal pain Nausea/vomiting Diarrhea
Other Deteriorating clinical symptom Yes/No
Orientation (only one option possible) Follow-up every 2 days Follow-up every day End of follow-up Reason for end of follow-up (multiple options
possible)
Followed by primary care Physician
Patient’s wish Death
Out of canton Clinical recovery
Lost to follow-up (unreachable for 2 consecutive days)
D30-45 assessment Date of assessment Unreachable
Hospitalization Not hospitalized
Hospitalized for COVID-related reasons Hospitalized for non-COVID-related reasons
Current symptoms Yes/No
List symptoms (Yes/No, multiple options possible) Fatigue
Loss of appetite Myalgias
Arthralgias Back pain Fever > 38C Cough Dyspnea Chest pain Palpitations Headache Paresthesias Anosmia Agueusia
Odynodysphagia Nausea
Vomiting Diarrhea Abdominal pain Rash
Current symptom intensity (one option possible) Mild Moderate Severe
Symptom evolution (one option possible) Never disappeared Recurred
Fluctuates Most predominant symptom (one option possible) Fatigue
Loss of appetite Myalgias Arthralgias Back pain Fever > 38C Cough Dyspnea Chest pain Palpitations Headache Paresthesias Anosmia Agueusia
Odynodysphagia Nausea
Vomiting Diarrhea Abdominal pain Rash
Most worrisome symptom (one option possible) Fatigue
Loss of appetite Myalgias Arthralgias Back pain Fever > 38C Cough Dyspnea Chest pain Palpitations Headache Paresthesias
Anosmia Agueusia
Odynodysphagia Nausea
Vomiting Diarrhea Abdominal pain Rash
If back pain, specify: Few days
Most days All days
If fatigue, specify: Normal activity, no limitations in daily activity
Limited activity but capable to do light work (office work, cleaning)
Limited activity but <50% in bed during the day
>50% in bed, but not bedbound Bedbound
If dyspnea, specify Dyspnea only with strenuous exercise Dyspnea when hurrying or walking up a slight hill
Has to stop for breath when walking at own pace on flat surface
Stops for breath after walking 90 meters or after a few minutes Too breathless to leave house or breathless when dressing
