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Anti-Apolipoprotein A-1 IgG Influences Neutrophil Extracellular Trap Content at Distinct Regions of Human Carotid Plaques

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Anti-Apolipoprotein A-1 IgG Influences Neutrophil Extracellular Trap Content at Distinct Regions of Human Carotid Plaques

DA SILVA, Rafaela, et al.

Abstract

Neutrophils accumulate in atherosclerotic plaques. Neutrophil extracellular traps (NET) were recently identified in experimental atherosclerosis and in complex human lesions. However, not much is known about the NET marker citrullinated histone-3 (H3Cit) expression and functionality in human carotid plaques. Moreover, the association between the proatherosclerotic autoantibody anti-apolipoprotein A-1 (anti-ApoA-1 IgG) and NET has never been investigated.

DA SILVA, Rafaela, et al. Anti-Apolipoprotein A-1 IgG Influences Neutrophil Extracellular Trap Content at Distinct Regions of Human Carotid Plaques. International Journal of Molecular Sciences, 2020, vol. 21, no. 20, p. 7721

PMID : 33086507

DOI : 10.3390/ijms21207721

Available at:

http://archive-ouverte.unige.ch/unige:152603

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Supplemental Figure 1. Estimation of H3Cit maximum distance to neutrophils. (A) Overlay of DAPI (blue), neutrophils labelled with Cy3 (yellow) and H3Cit labelled with Cy5 (red).

Neutrophils boundary is indicated in white. (C) Distance map to the neutrophils (yellow surfaces) expressed in μm is coded from dark purple (the closest) to white (the furthest). (D) H3Cit presence is indicated in white. (E) Relative position of the H3Cit with respect to the distance from the neutrophils (same map than in (C)). (F) Color-coding of each individual H3Cit region based on neutrophil maximum distance within this same region. The H3Cit-neutrophil distance expressed in μm is color-coded from dark purple (the closest) to while (the furthest).

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